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The map label for this gene is rmlA1 [H]

Identifier: 82701400

GI number: 82701400

Start: 288106

End: 288993

Strand: Direct

Name: rmlA1 [H]

Synonym: Nmul_A0266

Alternate gene names: 82701400

Gene position: 288106-288993 (Clockwise)

Preceding gene: 82701399

Following gene: 82701401

Centisome position: 9.05

GC content: 52.03

Gene sequence:

>888_bases
ATGATTCAGCGTAAAGGCATCATTCTTGCCGGCGGCTCCGGCACACGGCTCTATCCGGTGACAAAAGCAGTCTCCAAACA
ACTGCTGCCTATTTACGACAAGCCCATGATCTACTATCCGCTCAGCACATTGATGCTCGCGGGTATTCGCGACATTCTCA
TTATTTCCACTCCCCAGGATACCTCGCGTTTCGAGCAGCTTCTGGGCGATGGGGGCGGTTGGGGCTTGAATCTGCAATAT
GCGGTGCAAAACAGTCCGGATGGGCTCGCTCATGCTTTTATCATTGGCAGGGATTTCATTGGAAGGGATTCAAGCGCGCT
TGTGTTGGGTGATAACATTTTCTATGGTCACGATCTGCATCTGCAATTACAGCGTGCCATGGAAAGACAGGAAGGCGCGA
CGGTCTTTGCCTATCATGTCCAGGATCCGCAGCGCTACGGAGTCGTCGCCTTTGATGCAAATCACCGCGTTTCTTCGCTG
GAAGAAAAACCCGCCCAACCCAAAAGCAACTATGCGGTGACCGGCCTGTATTTCTACGATAATCAGGTAGTGGATATTGC
CAGTGACCTCAAGCCTTCCGCACGCGGCGAGCTGGAAATCACCGATGTCAATCGCACTTATCTCAAACACAATCAACTCA
ATGTGGAAATCATGGGGCGCGGCTATGCCTGGCTGGATACCGGCACGCACGAAAGCCTGATAGAAGCGAGCAACTTCATT
GAAACCATTGAGCATCGTCAGGGGCTCAAAGTGGCCTGTCCGGAAGAGATCGCCTTTCGCCAGGGTTTCATCAGTAGTGA
GCAACTTGAGAAGCTCGCGCAACCTCTGGCCAAGAATGGTTACGGCCAATACTTGAAACGCTTGCTAGAGGAACAGGTGG
TTACATGA

Upstream 100 bases:

>100_bases
GCCTCGATACCGCAAAACTGCAAAGCACATTCGATTTAAGCTTGCCGTCATGGGAGACAGGGGTTGCGCGCATGCTCACC
GAAATTCTCGAGAAACCACT

Downstream 100 bases:

>100_bases
AGGTTATCGCCACCTCTATCCCGGAGGTCATGATAATCGAGCCTAAAGTATTCGGAGATAGTCGCGGATTTTTCTTCGAA
AGCTTCAATCAGGAAAATTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIQRKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTSRFEQLLGDGGGWGLNLQY
AVQNSPDGLAHAFIIGRDFIGRDSSALVLGDNIFYGHDLHLQLQRAMERQEGATVFAYHVQDPQRYGVVAFDANHRVSSL
EEKPAQPKSNYAVTGLYFYDNQVVDIASDLKPSARGELEITDVNRTYLKHNQLNVEIMGRGYAWLDTGTHESLIEASNFI
ETIEHRQGLKVACPEEIAFRQGFISSEQLEKLAQPLAKNGYGQYLKRLLEEQVVT

Sequences:

>Translated_295_residues
MIQRKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTSRFEQLLGDGGGWGLNLQY
AVQNSPDGLAHAFIIGRDFIGRDSSALVLGDNIFYGHDLHLQLQRAMERQEGATVFAYHVQDPQRYGVVAFDANHRVSSL
EEKPAQPKSNYAVTGLYFYDNQVVDIASDLKPSARGELEITDVNRTYLKHNQLNVEIMGRGYAWLDTGTHESLIEASNFI
ETIEHRQGLKVACPEEIAFRQGFISSEQLEKLAQPLAKNGYGQYLKRLLEEQVVT
>Mature_295_residues
MIQRKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTSRFEQLLGDGGGWGLNLQY
AVQNSPDGLAHAFIIGRDFIGRDSSALVLGDNIFYGHDLHLQLQRAMERQEGATVFAYHVQDPQRYGVVAFDANHRVSSL
EEKPAQPKSNYAVTGLYFYDNQVVDIASDLKPSARGELEITDVNRTYLKHNQLNVEIMGRGYAWLDTGTHESLIEASNFI
ETIEHRQGLKVACPEEIAFRQGFISSEQLEKLAQPLAKNGYGQYLKRLLEEQVVT

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=284, Percent_Identity=22.1830985915493, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI11761619, Length=284, Percent_Identity=22.1830985915493, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788351, Length=291, Percent_Identity=76.6323024054983, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=64.9122807017544, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931050, Length=192, Percent_Identity=26.0416666666667, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=193, Percent_Identity=28.4974093264249, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355443, Length=191, Percent_Identity=25.6544502617801, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24644084, Length=191, Percent_Identity=25.6544502617801, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32990; Mature: 32990

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQRKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQD
CCCCCCEEEECCCCCEEEEEHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCC
TSRFEQLLGDGGGWGLNLQYAVQNSPDGLAHAFIIGRDFIGRDSSALVLGDNIFYGHDLH
HHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEECHHCCCCCCEEEEECCEEECCCHH
LQLQRAMERQEGATVFAYHVQDPQRYGVVAFDANHRVSSLEEKPAQPKSNYAVTGLYFYD
HHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEC
NQVVDIASDLKPSARGELEITDVNRTYLKHNQLNVEIMGRGYAWLDTGTHESLIEASNFI
CEEEEHHHHCCCCCCCCEEEEECCHHEEECCCEEEEEEECCEEEEECCCHHHHHHHHHHH
ETIEHRQGLKVACPEEIAFRQGFISSEQLEKLAQPLAKNGYGQYLKRLLEEQVVT
HHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIQRKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQD
CCCCCCEEEECCCCCEEEEEHHHHHHCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCC
TSRFEQLLGDGGGWGLNLQYAVQNSPDGLAHAFIIGRDFIGRDSSALVLGDNIFYGHDLH
HHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEECHHCCCCCCEEEEECCEEECCCHH
LQLQRAMERQEGATVFAYHVQDPQRYGVVAFDANHRVSSLEEKPAQPKSNYAVTGLYFYD
HHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEC
NQVVDIASDLKPSARGELEITDVNRTYLKHNQLNVEIMGRGYAWLDTGTHESLIEASNFI
CEEEEHHHHCCCCCCCCEEEEECCHHEEECCCEEEEEEECCEEEEECCCHHHHHHHHHHH
ETIEHRQGLKVACPEEIAFRQGFISSEQLEKLAQPLAKNGYGQYLKRLLEEQVVT
HHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]