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The map label for this gene is kbl [C]

Identifier: 82701362

GI number: 82701362

Start: 242379

End: 243566

Strand: Reverse

Name: kbl [C]

Synonym: Nmul_A0228

Alternate gene names: 82701362

Gene position: 243566-242379 (Counterclockwise)

Preceding gene: 82701363

Following gene: 82701360

Centisome position: 7.65

GC content: 55.81

Gene sequence:

>1188_bases
ATGAGTTTGCTAGATAAACTGGATGCCGTGGCGGCAGCGAGAAAAGCCCTGCTGCCTGAGGGTGTTGAGGTTTTTGGAAC
ACCCATAGAAGAAGTTTATTCCTCGACCGAGGCCAGGATCGGGGATCACCGGATATTGTTTCTGGGAACAAATAATTATC
TGGGCCTTACCTTCGCTCAGGAATGCCGGGACGCAGCGCAGGAAGCGATTCACAATGAAGGCACGGGTACAACCGGCTCG
CGCATGGCCAATGGCAGTTACAGCGGCCATCGTGCCCTCGAGCGCGAGTTTGCCGAGTTTTATCAATGCGGGTCCTGCAT
CGTATTTACCACGGGATATCAGGCCAACCTTGCAACCATCTCAGGGCTGGCCGGGGCCGGCGACATCGTTCTTATCGATG
GCGATTCCCACGCAAGCATCTACGATGGTTGCCGTTTGAGCGGCGCCGAAATAATCCGCTTCAGACACAACGATGCGGCC
GATCTGGAGAAGCGTCTCCGCCGCCTGGGAGAAAGATCGCGCTCCACCCTCATCATTGCCGAGGGCATCTACAGTATGCT
GGGAGACCGCGCGCCGCTGGCGGATATCGTCAAGGTAAAGGATGCGTATAACAGCACGCTTCTTCTTGATGAAGCGCATT
CCCTGGGGGTACTGGGTGAGACCGGACAGGGTCTGGTAGAAGAAACAGGCCTCCTCGATAGAGTAGACTTCATCACAGGC
ACCTTCAGTAAAAGCTTGGGGGGGATCGGCGGCTACTGTGTGAGCAATCATCCGCAACTGGATCAGTTGCGCTATGTGAG
CCGGCCTTATATTTTCACTGCGTCGCCTACGCCTGCCACCATCGCCTCAACCCGTGCAGCTCTCAAGCTGCTGAGGGAGG
GGGTCGAATTACGCCGACAGCTCTGGAAGAATGTGCACCAGCTCTACTCGCAACTCAAGGAACTGGGTTATCGCCTGGGA
CCGGAACCCAGCCCTGTTATCGCAACAATCCTTGAAACGCCGCAACAGGCGCTGGCACTGTGGAAAGGACTGCTTGAACA
GGGTATCTATGTGAATCTGGTCTTGCCGCCCGCAACGCCGGAGGGCAATTCGCTGGTGCGTTGCAGTGTAAGTGCCGTTC
ATACCAGCGAGCAGATGGATCATGTCGGCAAAACTTTCGCCATGTTGCGCGAGACTATTTTCCAGTAA

Upstream 100 bases:

>100_bases
AGGACGAGTTCGACATTTCCGTACCGATCAATGCTCTTGCGGATGTACAGACCGTTCATGAGCTCGCCAACTTGATCTAC
CGAATAAAGTCTCAAAAACA

Downstream 100 bases:

>100_bases
GGACCTTTCGTTTTTCAGGCGCATTCGCATTGAAAGCCGGCCTGAAAGGAAGATCTCGTCCTTACTATCCTACCTTACAC
CGCCCCCCACGTTAATCACC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSLLDKLDAVAAARKALLPEGVEVFGTPIEEVYSSTEARIGDHRILFLGTNNYLGLTFAQECRDAAQEAIHNEGTGTTGS
RMANGSYSGHRALEREFAEFYQCGSCIVFTTGYQANLATISGLAGAGDIVLIDGDSHASIYDGCRLSGAEIIRFRHNDAA
DLEKRLRRLGERSRSTLIIAEGIYSMLGDRAPLADIVKVKDAYNSTLLLDEAHSLGVLGETGQGLVEETGLLDRVDFITG
TFSKSLGGIGGYCVSNHPQLDQLRYVSRPYIFTASPTPATIASTRAALKLLREGVELRRQLWKNVHQLYSQLKELGYRLG
PEPSPVIATILETPQQALALWKGLLEQGIYVNLVLPPATPEGNSLVRCSVSAVHTSEQMDHVGKTFAMLRETIFQ

Sequences:

>Translated_395_residues
MSLLDKLDAVAAARKALLPEGVEVFGTPIEEVYSSTEARIGDHRILFLGTNNYLGLTFAQECRDAAQEAIHNEGTGTTGS
RMANGSYSGHRALEREFAEFYQCGSCIVFTTGYQANLATISGLAGAGDIVLIDGDSHASIYDGCRLSGAEIIRFRHNDAA
DLEKRLRRLGERSRSTLIIAEGIYSMLGDRAPLADIVKVKDAYNSTLLLDEAHSLGVLGETGQGLVEETGLLDRVDFITG
TFSKSLGGIGGYCVSNHPQLDQLRYVSRPYIFTASPTPATIASTRAALKLLREGVELRRQLWKNVHQLYSQLKELGYRLG
PEPSPVIATILETPQQALALWKGLLEQGIYVNLVLPPATPEGNSLVRCSVSAVHTSEQMDHVGKTFAMLRETIFQ
>Mature_394_residues
SLLDKLDAVAAARKALLPEGVEVFGTPIEEVYSSTEARIGDHRILFLGTNNYLGLTFAQECRDAAQEAIHNEGTGTTGSR
MANGSYSGHRALEREFAEFYQCGSCIVFTTGYQANLATISGLAGAGDIVLIDGDSHASIYDGCRLSGAEIIRFRHNDAAD
LEKRLRRLGERSRSTLIIAEGIYSMLGDRAPLADIVKVKDAYNSTLLLDEAHSLGVLGETGQGLVEETGLLDRVDFITGT
FSKSLGGIGGYCVSNHPQLDQLRYVSRPYIFTASPTPATIASTRAALKLLREGVELRRQLWKNVHQLYSQLKELGYRLGP
EPSPVIATILETPQQALALWKGLLEQGIYVNLVLPPATPEGNSLVRCSVSAVHTSEQMDHVGKTFAMLRETIFQ

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=343, Percent_Identity=34.1107871720117, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI284448556, Length=343, Percent_Identity=34.1107871720117, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4758668, Length=355, Percent_Identity=35.2112676056338, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI119220554, Length=355, Percent_Identity=34.3661971830986, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI83977444, Length=350, Percent_Identity=31.4285714285714, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI83977442, Length=350, Percent_Identity=31.4285714285714, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI83977440, Length=350, Percent_Identity=31.4285714285714, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI4502025, Length=359, Percent_Identity=28.4122562674095, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI40316939, Length=359, Percent_Identity=28.4122562674095, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI5454084, Length=370, Percent_Identity=27.8378378378378, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1790046, Length=348, Percent_Identity=34.7701149425287, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1786993, Length=345, Percent_Identity=30.7246376811594, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71994529, Length=351, Percent_Identity=34.7578347578348, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=367, Percent_Identity=33.5149863760218, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=364, Percent_Identity=32.1428571428571, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17560914, Length=364, Percent_Identity=32.1428571428571, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71982617, Length=269, Percent_Identity=26.0223048327138, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982625, Length=269, Percent_Identity=26.0223048327138, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320267, Length=354, Percent_Identity=33.6158192090396, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320438, Length=362, Percent_Identity=28.4530386740331, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=301, Percent_Identity=27.5747508305648, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24662918, Length=346, Percent_Identity=32.3699421965318, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137420, Length=336, Percent_Identity=31.547619047619, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI17136286, Length=355, Percent_Identity=32.3943661971831, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24653280, Length=311, Percent_Identity=30.8681672025724, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24653276, Length=311, Percent_Identity=30.8681672025724, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24653278, Length=311, Percent_Identity=30.8681672025724, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42975; Mature: 42844

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLDKLDAVAAARKALLPEGVEVFGTPIEEVYSSTEARIGDHRILFLGTNNYLGLTFAQ
CCHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCHHHCCCCEEEEEEECCCEEEEHHHH
ECRDAAQEAIHNEGTGTTGSRMANGSYSGHRALEREFAEFYQCGSCIVFTTGYQANLATI
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
SGLAGAGDIVLIDGDSHASIYDGCRLSGAEIIRFRHNDAADLEKRLRRLGERSRSTLIIA
HCCCCCCCEEEEECCCCCCHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEH
EGIYSMLGDRAPLADIVKVKDAYNSTLLLDEAHSLGVLGETGQGLVEETGLLDRVDFITG
HHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHH
TFSKSLGGIGGYCVSNHPQLDQLRYVSRPYIFTASPTPATIASTRAALKLLREGVELRRQ
HHHHHHCCCCCEECCCCCCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
LWKNVHQLYSQLKELGYRLGPEPSPVIATILETPQQALALWKGLLEQGIYVNLVLPPATP
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEECCCCC
EGNSLVRCSVSAVHTSEQMDHVGKTFAMLRETIFQ
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLLDKLDAVAAARKALLPEGVEVFGTPIEEVYSSTEARIGDHRILFLGTNNYLGLTFAQ
CHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCHHHCCCCEEEEEEECCCEEEEHHHH
ECRDAAQEAIHNEGTGTTGSRMANGSYSGHRALEREFAEFYQCGSCIVFTTGYQANLATI
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
SGLAGAGDIVLIDGDSHASIYDGCRLSGAEIIRFRHNDAADLEKRLRRLGERSRSTLIIA
HCCCCCCCEEEEECCCCCCHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEH
EGIYSMLGDRAPLADIVKVKDAYNSTLLLDEAHSLGVLGETGQGLVEETGLLDRVDFITG
HHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHH
TFSKSLGGIGGYCVSNHPQLDQLRYVSRPYIFTASPTPATIASTRAALKLLREGVELRRQ
HHHHHHCCCCCEECCCCCCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
LWKNVHQLYSQLKELGYRLGPEPSPVIATILETPQQALALWKGLLEQGIYVNLVLPPATP
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEECCCCC
EGNSLVRCSVSAVHTSEQMDHVGKTFAMLRETIFQ
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA