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The map label for this gene is ctaB

Identifier: 82701325

GI number: 82701325

Start: 200970

End: 201866

Strand: Direct

Name: ctaB

Synonym: Nmul_A0191

Alternate gene names: 82701325

Gene position: 200970-201866 (Clockwise)

Preceding gene: 82701324

Following gene: 82701326

Centisome position: 6.31

GC content: 53.62

Gene sequence:

>897_bases
ATGGCTACAACGAGTATTGCTTGGCAGCAAACTGCTTCGCGTGTGCAGCAGTTTTACCGGTTAACCAAGCCGCGAGTTGT
ATCGCTTATTGTTTTTACGGCCGTTATAGGCATGTTTCTGTCCGTTCCGGGCGTTGTACCCCTGGATACGCTCATTTTTG
CTACGGTGGGGATAGCGTTCGTTGCGGGAGCTGCTGCAGCTGTCAATTGCCTTGTCGAGCAGAAAATCGATGCTGTCATG
GCCCGCACGCGGGGGCGTCCGCTCCCCCGCGGTACCGTTACCTCGCCTGAAACCTTTGTGTTCCTGGCGCTTGTTGGCGG
CGCGGGTCTGCTGATACTGCATCAACTGGTCAATCCGCTGACCATGTGGCTCACGCTTGGAACCTTTGTCGGCTATGCGA
TCATCTACACTGTGATCTTGAAGCCGATGACCCCGCAAAATATCGTCATAGGCGGCGCTTCCGGAGCAATGCCACCAGTT
CTGGGTTGGGCAGCGGTAACGGGCGAAGTGTCGGCTGACGCTCTGCTTTTATTTCTGATTATTTTCGCCTGGACGCCGCC
CCACTTCTGGGCGCTTGCACTCTATCGCAAACTTGAATATGCAAAGGTTGGGATGCCGATGCTGCCGGTAACCCACGGCG
ACAAATTTACGCGCCTGCATGTTCTGCTGTACACACTGATACTCATCGCGGTGACATTGATGCCTTATGCCACTCAGATG
AGTGGGCTTATCTATCTGGCCGGCGCGATAGTGCTGGATGTGATATTTTTATACTATGCAGTAAAAATCTACCTCAACTA
CAGCGACCAGCTGGCCCGCAGCGCGTTTCGCTACTCGATCCTTTATCTGGCAGGATTGTTCGCGGTGCTCCTGGTAGACC
ATTACATACGTTTCTAA

Upstream 100 bases:

>100_bases
TGAGCAGCGGGGGCTGCTCTTGCATATAGACCAGTCGTGATTCACATTGATTTGTCGAAACGCCGGGCACCGAGCCCGCG
ATAATAGGAGACGAAACGTT

Downstream 100 bases:

>100_bases
GGGACATGCGTGAGGCATCGACCGCACTATTACAGACTTGTAGTATGGATAGCAGCGGCGCTACTGACGGCCCCGCTCCT
TTCGGCCTGTAGCAAGACAG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MATTSIAWQQTASRVQQFYRLTKPRVVSLIVFTAVIGMFLSVPGVVPLDTLIFATVGIAFVAGAAAAVNCLVEQKIDAVM
ARTRGRPLPRGTVTSPETFVFLALVGGAGLLILHQLVNPLTMWLTLGTFVGYAIIYTVILKPMTPQNIVIGGASGAMPPV
LGWAAVTGEVSADALLLFLIIFAWTPPHFWALALYRKLEYAKVGMPMLPVTHGDKFTRLHVLLYTLILIAVTLMPYATQM
SGLIYLAGAIVLDVIFLYYAVKIYLNYSDQLARSAFRYSILYLAGLFAVLLVDHYIRF

Sequences:

>Translated_298_residues
MATTSIAWQQTASRVQQFYRLTKPRVVSLIVFTAVIGMFLSVPGVVPLDTLIFATVGIAFVAGAAAAVNCLVEQKIDAVM
ARTRGRPLPRGTVTSPETFVFLALVGGAGLLILHQLVNPLTMWLTLGTFVGYAIIYTVILKPMTPQNIVIGGASGAMPPV
LGWAAVTGEVSADALLLFLIIFAWTPPHFWALALYRKLEYAKVGMPMLPVTHGDKFTRLHVLLYTLILIAVTLMPYATQM
SGLIYLAGAIVLDVIFLYYAVKIYLNYSDQLARSAFRYSILYLAGLFAVLLVDHYIRF
>Mature_297_residues
ATTSIAWQQTASRVQQFYRLTKPRVVSLIVFTAVIGMFLSVPGVVPLDTLIFATVGIAFVAGAAAAVNCLVEQKIDAVMA
RTRGRPLPRGTVTSPETFVFLALVGGAGLLILHQLVNPLTMWLTLGTFVGYAIIYTVILKPMTPQNIVIGGASGAMPPVL
GWAAVTGEVSADALLLFLIIFAWTPPHFWALALYRKLEYAKVGMPMLPVTHGDKFTRLHVLLYTLILIAVTLMPYATQMS
GLIYLAGAIVLDVIFLYYAVKIYLNYSDQLARSAFRYSILYLAGLFAVLLVDHYIRF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=193, Percent_Identity=36.2694300518135, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=31.5412186379928, Blast_Score=145, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71998235, Length=292, Percent_Identity=28.7671232876712, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325085, Length=276, Percent_Identity=28.6231884057971, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921064, Length=280, Percent_Identity=30, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_NITMU (Q2YCM2)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_410891.1
- STRING:   Q2YCM2
- GeneID:   3785864
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0191
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- PhylomeDB:   Q2YCM2
- ProtClustDB:   PRK04375
- BioCyc:   NMUL323848:NMUL_A0191-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32607; Mature: 32475

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfc207e0)-; HASH(0x10c3717c)-; HASH(0x10c2d2c8)-; HASH(0x10c3b0c4)-; HASH(0x107ab304)-; HASH(0x10a92fe0)-; HASH(0x119d3b78)-; HASH(0x10c4f308)-; HASH(0x119cd82c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTSIAWQQTASRVQQFYRLTKPRVVSLIVFTAVIGMFLSVPGVVPLDTLIFATVGIAF
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VAGAAAAVNCLVEQKIDAVMARTRGRPLPRGTVTSPETFVFLALVGGAGLLILHQLVNPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHH
TMWLTLGTFVGYAIIYTVILKPMTPQNIVIGGASGAMPPVLGWAAVTGEVSADALLLFLI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHH
IFAWTPPHFWALALYRKLEYAKVGMPMLPVTHGDKFTRLHVLLYTLILIAVTLMPYATQM
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLIYLAGAIVLDVIFLYYAVKIYLNYSDQLARSAFRYSILYLAGLFAVLLVDHYIRF
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
ATTSIAWQQTASRVQQFYRLTKPRVVSLIVFTAVIGMFLSVPGVVPLDTLIFATVGIAF
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VAGAAAAVNCLVEQKIDAVMARTRGRPLPRGTVTSPETFVFLALVGGAGLLILHQLVNPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHH
TMWLTLGTFVGYAIIYTVILKPMTPQNIVIGGASGAMPPVLGWAAVTGEVSADALLLFLI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHH
IFAWTPPHFWALALYRKLEYAKVGMPMLPVTHGDKFTRLHVLLYTLILIAVTLMPYATQM
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLIYLAGAIVLDVIFLYYAVKIYLNYSDQLARSAFRYSILYLAGLFAVLLVDHYIRF
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA