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The map label for this gene is pepP [H]

Identifier: 82701263

GI number: 82701263

Start: 133190

End: 134512

Strand: Direct

Name: pepP [H]

Synonym: Nmul_A0128

Alternate gene names: 82701263

Gene position: 133190-134512 (Clockwise)

Preceding gene: 82701262

Following gene: 82701264

Centisome position: 4.18

GC content: 56.99

Gene sequence:

>1323_bases
ATGACCCCCGTTAAATCCTTCGCCGATCGTCGCCACTCCCTGGCATGGCAAATGCAGGAAGGCGTTGCCATCATTCCCAC
TGCCCCTGAGCACCTGCGGAACCGGGATGCGCATTATCCTTACCGTTTCGACAGCTATTTCTATTATCTGACGGGCTTTA
CCGAGCCGGAGGCAGTGCTGGTGATCGTAGCCGGGCCCGTGGATGGGGTATCGAAACACATCCTGTTTTGCCGGGAGAAA
AATGCCGAGCGAGAGATATGGGATGGGTACCGTTATGGCCCCGAAGCGGCCCGGGAAGCGTTCGGGTTCGACGAGGCCTA
TTCCATCTCTGCACTGGATGAGCAGTTGCCCAAGCTGATTGCGGGACAACCGGCAATCTATTACTCGCTGGGTCACGACG
CGGCCTGGGACAGGCGGGTAGTGGGGTGGATCAATGAAGTGCGGCAACAGGTGCGCAGCGGCCTTACTCCCCCCGAGGAC
ATTCGCGATATTCGCCGGCTGCTGGACGAGATGCGTTTGTTCAAAAGCCCGGAAGAGCTGCAGGTTATGCGCCAGGCGGC
ACGGATTTCGGCGGGTGCGCATCAGCACGTCATGCGGAAAACTCGCGTTGGCATGAGGGAGTATGAAGTGGAGGCGGAAC
TGCTGCGCGAATTCCGCCGCCACGGAGCTCAAGCGCCGGCTTACACCCTGATTGTTGCCGGGGGAGCGAACGCTTGCGTG
CTTCATTATGTCGAAAACAAGGACAGGCTGAATGAAGGCGAATTGTTGCTGATCGACGCAGGCTGCGAACTGGACGGCTA
TGCATCTGATATCACGCGTACCTTTCCGGTCAACGGAAAATTCAGTGCGGCACAAAAGGATTTGTACGAACTGGTGTTAT
ATGCCCAGGCGGCGGCGATAGCCGAGGTAAGGCCCGGTAATTCCTGGGACGCTCCGCACAATGCAGCCATTGCCGTACTC
TCGCAGGGCTTCATTGAATACGGTCTGTGCCGCGGCAGCCTGGAGGAGGTAGTGGAAACGGAAGGCTACAAGCGTTTCTA
TATGCACCGCACCGGTCATTGGCTGGGGTTGGACGTGCATGACGCCGGGGAATACAAGCAGAATGGAAGATGGCGCGCTT
TACTCCCGGGAATGACCCTGACAGTGGAACCGGGGTGTTACATCCGCCCTGCGGATGATGTACCCGCCCATTTTCATAAT
ATCGGCATCCGTATCGAAGACGATGTTACGGTAACGGAGGAGGGGTGTGAAGTATTGACGTCAGCTGCTCCAAAGATGGT
GGATGAGATTGAAGAACTGATGCGACGGCGGAAATCGAAATAA

Upstream 100 bases:

>100_bases
ACCTCCCGGCGCTCCGGAATCAGGCGGGAGCGGGATCAGGGAAAAGAATGGGCCGATTTACTTTGCTTTATCATTCAGAT
ACTGTAAAAATGCTTGCTAA

Downstream 100 bases:

>100_bases
TGGATGAAAACCCTCGAATAGTTATCAGACGCATAACCCGCGATGGACGCACGGGAGCGCCGGAAGAGTCCCTCTTCAGA
GCGGGTGGAGGGGGTGGTCG

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MTPVKSFADRRHSLAWQMQEGVAIIPTAPEHLRNRDAHYPYRFDSYFYYLTGFTEPEAVLVIVAGPVDGVSKHILFCREK
NAEREIWDGYRYGPEAAREAFGFDEAYSISALDEQLPKLIAGQPAIYYSLGHDAAWDRRVVGWINEVRQQVRSGLTPPED
IRDIRRLLDEMRLFKSPEELQVMRQAARISAGAHQHVMRKTRVGMREYEVEAELLREFRRHGAQAPAYTLIVAGGANACV
LHYVENKDRLNEGELLLIDAGCELDGYASDITRTFPVNGKFSAAQKDLYELVLYAQAAAIAEVRPGNSWDAPHNAAIAVL
SQGFIEYGLCRGSLEEVVETEGYKRFYMHRTGHWLGLDVHDAGEYKQNGRWRALLPGMTLTVEPGCYIRPADDVPAHFHN
IGIRIEDDVTVTEEGCEVLTSAAPKMVDEIEELMRRRKSK

Sequences:

>Translated_440_residues
MTPVKSFADRRHSLAWQMQEGVAIIPTAPEHLRNRDAHYPYRFDSYFYYLTGFTEPEAVLVIVAGPVDGVSKHILFCREK
NAEREIWDGYRYGPEAAREAFGFDEAYSISALDEQLPKLIAGQPAIYYSLGHDAAWDRRVVGWINEVRQQVRSGLTPPED
IRDIRRLLDEMRLFKSPEELQVMRQAARISAGAHQHVMRKTRVGMREYEVEAELLREFRRHGAQAPAYTLIVAGGANACV
LHYVENKDRLNEGELLLIDAGCELDGYASDITRTFPVNGKFSAAQKDLYELVLYAQAAAIAEVRPGNSWDAPHNAAIAVL
SQGFIEYGLCRGSLEEVVETEGYKRFYMHRTGHWLGLDVHDAGEYKQNGRWRALLPGMTLTVEPGCYIRPADDVPAHFHN
IGIRIEDDVTVTEEGCEVLTSAAPKMVDEIEELMRRRKSK
>Mature_439_residues
TPVKSFADRRHSLAWQMQEGVAIIPTAPEHLRNRDAHYPYRFDSYFYYLTGFTEPEAVLVIVAGPVDGVSKHILFCREKN
AEREIWDGYRYGPEAAREAFGFDEAYSISALDEQLPKLIAGQPAIYYSLGHDAAWDRRVVGWINEVRQQVRSGLTPPEDI
RDIRRLLDEMRLFKSPEELQVMRQAARISAGAHQHVMRKTRVGMREYEVEAELLREFRRHGAQAPAYTLIVAGGANACVL
HYVENKDRLNEGELLLIDAGCELDGYASDITRTFPVNGKFSAAQKDLYELVLYAQAAAIAEVRPGNSWDAPHNAAIAVLS
QGFIEYGLCRGSLEEVVETEGYKRFYMHRTGHWLGLDVHDAGEYKQNGRWRALLPGMTLTVEPGCYIRPADDVPAHFHNI
GIRIEDDVTVTEEGCEVLTSAAPKMVDEIEELMRRRKSK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=448, Percent_Identity=32.8125, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI149589008, Length=478, Percent_Identity=31.7991631799163, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI260593665, Length=299, Percent_Identity=37.7926421404682, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI260593663, Length=486, Percent_Identity=27.5720164609054, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1789275, Length=431, Percent_Identity=45.9396751740139, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1788728, Length=263, Percent_Identity=35.361216730038, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790282, Length=282, Percent_Identity=31.2056737588652, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508215, Length=480, Percent_Identity=31.25, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=369, Percent_Identity=31.1653116531165, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320922, Length=408, Percent_Identity=33.0882352941176, Blast_Score=219, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6321118, Length=434, Percent_Identity=29.9539170506912, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI19920384, Length=407, Percent_Identity=37.8378378378378, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI21357079, Length=451, Percent_Identity=33.9246119733925, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49857; Mature: 49726

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPVKSFADRRHSLAWQMQEGVAIIPTAPEHLRNRDAHYPYRFDSYFYYLTGFTEPEAVL
CCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCCCCCEEECCEEEEEECCCCCCEEE
VIVAGPVDGVSKHILFCREKNAEREIWDGYRYGPEAAREAFGFDEAYSISALDEQLPKLI
EEEECCCCCCHHHEEEEECCCCCHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHH
AGQPAIYYSLGHDAAWDRRVVGWINEVRQQVRSGLTPPEDIRDIRRLLDEMRLFKSPEEL
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHH
QVMRQAARISAGAHQHVMRKTRVGMREYEVEAELLREFRRHGAQAPAYTLIVAGGANACV
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEE
LHYVENKDRLNEGELLLIDAGCELDGYASDITRTFPVNGKFSAAQKDLYELVLYAQAAAI
EEEECCCCCCCCCCEEEEECCCCCCCCHHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHH
AEVRPGNSWDAPHNAAIAVLSQGFIEYGLCRGSLEEVVETEGYKRFYMHRTGHWLGLDVH
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEC
DAGEYKQNGRWRALLPGMTLTVEPGCYIRPADDVPAHFHNIGIRIEDDVTVTEEGCEVLT
CCCCHHHCCCEEEEECCCEEEECCCCEECCCCCCCCHHHHCCEEEECCCEECHHHHHHHH
SAAPKMVDEIEELMRRRKSK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPVKSFADRRHSLAWQMQEGVAIIPTAPEHLRNRDAHYPYRFDSYFYYLTGFTEPEAVL
CCHHHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCCCCCEEECCEEEEEECCCCCCEEE
VIVAGPVDGVSKHILFCREKNAEREIWDGYRYGPEAAREAFGFDEAYSISALDEQLPKLI
EEEECCCCCCHHHEEEEECCCCCHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHH
AGQPAIYYSLGHDAAWDRRVVGWINEVRQQVRSGLTPPEDIRDIRRLLDEMRLFKSPEEL
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHH
QVMRQAARISAGAHQHVMRKTRVGMREYEVEAELLREFRRHGAQAPAYTLIVAGGANACV
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEE
LHYVENKDRLNEGELLLIDAGCELDGYASDITRTFPVNGKFSAAQKDLYELVLYAQAAAI
EEEECCCCCCCCCCEEEEECCCCCCCCHHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHH
AEVRPGNSWDAPHNAAIAVLSQGFIEYGLCRGSLEEVVETEGYKRFYMHRTGHWLGLDVH
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEC
DAGEYKQNGRWRALLPGMTLTVEPGCYIRPADDVPAHFHNIGIRIEDDVTVTEEGCEVLT
CCCCHHHCCCEEEEECCCEEEECCCCEECCCCCCCCHHHHCCEEEECCCEECHHHHHHHH
SAAPKMVDEIEELMRRRKSK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]