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The map label for this gene is speE [H]

Identifier: 82701237

GI number: 82701237

Start: 108092

End: 108877

Strand: Reverse

Name: speE [H]

Synonym: Nmul_A0102

Alternate gene names: 82701237

Gene position: 108877-108092 (Counterclockwise)

Preceding gene: 82701241

Following gene: 82701234

Centisome position: 3.42

GC content: 52.67

Gene sequence:

>786_bases
ATGAATCGATTTCTGAAACGCGGACGGCAGGCAAACGCCAGCAGAAATCCAGCCCTCGCAGACCCGGCACTCGTTCACCT
AAGTGAAGAGTACGGTATCCGCTCACTTCATCTGGGAAGCAGCATGGTCCAGAGCGCAATGCGCATCGCTGCCCCGAATG
AATTGCAGCTTGCCTATACCCAATGCATGATGTGTTTTCTGCTGTTTTGCCCACGACCCAAAAATGTTCTCATGATCGGG
TTGGGAGGGGGCTCGCTGACGAAATTTGTTTACTGGCAACTGCCAACGGTTAATACGACCGTGATCGAAATCAACCCCCA
GGTGGTTGCGGTCGCGCGCAGTCAATTCTATGTGCCGGCTGACGACGAGCGCCTGGAGGTGCTGATCGCGGAAGGCAGTG
AATACATTGCTGCCCATCCAGACAGCACGGACATTCTGATGGTCGATGGTTTCGACGATGGCAGGCAAGTAGCTTCTCTA
TGCACGCAGGCTTTTTATGATCAGGCAAGTGAAGCATTGACGAGAAATGGCGTGCTGGTTGTCAACCTGCTCAGCCGCGA
CGGAAGAGTTCATGAATATCTCGCGCGTCTTGAAAACAGTTTCGCTGGGCGTATAACCACCATACTGGCAGAGCCTTACG
GCAATCTGATCGTGTTCGCTTTCAAGCATGCGCCGACAAGGGCCGCCTGGGAAGAACTGCCAGCAACGGCAAAGATGCTG
GAAAAAGAATTTTCCCTGCCATTCTCAAAGTTCGCTCAAAAACTACCCCATCGCAGACCTTTTTAA

Upstream 100 bases:

>100_bases
TATCCGCCCAATCTAAACCTAGGCCAAAAAGAACAGCTTGTAAAGCTTGTCCGTGGCAACGGCAGAGGCAACAGCAACGG
GATAAGGAAAGGCTCCTTTC

Downstream 100 bases:

>100_bases
ACCTGGATGGCATTTCCTGATCCCCGGAGAGGCATGGATAAAGGACGGTTAAAGCATGGTCGCCATTCTTGATTGGTTGT
AGTGACTGTTAGTGAGTAAT

Product: spermidine synthase

Products: NA

Alternate protein names: Putrescine aminopropyltransferase; PAPT; SPDSY [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MNRFLKRGRQANASRNPALADPALVHLSEEYGIRSLHLGSSMVQSAMRIAAPNELQLAYTQCMMCFLLFCPRPKNVLMIG
LGGGSLTKFVYWQLPTVNTTVIEINPQVVAVARSQFYVPADDERLEVLIAEGSEYIAAHPDSTDILMVDGFDDGRQVASL
CTQAFYDQASEALTRNGVLVVNLLSRDGRVHEYLARLENSFAGRITTILAEPYGNLIVFAFKHAPTRAAWEELPATAKML
EKEFSLPFSKFAQKLPHRRPF

Sequences:

>Translated_261_residues
MNRFLKRGRQANASRNPALADPALVHLSEEYGIRSLHLGSSMVQSAMRIAAPNELQLAYTQCMMCFLLFCPRPKNVLMIG
LGGGSLTKFVYWQLPTVNTTVIEINPQVVAVARSQFYVPADDERLEVLIAEGSEYIAAHPDSTDILMVDGFDDGRQVASL
CTQAFYDQASEALTRNGVLVVNLLSRDGRVHEYLARLENSFAGRITTILAEPYGNLIVFAFKHAPTRAAWEELPATAKML
EKEFSLPFSKFAQKLPHRRPF
>Mature_261_residues
MNRFLKRGRQANASRNPALADPALVHLSEEYGIRSLHLGSSMVQSAMRIAAPNELQLAYTQCMMCFLLFCPRPKNVLMIG
LGGGSLTKFVYWQLPTVNTTVIEINPQVVAVARSQFYVPADDERLEVLIAEGSEYIAAHPDSTDILMVDGFDDGRQVASL
CTQAFYDQASEALTRNGVLVVNLLSRDGRVHEYLARLENSFAGRITTILAEPYGNLIVFAFKHAPTRAAWEELPATAKML
EKEFSLPFSKFAQKLPHRRPF

Specific function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor [H]

COG id: COG0421

COG function: function code E; Spermidine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the spermidine/spermine synthase family [H]

Homologues:

Organism=Homo sapiens, GI42542405, Length=184, Percent_Identity=31.5217391304348, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI42542403, Length=184, Percent_Identity=31.5217391304348, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI55956895, Length=184, Percent_Identity=31.5217391304348, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001045 [H]

Pfam domain/function: PF01564 Spermine_synth [H]

EC number: =2.5.1.16 [H]

Molecular weight: Translated: 29107; Mature: 29107

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFLKRGRQANASRNPALADPALVHLSEEYGIRSLHLGSSMVQSAMRIAAPNELQLAYT
CCHHHHCCCCCCCCCCCCCCCCHHEEEHHHCCCEEEECCHHHHHHHHHHCCCCCHHHHHH
QCMMCFLLFCPRPKNVLMIGLGGGSLTKFVYWQLPTVNTTVIEINPQVVAVARSQFYVPA
HHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEECCCEEEEEECEEECCC
DDERLEVLIAEGSEYIAAHPDSTDILMVDGFDDGRQVASLCTQAFYDQASEALTRNGVLV
CCCEEEEEEECCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
VNLLSRDGRVHEYLARLENSFAGRITTILAEPYGNLIVFAFKHAPTRAAWEELPATAKML
EEEECCCCHHHHHHHHHHHCCCCHHEEEEECCCCCEEEEEEECCCCHHHHHHCCHHHHHH
EKEFSLPFSKFAQKLPHRRPF
HHHHCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRFLKRGRQANASRNPALADPALVHLSEEYGIRSLHLGSSMVQSAMRIAAPNELQLAYT
CCHHHHCCCCCCCCCCCCCCCCHHEEEHHHCCCEEEECCHHHHHHHHHHCCCCCHHHHHH
QCMMCFLLFCPRPKNVLMIGLGGGSLTKFVYWQLPTVNTTVIEINPQVVAVARSQFYVPA
HHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEECCCEEEEEECEEECCC
DDERLEVLIAEGSEYIAAHPDSTDILMVDGFDDGRQVASLCTQAFYDQASEALTRNGVLV
CCCEEEEEEECCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
VNLLSRDGRVHEYLARLENSFAGRITTILAEPYGNLIVFAFKHAPTRAAWEELPATAKML
EEEECCCCHHHHHHHHHHHCCCCHHEEEEECCCCCEEEEEEECCCCHHHHHHCCHHHHHH
EKEFSLPFSKFAQKLPHRRPF
HHHHCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]