BacMap

Definition	Shigella boydii Sb227, complete genome.
Accession	NC_007613
Length	4,519,823

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The map label for this gene is hpaE [H]

Identifier: 82546705

GI number: 82546705

Start: 4464769

End: 4466235

Strand: Reverse

Name: hpaE [H]

Synonym: SBO_4411

Alternate gene names: 82546705

Gene position: 4466235-4464769 (Counterclockwise)

Preceding gene: 82546706

Following gene: 82546704

Centisome position: 98.81

GC content: 58.21

Gene sequence:

>1467_bases
ATGAAAAAAGTAAATCATTGGATCAACGGCAAAAATGTTGCAGGTAACGACTACTTCCAGACCACCAATCCGGCAACGGG
TGAAGTGCTGGCGGATATGGCCTCTGGCGGTGAAGCGGAGATCAATCAGGCGGTAGCGGCAGCGAAAGAGGCGTTCCCGA
AATGGGCCAATCTGCCGATGAAAGAGCGTGCGCGCCTGATGCGCCGTCTGGGCGATCTGATCGACCAGAACGTGCCAGAG
ATCGCCGCGATGGAAACCGCGGACACCGGCCTGCCGATCCATCAGACCAAAAATGTGTTGATCCCACGCGCTTCCCACAA
CTTTGAATTTTTCGCGGAAGTCTGCCAGCAGATGAACGGCAAGACCTATCCGGTTGACGACAAGATGCTCAACTACACGC
TGGTGCAGCCGGTGGGCGTTTGTGCGCTGGTATCGCCGTGGAACGTACCGTTTATGACCGCCACATGGAAGGTCGCGCCG
TGTCTGGCGCTGGGCAATACCGCGGTACTGAAAATGTCGGAACTCTCCCCGCTGACCGCTGACCGCCTGGGTGAGCTGGC
GCTGGAAGCCGGTATTCCGGCAGGCGTGCTGAACGTGGTACAGGGCTACGGCGCAACCGCAGGGGATGCGCTGGTTCGTG
ATCATGACGTACGTGCCGTGTCGTTCACCGGCGGTACGGCCACCGGGCGCAACATCATGAAAAACGCCGGGCTGAAAAAA
TACTCCATGGAACTGGGCGGTAAATCGCCGGTGCTGATTTTTGAAGATGCCGATATTGAACGCGCGCTGGACGCCGCCCT
GTTCACCATCTTCTCGATCAACGGCGAACGCTGCACCGCCGGTTCACGCATCTTTATTCAGCAAAGCATCTACCCGGAAT
TCGTTAAACGCTTTGCCGAACGCGCCAACCGTCTGCGCGTGGGCGATCCGAACGATCCGAATACCCAGGTTGGCGCGCTT
ATCAGCCAGCAGCACTGGGAAAAAGTCTCCGGCTATATCCGTCTCGGCATTGAAGAAGGCGCCACCCTGCTGGCGGGCGG
CCCGGATAAACCGTCTGACCTGCCTGCACACCTGAAAGGCGGCAACTTCCTGCGCCCAACGGTGCTGGCAGACGTTGATA
ACCGTATGCGAGTCGCCCAAGAAGAGATTTTCGGGCCGGTCGCCTGCCTGCTGCCGTTTAAAGACGAAGCTGAAGGCTTA
CGCCTGGCAAACGACGTGGAGTACGGCCTCGCGTCGTACATCTGGACACAGGATGTCAGCAAAGTGTTACGCCTGGCGCG
TGGCATTGAAGCTGGCATGGTGTTCGTCAACACCCAGAACGTGCGTGACCTGCGCCAGCCATTTGGCGGCGTAAAAGCCT
CCGGCACCGGGCGTGAAGGCGGTGAGTACAGCTTCGAAGTGTTCGCGGAAATGAAGAACGTCTGCATTTCCATGGGCGAC
CATCCAATTCCGAAATGGGGAGTCTGA

Upstream 100 bases:

>100_bases
CCAAAGGCTTATCTGACGTGGTGCCTGGCGATGAAGTAGTGGTGGAAGTAGAAGGCGTGGGCCGCCTGGTGAACCGAATT
GTGAGTGAGGATACAGCGAA

Downstream 100 bases:

>100_bases
TATGGGTAAGTTAGCGTTAGCCGCCAAGATCACGCACGTACCGTCGATGTATCTCTCTGAACTGCCAGGGAAAAACCACG
GTTGCCGCCAGGGCGCGATC

Product: 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase

Products: 5-carboxymethyl-2-hydroxymuconate; NADH; H+

Alternate protein names: CHMS dehydrogenase [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADMASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRDHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPNDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV

Sequences:

>Translated_488_residues
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADMASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRDHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPNDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV
>Mature_488_residues
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADMASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRDHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPNDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV

Specific function: Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM) [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI12007648, Length=477, Percent_Identity=41.7190775681342, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI25777730, Length=480, Percent_Identity=41.0416666666667, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI25777732, Length=480, Percent_Identity=40.8333333333333, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI153266822, Length=482, Percent_Identity=39.0041493775934, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI25777724, Length=480, Percent_Identity=39.375, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI115387104, Length=463, Percent_Identity=39.524838012959, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI238814322, Length=483, Percent_Identity=39.3374741200828, Blast_Score=344, Evalue=9e-95,
Organism=Homo sapiens, GI21361176, Length=480, Percent_Identity=38.125, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI21614513, Length=466, Percent_Identity=39.6995708154506, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI25777728, Length=420, Percent_Identity=40.4761904761905, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI25952152, Length=477, Percent_Identity=35.8490566037736, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI25777726, Length=477, Percent_Identity=36.2683438155136, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI301500698, Length=482, Percent_Identity=35.4771784232365, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI4507229, Length=483, Percent_Identity=35.8178053830228, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI25777721, Length=496, Percent_Identity=34.6774193548387, Blast_Score=265, Evalue=9e-71,
Organism=Homo sapiens, GI188035924, Length=495, Percent_Identity=27.0707070707071, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI310128093, Length=477, Percent_Identity=27.6729559748428, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI310128103, Length=477, Percent_Identity=27.4633123689727, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI11095441, Length=486, Percent_Identity=29.6296296296296, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI310128091, Length=470, Percent_Identity=27.4468085106383, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI310128089, Length=339, Percent_Identity=31.2684365781711, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI223972651, Length=464, Percent_Identity=28.0172413793103, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI238859541, Length=466, Percent_Identity=25.9656652360515, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI25777736, Length=466, Percent_Identity=25.9656652360515, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI25777734, Length=466, Percent_Identity=25.9656652360515, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI310128097, Length=263, Percent_Identity=33.0798479087452, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI310128095, Length=318, Percent_Identity=30.188679245283, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI206597441, Length=450, Percent_Identity=26.2222222222222, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI206597439, Length=450, Percent_Identity=26.2222222222222, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI22907049, Length=450, Percent_Identity=26.2222222222222, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4557303, Length=345, Percent_Identity=28.4057971014493, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73466520, Length=345, Percent_Identity=28.4057971014493, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI223972653, Length=462, Percent_Identity=25.1082251082251, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI73695881, Length=347, Percent_Identity=26.2247838616715, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI73695879, Length=347, Percent_Identity=26.2247838616715, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI71773324, Length=342, Percent_Identity=27.1929824561404, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI4502043, Length=342, Percent_Identity=27.1929824561404, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI238814371, Length=342, Percent_Identity=27.1929824561404, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI310128087, Length=294, Percent_Identity=23.8095238095238, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI310128101, Length=236, Percent_Identity=22.0338983050847, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI310128099, Length=236, Percent_Identity=22.0338983050847, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1787558, Length=480, Percent_Identity=39.1666666666667, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1789015, Length=478, Percent_Identity=37.8661087866109, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI87082295, Length=492, Percent_Identity=38.2113821138211, Blast_Score=331, Evalue=7e-92,
Organism=Escherichia coli, GI1786504, Length=463, Percent_Identity=38.6609071274298, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI87081896, Length=464, Percent_Identity=37.5, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1787715, Length=476, Percent_Identity=36.7647058823529, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1787684, Length=481, Percent_Identity=31.3929313929314, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87081926, Length=461, Percent_Identity=30.58568329718, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1788042, Length=474, Percent_Identity=29.746835443038, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787250, Length=466, Percent_Identity=26.1802575107296, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787653, Length=301, Percent_Identity=26.2458471760797, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25144435, Length=466, Percent_Identity=40.5579399141631, Blast_Score=360, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17562198, Length=480, Percent_Identity=39.5833333333333, Blast_Score=359, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI133930964, Length=485, Percent_Identity=37.7319587628866, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI25143876, Length=486, Percent_Identity=36.8312757201646, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI25143874, Length=486, Percent_Identity=36.8312757201646, Blast_Score=328, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI32564736, Length=420, Percent_Identity=40.4761904761905, Blast_Score=327, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17551164, Length=481, Percent_Identity=37.4220374220374, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI71995606, Length=485, Percent_Identity=33.6082474226804, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71995613, Length=421, Percent_Identity=33.729216152019, Blast_Score=251, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI17534119, Length=473, Percent_Identity=32.3467230443975, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI71986308, Length=442, Percent_Identity=31.6742081447964, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI115534176, Length=488, Percent_Identity=26.0245901639344, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32566756, Length=443, Percent_Identity=28.2167042889391, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25146391, Length=444, Percent_Identity=28.1531531531532, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI25146394, Length=444, Percent_Identity=28.1531531531532, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17534447, Length=485, Percent_Identity=26.1855670103093, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17564084, Length=447, Percent_Identity=27.7404921700224, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32564151, Length=445, Percent_Identity=26.5168539325843, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI115532534, Length=341, Percent_Identity=27.2727272727273, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71990744, Length=323, Percent_Identity=25.3869969040248, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324950, Length=474, Percent_Identity=38.1856540084388, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6320917, Length=484, Percent_Identity=37.8099173553719, Blast_Score=330, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6325196, Length=481, Percent_Identity=37.4220374220374, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6323822, Length=468, Percent_Identity=36.965811965812, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6323821, Length=468, Percent_Identity=35.8974358974359, Blast_Score=302, Evalue=9e-83,
Organism=Saccharomyces cerevisiae, GI6319478, Length=483, Percent_Identity=35.4037267080745, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6321828, Length=507, Percent_Identity=26.6272189349112, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6321826, Length=505, Percent_Identity=26.1386138613861, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323757, Length=359, Percent_Identity=27.5766016713092, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI20129399, Length=480, Percent_Identity=43.3333333333333, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24585660, Length=483, Percent_Identity=38.0952380952381, Blast_Score=334, Evalue=8e-92,
Organism=Drosophila melanogaster, GI281362580, Length=476, Percent_Identity=36.344537815126, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI62472918, Length=476, Percent_Identity=36.344537815126, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI62472926, Length=476, Percent_Identity=36.344537815126, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI62472936, Length=476, Percent_Identity=36.344537815126, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI21356737, Length=476, Percent_Identity=36.344537815126, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24650465, Length=471, Percent_Identity=39.4904458598726, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24666674, Length=474, Percent_Identity=26.7932489451477, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24638878, Length=439, Percent_Identity=31.4350797266515, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24638876, Length=439, Percent_Identity=31.4350797266515, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24668425, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24668417, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24668413, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI281360301, Length=355, Percent_Identity=26.4788732394366, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281360299, Length=355, Percent_Identity=26.4788732394366, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281360297, Length=355, Percent_Identity=26.4788732394366, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281360295, Length=355, Percent_Identity=26.4788732394366, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24586250, Length=355, Percent_Identity=26.4788732394366, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281360303, Length=356, Percent_Identity=25.8426966292135, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI45552499, Length=356, Percent_Identity=25.8426966292135, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28574525, Length=466, Percent_Identity=22.5321888412017, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571798, Length=494, Percent_Identity=22.2672064777328, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571796, Length=494, Percent_Identity=22.2672064777328, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571794, Length=494, Percent_Identity=22.2672064777328, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571802, Length=494, Percent_Identity=22.2672064777328, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571800, Length=494, Percent_Identity=22.2672064777328, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571806, Length=494, Percent_Identity=22.2672064777328, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR011985 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: 1.2.1.60

Molecular weight: Translated: 53038; Mature: 53038

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADMASGGEAEINQAVAAAKEAFPKWANLPM
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHCCCCH
KERARLMRRLGDLIDQNVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNG
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSELSPLTA
CCCCCCCHHHCEEEECCCCEEEEECCCCCCEEEEECCHHHHHEECCCEEEEECCCCCCCH
DRLGELALEAGIPAGVLNVVQGYGATAGDALVRDHDVRAVSFTGGTATGRNIMKNAGLKK
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHCCCCE
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAE
EHHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCEEEEEHHHHHHHHHHHHH
RANRLRVGDPNDPNTQVGALISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKG
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCCCCCCCCCC
GNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGLRLANDVEYGLASYIWTQDVS
CCEECCHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHH
KVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
HPIPKWGV
CCCCCCCC
>Mature Secondary Structure
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADMASGGEAEINQAVAAAKEAFPKWANLPM
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHCCCCH
KERARLMRRLGDLIDQNVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNG
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSELSPLTA
CCCCCCCHHHCEEEECCCCEEEEECCCCCCEEEEECCHHHHHEECCCEEEEECCCCCCCH
DRLGELALEAGIPAGVLNVVQGYGATAGDALVRDHDVRAVSFTGGTATGRNIMKNAGLKK
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHCCCCE
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAE
EHHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCEEEEEHHHHHHHHHHHHH
RANRLRVGDPNDPNTQVGALISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKG
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCCCCCCCCCC
GNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGLRLANDVEYGLASYIWTQDVS
CCEECCHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHH
KVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
HPIPKWGV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-carboxymethyl-2-hydroxymuconate semialdehyde; H2O; NAD+

Specific reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737515 [H]