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The map label for this gene is aidB [H]

Identifier: 82546571

GI number: 82546571

Start: 4317706

End: 4319346

Strand: Reverse

Name: aidB [H]

Synonym: SBO_4268

Alternate gene names: 82546571

Gene position: 4319346-4317706 (Counterclockwise)

Preceding gene: 82546572

Following gene: 82546568

Centisome position: 95.56

GC content: 54.11

Gene sequence:

>1641_bases
ATGGAGGGAGACACAGTGCACTGGCAAACTCACACCGTTTTTAATCAACCTATACCATTAAATAACAGCAACTTATACCT
GTCTGATGGCGCGCTCTGTGAAGCGGTAACGCGTGAAGGTGCTGGCTGGGATAGCGATTTTCTAGCCAGTATTGGTCAGC
AGTTAGGAACGGCTGAATCTCTTGAACTGGGGCGGCTGGCGAATGTGAATCCGCCTGAATTATTGCGCTACGATGCGCAA
GGACGCCGTCTGGACGATGTGCGTTTTCACCCCGCCTGGCACCTGCTGATGCAGGCGTTATGTACCAATCGGGTGCACAA
TCTTGCCTGGGAAGAAGACGCTCGCTCCGGCGCATTTGTGGCGCGCGCGGCGCGTTTTATGTTACATGCGCAGGTTGAGG
CTGGGTCGTTATGTCCAATAACGATGACCTTTGCCGCCACGCCATTGTTGTTACAGATGTTACCCACGCCGTTTCAGGAC
TGGACCACGCCGCTGCTGAGCGATCGCTACGATTCTCTCTTATTGCCAGGTGGGCAAAAACGCGGTTTGTTGATTGGCAT
GGGAATGACGGAAAAGCAGGGCGGTTCCGATGTCATGAGCAACACCACCCGTGCAGAGCGTCTGGAAGATGGCTCTTATC
GGCTGGTGGGGCATAAATGGTTTTTCTCGGTGCCGCAAAGCGATGCGCATCTGGTGCTGGCGCAGACTACGGGCGGTTTG
TCCTGCTTTTTTGTGCCGCGCTTTTTGCCTGATGGGCAACGCAACGCGATTCGCCTCGAGCGGCTGAAAGATAAGCTGGG
TAATCGCTCTAACGCCAGTTGCGAAGTGGAGTTTCAGGATGCCATTGGCTGGTTGTTGGGGCAGGAAGGGGAAGGAATTC
GTCTGATCCTGAAAATGGGTGGGATGACGCGTTTTGATTGCGCCCTGGGTAGCCATGCCATGATGCGCCGTGCATTTTCG
CTGGCGATTTATCATGCACATCAACGCCATGTTTTTGGTAATCCATTGATCCAACAGCCCCTTATGTGTCATGTCTTAAG
TCGCATGGCACTTCAGCTTGAAGGGCAAACGGCGTTGCTGTTTCGTCTTGCGCGAGCGTGGGACCGGCGTGCCGATGCCA
AAGAAGCCCTGTGGGCGCGTTTATTTACGCCTGCGGCAAAATTTGTGATCTGCAAAAGAGGTATGCCGTTTGTGGCCGAA
GCGATGGAGGTGCTGGGCGGCATTGGTTATTGCGAGGAGAGCGAGCTGCCGCGGCTTTACCGGGAGATGCCGGTAAACAG
TATTTGGGAAGGTTCCGGCAATATTATGTGCCTGGATGTGTTGCGCGTTCTCAATAAGCAAGCGGGCGTATACGACTTAT
TGTCGGAAGCATTTGTGGAAGTGAAAGGGCAGGATCGCTATTTTGATCGCGCGGTTCGTCGTTTACAGCAGCAGCTGCGT
AAGCCAGCTGAAGAACTGGGGCGAGAGATTACTCATCAGCTATTCCTGCTGGGCTGCGGTGCGCAAATGTTGAAATATGC
TTCTCCGCCAATGGCGCAGGCGTGGTGTCAGGTGATGTTAGATACGCGCGGCGGCGTACGGTTGTCAGAGCAGATCCAGA
ATGATTTATTGCTGCGGGCGACGGGGGGAGTGTGTGTGTAA

Upstream 100 bases:

>100_bases
CACGTTTCGTTCCGCATTACATTGCTGGATAAGAATGTTTTAGCAATCTCTTTCTGTCAGGAATCCATGGCAGTGACCAT
ACTAAGGGTGACTGCCATTG

Downstream 100 bases:

>100_bases
GCGTATACGACTGATGCGACGCTGGTTTCGATTAACTCAATGAAATATGTGAAAATTGTAGGCCGGACAAGGCGCTCGCG
CCGAATCCGGCATTGTTCAT

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MEGDTVHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQ
GRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPTPFQD
WTTPLLSDRYDSLLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGL
SCFFVPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFS
LAIYHAHQRHVFGNPLIQQPLMCHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGMPFVAE
AMEVLGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLR
KPAEELGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVCV

Sequences:

>Translated_546_residues
MEGDTVHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQ
GRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPTPFQD
WTTPLLSDRYDSLLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGL
SCFFVPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFS
LAIYHAHQRHVFGNPLIQQPLMCHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGMPFVAE
AMEVLGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLR
KPAEELGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVCV
>Mature_546_residues
MEGDTVHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQ
GRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPTPFQD
WTTPLLSDRYDSLLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGL
SCFFVPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFS
LAIYHAHQRHVFGNPLIQQPLMCHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGMPFVAE
AMEVLGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLR
KPAEELGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVCV

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=292, Percent_Identity=29.4520547945205, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI226958414, Length=271, Percent_Identity=24.7232472324723, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI226958412, Length=271, Percent_Identity=24.7232472324723, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI4501859, Length=264, Percent_Identity=23.8636363636364, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI7656849, Length=266, Percent_Identity=27.8195488721804, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4557231, Length=274, Percent_Identity=25.1824817518248, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI187960098, Length=274, Percent_Identity=25.1824817518248, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI21361497, Length=260, Percent_Identity=24.2307692307692, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082384, Length=541, Percent_Identity=98.8909426987061, Blast_Score=1099, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=329, Percent_Identity=25.531914893617, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081958, Length=258, Percent_Identity=26.3565891472868, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=538, Percent_Identity=29.9256505576208, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI86563383, Length=538, Percent_Identity=29.9256505576208, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17538396, Length=271, Percent_Identity=28.7822878228782, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508101, Length=267, Percent_Identity=23.5955056179775, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=270, Percent_Identity=24.0740740740741, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=277, Percent_Identity=24.187725631769, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534899, Length=269, Percent_Identity=24.5353159851301, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=268, Percent_Identity=24.2537313432836, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17505929, Length=298, Percent_Identity=26.510067114094, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21356377, Length=312, Percent_Identity=25.3205128205128, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355753, Length=274, Percent_Identity=28.8321167883212, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=23.7536656891496, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24646207, Length=274, Percent_Identity=25.5474452554745, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24660351, Length=279, Percent_Identity=25.4480286738351, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666513, Length=271, Percent_Identity=22.140221402214, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 61090; Mature: 61090

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGDTVHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAES
CCCCEEEEEEEEEECCCCCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
LELGRLANVNPPELLRYDAQGRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFV
CCCCCCCCCCCHHHEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
ARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPTPFQDWTTPLLSDRYDSLLLPGGQK
HHHHHHHHHEECCCCCCCCEEHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCCEECCCCCC
RGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGL
CCEEEECCCCCCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCE
SCFFVPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMG
EEEEEHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEEC
GMTRFDCALGSHAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMCHVLSRMALQLEGQTALL
CCEEEHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
FRLARAWDRRADAKEALWARLFTPAAKFVICKRGMPFVAEAMEVLGGIGYCEESELPRLY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHH
REMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLR
HHCCCCCEECCCCCEEHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KPAEELGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRA
HHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEHHHHHCCEEEEE
TGGVCV
CCCCCC
>Mature Secondary Structure
MEGDTVHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAES
CCCCEEEEEEEEEECCCCCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
LELGRLANVNPPELLRYDAQGRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFV
CCCCCCCCCCCHHHEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
ARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPTPFQDWTTPLLSDRYDSLLLPGGQK
HHHHHHHHHEECCCCCCCCEEHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCCEECCCCCC
RGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGL
CCEEEECCCCCCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCE
SCFFVPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMG
EEEEEHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEEC
GMTRFDCALGSHAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMCHVLSRMALQLEGQTALL
CCEEEHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
FRLARAWDRRADAKEALWARLFTPAAKFVICKRGMPFVAEAMEVLGGIGYCEESELPRLY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHH
REMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLR
HHCCCCCEECCCCCEEHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KPAEELGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRA
HHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEHHHHHCCEEEEE
TGGVCV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]