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The map label for this gene is treR [H]

Identifier: 82546512

GI number: 82546512

Start: 4255153

End: 4256118

Strand: Direct

Name: treR [H]

Synonym: SBO_4205

Alternate gene names: 82546512

Gene position: 4255153-4256118 (Clockwise)

Preceding gene: 82546510

Following gene: 82546513

Centisome position: 94.14

GC content: 54.04

Gene sequence:

>966_bases
ATGCAAAATCGGCTGACCATCAAAGACATCGCGCGCTTAAGCGGCGTGGGGAAATCTACAGTTTCCCGGGTGCTGAATAA
CGAAAGCGGCGTGAGCCAGCGCACCCGCGAGCGTGTTGAAGCAGTGATGAATCAGCATGGATTTTCCCCTTCCCGCTCTG
CGCGCGCTATGCGTGGGCAAAGCGATAAAGTGGTCGCCATCATTGTTACCCGCCTGGATTCGTTGTCAGAAAATCTCGCC
GTTCAAACCATGCTGCCAGAGTTCTATGAACAAGGTTACGACCCAATCATGATGGAAAGTCAGTTTTCCCCGCAATTAGT
TGCCGAACATTTGGGGGTGCTGAAACGGCGTAATATCGACGGCGTAGTGCTGTTCGGTTTTACCGGCATAACAGAAGAAA
TGTTAGCCCACTGGCAGTCATCGCTGGTTCTGCTGGCGCGTGACGCAAAAGGCTTTGCTTCGGTCTGTTATGACGACGAA
GGGGCAATCAAGATCCTGATGCAACGGCTGTATGACCAGGGGCATCGTAATATCAGTTATCTCGGCGTGCCGCACAGTGA
CGTGACGACCGGTAAGCGACGTCACGAAGCCTACCTGGCGTTCTGCAAAGCGCATAAACTGCATCCCGTTGCCGCTCTGC
CAGGCCTTGCTATGAAGCAAGGCTATGAGAACGTAGCAAAAGTGATTACGCCTGAAACTACCGCCTTACTGTGCGCAACC
GACACGCTGGCACTTGGCGCAAGTAAATACCTGCAAGAGCAACGCATCGACACCTTGCAACTGGCGAGCGTCGGTAATAC
GCCGTTAATGAAATTCCTCCATCCGGAGATCGTCACCGTAGATCCCGGTTACACCGAAGCTGGACGCCAGGCGGCCTGCC
AGTTGATCGCACAGGTAACCGGGCGCAGCGAACCGCAACAAATCATCATCCCCGCCACCCTGTCCAGATCGTTTCCTGAA
CGATAA

Upstream 100 bases:

>100_bases
GCTGGCAACTAAACCAACGATAAACCAGACTTTACCCATTGCTGAATGCACGGGTAAAGTTAGGCTCAAATAATTAAACA
ACACGTTACAGGACAACAGG

Downstream 100 bases:

>100_bases
ATTGTGATCTTCGCTGCGTTTCGGGAACGTTCCCGTTTTTAAATTTTTCCGCGCAATATATTCTGCAGCCAACCAAAAAT
GTCATCTGCCATGGGGCTTT

Product: trehalose repressor

Products: NA

Alternate protein names: Trehalose operon repressor [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQRTRERVEAVMNQHGFSPSRSARAMRGQSDKVVAIIVTRLDSLSENLA
VQTMLPEFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNIDGVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDE
GAIKILMQRLYDQGHRNISYLGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCAT
DTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYTEAGRQAACQLIAQVTGRSEPQQIIIPATLSRSFPE
R

Sequences:

>Translated_321_residues
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQRTRERVEAVMNQHGFSPSRSARAMRGQSDKVVAIIVTRLDSLSENLA
VQTMLPEFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNIDGVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDE
GAIKILMQRLYDQGHRNISYLGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCAT
DTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYTEAGRQAACQLIAQVTGRSEPQQIIIPATLSRSFPE
R
>Mature_321_residues
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQRTRERVEAVMNQHGFSPSRSARAMRGQSDKVVAIIVTRLDSLSENLA
VQTMLPEFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNIDGVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDE
GAIKILMQRLYDQGHRNISYLGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCAT
DTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYTEAGRQAACQLIAQVTGRSEPQQIIIPATLSRSFPE
R

Specific function: Repressor of the treBC operon. Binds trehalose 6- phosphate as an inducer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790689, Length=315, Percent_Identity=99.0476190476191, Blast_Score=646, Evalue=0.0,
Organism=Escherichia coli, GI1788474, Length=291, Percent_Identity=25.4295532646048, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787906, Length=267, Percent_Identity=28.0898876404494, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787580, Length=329, Percent_Identity=28.2674772036474, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790194, Length=327, Percent_Identity=24.1590214067278, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI48994940, Length=327, Percent_Identity=23.2415902140673, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1789202, Length=290, Percent_Identity=25.5172413793103, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786540, Length=260, Percent_Identity=25.7692307692308, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790369, Length=315, Percent_Identity=25.0793650793651, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787948, Length=320, Percent_Identity=23.4375, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790715, Length=313, Percent_Identity=21.405750798722, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761
- InterPro:   IPR012771 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35435; Mature: 35435

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQRTRERVEAVMNQHGFSPSRSARAMRGQ
CCCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
SDKVVAIIVTRLDSLSENLAVQTMLPEFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNID
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHCCCC
GVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDEGAIKILMQRLYDQGHRNISY
EEEEEECCCHHHHHHHHHHHCEEEEEECCCCHHHHEECCCHHHHHHHHHHHHCCCCCEEE
LGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCAT
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEC
DTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYTEAGRQAACQLIAQVT
HHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHH
GRSEPQQIIIPATLSRSFPER
CCCCCCEEEEEHHHCCCCCCC
>Mature Secondary Structure
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQRTRERVEAVMNQHGFSPSRSARAMRGQ
CCCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
SDKVVAIIVTRLDSLSENLAVQTMLPEFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNID
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHCCCC
GVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDEGAIKILMQRLYDQGHRNISY
EEEEEECCCHHHHHHHHHHHCEEEEEECCCCHHHHEECCCHHHHHHHHHHHHCCCCCEEE
LGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCAT
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEC
DTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYTEAGRQAACQLIAQVT
HHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHH
GRSEPQQIIIPATLSRSFPER
CCCCCCEEEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9148912; 7610040; 9278503; 7608078; 9865945 [H]