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The map label for this gene is pepQ [H]

Identifier: 82546197

GI number: 82546197

Start: 3884436

End: 3885767

Strand: Direct

Name: pepQ [H]

Synonym: SBO_3859

Alternate gene names: 82546197

Gene position: 3884436-3885767 (Clockwise)

Preceding gene: 82546195

Following gene: 82546198

Centisome position: 85.94

GC content: 53.45

Gene sequence:

>1332_bases
ATGGAATCACTGGCCTCGCTCTATAAAAATCATATAGCTACCTTACAAGAACGGACTCGCGATGCGCTGGCGCGCTTCAA
GCTGGATGCATTACTTATTCACTCCGGCGAGCTGTTCAACGTTTTTCTCGACGATCATCCCTATCCGTTTAAAGTGAACC
CGCAATTCAAAGCGTGGGTGCCGGTAACTCAGGTGCCAAACTGCTGGTTGCTGGTGGATGGCGTGAACAAGCCGAAACTG
TGGTTCTATCTGCCGGTTGATTACTGGCACAACGTCGAACCGCTGCCGACCTCCTTCTGGACTGAAGATGTGGAAGTGAT
CGCACTGCCGAAAGCCGATGGCATTGGTAGCCTGCTGCCCGCTGCGCGCGGCAATATCGGTTATATCGGTCCGGTGCCGG
AACGTGCGCTGCAACTGGGTATTGAGGCCAGCAACATCAACCCGAAAGGGGTGATCGACTACCTGCATTACTACCGCTCC
TTCAAAACCGAGTACGAACTGGCCTGTATGCGTGAAGCGCAGAAAATGGCGGTCAACGGTCATCGTGCGGCAGAAGAAGC
GTTCCGTTCTGGCATGAGCGAGTTCGATATCAACATCGCCTATCTGACCGCGACCGGTCATCGTGATACCGACGTACCTT
ACAGCAACATTGTGGCGCTTAACGAACACGCTTCGGTGCTGCATTACACCAAACTGGATCATCAGGCACCGGAAGAGATG
CGCAGCTTCCTGCTGGATGCCGGGGCCGAATATAACGGCTATGCGGCTGACCTGACTCGTACCTGGTCGGCAAAAAGCGA
CAACGACTACGCACAGCTGGTGAAAGACGTAAATGATGAACAACTTGCGCTGATCGCTACCATGAAAGCTGGCGTCAGCT
ATGTGGATTACCACCTCCAGTTCCATCAGCGCATCGCCAAATTGCTGCGTAAACATCAAATCATCACCGATATGAGTGAA
GAAGCGATGGTCGAAAACGATCTCACCGGACCGTTTATGCCGCACGGTATCGGCCATCCGCTGGGCCTGCAGGTGCATGA
CGTAGCCGGTTTTATGCAGGATGATAGCGGTACACACCTCGCGGCACCGGCAAAATATCCGTACCTGCGCTGCACCCGTA
TTCTCCAGCCGGGCATGGTGTTAACCATCGAACCGGGTATCTACTTCATCGAATCGCTACTGGCACCGTGGCGTGAAGGG
CAGTTCAGCAAGCACTTCAACTGGCAGAAAATTGAAGCACTGAAACCGTTCAGCGGCATTCGTATCGAAGACAACGTGGT
GATCCACGAAAATAACGTGGAAAACATGACCCGGGATCTGAAACTGGCGTGA

Upstream 100 bases:

>100_bases
AAGAAATGCCGATCTGATCACGCTCGGCAGAAATCACGCTCTGGATGAACGATGTGCTAAGATGCGGAGACTTAAGGTCA
AAAAAACAGAAGGGTAAAAA

Downstream 100 bases:

>100_bases
TGGAAAGCTGGTTAATTCCTGCGGCACCGGTCACGGTCGTTGAAGAGATCAAAAAGAGCCGCTTCATAACGATGTTGGCG
CATACCGATGGCGTTGAGGC

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRS
FKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHQAPEEM
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHLQFHQRIAKLLRKHQIITDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREG
QFSKHFNWQKIEALKPFSGIRIEDNVVIHENNVENMTRDLKLA

Sequences:

>Translated_443_residues
MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRS
FKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHQAPEEM
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHLQFHQRIAKLLRKHQIITDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREG
QFSKHFNWQKIEALKPFSGIRIEDNVVIHENNVENMTRDLKLA
>Mature_443_residues
MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRS
FKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHQAPEEM
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHLQFHQRIAKLLRKHQIITDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREG
QFSKHFNWQKIEALKPFSGIRIEDNVVIHENNVENMTRDLKLA

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=466, Percent_Identity=28.9699570815451, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI260593665, Length=338, Percent_Identity=32.5443786982249, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI260593663, Length=328, Percent_Identity=31.0975609756098, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI11559925, Length=296, Percent_Identity=27.7027027027027, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1790282, Length=443, Percent_Identity=99.3227990970655, Blast_Score=920, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=330, Percent_Identity=31.2121212121212, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=26.2745098039216, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508215, Length=289, Percent_Identity=32.8719723183391, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321118, Length=286, Percent_Identity=29.3706293706294, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320922, Length=286, Percent_Identity=29.020979020979, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357079, Length=290, Percent_Identity=31.7241379310345, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI19920384, Length=293, Percent_Identity=29.6928327645051, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 50223; Mature: 50223

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEECCCCCCEEECCCCEEEE
PVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLP
CCCCCCCCEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHH
AARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNG
HCCCCCCCCCCCCHHHHHCCCEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
HRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHQAPEEM
HHHHHHHHHCCCCHHCEEEEEEEECCCCCCCCCHHHEEEECCCCCEEEEECCCCCCHHHH
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHLQ
HHHHHHCCCCCCCEEECCEEECCCCCCCHHHHHHHCCCCCCEEEEEEHHHCCHHHHHHHH
FHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHL
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHCEEECCCCCEE
AAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFSGI
ECCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHCHHHCCCCCCCCCCHHHHHCCCCCCC
RIEDNVVIHENNVENMTRDLKLA
EEECCEEEECCCHHHHHHHCCCC
>Mature Secondary Structure
MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEECCCCCCEEECCCCEEEE
PVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLP
CCCCCCCCEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHH
AARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNG
HCCCCCCCCCCCCHHHHHCCCEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
HRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHASVLHYTKLDHQAPEEM
HHHHHHHHHCCCCHHCEEEEEEEECCCCCCCCCHHHEEEECCCCCEEEEECCCCCCHHHH
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHLQ
HHHHHHCCCCCCCEEECCEEECCCCCCCHHHHHHHCCCCCCEEEEEEHHHCCHHHHHHHH
FHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHL
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHCEEECCCCCEE
AAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFSGI
ECCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHCHHHCCCCCCCCCCHHHHHCCCCCCC
RIEDNVVIHENNVENMTRDLKLA
EEECCEEEECCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA