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The map label for this gene is serA [H]

Identifier: 82545112

GI number: 82545112

Start: 2704227

End: 2705174

Strand: Reverse

Name: serA [H]

Synonym: SBO_2700

Alternate gene names: 82545112

Gene position: 2705174-2704227 (Counterclockwise)

Preceding gene: 82545113

Following gene: 82545111

Centisome position: 59.85

GC content: 43.67

Gene sequence:

>948_bases
ATGAAAAATGTTCTGGTCACCGTCCCCAGCTTTTCAGCACGCTGTGTTTCCGCCAGCAAGTTGCTAAGAGAGAATAATTT
TAATCTTATTATTAAGAATAATGTGGAGCATCTGCTTAAATCAGAATCCACTGCATTACGAGAATCTATTTGCGCGGTCA
TCGCCGGAAAAGATTGTTATCAGGCGGACACGCTATCATTGCTGCCTGGTGTGAAAATAATATCGAGATTCGGGACGGGG
ATAGATAATATTGATCTTCGTGCAGCACAACAATCCGGTATTGTAGTCAATAATGCGGTTGGGATTAATTCAAATGCTGT
CGCGGAATTTATCATTGGACTTATCTTCGCGAGCATGAGAAATATTCCCGGCAGCTATCATGCGATGCAAAATGGCTACT
GGGGTGAGTCGCATGGCTGTGAATTACAAGGGAAACGGATTGGCCTGGTTGGCTACGGTAATATAGGTAAAACTCTGGCG
AAAAGGTTATCCGGTTTTGATGTTGAGCTTTTAGCTTATGACAAACAACCCGATTATCAGGTTGCTGACAAAGTTGGAGT
TCAGTTTGTATCAATTGAAGATATCTTTATGCAGTCGCATGTCATCATTGTTCTTTTGCCTTTTTCTCCTGAGCTGGAGA
ACTTCATTAGTCATAAATATTTGTCGATGATGCGCAATGGTGCTCTAATCATCAATGCCGCAAGGGGAAAGTTGCTGGAT
GAGGGCGCTTTACTACAGGTGATTGAAGAACGAAATGTGTTTGCGGCGCTGGATGTGTTTAGCTCTGAACCGTTGGCGCA
ATTTAGCCCACTGCTACATGCCAAAAATATCATTACAACGCCGCATATTGCGGCCGCCACCGTTGAGTCATACCAGCAAA
CCGGTACACACGTTGCCCAGTCGATAATTGATTACTTCGCAGGAAGGGAGATAAAAAACGTGTTGTGA

Upstream 100 bases:

>100_bases
GTGCACTCGGCATTAAAGCAAATTCATAATTTCAAAGTATAAATACAGTGACCGGTCACGCCATCTTTTGGGGTGGCGTT
CATTGAAGTGAGTGTCAGCT

Downstream 100 bases:

>100_bases
GTTCAGCGAACGAAGTTTTTAAATACAAAAAAACCGCAATTTGTGGAACACATTGCGGTTTATCAGCATTCTAAGTATTG
GTTGCGGGGGCCGGATTTGA

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGKDCYQADTLSLLPGVKIISRFGTG
IDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFASMRNIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGKTLA
KRLSGFDVELLAYDKQPDYQVADKVGVQFVSIEDIFMQSHVIIVLLPFSPELENFISHKYLSMMRNGALIINAARGKLLD
EGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGTHVAQSIIDYFAGREIKNVL

Sequences:

>Translated_315_residues
MKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGKDCYQADTLSLLPGVKIISRFGTG
IDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFASMRNIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGKTLA
KRLSGFDVELLAYDKQPDYQVADKVGVQFVSIEDIFMQSHVIIVLLPFSPELENFISHKYLSMMRNGALIINAARGKLLD
EGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGTHVAQSIIDYFAGREIKNVL
>Mature_315_residues
MKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGKDCYQADTLSLLPGVKIISRFGTG
IDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFASMRNIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGKTLA
KRLSGFDVELLAYDKQPDYQVADKVGVQFVSIEDIFMQSHVIIVLLPFSPELENFISHKYLSMMRNGALIINAARGKLLD
EGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGTHVAQSIIDYFAGREIKNVL

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=300, Percent_Identity=31.3333333333333, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=28.968253968254, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=30.2919708029197, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI145580578, Length=273, Percent_Identity=29.6703296703297, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4557499, Length=273, Percent_Identity=29.6703296703297, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI61743967, Length=277, Percent_Identity=29.2418772563177, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4557497, Length=277, Percent_Identity=29.2418772563177, Blast_Score=109, Evalue=3e-24,
Organism=Escherichia coli, GI1789279, Length=239, Percent_Identity=32.6359832635983, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=27.1317829457364, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=28.2442748091603, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87081824, Length=230, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=297, Percent_Identity=28.6195286195286, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=280, Percent_Identity=27.1428571428571, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322116, Length=244, Percent_Identity=30.327868852459, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=248, Percent_Identity=29.8387096774194, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=27.0042194092827, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=26.9662921348315, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=160, Percent_Identity=28.75, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=238, Percent_Identity=31.9327731092437, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28574286, Length=289, Percent_Identity=25.6055363321799, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI45552429, Length=251, Percent_Identity=25.8964143426295, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551003, Length=251, Percent_Identity=25.8964143426295, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585514, Length=251, Percent_Identity=25.8964143426295, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574282, Length=251, Percent_Identity=25.8964143426295, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574284, Length=251, Percent_Identity=25.8964143426295, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585516, Length=323, Percent_Identity=26.9349845201238, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28571528, Length=281, Percent_Identity=27.7580071174377, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24646446, Length=274, Percent_Identity=29.9270072992701, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646448, Length=274, Percent_Identity=29.9270072992701, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646452, Length=274, Percent_Identity=29.9270072992701, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646450, Length=274, Percent_Identity=29.9270072992701, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI62472511, Length=274, Percent_Identity=29.9270072992701, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34409; Mature: 34409

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGKDCY
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHCCCCCC
QADTLSLLPGVKIISRFGTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFASMR
CCCHHHHCCHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
NIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGKTLAKRLSGFDVELLAYDKQPDYQ
CCCCCHHHHCCCCCCCCCCCEECCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCHH
VADKVGVQFVSIEDIFMQSHVIIVLLPFSPELENFISHKYLSMMRNGALIINAARGKLLD
HHHHHCEEEEEHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
EGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGTHVAQ
CCHHHHHHHHCCEEEEEEHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
SIIDYFAGREIKNVL
HHHHHHCCCHHHHCC
>Mature Secondary Structure
MKNVLVTVPSFSARCVSASKLLRENNFNLIIKNNVEHLLKSESTALRESICAVIAGKDCY
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHCCCCCC
QADTLSLLPGVKIISRFGTGIDNIDLRAAQQSGIVVNNAVGINSNAVAEFIIGLIFASMR
CCCHHHHCCHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
NIPGSYHAMQNGYWGESHGCELQGKRIGLVGYGNIGKTLAKRLSGFDVELLAYDKQPDYQ
CCCCCHHHHCCCCCCCCCCCEECCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCHH
VADKVGVQFVSIEDIFMQSHVIIVLLPFSPELENFISHKYLSMMRNGALIINAARGKLLD
HHHHHCEEEEEHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
EGALLQVIEERNVFAALDVFSSEPLAQFSPLLHAKNIITTPHIAAATVESYQQTGTHVAQ
CCHHHHHHHHCCEEEEEEHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
SIIDYFAGREIKNVL
HHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]