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The map label for this gene is ipaH_6 [H]

Identifier: 82544544

GI number: 82544544

Start: 2054932

End: 2056695

Strand: Reverse

Name: ipaH_6 [H]

Synonym: SBO_2084

Alternate gene names: 82544544

Gene position: 2056695-2054932 (Counterclockwise)

Preceding gene: 82544547

Following gene: 82544541

Centisome position: 45.5

GC content: 50.11

Gene sequence:

>1764_bases
ATGAAACCTGCCCACAATCCTTCTTTTTTCCGCTCCTTTTGTGGTTTAGGATGTATATCCCGTTTATCCGTAGAAGAGCA
AAATATCACGGATTATCACCGCATCTGGGATAACTGGGCCAAGGAAGGTGCTGCAACAGAAGACCGAACACAGGCAGTTC
GATTACTGAAAATATGTCTGGCTTTTCAAGAGCCAGCCCTCAATTTAAGTTTACTCAGATTACGCTCTCTCCCATACCTG
CCCCCGCACATACAAGAACTTAACATCTCTAGCAATGAGCTACGCTCTCTGCCAGAACTCCCTCCGTCCTTAACTGTACT
TAAAGCCAGCGATAACAGACTGAGCAGGCTCCCGGCTCTTCCGCCTCACCTGGTCGCTCTTGATGTTTCACTTAACAGAG
TTTTAACATGTTTACCTTCTCTTCCATCTTCCTTGCAGTCACTCTCAGCCCTTCTCAATAGCCTGGAGACGCTACCTGAT
CTTCCCCCGGCTCTACAAAAACTTTCTGTTGGCAACAACCAGCTTACTGCCTTACCAGAATTACCATGTGAACTACAGGA
ACTAAGTGCTTTTGATAACAGATTACAAGAGCTACCGCCCCTTCCTCAAAATCTGAGGCTTTTAAACGTTGGGGAAAACC
AACTACACAGACTGCCCGAACTTCCACAACGTCTGCAATCACTATATATCCCTAACAATCAGCTGAACACATTGCCAGAC
AGTATCATGAATCTGCACATTTATGCAGATGTTAATATTTATAACAATCCATTGTCGACTCGCACTCTGCAAGCCCTGCA
AAGATTAACCTCTTCGCCGGACTACCACGGCCCACGGATTTACTTCTCCATGAGTGACGGACAACAGAATACACTCCATC
GCCCCCTGGCTGATGCCGTGACAGCATGGTTCCCGGAAAACAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAA
CATGAAGAGCACGCCAACACCTTTTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCCGGATT
CCGTGAACAGGTCGCTGCATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGCTGCTG
ATGCCACTGAGAGCTGTGAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAAAACCCTCCTGGTCCATCAGGCATCA
GAAGGCCTTTTCGATAATGATACCGGCGCTCTGCTCTCCCTGGGCAGGGAAATGTTCCGCCTCGAAATTCTGGAGGACAT
TGCCCGGGATAAAGTCAGAACTCTCCATTTTGTGGATGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGA
AACTTCAGCTCTCCACTGCCGTGAAGGAAATGCGTTTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCC
GAAGCCATGGTCAGAAGCCGTGAAGAGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAA
GCGTACGGAAGCTGACCGCTGGGCGCTGGCAGAAGAGCAGAAATATGAGATGCTGGAGAATGAGTACCCTCAGAGGGTGG
CTGACCGGCTGAAAGCATCAGGTCTGAGCGGTGATGCGGATGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTGAGACT
GAACAGCAGATTTACCGTCAGCTGACTGACGAGGTACTGGCCCTGCGATTGCCTGAAAACGGCTCACAACTGCACCATTC
ATAA

Upstream 100 bases:

>100_bases
TTCTTCCTGTTCTTAACTATTTACAGGAGCGTTTTTTTAAAGAATCCTCACTCCATTTGCACGAACATATTAATATATAA
ACAATGAGGATCAATAATAA

Downstream 100 bases:

>100_bases
TCACATCGCATAAACCACAGACCGGACTGACTCCGGAAAAACAGAGGCCCGCCCCCGGGCCTCCCCGGATTCATCCGTTT
CCCTGTTCAGCCTGACAGCA

Product: invasion plasmid antigen

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MKPAHNPSFFRSFCGLGCISRLSVEEQNITDYHRIWDNWAKEGAATEDRTQAVRLLKICLAFQEPALNLSLLRLRSLPYL
PPHIQELNISSNELRSLPELPPSLTVLKASDNRLSRLPALPPHLVALDVSLNRVLTCLPSLPSSLQSLSALLNSLETLPD
LPPALQKLSVGNNQLTALPELPCELQELSAFDNRLQELPPLPQNLRLLNVGENQLHRLPELPQRLQSLYIPNNQLNTLPD
SIMNLHIYADVNIYNNPLSTRTLQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFE
HEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQAS
EGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTA
EAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRET
EQQIYRQLTDEVLALRLPENGSQLHHS

Sequences:

>Translated_587_residues
MKPAHNPSFFRSFCGLGCISRLSVEEQNITDYHRIWDNWAKEGAATEDRTQAVRLLKICLAFQEPALNLSLLRLRSLPYL
PPHIQELNISSNELRSLPELPPSLTVLKASDNRLSRLPALPPHLVALDVSLNRVLTCLPSLPSSLQSLSALLNSLETLPD
LPPALQKLSVGNNQLTALPELPCELQELSAFDNRLQELPPLPQNLRLLNVGENQLHRLPELPQRLQSLYIPNNQLNTLPD
SIMNLHIYADVNIYNNPLSTRTLQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFE
HEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQAS
EGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTA
EAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRET
EQQIYRQLTDEVLALRLPENGSQLHHS
>Mature_587_residues
MKPAHNPSFFRSFCGLGCISRLSVEEQNITDYHRIWDNWAKEGAATEDRTQAVRLLKICLAFQEPALNLSLLRLRSLPYL
PPHIQELNISSNELRSLPELPPSLTVLKASDNRLSRLPALPPHLVALDVSLNRVLTCLPSLPSSLQSLSALLNSLETLPD
LPPALQKLSVGNNQLTALPELPCELQELSAFDNRLQELPPLPQNLRLLNVGENQLHRLPELPQRLQSLYIPNNQLNTLPD
SIMNLHIYADVNIYNNPLSTRTLQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFE
HEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQAS
EGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTA
EAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRET
EQQIYRQLTDEVLALRLPENGSQLHHS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway [H]

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm (Probable). Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 66504; Mature: 66504

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAHNPSFFRSFCGLGCISRLSVEEQNITDYHRIWDNWAKEGAATEDRTQAVRLLKICL
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AFQEPALNLSLLRLRSLPYLPPHIQELNISSNELRSLPELPPSLTVLKASDNRLSRLPAL
HHCCCCCCHHHHHHHCCCCCCCCHHHCCCCHHHHHCCCCCCCCEEEEECCCCHHHHCCCC
PPHLVALDVSLNRVLTCLPSLPSSLQSLSALLNSLETLPDLPPALQKLSVGNNQLTALPE
CCCCEEEECHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEECCC
LPCELQELSAFDNRLQELPPLPQNLRLLNVGENQLHRLPELPQRLQSLYIPNNQLNTLPD
CCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHCCH
SIMNLHIYADVNIYNNPLSTRTLQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAV
HHEEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
TAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFR
HHHHHHHHHHHHCCCHHHHHCCEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
EAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKAS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
GLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure
MKPAHNPSFFRSFCGLGCISRLSVEEQNITDYHRIWDNWAKEGAATEDRTQAVRLLKICL
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AFQEPALNLSLLRLRSLPYLPPHIQELNISSNELRSLPELPPSLTVLKASDNRLSRLPAL
HHCCCCCCHHHHHHHCCCCCCCCHHHCCCCHHHHHCCCCCCCCEEEEECCCCHHHHCCCC
PPHLVALDVSLNRVLTCLPSLPSSLQSLSALLNSLETLPDLPPALQKLSVGNNQLTALPE
CCCCEEEECHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEECCC
LPCELQELSAFDNRLQELPPLPQNLRLLNVGENQLHRLPELPQRLQSLYIPNNQLNTLPD
CCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHCCH
SIMNLHIYADVNIYNNPLSTRTLQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAV
HHEEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
TAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFR
HHHHHHHHHHHHCCCHHHHHCCEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
EAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKAS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
GLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1791758; 11115111; 11292750; 12384590; 1690703 [H]