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The map label for this gene is trpE [H]

Identifier: 82544282

GI number: 82544282

Start: 1780755

End: 1782317

Strand: Direct

Name: trpE [H]

Synonym: SBO_1802

Alternate gene names: 82544282

Gene position: 1780755-1782317 (Clockwise)

Preceding gene: 82544281

Following gene: 82544283

Centisome position: 39.4

GC content: 55.02

Gene sequence:

>1563_bases
ATGCAAACACAAAAACCGACTCTCGAACTGCTAACCTGCGAAGGCGCTTATCGCGACAACCCGACTGCGCTTTTTCACCA
GTTGTGTGGGGATCGTCCGGCAACGCTGCTGCTGGAATCCGCAGATATCGACAGCAAAGATGATTTAAAAAGCCTGCTAC
TGGTAGACAGTGCGCTGCGCATTACAGCATTAGGTGACACTGTCACAATTCAGGCACTTTCCGGCAACGGCGAAGCCCTG
CTGACACTACTGGATAACGCCCTGCCTGCGGGTGTGGAAAATGAACAATCACCAAACTGCCGTGTGCTGCGCTTCCCCCC
TGTCAGTCCACTGCTGGATGAAGACGCTCGCTTATGCTCCCTTTCGGTTTTTGACGCTTTCCGTTTATTGCAGAATCTGT
TGAATGTACCGAAGGAAGAACGAGAAGCAATGTTCTTCGGCGGCCTGTTCTCTTATGACCTTGTGGCGGGATTTGAAGAT
TTACCGCAACTGTCAGCGGAAAATAACTGCCCTGATTTCTGTTTTTATCTCGCTGAAACGCTGATGGTGATTGACCATCA
GAAAAAAAACACCCGCATTCAGGCCAGCCTGTTTGCTCCGAATGAAGAAGAAAAACAACGTCTCACTGCTCGCCTGAACG
ATCTTCGCCAGCAGCTGACCGAAGCCGCGCCGCCGCTGCCGGTGGTTTCCGTGCCGCATATGCGTTGTGAATGTAACCAG
AGCGATGAAGAGTTCGGTGGCGTGGTGCGTTTGTTGCAAAAAGCGATTCGCACCGGAGAAATTTTCCAGGTGGTGCCGTC
TCGCCGTTTCTCTCTGCCCTGCCCGTCACCGCTGGCGGCCTATTACGTGCTGAAAAAGAGTAATCCCTGCCCGTACATGT
TTTTTATGCAGGATAATGATTTCACCCTGTTTGGCGCGTCGCCGGAAAGTTCGCTCAAGTATGACGCCACCAGCCGCCAG
ATTGAGATCTACCCGATTGCCGGAACACGCCCGCGCGGTCGTCGCGCCGATGGTTCACTGGACAGAGACCTCGACAGCCG
CATCGAACTGGAAATGCGTACCGATCATAAAGAGCTTTCTGAACATCTGATGCTGGTGGATCTCGCCCGTAATGATCTGG
CACGCATTTGCACCCCCGGCAGCCGCTACGTCGCCGATCTTACCAAAGTTGACCGTTACTCTTACGTGATGCACCTGGTC
TCCCGCGTGGTCGGTGAGCTGCGCCACGATCTCGACGCCCTGCACGCTTACCGCGCCTGTATGAATATGGGGACGTTAAG
CGGTGCGCCGAAAGTACGCGCCATGCAGTTAATTGCCGAGGCGGAAGGTCGTCGCCGCGGCAGCTACGGCGGCGCGGTAG
GTTATTTCACCGCGCATGGCGATCTCGACACCTGCATTGTGATCCGCTCGGCGCTGGTGGAAAACGGTATCGCCACCGTG
CAAGCCGGTGCTGGCATAGTCCTTGATTCTGTTCCGCAGTCGGAAGCCGACGAAACCCGTAATAAAGCCCGCGCTGTACT
GCGCGCTATTGCCACCGCGCATCATGCACAGGAGACTTTCTGA

Upstream 100 bases:

>100_bases
ACTTCCTGAAACGGGCAGTGTATTCACCATGCGTAAAGCAATCAGATACCCAGCCCGCCTAATGAGCGGGCTTTTTTTTG
AACAAAATTAGAGAATAACA

Downstream 100 bases:

>100_bases
TGGCTGACATTCTGCTGCTCGATAATATCGACTCTTTTACGTACAACCTGGCAGATCAGTTGCGCAGCAATGGGCATAAT
GTGGTGATTTACCGCAACCA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSGNGEAL
LTLLDNALPAGVENEQSPNCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFED
LPQLSAENNCPDFCFYLAETLMVIDHQKKNTRIQASLFAPNEEEKQRLTARLNDLRQQLTEAAPPLPVVSVPHMRCECNQ
SDEEFGGVVRLLQKAIRTGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPCPYMFFMQDNDFTLFGASPESSLKYDATSRQ
IEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLV
SRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
QAGAGIVLDSVPQSEADETRNKARAVLRAIATAHHAQETF

Sequences:

>Translated_520_residues
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSGNGEAL
LTLLDNALPAGVENEQSPNCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFED
LPQLSAENNCPDFCFYLAETLMVIDHQKKNTRIQASLFAPNEEEKQRLTARLNDLRQQLTEAAPPLPVVSVPHMRCECNQ
SDEEFGGVVRLLQKAIRTGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPCPYMFFMQDNDFTLFGASPESSLKYDATSRQ
IEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLV
SRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
QAGAGIVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
>Mature_520_residues
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSGNGEAL
LTLLDNALPAGVENEQSPNCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFED
LPQLSAENNCPDFCFYLAETLMVIDHQKKNTRIQASLFAPNEEEKQRLTARLNDLRQQLTEAAPPLPVVSVPHMRCECNQ
SDEEFGGVVRLLQKAIRTGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPCPYMFFMQDNDFTLFGASPESSLKYDATSRQ
IEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLV
SRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
QAGAGIVLDSVPQSEADETRNKARAVLRAIATAHHAQETF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=520, Percent_Identity=98.6538461538462, Blast_Score=1054, Evalue=0.0,
Organism=Escherichia coli, GI1788114, Length=422, Percent_Identity=29.8578199052133, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI87082077, Length=299, Percent_Identity=28.0936454849498, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786809, Length=256, Percent_Identity=28.125, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=399, Percent_Identity=37.0927318295739, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6324361, Length=274, Percent_Identity=28.4671532846715, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57625; Mature: 57625

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALR
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCEE
ITALGDTVTIQALSGNGEALLTLLDNALPAGVENEQSPNCRVLRFPPVSPLLDEDARLCS
EEEECCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
LSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFEDLPQLSAENNCPDFCFYLAET
HHHHHHHHHHHHHHCCCHHHHCEEEECCHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHH
LMVIDHQKKNTRIQASLFAPNEEEKQRLTARLNDLRQQLTEAAPPLPVVSVPHMRCECNQ
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEECCCC
SDEEFGGVVRLLQKAIRTGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPCPYMFFMQDND
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHEEEEEECCCCCCEEEEEECCC
FTLFGASPESSLKYDATSRQIEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELS
EEEEECCCCCCCEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHH
EHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRAC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
HHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEE
QAGAGIVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
ECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALR
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCEE
ITALGDTVTIQALSGNGEALLTLLDNALPAGVENEQSPNCRVLRFPPVSPLLDEDARLCS
EEEECCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
LSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFEDLPQLSAENNCPDFCFYLAET
HHHHHHHHHHHHHHCCCHHHHCEEEECCHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHH
LMVIDHQKKNTRIQASLFAPNEEEKQRLTARLNDLRQQLTEAAPPLPVVSVPHMRCECNQ
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEECCCC
SDEEFGGVVRLLQKAIRTGEIFQVVPSRRFSLPCPSPLAAYYVLKKSNPCPYMFFMQDND
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHEEEEEECCCCCCEEEEEECCC
FTLFGASPESSLKYDATSRQIEIYPIAGTRPRGRRADGSLDRDLDSRIELEMRTDHKELS
EEEEECCCCCCCEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHH
EHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRAC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
HHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEE
QAGAGIVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
ECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7038627; 7021857; 9097039; 9278503; 351195; 4598537 [H]