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The map label for this gene is argG [H]

Identifier: 78780185

GI number: 78780185

Start: 1696181

End: 1697395

Strand: Reverse

Name: argG [H]

Synonym: PMT9312_1800

Alternate gene names: 78780185

Gene position: 1697395-1696181 (Counterclockwise)

Preceding gene: 78780189

Following gene: 78780182

Centisome position: 99.31

GC content: 34.65

Gene sequence:

>1215_bases
ATGCAGCAGGTAAACAAAGTTGTACTAGCCTATTCCGGTGGAGTTGATACGAGCGTTTGTATTCCATATTTAAAGAATGA
ATATGGCATTTCAGAAGTGGTTACTTTTGTGGCAGATCTTGGACAAGGCGAGGATTTGGAACTTATTAGGAAAAAAGCCT
TAAATTCAGGTGCATCTAAATCAATAATTGGTAATTTAGTTAGTAGTTTTGTTGAGAGATATGCTTTTCCTGCTATTAGA
GCAAATGCACTCTATCTAGATAAATATCCTTTATCTACAGCTCTTGCTAGGCCTTTAATTGCTGAAAACCTGGTAAATAT
TGCTCGAGAGATTAATGCCGATGCAGTAGCTCATGGATGTACTGGTAAAGGGAATGATCAAGTTCGATTTGATTTAGCAA
TTAATGCTTTAGGCCCTGATTTGAAAATAATTACTCCCGCAAGGGAGTGGAATATGAGTAGGGAAGAGGCAATATTGTAT
GGAGAAAAATTTGGTATTCCTGCACCAGTATCTAAAAAATCACCATATTCAATAGACGTTAACTTACTTGGTAGGAGTAT
TGAAGCCGGTATATTAGAAGATCCCATGCAAGAGGCACCTGAAGATATTTTTGCAATGACATCATCAATTAATAATTCAC
CTGAGTCTCCGTTAGATATAGAAATTATTTTTAAAAATGGCTTCCCAGTTGGAATCAACAATGAATTTTTAAATCCAGTG
GAGATTATCCAAAAAGCTAATGTTCTTGCAGGTGAATATGGTTTTGGAAGAATAGATATGATGGAAGATCGAGTGGTAGG
AATTAAAAGTAGAGAGATTTATGAAACGCCTGGTCTCTTACTATTAATAAAAGCTCACAAGGAATTGGAAAGTATTACAT
TAAATCCAGATGTTATTGATTTTAAAGGAGTCGTCGAAAAAAAATGGGGTCAATTAGTTTATCAAGGTTTTTGGTTTGGT
CCTCTCAAGGAGAGTTTAGATGCTTTTATTGCATCGACTCAAACTTCAGTTAATGGACGAGTAAAGATTAGACTTCATAA
GGGGAATGCAATAGTAATTGGAAGAATCTCAGAAAATAATTCACTTTATAGAGAGGATTTGGCAACTTATAGTCAAGACG
ATGTTTTTAAACATTCCTTAGCGGAGGGTTTTATTTATATGTGGGGTATGTCTAATAAAATATGGGCAGAGTTAAATTCA
AAAAAAATTGATTAA

Upstream 100 bases:

>100_bases
AGTTTTTGGTCCAGCTCTTTTAGTTACAATAATATTAGTTTTTAATAAGTTATCAAATTCTTAATTACGTCAAAAATTTA
AATTTATGGAGCAAATTTAA

Downstream 100 bases:

>100_bases
CAATATCTAAGATTCTGTATTTTCTTTAATTTCATTATCGTCTTTTTTTGTTGTTGAAGTATCAGAGTTTGTTACTGATT
GCTCTTCTTTAGATTCAACT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQQVNKVVLAYSGGVDTSVCIPYLKNEYGISEVVTFVADLGQGEDLELIRKKALNSGASKSIIGNLVSSFVERYAFPAIR
ANALYLDKYPLSTALARPLIAENLVNIAREINADAVAHGCTGKGNDQVRFDLAINALGPDLKIITPAREWNMSREEAILY
GEKFGIPAPVSKKSPYSIDVNLLGRSIEAGILEDPMQEAPEDIFAMTSSINNSPESPLDIEIIFKNGFPVGINNEFLNPV
EIIQKANVLAGEYGFGRIDMMEDRVVGIKSREIYETPGLLLLIKAHKELESITLNPDVIDFKGVVEKKWGQLVYQGFWFG
PLKESLDAFIASTQTSVNGRVKIRLHKGNAIVIGRISENNSLYREDLATYSQDDVFKHSLAEGFIYMWGMSNKIWAELNS
KKID

Sequences:

>Translated_404_residues
MQQVNKVVLAYSGGVDTSVCIPYLKNEYGISEVVTFVADLGQGEDLELIRKKALNSGASKSIIGNLVSSFVERYAFPAIR
ANALYLDKYPLSTALARPLIAENLVNIAREINADAVAHGCTGKGNDQVRFDLAINALGPDLKIITPAREWNMSREEAILY
GEKFGIPAPVSKKSPYSIDVNLLGRSIEAGILEDPMQEAPEDIFAMTSSINNSPESPLDIEIIFKNGFPVGINNEFLNPV
EIIQKANVLAGEYGFGRIDMMEDRVVGIKSREIYETPGLLLLIKAHKELESITLNPDVIDFKGVVEKKWGQLVYQGFWFG
PLKESLDAFIASTQTSVNGRVKIRLHKGNAIVIGRISENNSLYREDLATYSQDDVFKHSLAEGFIYMWGMSNKIWAELNS
KKID
>Mature_404_residues
MQQVNKVVLAYSGGVDTSVCIPYLKNEYGISEVVTFVADLGQGEDLELIRKKALNSGASKSIIGNLVSSFVERYAFPAIR
ANALYLDKYPLSTALARPLIAENLVNIAREINADAVAHGCTGKGNDQVRFDLAINALGPDLKIITPAREWNMSREEAILY
GEKFGIPAPVSKKSPYSIDVNLLGRSIEAGILEDPMQEAPEDIFAMTSSINNSPESPLDIEIIFKNGFPVGINNEFLNPV
EIIQKANVLAGEYGFGRIDMMEDRVVGIKSREIYETPGLLLLIKAHKELESITLNPDVIDFKGVVEKKWGQLVYQGFWFG
PLKESLDAFIASTQTSVNGRVKIRLHKGNAIVIGRISENNSLYREDLATYSQDDVFKHSLAEGFIYMWGMSNKIWAELNS
KKID

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=414, Percent_Identity=41.0628019323672, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI16950633, Length=414, Percent_Identity=41.0628019323672, Blast_Score=283, Evalue=2e-76,
Organism=Escherichia coli, GI1789563, Length=405, Percent_Identity=28.3950617283951, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324514, Length=412, Percent_Identity=38.5922330097087, Blast_Score=280, Evalue=2e-76,
Organism=Drosophila melanogaster, GI21358151, Length=392, Percent_Identity=39.7959183673469, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 44697; Mature: 44697

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQVNKVVLAYSGGVDTSVCIPYLKNEYGISEVVTFVADLGQGEDLELIRKKALNSGASK
CCCCCEEEEEECCCCCCCEEHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHH
SIIGNLVSSFVERYAFPAIRANALYLDKYPLSTALARPLIAENLVNIAREINADAVAHGC
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
TGKGNDQVRFDLAINALGPDLKIITPAREWNMSREEAILYGEKFGIPAPVSKKSPYSIDV
CCCCCCEEEEEEEEECCCCCEEEECCHHHCCCCHHHEEEEEHHCCCCCCCCCCCCCEEEE
NLLGRSIEAGILEDPMQEAPEDIFAMTSSINNSPESPLDIEIIFKNGFPVGINNEFLNPV
EEECCCCCCCHHCCHHHHCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCHH
EIIQKANVLAGEYGFGRIDMMEDRVVGIKSREIYETPGLLLLIKAHKELESITLNPDVID
HHHHHCCCEECCCCCCEEEECCCCEECCCCCEEECCCCEEEEEECCCCHHEEECCCCCCC
FKGVVEKKWGQLVYQGFWFGPLKESLDAFIASTQTSVNGRVKIRLHKGNAIVIGRISENN
HHHHHHHHHHHHHHHCEECCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCCC
SLYREDLATYSQDDVFKHSLAEGFIYMWGMSNKIWAELNSKKID
CHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCHHEEECCCCCCC
>Mature Secondary Structure
MQQVNKVVLAYSGGVDTSVCIPYLKNEYGISEVVTFVADLGQGEDLELIRKKALNSGASK
CCCCCEEEEEECCCCCCCEEHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHH
SIIGNLVSSFVERYAFPAIRANALYLDKYPLSTALARPLIAENLVNIAREINADAVAHGC
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
TGKGNDQVRFDLAINALGPDLKIITPAREWNMSREEAILYGEKFGIPAPVSKKSPYSIDV
CCCCCCEEEEEEEEECCCCCEEEECCHHHCCCCHHHEEEEEHHCCCCCCCCCCCCCEEEE
NLLGRSIEAGILEDPMQEAPEDIFAMTSSINNSPESPLDIEIIFKNGFPVGINNEFLNPV
EEECCCCCCCHHCCHHHHCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCHH
EIIQKANVLAGEYGFGRIDMMEDRVVGIKSREIYETPGLLLLIKAHKELESITLNPDVID
HHHHHCCCEECCCCCCEEEECCCCEECCCCCEEECCCCEEEEEECCCCHHEEECCCCCCC
FKGVVEKKWGQLVYQGFWFGPLKESLDAFIASTQTSVNGRVKIRLHKGNAIVIGRISENN
HHHHHHHHHHHHHHHCEECCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCCC
SLYREDLATYSQDDVFKHSLAEGFIYMWGMSNKIWAELNSKKID
CHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA