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The map label for this gene is tetA [H]

Identifier: 78780173

GI number: 78780173

Start: 1680413

End: 1681681

Strand: Direct

Name: tetA [H]

Synonym: PMT9312_1788

Alternate gene names: 78780173

Gene position: 1680413-1681681 (Clockwise)

Preceding gene: 78780171

Following gene: 78780174

Centisome position: 98.32

GC content: 31.84

Gene sequence:

>1269_bases
GTGAAAGAAAGTTTATTAAAACCAAATAAAAAATTTACTCTCCTTAGTGCGTTTATCACTCTTCTCAATGATCGTTTAAG
TGAAAGTATACTGTTACCCATATTACCCTCTTTTGTTTTACTTTTTGACTCTAAAGCAAGTACATATGGTTTATTATCCT
GCACTTACCAATTAGCTCAATTTACAGCTTCTCCTTTTATAGGAATTATGAGTGATAGATATGGAAGAAGACCTGTCACT
CTTTTTTGTATTACTGGTTCAGTAATAGGAATATCAATATTATCTTTTACGGTTCTTTTTAATTGGTCAAATTCAATAGC
CTCTATCCCGTTATTTTTATTATTTTTAGCGCGACTAATTGACGGTTTAAGTGGGGGGACTGCAGCTACTGCAACAACAA
TTCTTGCAGATATTTCAAGCCCTGAAAAAAGAGCAAAAACATTTGGTCTTATTGGTGTAGCTTTTGGTTTAAGTTTTTTC
TTGGGTAATATTTTTGTTGTAATTTTTGCAAAAAATACAAATAATAATTTTATTATTCCAGTTTTGATAGCCTCAATCAT
TCCAATAATCAATTTCCTCCTTGTATTTTTTTACTTGCCAGAAACCAAGCCTAATAGTGACTCAAATAAATCAACAACTA
TTTTTAAAAACCCTATAAAAGAGCTATTTAAAGTTTTCAAAGAAGAAAAGATTAAAAAATTATCATTAGCTTTTTTTATT
TACTTTATTGCTTTTACTGGATTGACCAATATCCTTATATTTTTCCTTCAAGAATCTTTAAACTGGACGACCAAAGCATC
AAGTGGAACTCTTGTTGTAGTAGGAATCATTGCAATTATCGTTCAGGGAGGACTAATTGGACCTCTGGTAAAGCAATTTG
GCGAAATGCGATTAACACTTATTGGATCAGGCTTCATTCTTGTGGCATGTGCTCTTTTAATAACTGCTCCAAAAGAAAAT
GCGACAATTAATATTTATTCAGCTGTTTCATTTTTAGCCGTTGGGGCAGGGTTAATTACTCCCACCTTAAGAGCACTAAT
ATCAAAGAAATTAGACGTTGATAAACAAGGATCAATTTTAAGTAACCTTCAGGGTCTACAGAGTCTTGGAGGAGTCTTAG
GAATTGCAATGGCCGGAAGGGTTTATGATAGTTTTGGTCCTAAATCACCTTTTATAGCTGGTTCCGTTATCTTAATTTTC
ATGATATACCTTATTGCAGAGGGTAAAAATAATAATTCTTTTAAGAATCAAAAATCAAAAGTATTTTAA

Upstream 100 bases:

>100_bases
GGTCACCAGGACCTGCTCCAACTAAATAAACAATGCCAGGCACAATAATCTCCATTAACAAGTATGGTAGTAGAAGTTAA
TCGTAATGAAGGTAAATATT

Downstream 100 bases:

>100_bases
TGAAAAGACAGGCTGATGTTTTTATTAATAGAGAATTAAGTTGGATTAAGTTCAATAAAAGAGTACTCCTAACTGGAATG
GAAAAGGAATACAAAATCCT

Product: major facilitator superfamily multidrug-efflux transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGIMSDRYGRRPVT
LFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVLIASIIPIINFLLVFFYLPETKPNSDSNKSTTIFKNPIKELFKVFKEEKIKKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTLIGSGFILVACALLITAPKEN
ATINIYSAVSFLAVGAGLITPTLRALISKKLDVDKQGSILSNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILIF
MIYLIAEGKNNNSFKNQKSKVF

Sequences:

>Translated_422_residues
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGIMSDRYGRRPVT
LFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVLIASIIPIINFLLVFFYLPETKPNSDSNKSTTIFKNPIKELFKVFKEEKIKKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTLIGSGFILVACALLITAPKEN
ATINIYSAVSFLAVGAGLITPTLRALISKKLDVDKQGSILSNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILIF
MIYLIAEGKNNNSFKNQKSKVF
>Mature_422_residues
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGIMSDRYGRRPVT
LFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLIDGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFF
LGNIFVVIFAKNTNNNFIIPVLIASIIPIINFLLVFFYLPETKPNSDSNKSTTIFKNPIKELFKVFKEEKIKKLSLAFFI
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTLIGSGFILVACALLITAPKEN
ATINIYSAVSFLAVGAGLITPTLRALISKKLDVDKQGSILSNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILIF
MIYLIAEGKNNNSFKNQKSKVF

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=253, Percent_Identity=26.8774703557312, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI225703102, Length=253, Percent_Identity=26.8774703557312, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI39753965, Length=361, Percent_Identity=21.606648199446, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17551570, Length=366, Percent_Identity=24.5901639344262, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71996331, Length=338, Percent_Identity=21.301775147929, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17738085, Length=375, Percent_Identity=26.1333333333333, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45805; Mature: 45805

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FTASPFIGIMSDRYGRRPVTLFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLI
HHCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHH
DGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFFLGNIFVVIFAKNTNNNFIIP
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCEEHH
VLIASIIPIINFLLVFFYLPETKPNSDSNKSTTIFKNPIKELFKVFKEEKIKKLSLAFFI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTL
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEEEE
IGSGFILVACALLITAPKENATINIYSAVSFLAVGAGLITPTLRALISKKLDVDKQGSIL
ECCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
SNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILIFMIYLIAEGKNNNSFKNQKSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCC
VF
CC
>Mature Secondary Structure
MKESLLKPNKKFTLLSAFITLLNDRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FTASPFIGIMSDRYGRRPVTLFCITGSVIGISILSFTVLFNWSNSIASIPLFLLFLARLI
HHCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHH
DGLSGGTAATATTILADISSPEKRAKTFGLIGVAFGLSFFLGNIFVVIFAKNTNNNFIIP
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCEEHH
VLIASIIPIINFLLVFFYLPETKPNSDSNKSTTIFKNPIKELFKVFKEEKIKKLSLAFFI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFIAFTGLTNILIFFLQESLNWTTKASSGTLVVVGIIAIIVQGGLIGPLVKQFGEMRLTL
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEEEE
IGSGFILVACALLITAPKENATINIYSAVSFLAVGAGLITPTLRALISKKLDVDKQGSIL
ECCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
SNLQGLQSLGGVLGIAMAGRVYDSFGPKSPFIAGSVILIFMIYLIAEGKNNNSFKNQKSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCC
VF
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]