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The map label for this gene is dapA [H]

Identifier: 78780130

GI number: 78780130

Start: 1635326

End: 1636228

Strand: Reverse

Name: dapA [H]

Synonym: PMT9312_1745

Alternate gene names: 78780130

Gene position: 1636228-1635326 (Counterclockwise)

Preceding gene: 78780131

Following gene: 78780129

Centisome position: 95.73

GC content: 37.98

Gene sequence:

>903_bases
ATGATTCCAGACAACACTAAGTTTACTAATCCATTTTTTGGAAGAATATTGACTGCAATGGTTACTCCATTTACTGAAAA
TGGAAATGTAGATTATGAACTAGCTATAAAACTTTCTAATTATCTTTTTGAGAACGGTTCTGATGGCATTGTGCTATGTG
GTACTACTGGAGAATCTCCGACTCTTTCATGGGCGGAACAGCATGATTTATTTATTGCAGTAAAAGGATCTTTGGATTCA
AGCTGTAAAGTTATAGTTGGTACTGGGAGTAATTGCACAAGTGAGGCTGTAGAAGCTACAAAAAAAGCCTATGACTCTGG
TGCGGACGGTGCTTTGGTTGTTGTTCCTTATTACAATAAACCACCTCAAGAAGGTCTTTATAAACATTTCAGTTCCATTG
CTAATTCTGCAAAGGATTTGCCTTTAATGCTTTACAACATACCTGGAAGGACAGGGTGCAATTTATTACCTGATACTGTG
AAGAAACTTATGGATTTCTCGAATATTCTCAGTATTAAAGCGGCAAGCGGTAGAATAGAAGAAGTAACAGAATTAAGAGC
TATTTGTGGCTCCGAACTCTCTGTATATAGTGGCGACGATTCATTGTTGCTTCCAATGTTATCTGTGGGTGCTGTAGGAG
TAGTAAGTGTTGCAAGTCATTTGGTTGGCTTGCAACTGAAAGAGATGATTCAATCCTTTCAAAGTGGAAAAGTTGCTAAT
GCGCTTGCAATTCATGAAAAACTTCAGCCTCTTTTCAAAGCACTTTTTATGACCACCAATCCAATCCCAATTAAGGCTGC
TTTGGAGCTATCGGGATGGAATGTAGGTAAACCTAGAAGTCCTTTGTCACCATTAAGCAATGACATGAAAAAGCAACTAT
CTTTTATCCTGACATCGCTATAA

Upstream 100 bases:

>100_bases
GTCAGACAAATGGATTAGAATTATGGTTATGTGGAGATCAAATAAGAAAAGGAGCAGCTCTTAATGCTGTTCAAATAGCT
GAGTTATTAATTCCAAAAAA

Downstream 100 bases:

>100_bases
TAGGGATTATATTTAACTTGATAATTAAATTTAAATAAACCTTATTTGATTACAAGCCGGCCTTTATAAATTTCAAAATT
ATGCAATCAAGTTCAAATTC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MIPDNTKFTNPFFGRILTAMVTPFTENGNVDYELAIKLSNYLFENGSDGIVLCGTTGESPTLSWAEQHDLFIAVKGSLDS
SCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNKPPQEGLYKHFSSIANSAKDLPLMLYNIPGRTGCNLLPDTV
KKLMDFSNILSIKAASGRIEEVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIQSFQSGKVAN
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWNVGKPRSPLSPLSNDMKKQLSFILTSL

Sequences:

>Translated_300_residues
MIPDNTKFTNPFFGRILTAMVTPFTENGNVDYELAIKLSNYLFENGSDGIVLCGTTGESPTLSWAEQHDLFIAVKGSLDS
SCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNKPPQEGLYKHFSSIANSAKDLPLMLYNIPGRTGCNLLPDTV
KKLMDFSNILSIKAASGRIEEVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIQSFQSGKVAN
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWNVGKPRSPLSPLSNDMKKQLSFILTSL
>Mature_300_residues
MIPDNTKFTNPFFGRILTAMVTPFTENGNVDYELAIKLSNYLFENGSDGIVLCGTTGESPTLSWAEQHDLFIAVKGSLDS
SCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNKPPQEGLYKHFSSIANSAKDLPLMLYNIPGRTGCNLLPDTV
KKLMDFSNILSIKAASGRIEEVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIQSFQSGKVAN
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWNVGKPRSPLSPLSNDMKKQLSFILTSL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=26.551724137931, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=28.4280936454849, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788823, Length=287, Percent_Identity=39.7212543554007, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1786463, Length=295, Percent_Identity=30.1694915254237, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=27.7591973244147, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=23.4265734265734, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32213; Mature: 32213

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPDNTKFTNPFFGRILTAMVTPFTENGNVDYELAIKLSNYLFENGSDGIVLCGTTGESP
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHCCCCCCEEEEECCCCCC
TLSWAEQHDLFIAVKGSLDSSCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNK
CCCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCC
PPQEGLYKHFSSIANSAKDLPLMLYNIPGRTGCNLLPDTVKKLMDFSNILSIKAASGRIE
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCHH
EVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIQSFQSGKVAN
HHHHHHHHHCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWNVGKPRSPLSPLSNDMKKQLSFILTSL
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIPDNTKFTNPFFGRILTAMVTPFTENGNVDYELAIKLSNYLFENGSDGIVLCGTTGESP
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHCCCCCCEEEEECCCCCC
TLSWAEQHDLFIAVKGSLDSSCKVIVGTGSNCTSEAVEATKKAYDSGADGALVVVPYYNK
CCCCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCC
PPQEGLYKHFSSIANSAKDLPLMLYNIPGRTGCNLLPDTVKKLMDFSNILSIKAASGRIE
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCHH
EVTELRAICGSELSVYSGDDSLLLPMLSVGAVGVVSVASHLVGLQLKEMIQSFQSGKVAN
HHHHHHHHHCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALAIHEKLQPLFKALFMTTNPIPIKAALELSGWNVGKPRSPLSPLSNDMKKQLSFILTSL
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA