Click here to switch to the map view.

The map label for this gene is napA [H]

Identifier: 78780077

GI number: 78780077

Start: 1580651

End: 1582018

Strand: Reverse

Name: napA [H]

Synonym: PMT9312_1692

Alternate gene names: 78780077

Gene position: 1582018-1580651 (Counterclockwise)

Preceding gene: 78780079

Following gene: 78780076

Centisome position: 92.56

GC content: 38.74

Gene sequence:

>1368_bases
ATGTATCCTTTACTTGCTGAATTAAGTGCTCATGATTTAGAAGTTGCTGAAACACTTATAGGAGTAATACGATTTCTACT
GATATTTTTAGCTGCAAGAGCATTAGCAGAAGTACTAGTAAGACTCAGTTTGCCGACTATTGTAGGTGAGCTTCTTGCAG
GGGTTGTAATAGGAGCATCAGGATTCCATTTGTTAATACCACCATCAGCTGGAACTGAACTTAATGGAGGTCTTGTAAAT
GTTATAAGTTCATTAGCTTCAATTCCCCCGGAAGCAGTGCCTGATGTTTACTTCGAAAGTTTTCCATCCCTCCAAGCAGT
AGCAACACTTGGGTTATATGCACTTTTATTCTTAACAGGATTAGAAAGTGAGTTAGAGGAATTAGTAGCTGTCGGTGCAC
AGGCTTTTACTGTTGCTATGGCTGGGGTAATTTTACCGTTTGCCTTTGGAACTCTGGGATTAATGTTTATTTTCCAAGTA
GATCTTATTCCAGCAGTTTTTGCTGGAGCATCTATGACAGCAACAAGTATAGGAATTACTGCAAGTGTTTTCGGTGAATT
AGGATATTTGAAAACTAGAGAAGGACAGATTGTTATTGGTGCAGCAGTTCTAGACGATATTTTGGGAATTGTTATTCTCG
CAGTTGTTGTGGCACTTGCTGCAGGAGGTTCTCTAGAAATTGCTCCTATCGTTAAATTAGTTGCAGCAGCTGTAGTATTT
GTTATTGCGGCTATAGCATTAAGTAGAACAGCAGCCCCAGGTTTTGATTGGCTTTTAGATCGATTAAAAGCTCCTGGAGC
TGTAGTGGTGGCATCTTTTGTGATACTTGTGTTGTGTTGTTTTGTTGCTACAGCCATTGGATTAGAAGCAGCTTTAGGTG
CTTTTGCAGCTGGATTGATCCTTAGTAGTTCTAAAAATAATCATGCAATTCAACAATCCGTTTTACCTTTAGTATCTTTA
TTCGCAACTATTTTCTTTGTATTAGTGGGAGCTGGTATGGATCTATCAGTTATCAATCCACTGGATCCAACAAGTAGATC
AGCACTTGTAGTTGCAGGATTTTTATTAGTTGTTGCAATTATTGGAAAAATTGCAGCAGGATGGGTATTTTCAAGTGATA
AACCTACAAATAGATTAGTTGTGGGTTTGGGTATGATGCCTAGAGGAGAGGTTGGTTTAATTTTTCTTGGGCTAGGAACA
AGCGCTAAGTTATTAACTCCTTCTCTTGAAGCGGCTATTTTATTAATGGTTATTGGAACCACATTTCTTGCACCTGTTCT
CTTGAGAATTGTTCTAAAAGATAAGCCTCCAAGTGATGGCAATAAAATTTCAGATGATGTTGCAGCTGATCCTGTGGGTC
TTCGTTAG

Upstream 100 bases:

>100_bases
CACACTTGTTGAGTATTTTTGCTTTTTTTTACATAGTTCTTAAAGTGGGCCCTCAATAAACTATCTTCCAGTTAGATAGT
TTATTTTTTTTGCATTTCAA

Downstream 100 bases:

>100_bases
GAAATAAGTTTATTAGAATCAATTAACATAAGACTTTCAATAAATGGAAAAATCAGCTCTGTTAGATAGTGATGTTAATT
ATGACTGGAATTTCTTAAAT

Product: CPA2 family Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MYPLLAELSAHDLEVAETLIGVIRFLLIFLAARALAEVLVRLSLPTIVGELLAGVVIGASGFHLLIPPSAGTELNGGLVN
VISSLASIPPEAVPDVYFESFPSLQAVATLGLYALLFLTGLESELEELVAVGAQAFTVAMAGVILPFAFGTLGLMFIFQV
DLIPAVFAGASMTATSIGITASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALAAGGSLEIAPIVKLVAAAVVF
VIAAIALSRTAAPGFDWLLDRLKAPGAVVVASFVILVLCCFVATAIGLEAALGAFAAGLILSSSKNNHAIQQSVLPLVSL
FATIFFVLVGAGMDLSVINPLDPTSRSALVVAGFLLVVAIIGKIAAGWVFSSDKPTNRLVVGLGMMPRGEVGLIFLGLGT
SAKLLTPSLEAAILLMVIGTTFLAPVLLRIVLKDKPPSDGNKISDDVAADPVGLR

Sequences:

>Translated_455_residues
MYPLLAELSAHDLEVAETLIGVIRFLLIFLAARALAEVLVRLSLPTIVGELLAGVVIGASGFHLLIPPSAGTELNGGLVN
VISSLASIPPEAVPDVYFESFPSLQAVATLGLYALLFLTGLESELEELVAVGAQAFTVAMAGVILPFAFGTLGLMFIFQV
DLIPAVFAGASMTATSIGITASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALAAGGSLEIAPIVKLVAAAVVF
VIAAIALSRTAAPGFDWLLDRLKAPGAVVVASFVILVLCCFVATAIGLEAALGAFAAGLILSSSKNNHAIQQSVLPLVSL
FATIFFVLVGAGMDLSVINPLDPTSRSALVVAGFLLVVAIIGKIAAGWVFSSDKPTNRLVVGLGMMPRGEVGLIFLGLGT
SAKLLTPSLEAAILLMVIGTTFLAPVLLRIVLKDKPPSDGNKISDDVAADPVGLR
>Mature_455_residues
MYPLLAELSAHDLEVAETLIGVIRFLLIFLAARALAEVLVRLSLPTIVGELLAGVVIGASGFHLLIPPSAGTELNGGLVN
VISSLASIPPEAVPDVYFESFPSLQAVATLGLYALLFLTGLESELEELVAVGAQAFTVAMAGVILPFAFGTLGLMFIFQV
DLIPAVFAGASMTATSIGITASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALAAGGSLEIAPIVKLVAAAVVF
VIAAIALSRTAAPGFDWLLDRLKAPGAVVVASFVILVLCCFVATAIGLEAALGAFAAGLILSSSKNNHAIQQSVLPLVSL
FATIFFVLVGAGMDLSVINPLDPTSRSALVVAGFLLVVAIIGKIAAGWVFSSDKPTNRLVVGLGMMPRGEVGLIFLGLGT
SAKLLTPSLEAAILLMVIGTTFLAPVLLRIVLKDKPPSDGNKISDDVAADPVGLR

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=408, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786232, Length=447, Percent_Identity=24.8322147651007, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322367, Length=453, Percent_Identity=22.2958057395143, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46693; Mature: 46693

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLLAELSAHDLEVAETLIGVIRFLLIFLAARALAEVLVRLSLPTIVGELLAGVVIGAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GFHLLIPPSAGTELNGGLVNVISSLASIPPEAVPDVYFESFPSLQAVATLGLYALLFLTG
CCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHC
LESELEELVAVGAQAFTVAMAGVILPFAFGTLGLMFIFQVDLIPAVFAGASMTATSIGIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALAAGGSLEIAPIVKLVAAAVVF
HHHHHHHCCCEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VIAAIALSRTAAPGFDWLLDRLKAPGAVVVASFVILVLCCFVATAIGLEAALGAFAAGLI
HHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSSSKNNHAIQQSVLPLVSLFATIFFVLVGAGMDLSVINPLDPTSRSALVVAGFLLVVAI
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
IGKIAAGWVFSSDKPTNRLVVGLGMMPRGEVGLIFLGLGTSAKLLTPSLEAAILLMVIGT
HHHHHHCCEECCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHCCCHHHHHHHHHHHHH
TFLAPVLLRIVLKDKPPSDGNKISDDVAADPVGLR
HHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MYPLLAELSAHDLEVAETLIGVIRFLLIFLAARALAEVLVRLSLPTIVGELLAGVVIGAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GFHLLIPPSAGTELNGGLVNVISSLASIPPEAVPDVYFESFPSLQAVATLGLYALLFLTG
CCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHC
LESELEELVAVGAQAFTVAMAGVILPFAFGTLGLMFIFQVDLIPAVFAGASMTATSIGIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ASVFGELGYLKTREGQIVIGAAVLDDILGIVILAVVVALAAGGSLEIAPIVKLVAAAVVF
HHHHHHHCCCEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VIAAIALSRTAAPGFDWLLDRLKAPGAVVVASFVILVLCCFVATAIGLEAALGAFAAGLI
HHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSSSKNNHAIQQSVLPLVSLFATIFFVLVGAGMDLSVINPLDPTSRSALVVAGFLLVVAI
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
IGKIAAGWVFSSDKPTNRLVVGLGMMPRGEVGLIFLGLGTSAKLLTPSLEAAILLMVIGT
HHHHHHCCEECCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHCCCHHHHHHHHHHHHH
TFLAPVLLRIVLKDKPPSDGNKISDDVAADPVGLR
HHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]