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The map label for this gene is panC/cmk

Identifier: 78780067

GI number: 78780067

Start: 1571123

End: 1572655

Strand: Direct

Name: panC/cmk

Synonym: PMT9312_1682

Alternate gene names: 78780067

Gene position: 1571123-1572655 (Clockwise)

Preceding gene: 78780061

Following gene: 78780073

Centisome position: 91.92

GC content: 29.42

Gene sequence:

>1533_bases
GTGAAGAAAGTAATCATAAGGAAAACAGAAGAAATAAAAAATTGGAGAAGAAATATAAATAGTGATATTAACTTCATTCC
AACAATGGGTAATCTTCATAATGGACATAAAACCCTAATATCAACAGCAAAAAATGCTAATTCCAATGTTAATTTAGTAA
GTATATTTGTTAATCCACTTCAATTTGATAACAAGTCAGATTTAGAGAATTATCCTAAAACAATTGACAATGATATTAAA
ATATCCTTTGAGAATGGCGCAGATGTCATCTTCATCCCTAGTACTGAAGAGATATATCCATCGGATAATAAAAATATTAC
ATTCCTGAAAGCTCCCTTAGAGTTATCTTCGTCATTATGTGGGTTAAATCGAATTGGACATTTTGATGGCGTTTGTACTG
TAGTTTATAAATTACTTAATCTCATCAAGCCAAAAAATCTTTATTTAGGAGAAAAAGATTGGCAGCAACTATTAATATTA
AAAAATCTTGTCTTAACAAAGAAATTGGATGTAGCTATTAAATCTATTCCTACTCAGAGAGACTTTGATGGAATTCCTTT
AAGTTCTCGTAATGTACATCTATCAAATAACGAAAGAAAATTAATTAGATTTTTCTCACATGAATTATTAGTAGCAAAAG
AAAATTTTCAACAAGAAAAAAAGATCAATTTAAAAGAAATAATTCAAAAGCTGTCAGCACAAAAAATTTCAATTGAATAT
TTAGAACATTTACACCCTTATACCCTTCAAGAATCAAAAGTTGAGGACAATATTTCAATATTGGCTGGTGCGATAAGATG
TGGAGAGACAAGATTAATTGATCACGTTTTTCTAATGAAAAGAAGTCCAATTATTGCAATAGATGGCCCTGCAGGGTCAG
GTAAAAGTACTGTGACACAGTTAATAGCGAAGAAACTTAAACTTTTATATTTAGATACTGGAGCAATGTATAGGGCATTG
AGTTGGCTCTTAATAAAAGAAAATATTGATTATAAAGAAGAAAAAAAATTGCAGAATATCCTTAAAGATATTTCTATTGT
GTTCAAGTCAAATACAAATTCACAACAGGATGTTTTTATTAATAATTACTGTGTTACTGAAGAAATTCGTTCACAAGAGA
TAAGTTCGATAGTATCTAAAATTTCCTCCATTAAAGAAGTCAGAGAATTCTTAGTAGAAGAACAAAGAAAAATTGGAGAA
TCAGGCGGACTAGTAGCTGAAGGAAGAGATATAGGAACTACTGTTTTTCCTGATGCAGAACTTAAAATATTTTTAACTGC
AAGCATAGATGAAAGAGCAAAAAGAAGAAAGTCTGACAAAAAAAGTAAAGACTCACAAGAAATAGACCTTCATAAATTAA
AAGAACTTATAAAGAAAAGAGATTTTGAAGATTCTAATAGGGAAATCTCACCTCTTATAAAAGCAAATGACGCAATAGAA
ATTATTACGGATGGATGTTCAATTAATGAGGTAGTAGATAAAATTATTGATCTTTATAATGACAAGATCCCTAAAGAGAC
TCAGATCCGATAA

Upstream 100 bases:

>100_bases
ATGAAATAAAAATGATAGACTTTCCCTATATAGATATTCCTCCGAAGATTGCTTTTGTCCAGTAATTATTTATCAAATAG
ATTTATTTTTTAAAAACAAA

Downstream 100 bases:

>100_bases
ATTCAAGACATACTTTCCAAAAAGCCGCTCACAGAATCTTCTAATATATCAAGAACATAATCAAAGCCGTCATCACCTCC
AAAATAGGGGTCAGGAACTT

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Pantothenate synthetase; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKKVIIRKTEEIKNWRRNINSDINFIPTMGNLHNGHKTLISTAKNANSNVNLVSIFVNPLQFDNKSDLENYPKTIDNDIK
ISFENGADVIFIPSTEEIYPSDNKNITFLKAPLELSSSLCGLNRIGHFDGVCTVVYKLLNLIKPKNLYLGEKDWQQLLIL
KNLVLTKKLDVAIKSIPTQRDFDGIPLSSRNVHLSNNERKLIRFFSHELLVAKENFQQEKKINLKEIIQKLSAQKISIEY
LEHLHPYTLQESKVEDNISILAGAIRCGETRLIDHVFLMKRSPIIAIDGPAGSGKSTVTQLIAKKLKLLYLDTGAMYRAL
SWLLIKENIDYKEEKKLQNILKDISIVFKSNTNSQQDVFINNYCVTEEIRSQEISSIVSKISSIKEVREFLVEEQRKIGE
SGGLVAEGRDIGTTVFPDAELKIFLTASIDERAKRRKSDKKSKDSQEIDLHKLKELIKKRDFEDSNREISPLIKANDAIE
IITDGCSINEVVDKIIDLYNDKIPKETQIR

Sequences:

>Translated_510_residues
MKKVIIRKTEEIKNWRRNINSDINFIPTMGNLHNGHKTLISTAKNANSNVNLVSIFVNPLQFDNKSDLENYPKTIDNDIK
ISFENGADVIFIPSTEEIYPSDNKNITFLKAPLELSSSLCGLNRIGHFDGVCTVVYKLLNLIKPKNLYLGEKDWQQLLIL
KNLVLTKKLDVAIKSIPTQRDFDGIPLSSRNVHLSNNERKLIRFFSHELLVAKENFQQEKKINLKEIIQKLSAQKISIEY
LEHLHPYTLQESKVEDNISILAGAIRCGETRLIDHVFLMKRSPIIAIDGPAGSGKSTVTQLIAKKLKLLYLDTGAMYRAL
SWLLIKENIDYKEEKKLQNILKDISIVFKSNTNSQQDVFINNYCVTEEIRSQEISSIVSKISSIKEVREFLVEEQRKIGE
SGGLVAEGRDIGTTVFPDAELKIFLTASIDERAKRRKSDKKSKDSQEIDLHKLKELIKKRDFEDSNREISPLIKANDAIE
IITDGCSINEVVDKIIDLYNDKIPKETQIR
>Mature_510_residues
MKKVIIRKTEEIKNWRRNINSDINFIPTMGNLHNGHKTLISTAKNANSNVNLVSIFVNPLQFDNKSDLENYPKTIDNDIK
ISFENGADVIFIPSTEEIYPSDNKNITFLKAPLELSSSLCGLNRIGHFDGVCTVVYKLLNLIKPKNLYLGEKDWQQLLIL
KNLVLTKKLDVAIKSIPTQRDFDGIPLSSRNVHLSNNERKLIRFFSHELLVAKENFQQEKKINLKEIIQKLSAQKISIEY
LEHLHPYTLQESKVEDNISILAGAIRCGETRLIDHVFLMKRSPIIAIDGPAGSGKSTVTQLIAKKLKLLYLDTGAMYRAL
SWLLIKENIDYKEEKKLQNILKDISIVFKSNTNSQQDVFINNYCVTEEIRSQEISSIVSKISSIKEVREFLVEEQRKIGE
SGGLVAEGRDIGTTVFPDAELKIFLTASIDERAKRRKSDKKSKDSQEIDLHKLKELIKKRDFEDSNREISPLIKANDAIE
IITDGCSINEVVDKIIDLYNDKIPKETQIR

Specific function: Pantothenate biosynthesis; last step. [C]

COG id: COG0283

COG function: function code F; Cytidylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786325, Length=257, Percent_Identity=37.3540856031128, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1787139, Length=222, Percent_Identity=37.8378378378378, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322046, Length=208, Percent_Identity=37.9807692307692, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANCY_PROM9 (Q318F2)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_398179.1
- ProteinModelPortal:   Q318F2
- SMR:   Q318F2
- STRING:   Q318F2
- GeneID:   3766505
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_1682
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   LGEKDWQ
- ProtClustDB:   PRK13477
- BioCyc:   PMAR74546:PMT9312_1682-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01349
- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00017
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase

EC number: =6.3.2.1; =2.7.4.14

Molecular weight: Translated: 58206; Mature: 58206

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVIIRKTEEIKNWRRNINSDINFIPTMGNLHNGHKTLISTAKNANSNVNLVSIFVNPL
CCCEEEECHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCC
QFDNKSDLENYPKTIDNDIKISFENGADVIFIPSTEEIYPSDNKNITFLKAPLELSSSLC
CCCCCCHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHHHHH
GLNRIGHFDGVCTVVYKLLNLIKPKNLYLGEKDWQQLLILKNLVLTKKLDVAIKSIPTQR
CHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DFDGIPLSSRNVHLSNNERKLIRFFSHELLVAKENFQQEKKINLKEIIQKLSAQKISIEY
CCCCCCCCCCCEEECCCHHHHHHHHHHHHEEEHHHHHHHHCCCHHHHHHHHHHCHHHHHH
LEHLHPYTLQESKVEDNISILAGAIRCGETRLIDHVFLMKRSPIIAIDGPAGSGKSTVTQ
HHHCCCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
LIAKKLKLLYLDTGAMYRALSWLLIKENIDYKEEKKLQNILKDISIVFKSNTNSQQDVFI
HHHHHHHEEEECCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHEEEECCCCCCCCEEE
NNYCVTEEIRSQEISSIVSKISSIKEVREFLVEEQRKIGESGGLVAEGRDIGTTVFPDAE
ECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCC
LKIFLTASIDERAKRRKSDKKSKDSQEIDLHKLKELIKKRDFEDSNREISPLIKANDAIE
EEEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHCCCCCEE
IITDGCSINEVVDKIIDLYNDKIPKETQIR
EEECCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKVIIRKTEEIKNWRRNINSDINFIPTMGNLHNGHKTLISTAKNANSNVNLVSIFVNPL
CCCEEEECHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCC
QFDNKSDLENYPKTIDNDIKISFENGADVIFIPSTEEIYPSDNKNITFLKAPLELSSSLC
CCCCCCHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHHHHH
GLNRIGHFDGVCTVVYKLLNLIKPKNLYLGEKDWQQLLILKNLVLTKKLDVAIKSIPTQR
CHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DFDGIPLSSRNVHLSNNERKLIRFFSHELLVAKENFQQEKKINLKEIIQKLSAQKISIEY
CCCCCCCCCCCEEECCCHHHHHHHHHHHHEEEHHHHHHHHCCCHHHHHHHHHHCHHHHHH
LEHLHPYTLQESKVEDNISILAGAIRCGETRLIDHVFLMKRSPIIAIDGPAGSGKSTVTQ
HHHCCCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
LIAKKLKLLYLDTGAMYRALSWLLIKENIDYKEEKKLQNILKDISIVFKSNTNSQQDVFI
HHHHHHHEEEECCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHEEEECCCCCCCCEEE
NNYCVTEEIRSQEISSIVSKISSIKEVREFLVEEQRKIGESGGLVAEGRDIGTTVFPDAE
ECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCC
LKIFLTASIDERAKRRKSDKKSKDSQEIDLHKLKELIKKRDFEDSNREISPLIKANDAIE
EEEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHCCCCCEE
IITDGCSINEVVDKIIDLYNDKIPKETQIR
EEECCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA