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The map label for this gene is pepP [H]

Identifier: 78779919

GI number: 78779919

Start: 1430718

End: 1432043

Strand: Reverse

Name: pepP [H]

Synonym: PMT9312_1535

Alternate gene names: 78779919

Gene position: 1432043-1430718 (Counterclockwise)

Preceding gene: 78779924

Following gene: 78779918

Centisome position: 83.78

GC content: 33.79

Gene sequence:

>1326_bases
ATGTTTAAACCTGACAATAAAGTTTTTGAAGAAAGAAGAGAAATTTTCCTAAATAAATTAGATGGTAAAGCTGCTATTAT
CCCTGGAGCTAATCTTGTAAAACATCATGCCGATTGTGAATATCCTTTTAGACAAGATAGTAATTTTTGGTATTTAACTG
GTTTTGATGAGCCGGATGCTATCGCTCTTTTCTTATCTCATAAGCCAGAGGGAGAGAGATTTATTTTGTTTGTTGCTCCT
AAAGATGTTATTAGCGAGGTTTGGCATGGCTTTAGATGGGGTTTAGAAGGCGCTGAAAAAATATTTAAGGCCGACAAGGC
TCACTCAATAAATGAACTAAGAGATTTGCTTCCAGGTTATATAAATGGTTCTGATGAACTTGTCTTTTCAATTGGTAAGC
ATGCATCGATTGAAAAAATAGTACTTGAGATATTTTCACAACAACTGGAAAATATCTCAAGATTGGGCATTGGTGCAAAT
TCTATAAAATCCCCAGAAATTTATTTAAATGAGATGAGATTAATTAAAAGTGAATTTGAAATTAAGAGAATGAAAGAGGC
TATACAAATTTCCGCAGAAGCTCATGAACTAGTTAGAGAATCTATCTCATCCAAGAAAAATGAAAGACAAATTCAGGGTC
TTTTAGAGGGATTCTTTTTGGAAAAAGGGGCGAGAGGTCCTGCCTATAATTCTATTGTTGCTTCAGGAGATAATGCATGT
ATTTTGCATTACACCTCAAATAACGCACCCTTGAATAAAGGAGATTTATTGTTGGTAGATGCTGGCTGTTCATTAACTGA
TTATTACAATGGAGACATAACACGAACTATTCCTATAAGCGGTAAATTTTCAAAAGAACAAAAAGTCATTTATGAAATTG
TATTGAGTGCTCAGAAAACTGCAATTAAAAGTGCCACAATTGGATCAAATTCTAATACTGTGCATAATGTTGCTTTAACA
ATTTTAATAGAAGGCTTAAAAGAAATTGGTTTATTGTCAGGCAGTACTGAGGATATAATTGAGAATCAATCATATAAACA
CCTTTACATGCATAGAACTGGTCATTGGCTTGGCTTAGATGTTCATGATGTTGGAGCATATAGAATGGGAGAATATGAAG
TGCCATTTCAGAATGGAATGGTTCTTACTGTAGAACCTGGTATTTATATAAGTGACAGGATCCCAGTTCCTGAAGGGCAA
CCCAGGATTGATGAAAAATGGAAAGGCATTGGGATAAGAATTGAAGATGATGTCTTAGTCAAAGATAAAAATCCAGAAGT
TTTAAGTATTGCTGCACTTAAAGAAATTTCTGATTTAGAATTTTAA

Upstream 100 bases:

>100_bases
ATTAAACCGTAAACACTTGGTTCCATTAAAATAGATTAGGAAATAAATCTTTTTTAATTCATTCTTCCATTTTTTTTTAA
AATACGCCAATACACATTTT

Downstream 100 bases:

>100_bases
AAATTTGACTTATCTAGTTAATAGATTTATTTTTTATAAAGTTTAAAATTCAAAAATGAATAAGTCAGATTCATATGATT
CGAAACTTTCTCAAGCAAGA

Product: putative aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MFKPDNKVFEERREIFLNKLDGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPEGERFILFVAP
KDVISEVWHGFRWGLEGAEKIFKADKAHSINELRDLLPGYINGSDELVFSIGKHASIEKIVLEIFSQQLENISRLGIGAN
SIKSPEIYLNEMRLIKSEFEIKRMKEAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNAPLNKGDLLLVDAGCSLTDYYNGDITRTIPISGKFSKEQKVIYEIVLSAQKTAIKSATIGSNSNTVHNVALT
ILIEGLKEIGLLSGSTEDIIENQSYKHLYMHRTGHWLGLDVHDVGAYRMGEYEVPFQNGMVLTVEPGIYISDRIPVPEGQ
PRIDEKWKGIGIRIEDDVLVKDKNPEVLSIAALKEISDLEF

Sequences:

>Translated_441_residues
MFKPDNKVFEERREIFLNKLDGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPEGERFILFVAP
KDVISEVWHGFRWGLEGAEKIFKADKAHSINELRDLLPGYINGSDELVFSIGKHASIEKIVLEIFSQQLENISRLGIGAN
SIKSPEIYLNEMRLIKSEFEIKRMKEAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNAPLNKGDLLLVDAGCSLTDYYNGDITRTIPISGKFSKEQKVIYEIVLSAQKTAIKSATIGSNSNTVHNVALT
ILIEGLKEIGLLSGSTEDIIENQSYKHLYMHRTGHWLGLDVHDVGAYRMGEYEVPFQNGMVLTVEPGIYISDRIPVPEGQ
PRIDEKWKGIGIRIEDDVLVKDKNPEVLSIAALKEISDLEF
>Mature_441_residues
MFKPDNKVFEERREIFLNKLDGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPEGERFILFVAP
KDVISEVWHGFRWGLEGAEKIFKADKAHSINELRDLLPGYINGSDELVFSIGKHASIEKIVLEIFSQQLENISRLGIGAN
SIKSPEIYLNEMRLIKSEFEIKRMKEAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNAPLNKGDLLLVDAGCSLTDYYNGDITRTIPISGKFSKEQKVIYEIVLSAQKTAIKSATIGSNSNTVHNVALT
ILIEGLKEIGLLSGSTEDIIENQSYKHLYMHRTGHWLGLDVHDVGAYRMGEYEVPFQNGMVLTVEPGIYISDRIPVPEGQ
PRIDEKWKGIGIRIEDDVLVKDKNPEVLSIAALKEISDLEF

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=415, Percent_Identity=33.4939759036145, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI149589008, Length=467, Percent_Identity=27.6231263383298, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI260593665, Length=300, Percent_Identity=33, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI260593663, Length=249, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1789275, Length=434, Percent_Identity=37.0967741935484, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI1788728, Length=261, Percent_Identity=30.2681992337165, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790282, Length=311, Percent_Identity=29.5819935691318, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17508215, Length=477, Percent_Identity=28.0922431865828, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71989583, Length=280, Percent_Identity=31.0714285714286, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=445, Percent_Identity=33.2584269662921, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6321118, Length=420, Percent_Identity=29.7619047619048, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI19920384, Length=407, Percent_Identity=32.6781326781327, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI21357079, Length=439, Percent_Identity=30.0683371298405, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49504; Mature: 49504

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKPDNKVFEERREIFLNKLDGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDA
CCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCE
IALFLSHKPEGERFILFVAPKDVISEVWHGFRWGLEGAEKIFKADKAHSINELRDLLPGY
EEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCCC
INGSDELVFSIGKHASIEKIVLEIFSQQLENISRLGIGANSIKSPEIYLNEMRLIKSEFE
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IKRMKEAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
ILHYTSNNAPLNKGDLLLVDAGCSLTDYYNGDITRTIPISGKFSKEQKVIYEIVLSAQKT
EEEECCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
AIKSATIGSNSNTVHNVALTILIEGLKEIGLLSGSTEDIIENQSYKHLYMHRTGHWLGLD
HHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEECCCEEEEE
VHDVGAYRMGEYEVPFQNGMVLTVEPGIYISDRIPVPEGQPRIDEKWKGIGIRIEDDVLV
EECCCCEECCCEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCHHHCCCCEEEECCEEE
KDKNPEVLSIAALKEISDLEF
ECCCCCEEEEHHHHHHHCCCC
>Mature Secondary Structure
MFKPDNKVFEERREIFLNKLDGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDA
CCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCE
IALFLSHKPEGERFILFVAPKDVISEVWHGFRWGLEGAEKIFKADKAHSINELRDLLPGY
EEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCCC
INGSDELVFSIGKHASIEKIVLEIFSQQLENISRLGIGANSIKSPEIYLNEMRLIKSEFE
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IKRMKEAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
ILHYTSNNAPLNKGDLLLVDAGCSLTDYYNGDITRTIPISGKFSKEQKVIYEIVLSAQKT
EEEECCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
AIKSATIGSNSNTVHNVALTILIEGLKEIGLLSGSTEDIIENQSYKHLYMHRTGHWLGLD
HHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEECCCEEEEE
VHDVGAYRMGEYEVPFQNGMVLTVEPGIYISDRIPVPEGQPRIDEKWKGIGIRIEDDVLV
EECCCCEECCCEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCHHHCCCCEEEECCEEE
KDKNPEVLSIAALKEISDLEF
ECCCCCEEEEHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]