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The map label for this gene is groEL

Identifier: 78779913

GI number: 78779913

Start: 1425792

End: 1427429

Strand: Reverse

Name: groEL

Synonym: PMT9312_1529

Alternate gene names: 78779913

Gene position: 1427429-1425792 (Counterclockwise)

Preceding gene: 78779914

Following gene: 78779910

Centisome position: 83.51

GC content: 38.58

Gene sequence:

>1638_bases
ATGGCTAAAAGAATTATTTACAATGAGCAAGCTCGTAGAGCGCTCGAGAGAGGAATCGATATCCTTGCTGAGTCTGTTGC
TGTAACGCTTGGACCAAAAGGAAGAAATGTTGTCTTAGAAAAAAAATTTGGTGCTCCACAAATTATTAATGATGGTGTCA
CAATCGCTAAGGAGATTGAATTAGAGGACCACATTGAAAACACAGGGGTTGCTTTAATCAGACAAGCAGCTTCAAAAACT
AATGATGCAGCTGGAGATGGTACTACTACAGCTACCGTTTTGGCACATGCAATGGTTAAAGCAGGGTTGAGAAACGTTGC
GGCAGGAGCTAATGCAATCACCTTGAAAAAAGGTATTGATAAAGCGACTGAATTTCTAGTTGGTAAAATTCAAGAGAATT
CCAAGCCTATAAGTGATAGTAACGCTATAGCTCAATGTGGAACTATTGCTGCTGGAAACGACGACGAAGTAGGTCAAATG
ATAGCCAATGCTATGGATAAAGTTGGAAAAGAAGGTGTTATTTCCTTAGAAGAAGGAAAATCAATGACTACTGAATTAGA
AGTTACTGAGGGGATGCGTTTTGATAAAGGCTACATTTCACCATATTTCGCAACAGACACTGAGAGAATGGAGGCTGTTT
TAGATGAACCTTATATCCTTCTGACTGATAAAAAAATTGCCTTAGTTCAAGATTTAGTTCCTGTTTTGGAACAAATAGCT
AAAACAGGTAAACCACTAGTCATTATTGCAGAAGATATTGAAAAAGAGGCTTTAGCAACTCTTGTTGTTAATAGATTACG
AGGTGTGTTAAATGTTGCTGCAGTAAAAGCGCCTGGATTTGGTGATAGAAGAAAAGCCATGCTTGAAGATATGGCAGTTT
TAACTAATGGACAACTTATTACTGAAGATGCAGGCTTGAAATTAGAGAATGCTACCTTAGATATGCTTGGAACTGGTAGA
AGAATAACTATCAATAAAGAAACTACAACTATTGTAGCTGAAGGTAATGAGCAAGCAGTTAAAGCTAGATGTGATCAAAT
TAAGAAGCAAATGGATGAAACCGATTCTTCGTACGATAAAGAAAAGCTTCAAGAACGTCTAGCCAAGTTAGCTGGAGGAG
TTGCAGTAATTAAGGTTGGGGCTGCTACTGAAACTGAGATGAAGGATAAAAAGCTTCGTCTTGAGGATGCTATTAACGCA
ACAAAAGCAGCTGTTGAAGAAGGAATTGTACCTGGAGGCGGAACAACTCTCGCTCATTTATCTCCTATTTTAAAAGAATG
GGCTGATAAAAATTTAGAAGGAGAGGAATTAATTGGAGCTAACATTGTTGAAGCTTCATTGACGGCTCCTCTTATGAGAA
TTGCAGAAAATGCTGGTTCTAATGGTGCTGTGATTGCTGAAAATGTAAAATCTAAGCCATTTAATGATGGATTTAACGCT
GCTACTGGGGAATACGTTGATATGTCCTCCGCTGGTATTGTTGATCCTGCAAAAGTTACACGTTCAGGATTACAAAATGC
AGCTTCAATTGCAGGAATGGTTTTAACCACTGAATGTATAGTTGCAGATTTACCTGAGAAAAAAGATGCAGCTACTCCTG
GAGGCGCTCCAGGTATGGGTGGTGACTTTGATTATTAA

Upstream 100 bases:

>100_bases
TGAATATGTCTTGCTCTCGGAAAAGGATATTTTAGCTGTAGTAGGCTAAAATATTTGTTTCAAAAATTATTAAAACTTAT
TACTAAATTGCTGCCTAAAC

Downstream 100 bases:

>100_bases
CTAAATATTAGTTAATAAATTAACTTTTTAAAGAGAGATCATTTTGAATGATCTCTCTTTTTTATTCAATTATTATGAAA
TCCAACCAGCGCTAAGAATA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQM
IANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTGR
RITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLSPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNA
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDAATPGGAPGMGGDFDY

Sequences:

>Translated_545_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQM
IANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTGR
RITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLSPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNA
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDAATPGGAPGMGGDFDY
>Mature_544_residues
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKTN
DAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQMI
ANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIAK
TGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTGRR
ITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINAT
KAAVEEGIVPGGGTTLAHLSPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNAA
TGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDAATPGGAPGMGGDFDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=44.0677966101695, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=44.0677966101695, Blast_Score=451, Evalue=1e-127,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=56.8738229755179, Blast_Score=585, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=44.7169811320755, Blast_Score=456, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=41.7061611374408, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=49.0494296577947, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322524, Length=580, Percent_Identity=22.2413793103448, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=46.0227272727273, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=46.0227272727273, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=42.9657794676806, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=42.9657794676806, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=42.9657794676806, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=37.8326996197719, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=34.3396226415094, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=34.3396226415094, Blast_Score=294, Evalue=1e-79,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57654; Mature: 57522

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCEEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
KATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQMIANAMDKVGKEGVISLEEGK
HHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENATLDMLGTGRRITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDK
ECCCCCEEECCEEEEECCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNA
HHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDAATPGGAPGMG
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GDFDY
CCCCC
>Mature Secondary Structure 
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCEEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
KATEFLVGKIQENSKPISDSNAIAQCGTIAAGNDDEVGQMIANAMDKVGKEGVISLEEGK
HHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENATLDMLGTGRRITINKETTTIVAEGNEQAVKARCDQIKKQMDETDSSYDK
ECCCCCEEECCEEEEECCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SPILKEWADKNLEGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNA
HHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDAATPGGAPGMG
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GDFDY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA