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The map label for this gene is pdhA [H]

Identifier: 78779768

GI number: 78779768

Start: 1298354

End: 1299427

Strand: Direct

Name: pdhA [H]

Synonym: PMT9312_1384

Alternate gene names: 78779768

Gene position: 1298354-1299427 (Clockwise)

Preceding gene: 78779762

Following gene: 78779771

Centisome position: 75.96

GC content: 38.18

Gene sequence:

>1074_bases
ATGTTAACAAATCAAAACTTCATTAAGGTATTTTTCTTGGAAACACATGTAGAGAGAATCTCAAATCTTCAAGACATAAA
AAAAGCCAAATTAGATCGAGAAACCGGATTATTTCTTTATGAAGACATGACGCTTGGTCGAAGATTCGAAGATAAGTGTG
CAGAAATGTATTACAGGGGGAAAATGTTTGGTTTCGTTCATTTATATAACGGGCAAGAGGCTATAAGCACGGGAGTAATT
GGTGCTATGAGAAAGAAACATGATTGGTTTTGTAGCACTTACCGCGATCATGTTCATGCACTAAGCGCTGGTGTTCCCTC
CTTTGAAGTAATGAGTGAACTTTTTGGTAAAGCTACAGGTTGTAGCAAAGGCCGAGGGGGGTCCATGCACTTATTTTCAA
AAGAGCATCACTTACTAGGAGGATATGCATTTATTGGAGAAGGAATTCCAGTAGCTTTAGGTGCAGCCTTTTCAAGTAAA
TACAAAAAGGAAGTTGCTGGCAATAATAGTAGTGATTCTGTAACTGCAGCATTCTTTGGAGATGGGACTTGCAATAATGG
GCAGTTTTTTGAATGTTTAAATATGGCCCAATTATGGAAATTACCCATAATTTTTGTTGTTGAGAATAATAAATGGGCTA
TTGGTATGGCTCACGATAGAGCCACTAGCAATCCTGAAATCTGGAGAAAAGCCTCTGCTTTTGGAATGCATGGCGAGGAA
GTTGATGGGATGGATGTATTAGCAGTGAGAGGAGCGGCACAAAGAGCAATTGAGCGTGCTAGAGCGGGAGAAGGGCCCAC
ACTTTTAGAATGCTTGACTTATAGATACAGAGGACATTCTCTTGCAGATCCAGATGAATTAAGGTCTGAAAGAGAGAAAG
AGTTTTGGAGTAAAAGAGATCCCATTAAGAAATTAGCCCACGAAATTATTAATGGTAAATTTGCAACGGAAGAAGAATTA
AAAATTATTGAGAAGAAAATTGATACCGAAATATCTGAGTCAGTTAAAAATGCTTTAGAAGCACCTGAACCTCCTTCACA
AGAATTAACTAAATATATTTGGGCTGAAGATTAG

Upstream 100 bases:

>100_bases
TGAAAATTCTTAGACAAATTTTATCAAGTTAAAAATTTTTTTCATAAGGTCTTATAGACTTTTAAAAAAAAATAATGAAA
ATCGCCCTTCACAGCTTAGA

Downstream 100 bases:

>100_bases
ATTAAATCCCACTGGGTAATTTTCTGGTTAAATTTCTTAATTTTCTTAATGCCTTTAGTTCAACTTGTCTAACTCTTTCC
CTAGAAACTTCTAATAATCT

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLTNQNFIKVFFLETHVERISNLQDIKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMRKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNNSSDSVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEREKEFWSKRDPIKKLAHEIINGKFATEEEL
KIIEKKIDTEISESVKNALEAPEPPSQELTKYIWAED

Sequences:

>Translated_357_residues
MLTNQNFIKVFFLETHVERISNLQDIKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMRKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNNSSDSVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEREKEFWSKRDPIKKLAHEIINGKFATEEEL
KIIEKKIDTEISESVKNALEAPEPPSQELTKYIWAED
>Mature_357_residues
MLTNQNFIKVFFLETHVERISNLQDIKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMRKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNNSSDSVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEREKEFWSKRDPIKKLAHEIINGKFATEEEL
KIIEKKIDTEISESVKNALEAPEPPSQELTKYIWAED

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=39.209726443769, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI4505685, Length=329, Percent_Identity=38.9057750759878, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI291084742, Length=329, Percent_Identity=38.9057750759878, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=38.0952380952381, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=35.258358662614, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI11386135, Length=328, Percent_Identity=28.3536585365854, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI258645172, Length=333, Percent_Identity=28.5285285285285, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=38.3435582822086, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=38.3435582822086, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI86563355, Length=312, Percent_Identity=28.2051282051282, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI86563357, Length=312, Percent_Identity=28.2051282051282, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=320, Percent_Identity=38.125, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24639748, Length=363, Percent_Identity=38.0165289256198, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24639744, Length=310, Percent_Identity=39.0322580645161, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI28571106, Length=310, Percent_Identity=39.0322580645161, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24639740, Length=310, Percent_Identity=39.0322580645161, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24639746, Length=291, Percent_Identity=39.8625429553265, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI21355903, Length=339, Percent_Identity=25.6637168141593, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40200; Mature: 40200

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNQNFIKVFFLETHVERISNLQDIKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRG
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCHHCCEEEEECCHHCCHHHHHHHHHHHHC
KMFGFVHLYNGQEAISTGVIGAMRKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATG
CEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
CSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGAAFSSKYKKEVAGNNSSDSVTAAFFG
CCCCCCCCEEEECCCCHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
DGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEREKEFWSKRD
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
PIKKLAHEIINGKFATEEELKIIEKKIDTEISESVKNALEAPEPPSQELTKYIWAED
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MLTNQNFIKVFFLETHVERISNLQDIKKAKLDRETGLFLYEDMTLGRRFEDKCAEMYYRG
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCHHCCEEEEECCHHCCHHHHHHHHHHHHC
KMFGFVHLYNGQEAISTGVIGAMRKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATG
CEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
CSKGRGGSMHLFSKEHHLLGGYAFIGEGIPVALGAAFSSKYKKEVAGNNSSDSVTAAFFG
CCCCCCCCEEEECCCCHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
DGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEREKEFWSKRD
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
PIKKLAHEIINGKFATEEELKIIEKKIDTEISESVKNALEAPEPPSQELTKYIWAED
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]