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The map label for this gene is capL [H]

Identifier: 78779682

GI number: 78779682

Start: 1205763

End: 1207088

Strand: Direct

Name: capL [H]

Synonym: PMT9312_1299

Alternate gene names: 78779682

Gene position: 1205763-1207088 (Clockwise)

Preceding gene: 78779681

Following gene: 78779683

Centisome position: 70.55

GC content: 30.17

Gene sequence:

>1326_bases
ATGACTTCGGATAAGAGAGAATTAATAAATAATTTCAAGGAAAATTTATGCAAAAAAGATAAAAGTATTGCGATAGTAGG
TCTTGGATATGTCGGTTTGCCTTTGGCGCTTACTTTTGCCGAAAAAAACTTTTCTGTTATTGGAATAGATATTGACAAAA
AAAAAGTTGCCAAGTTGAGAAATAAAGAGAGCTATCTTAGACATATCAACAATTCAAGGATCTCTGAAGTCATTCAAAAT
AGCAAATTTAAACCAACATCAGATTTCTCAGAAGCAGAGAAATGTATAGCTATTATTTTATGCGTACCTACACCTTTAAA
TAAAAATAGAGAGCCAGACTTACAGTACATAACCACAACATTAAATTCTTTAAAAAAATATTTCCAAAAAGGTCAGCTAT
TAAGTTTAGAAAGTACTACTTATCCTGGGACGACTGAAGAAGTATTAAAACCATTAATTGAATCTTCTGGTTTTAAAATT
GGGAATAATTTCTTCCTTGTATATTCACCAGAGAGAGAAGATCCTGGGAATAAAGACTATTCAACGGGATCTATACCTAA
AATCATCGGAGGTATTACCCCAATTTGCAGAGAAATAGGAATTGAATTATACTCCAAAATAATTGAAAGACTTGTACCAG
TTTCCTCAACACGAGCTGCTGAAATAACAAAGTTATTAGAAAATATTCATAGAGCTGTAAATATTGGACTTATGAATGAG
TTAAAAATCCTGTCCGATAAAATGAATATTGATTTATATGAAATAATAGATGCCGCAGCAACAAAACCCTTTGGTTTTAC
TCCTTATTATCCAGGCCCTGGTTTAGGTGGACACTGTATACCAATTGATCCATTTTATTTAACTTGGAAGGCTAGAGAAT
ATGGTATGAATACAAAATTCATTGAATTAGCGGGTGAAATTAATGCTTCAATGCCTCAATATGTAATAGAAAAGATTTTT
AATTTACTCAATAATAGAAGTAAATCAATAAAAAACAGTAAGATTCTTGTCCTTGGATTATCTTATAAAAAAAATATAGA
TGACATTAGAGAATCTCCATCCTTAGATATTATTTATGAACTTTTAAAAAGAGGCGCAGTAGTTAAATATAACGATCCAT
ACATCCCAAAATTGCCAAAAGTCAGAAAATATAATTTAGAAATCGAGCATTGCAAAATAACAGCAGATCTTTTAAGTTCC
TTCGATTGCGTTTTACTACTAACTGATCATGATGATTTCCCTTATGAATTAATTAAAAAACATAGCAATTTAATTATTGA
TACTAGAGGAAGATTTACTCTTTCAGAAAATATTTTTAGAGCTTAA

Upstream 100 bases:

>100_bases
AAAATGAATATTAAATATTCTTTGAAACAATCAGAAATTTTTGCTGAGAAGATATAGTAGATTAATTTATTGGAATAGCC
AAAAATCTTTATTGGATATT

Downstream 100 bases:

>100_bases
GTTTATTTGACTATGAAAGATATAATTCCCAGAAAAATCAACATAGCTATTATTGGATGTGGAAGAATTTGCAAAAAACA
TATTCTGGCAATTATTAGTG

Product: UDP-glucose 6-dehydrogenase

Products: UDP-glucuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTSDKRELINNFKENLCKKDKSIAIVGLGYVGLPLALTFAEKNFSVIGIDIDKKKVAKLRNKESYLRHINNSRISEVIQN
SKFKPTSDFSEAEKCIAIILCVPTPLNKNREPDLQYITTTLNSLKKYFQKGQLLSLESTTYPGTTEEVLKPLIESSGFKI
GNNFFLVYSPEREDPGNKDYSTGSIPKIIGGITPICREIGIELYSKIIERLVPVSSTRAAEITKLLENIHRAVNIGLMNE
LKILSDKMNIDLYEIIDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGMNTKFIELAGEINASMPQYVIEKIF
NLLNNRSKSIKNSKILVLGLSYKKNIDDIRESPSLDIIYELLKRGAVVKYNDPYIPKLPKVRKYNLEIEHCKITADLLSS
FDCVLLLTDHDDFPYELIKKHSNLIIDTRGRFTLSENIFRA

Sequences:

>Translated_441_residues
MTSDKRELINNFKENLCKKDKSIAIVGLGYVGLPLALTFAEKNFSVIGIDIDKKKVAKLRNKESYLRHINNSRISEVIQN
SKFKPTSDFSEAEKCIAIILCVPTPLNKNREPDLQYITTTLNSLKKYFQKGQLLSLESTTYPGTTEEVLKPLIESSGFKI
GNNFFLVYSPEREDPGNKDYSTGSIPKIIGGITPICREIGIELYSKIIERLVPVSSTRAAEITKLLENIHRAVNIGLMNE
LKILSDKMNIDLYEIIDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGMNTKFIELAGEINASMPQYVIEKIF
NLLNNRSKSIKNSKILVLGLSYKKNIDDIRESPSLDIIYELLKRGAVVKYNDPYIPKLPKVRKYNLEIEHCKITADLLSS
FDCVLLLTDHDDFPYELIKKHSNLIIDTRGRFTLSENIFRA
>Mature_440_residues
TSDKRELINNFKENLCKKDKSIAIVGLGYVGLPLALTFAEKNFSVIGIDIDKKKVAKLRNKESYLRHINNSRISEVIQNS
KFKPTSDFSEAEKCIAIILCVPTPLNKNREPDLQYITTTLNSLKKYFQKGQLLSLESTTYPGTTEEVLKPLIESSGFKIG
NNFFLVYSPEREDPGNKDYSTGSIPKIIGGITPICREIGIELYSKIIERLVPVSSTRAAEITKLLENIHRAVNIGLMNEL
KILSDKMNIDLYEIIDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGMNTKFIELAGEINASMPQYVIEKIFN
LLNNRSKSIKNSKILVLGLSYKKNIDDIRESPSLDIIYELLKRGAVVKYNDPYIPKLPKVRKYNLEIEHCKITADLLSSF
DCVLLLTDHDDFPYELIKKHSNLIIDTRGRFTLSENIFRA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=429, Percent_Identity=22.6107226107226, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994968, Length=430, Percent_Identity=30.9302325581395, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17560350, Length=436, Percent_Identity=23.8532110091743, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136908, Length=375, Percent_Identity=22.1333333333333, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.22

Molecular weight: Translated: 49992; Mature: 49860

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDKRELINNFKENLCKKDKSIAIVGLGYVGLPLALTFAEKNFSVIGIDIDKKKVAKLR
CCCHHHHHHHHHHHHHHCCCCCEEEEEECHHCCCEEEEEECCCCEEEEEECCHHHHHHHH
NKESYLRHINNSRISEVIQNSKFKPTSDFSEAEKCIAIILCVPTPLNKNREPDLQYITTT
HHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHH
LNSLKKYFQKGQLLSLESTTYPGTTEEVLKPLIESSGFKIGNNFFLVYSPEREDPGNKDY
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCEECCEEEEEECCCCCCCCCCCC
STGSIPKIIGGITPICREIGIELYSKIIERLVPVSSTRAAEITKLLENIHRAVNIGLMNE
CCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHH
LKILSDKMNIDLYEIIDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGMNTKF
HHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEHHHHCCCCEE
IELAGEINASMPQYVIEKIFNLLNNRSKSIKNSKILVLGLSYKKNIDDIRESPSLDIIYE
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCHHHHHH
LLKRGAVVKYNDPYIPKLPKVRKYNLEIEHCKITADLLSSFDCVLLLTDHDDFPYELIKK
HHHCCCEEEECCCCCCCCCCCEEECEEEEEEEEEHHHHCCCCEEEEEECCCCCCHHHHHC
HSNLIIDTRGRFTLSENIFRA
CCCEEEECCCCEEECCHHHCC
>Mature Secondary Structure 
TSDKRELINNFKENLCKKDKSIAIVGLGYVGLPLALTFAEKNFSVIGIDIDKKKVAKLR
CCHHHHHHHHHHHHHHCCCCCEEEEEECHHCCCEEEEEECCCCEEEEEECCHHHHHHHH
NKESYLRHINNSRISEVIQNSKFKPTSDFSEAEKCIAIILCVPTPLNKNREPDLQYITTT
HHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHH
LNSLKKYFQKGQLLSLESTTYPGTTEEVLKPLIESSGFKIGNNFFLVYSPEREDPGNKDY
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCEECCEEEEEECCCCCCCCCCCC
STGSIPKIIGGITPICREIGIELYSKIIERLVPVSSTRAAEITKLLENIHRAVNIGLMNE
CCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHH
LKILSDKMNIDLYEIIDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGMNTKF
HHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEHHHHCCCCEE
IELAGEINASMPQYVIEKIFNLLNNRSKSIKNSKILVLGLSYKKNIDDIRESPSLDIIYE
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCHHHHHH
LLKRGAVVKYNDPYIPKLPKVRKYNLEIEHCKITADLLSSFDCVLLLTDHDDFPYELIKK
HHHCCCEEEECCCCCCCCCCCEEECEEEEEEEEEHHHHCCCCEEEEEECCCCCCHHHHHC
HSNLIIDTRGRFTLSENIFRA
CCCEEEECCCCEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucose; NAD+; H2O

Specific reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + 2 H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]