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The map label for this gene is macA [H]

Identifier: 78779618

GI number: 78779618

Start: 1148350

End: 1149411

Strand: Direct

Name: macA [H]

Synonym: PMT9312_1235

Alternate gene names: 78779618

Gene position: 1148350-1149411 (Clockwise)

Preceding gene: 78779614

Following gene: 78779619

Centisome position: 67.19

GC content: 29.85

Gene sequence:

>1062_bases
ATGCTTGATTTAATAAAAAAAAATATAAATCTAAGAAGTGGAATTATATTGCTTTCTCTAGCTATATTTTTCGTTTTTAT
AACCAATTCCTTCAAGAAAAATAAATCAAAAGATATTTCTGATTTTGTCGTTCAAGTTGAAAAAGGAATCCTCTCAGATT
CAATTAATACAAGTGGTGAAGTAAAAGCAATCAGGACAAGCAATATTGGTCCTAGGAAGCAAGGTGTAATAAAAGAAATT
AAAGTAGAGGAAGGCGATCTTGTAAAAAAAGATCAGGTTTTGGCTTCTCTTGATGATGAAGATTTCATCTATAAAATTGA
AGAACTTGAATTAAATATAGAAAAACAAAAATCTGAATTTTTAAGAAGAGAATATTTATATCAAGAAGGTGCAGTAAGCA
AAGAAGATTACGAAAGTTATAAAAATAGCTACGACATTAGTAGCGCCAAACTTAATGATGCAAAAGCTGAAAAAAGTTTT
TATATAATTAAAGCTCCTTATGGAGGAAAGATAACTGCAAAATATGCGGAGATAGGATCTTATGTCACCCCAAGCACAAA
TTTAAGTTCAGACTCTAAAACGAAAAACTTTATTTTTGAACTATCAGAGGGCCTCGAAATTGTTGCGAAAGTTCCTGAGA
GTGACATTGGTAGAATAAAAATAGGTCAAGAAGCTTCTGTAAGAATTGAGGCTTATCCATCAAAAAAATATACTGCCATA
GTTGAAAAAATAGCTACAAGAGCTGTAAAAGATAATAATGTTACCTCATTCGAAGTAACTTTAAATTTTAAAGATATTTC
TGAAGAAATAAAAATTGGAATGACTGCTGATCTTGAATTTAGAGTTGAAGGTAATGAAGAAAAAATCCTAGTACCAACAG
TTTCTATTGTCACTGAAAAAGGTGAAAAGGGAATCTTGAAAGTTGATAAAAACAATTCTCCCAAATTTGAAAAAATAGAA
ATTGGTATTAGTAGTGGAAATAAAACTTCAGTAATTAATGGATTAGAACCTGGAGAGCAAATCTTTATTGATATTCCACC
TTGGGCTAAGAAAAGAAAATGA

Upstream 100 bases:

>100_bases
AATATAGTATTTACTTAACCAATCTTGGATAAGTTAATTATAATCGTCTTGATTATTTATTTAGTTTCTAAATATTATCT
ACTGCCGTTTTTCAAAAGAA

Downstream 100 bases:

>100_bases
GTTTAAAATCAGAAAACTCTAAAAAACCAATTTTACTTTTAGTCGATGGTCACTCACTTGCTTTTAGAAGCTTCTATGCA
TTTAGCAAAGGGATTGATGG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MLDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAIRTSNIGPRKQGVIKEI
KVEEGDLVKKDQVLASLDDEDFIYKIEELELNIEKQKSEFLRREYLYQEGAVSKEDYESYKNSYDISSAKLNDAKAEKSF
YIIKAPYGGKITAKYAEIGSYVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYTAI
VEKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVINGLEPGEQIFIDIPPWAKKRK

Sequences:

>Translated_353_residues
MLDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAIRTSNIGPRKQGVIKEI
KVEEGDLVKKDQVLASLDDEDFIYKIEELELNIEKQKSEFLRREYLYQEGAVSKEDYESYKNSYDISSAKLNDAKAEKSF
YIIKAPYGGKITAKYAEIGSYVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYTAI
VEKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVINGLEPGEQIFIDIPPWAKKRK
>Mature_353_residues
MLDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAIRTSNIGPRKQGVIKEI
KVEEGDLVKKDQVLASLDDEDFIYKIEELELNIEKQKSEFLRREYLYQEGAVSKEDYESYKNSYDISSAKLNDAKAEKSF
YIIKAPYGGKITAKYAEIGSYVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYTAI
VEKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVINGLEPGEQIFIDIPPWAKKRK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=329, Percent_Identity=22.1884498480243, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39565; Mature: 39565

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGE
CCCHHHCCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
VKAIRTSNIGPRKQGVIKEIKVEEGDLVKKDQVLASLDDEDFIYKIEELELNIEKQKSEF
EEEEEECCCCCCCCCCHHEEECCCCCCCCHHHHHHCCCCCHHEEEEEEEEEEEHHHHHHH
LRREYLYQEGAVSKEDYESYKNSYDISSAKLNDAKAEKSFYIIKAPYGGKITAKYAEIGS
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHHCC
YVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYTAI
EECCCCCCCCCCCHHHHHEEHHCCCEEEEECCCCCCCEEEECCCCEEEEEECCCCHHHHH
VEKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEK
HHHHHHHHHCCCCCEEEEEEEEHHHCCCHHEECEEEEEEEEEECCCCEEEEEEEEEEECC
GEKGILKVDKNNSPKFEKIEIGISSGNKTSVINGLEPGEQIFIDIPPWAKKRK
CCCCEEEEECCCCCCEEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MLDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGE
CCCHHHCCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
VKAIRTSNIGPRKQGVIKEIKVEEGDLVKKDQVLASLDDEDFIYKIEELELNIEKQKSEF
EEEEEECCCCCCCCCCHHEEECCCCCCCCHHHHHHCCCCCHHEEEEEEEEEEEHHHHHHH
LRREYLYQEGAVSKEDYESYKNSYDISSAKLNDAKAEKSFYIIKAPYGGKITAKYAEIGS
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHHCC
YVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYTAI
EECCCCCCCCCCCHHHHHEEHHCCCEEEEECCCCCCCEEEECCCCEEEEEECCCCHHHHH
VEKIATRAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEK
HHHHHHHHHCCCCCEEEEEEEEHHHCCCHHEECEEEEEEEEEECCCCEEEEEEEEEEECC
GEKGILKVDKNNSPKFEKIEIGISSGNKTSVINGLEPGEQIFIDIPPWAKKRK
CCCCEEEEECCCCCCEEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]