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The map label for this gene is hofD [H]

Identifier: 78779569

GI number: 78779569

Start: 1105215

End: 1106063

Strand: Direct

Name: hofD [H]

Synonym: PMT9312_1186

Alternate gene names: 78779569

Gene position: 1105215-1106063 (Clockwise)

Preceding gene: 78779566

Following gene: 78779573

Centisome position: 64.66

GC content: 25.21

Gene sequence:

>849_bases
ATGATTAATATTAAATTAAATAATAATTTAGTAATGCTTTATTCCAAAATATTATTTAGTTGCACTTCAATATTTTTTGG
ACTTATATTTGGGAGTTTTCTAAATGTAGTAATTTATAGGCTTCCAAATAATCAGTCAATCCTTACACCTAGAAGTTTTT
GTCCTAAATGCAATAAAAAATTAAGCTGGCATGAAAATATACCAATCTATAGTTGGATAAAACTCAAAGGAAAATGTTCT
AATTGTGATAAAGCAATTTCTACTAAATATCCATTGACAGAATTAGCAACTGGCATGTTATTTCTTTTTAGTTTTAACGC
TATCCCTAAAGATATATATTTTGAAAATTTTGCTTTTAATCTTTTTTTTAGTTGGGCACTTATTTTAATCTTATTATCAA
TTTCAATTATTGATTATGAATTTCTTTGGATTCCTAATTCAATAATAATGATTGGATTTTTATTTGGGTTGGCATCATCA
ATATTTTCTGCAATAGTAAATGATCAAAATATAGTAATTCAATTATTTGTAAATTTAATTTCGGGCATTTTAGGTTTTTT
AATAATAATTTTGATAATGAAATCCGGTGAACTAGTTTTCAAAAAACCATCAATGGGTTTAGGAGATGCTAAGTTAGCTG
GAATGATAGGTTTTTGGATTGGTTTACCTGGAGTAATTATTTCAATCTGGTTATCTTTCATAATCTCTGGGCTATTTGTT
ATTTTGGGATTAGCAACAAAAAAAATTAAGAAAGGACAATTAATACCTTTTGGTCCATTTTTATCTATTAGTGGATTTTT
AATTTGGTTATTTGGTGAGGATATTTTTCTTAAAATTATTTTTCAATAA

Upstream 100 bases:

>100_bases
ATTAAATATATTAGTTTTTTATAGAATTGGCAATTTTATTTTTAAAATTATAATTTAAAAGAAAAATCTTTTATCCCAAA
AATCTATATGATTTTTATAA

Downstream 100 bases:

>100_bases
AAAATATTTAATACTATTTTTTTCGATTTTAGCCAACTGTATCCATCATACTAAACATAGGTAGATACATAGCTATTAAT
ATAACCGCTACAATAACTGC

Product: leader peptidase (prepilin peptidase) / N-methyltransferase

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MINIKLNNNLVMLYSKILFSCTSIFFGLIFGSFLNVVIYRLPNNQSILTPRSFCPKCNKKLSWHENIPIYSWIKLKGKCS
NCDKAISTKYPLTELATGMLFLFSFNAIPKDIYFENFAFNLFFSWALILILLSISIIDYEFLWIPNSIIMIGFLFGLASS
IFSAIVNDQNIVIQLFVNLISGILGFLIIILIMKSGELVFKKPSMGLGDAKLAGMIGFWIGLPGVIISIWLSFIISGLFV
ILGLATKKIKKGQLIPFGPFLSISGFLIWLFGEDIFLKIIFQ

Sequences:

>Translated_282_residues
MINIKLNNNLVMLYSKILFSCTSIFFGLIFGSFLNVVIYRLPNNQSILTPRSFCPKCNKKLSWHENIPIYSWIKLKGKCS
NCDKAISTKYPLTELATGMLFLFSFNAIPKDIYFENFAFNLFFSWALILILLSISIIDYEFLWIPNSIIMIGFLFGLASS
IFSAIVNDQNIVIQLFVNLISGILGFLIIILIMKSGELVFKKPSMGLGDAKLAGMIGFWIGLPGVIISIWLSFIISGLFV
ILGLATKKIKKGQLIPFGPFLSISGFLIWLFGEDIFLKIIFQ
>Mature_282_residues
MINIKLNNNLVMLYSKILFSCTSIFFGLIFGSFLNVVIYRLPNNQSILTPRSFCPKCNKKLSWHENIPIYSWIKLKGKCS
NCDKAISTKYPLTELATGMLFLFSFNAIPKDIYFENFAFNLFFSWALILILLSISIIDYEFLWIPNSIIMIGFLFGLASS
IFSAIVNDQNIVIQLFVNLISGILGFLIIILIMKSGELVFKKPSMGLGDAKLAGMIGFWIGLPGVIISIWLSFIISGLFV
ILGLATKKIKKGQLIPFGPFLSISGFLIWLFGEDIFLKIIFQ

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=261, Percent_Identity=31.0344827586207, Blast_Score=110, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 31794; Mature: 31794

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIKLNNNLVMLYSKILFSCTSIFFGLIFGSFLNVVIYRLPNNQSILTPRSFCPKCNKK
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHCCHHCCC
LSWHENIPIYSWIKLKGKCSNCDKAISTKYPLTELATGMLFLFSFNAIPKDIYFENFAFN
CCCCCCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LFFSWALILILLSISIIDYEFLWIPNSIIMIGFLFGLASSIFSAIVNDQNIVIQLFVNLI
HHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SGILGFLIIILIMKSGELVFKKPSMGLGDAKLAGMIGFWIGLPGVIISIWLSFIISGLFV
HHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILGLATKKIKKGQLIPFGPFLSISGFLIWLFGEDIFLKIIFQ
HHHHHHHHHCCCCCCCCCCHHHHHHEEEEEECCCEEEEEECC
>Mature Secondary Structure
MINIKLNNNLVMLYSKILFSCTSIFFGLIFGSFLNVVIYRLPNNQSILTPRSFCPKCNKK
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHCCHHCCC
LSWHENIPIYSWIKLKGKCSNCDKAISTKYPLTELATGMLFLFSFNAIPKDIYFENFAFN
CCCCCCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LFFSWALILILLSISIIDYEFLWIPNSIIMIGFLFGLASSIFSAIVNDQNIVIQLFVNLI
HHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SGILGFLIIILIMKSGELVFKKPSMGLGDAKLAGMIGFWIGLPGVIISIWLSFIISGLFV
HHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILGLATKKIKKGQLIPFGPFLSISGFLIWLFGEDIFLKIIFQ
HHHHHHHHHCCCCCCCCCCHHHHHHEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]