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The map label for this gene is lysA [H]

Identifier: 78779484

GI number: 78779484

Start: 1014533

End: 1015906

Strand: Direct

Name: lysA [H]

Synonym: PMT9312_1101

Alternate gene names: 78779484

Gene position: 1014533-1015906 (Clockwise)

Preceding gene: 78779479

Following gene: 78779485

Centisome position: 59.36

GC content: 32.17

Gene sequence:

>1374_bases
ATGGAAGAAAAAAAATCCTTTTTAAAAAAAAAGATTGACCTCAAAAGTCCTAATAAAAATATTGTACCTATTACTACAAC
CATTGGAAATGATGGGAAGTTATCAGTTGGTGGATGTTCTATTGAAGAATTAGTTAAAAAATATGATTCTCCTCTTTATA
TATTGGATGAAATCACTTTAAGAAACTCATGTAGAGCTTACAAAAATGCCTTGGAAAAATATTACCCAGGGAAATCTCTG
CCAATATATGCCTCGAAGGCAAATAGTTCTATCTTTATGAGTAACCTTGTTTCCTCAGAAGGATTAGGACTTGATGCGGT
TTCAGAAGGAGAACTATTAACTGCTCTTAAAGGTGGGGTACCAAATGAAAAAATTGTTTTTCATGGTAACAATAAATCAG
ACAAAGAGATAGAGTTTGCAGTTAGAAATAATATTCAAGTAATTGTAGATAATGATTATGACTTAGAAAGATTAGAGGGC
ATTTCAAATTCATTTAATCGTGATTTAGAAATAATGATTCGCTTTACTCCCGGAATAGAATGCCATACACATGAATACAT
AAGAACGGGATCATTTGATAGCAAATTTGGTTTCGGAATTGAATATTTAAATATTTTATTTGACAGAATCAATAATACAA
AACATTTAAAATTAAAAGGATTACATGCTCATATTGGTTCCCAGATTTTTGAATTAGACCCACACAAGGATCTGGGAGAA
ATAATGGTAAATGTTATTTTAGATGCCAAAAAATTTGGCCATAATATTCAAAAATTGAATCTAGGTGGAGGTTTAGGTAT
TAAATATACAGAGAATGACGATCCTCCTTCAATTGATGAATGGGTAAAAACAATTTCCACATCCGTTGTTAAAGCTTGTA
AAAAACACAATTTAGATTTACCTACATTGATGTGTGAGCCTGGAAGATCTATCGTATCTACAGCAGGAATAACAATTTAC
AAAATAGGTGCCTTTAAAGAAATCCCCGGGATCAGAACGTATTTGTCAGTTGATGGTGGCATGAGTGACAATCCAAGACC
AATAACATATCAATCGAATTATTCTGCATGTTTGGTAAGTAATCCCTTTAATATTAATTCCAAAAATAAATATACTATTG
CTGGCAAGCACTGCGAATCAGGAGATGTATTGTTTAAGGAAATAGAACTAGCAGATTGCAAAACAGGAGATCTTATATGT
GTTTTTGGTACTGGTGCATACAATAATTCAATGAGTTCTAACTACAACAGAATTCCAAGACCTGCCGCTCTCTTAGTTTG
TAATGGTGAAGCAGAAATCATTCAAAAAAGAGAAAGTCCATTTGATCTTTTAAAATATGATGTCTTGCCTGATCGCTTTC
TCAAACAAAATTAG

Upstream 100 bases:

>100_bases
AATGGATATCATTTTATAATAAATATAAAACTTAAAAAATTTGAAATTAAAGTCATTATATATATGACAATTTTAGAATA
ACTCTACTTGAAATTCTCCC

Downstream 100 bases:

>100_bases
GTACATTTAAATTAAATTTGTTTTTAATGTGAATTTCTGGGGGATTATAAATTTAAAGCTTTTATTAGATGTTTTATTCG
CTGTCGGTTTCGGACTTTTA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MEEKKSFLKKKIDLKSPNKNIVPITTTIGNDGKLSVGGCSIEELVKKYDSPLYILDEITLRNSCRAYKNALEKYYPGKSL
PIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIEFAVRNNIQVIVDNDYDLERLEG
ISNSFNRDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNILFDRINNTKHLKLKGLHAHIGSQIFELDPHKDLGE
IMVNVILDAKKFGHNIQKLNLGGGLGIKYTENDDPPSIDEWVKTISTSVVKACKKHNLDLPTLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVSNPFNINSKNKYTIAGKHCESGDVLFKEIELADCKTGDLIC
VFGTGAYNNSMSSNYNRIPRPAALLVCNGEAEIIQKRESPFDLLKYDVLPDRFLKQN

Sequences:

>Translated_457_residues
MEEKKSFLKKKIDLKSPNKNIVPITTTIGNDGKLSVGGCSIEELVKKYDSPLYILDEITLRNSCRAYKNALEKYYPGKSL
PIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIEFAVRNNIQVIVDNDYDLERLEG
ISNSFNRDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNILFDRINNTKHLKLKGLHAHIGSQIFELDPHKDLGE
IMVNVILDAKKFGHNIQKLNLGGGLGIKYTENDDPPSIDEWVKTISTSVVKACKKHNLDLPTLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVSNPFNINSKNKYTIAGKHCESGDVLFKEIELADCKTGDLIC
VFGTGAYNNSMSSNYNRIPRPAALLVCNGEAEIIQKRESPFDLLKYDVLPDRFLKQN
>Mature_457_residues
MEEKKSFLKKKIDLKSPNKNIVPITTTIGNDGKLSVGGCSIEELVKKYDSPLYILDEITLRNSCRAYKNALEKYYPGKSL
PIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGVPNEKIVFHGNNKSDKEIEFAVRNNIQVIVDNDYDLERLEG
ISNSFNRDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNILFDRINNTKHLKLKGLHAHIGSQIFELDPHKDLGE
IMVNVILDAKKFGHNIQKLNLGGGLGIKYTENDDPPSIDEWVKTISTSVVKACKKHNLDLPTLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVSNPFNINSKNKYTIAGKHCESGDVLFKEIELADCKTGDLIC
VFGTGAYNNSMSSNYNRIPRPAALLVCNGEAEIIQKRESPFDLLKYDVLPDRFLKQN

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=27.9805352798054, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1789307, Length=278, Percent_Identity=23.7410071942446, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24586472, Length=398, Percent_Identity=23.1155778894472, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586474, Length=385, Percent_Identity=23.3766233766234, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 50870; Mature: 50870

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKKSFLKKKIDLKSPNKNIVPITTTIGNDGKLSVGGCSIEELVKKYDSPLYILDEITL
CCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEEECCCCHHHHHHHCCCCEEEEEEHHH
RNSCRAYKNALEKYYPGKSLPIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGV
HHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCEEHHHHCCC
PNEKIVFHGNNKSDKEIEFAVRNNIQVIVDNDYDLERLEGISNSFNRDLEIMIRFTPGIE
CCCEEEEECCCCCCCEEEEEEECCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCE
CHTHEYIRTGSFDSKFGFGIEYLNILFDRINNTKHLKLKGLHAHIGSQIFELDPHKDLGE
ECCCHHEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEHHHHHCCEEEECCCCCCHHH
IMVNVILDAKKFGHNIQKLNLGGGLGIKYTENDDPPSIDEWVKTISTSVVKACKKHNLDL
HHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PTLMCEPGRSIVSTAGITIYKIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVS
CEEEECCCCHHHHHCCEEEEEECCHHCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEE
NPFNINSKNKYTIAGKHCESGDVLFKEIELADCKTGDLICVFGTGAYNNSMSSNYNRIPR
CCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCC
PAALLVCNGEAEIIQKRESPFDLLKYDVLPDRFLKQN
CEEEEEECCCHHHHHCCCCCHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MEEKKSFLKKKIDLKSPNKNIVPITTTIGNDGKLSVGGCSIEELVKKYDSPLYILDEITL
CCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEEECCCCHHHHHHHCCCCEEEEEEHHH
RNSCRAYKNALEKYYPGKSLPIYASKANSSIFMSNLVSSEGLGLDAVSEGELLTALKGGV
HHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCEEHHHHCCC
PNEKIVFHGNNKSDKEIEFAVRNNIQVIVDNDYDLERLEGISNSFNRDLEIMIRFTPGIE
CCCEEEEECCCCCCCEEEEEEECCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCE
CHTHEYIRTGSFDSKFGFGIEYLNILFDRINNTKHLKLKGLHAHIGSQIFELDPHKDLGE
ECCCHHEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEHHHHHCCEEEECCCCCCHHH
IMVNVILDAKKFGHNIQKLNLGGGLGIKYTENDDPPSIDEWVKTISTSVVKACKKHNLDL
HHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PTLMCEPGRSIVSTAGITIYKIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVS
CEEEECCCCHHHHHCCEEEEEECCHHCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEE
NPFNINSKNKYTIAGKHCESGDVLFKEIELADCKTGDLICVFGTGAYNNSMSSNYNRIPR
CCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCC
PAALLVCNGEAEIIQKRESPFDLLKYDVLPDRFLKQN
CEEEEEECCCHHHHHCCCCCHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]