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The map label for this gene is gyrA [H]

Identifier: 78779457

GI number: 78779457

Start: 981665

End: 984256

Strand: Direct

Name: gyrA [H]

Synonym: PMT9312_1074

Alternate gene names: 78779457

Gene position: 981665-984256 (Clockwise)

Preceding gene: 161350033

Following gene: 78779458

Centisome position: 57.43

GC content: 36.19

Gene sequence:

>2592_bases
ATGTCTGATATTATAGATTCCGGAAATTCTGGATTAAGCGAAGATAACGATCGAATTATTCAGACAGACTTAAGAAATGA
GATGTCTCGCTCTTATCTCGAGTATGCAATGAGCGTCATAGTAGGTCGTGCCCTTCCTGACGCGAGAGATGGATTAAAGC
CTGTTCATAGAAGAATTCTTTATGCAATGTATGAACTTGGTTTAACAAGCGGTAGACCTTACAGAAAATGTGCAAGGGTC
GTTGGGGAGGTACTTGGTAAATATCACCCCCATGGTGACACTGCTGTCTATGATGCCTTGGTGAGGATGGCTCAAGATTT
TTCTATGAGAATGCCACTTATAGATGGTCATGGGAACTTTGGTTCTGTCGATAACGACCCTCCCGCAGCAATGAGATATA
CAGAATCTCGGCTACAGTCTCTTACAGATGAAAGTTTACTAGAGGATATTGAATCTGAAACTGTAGATTTCTCTGATAAT
TTTGACGGATCACAACAAGAGCCAACAGTCTTACCTGCAAGAATTCCTCAACTACTTTTAAATGGATCATCTGGAATAGC
AGTAGGTATGGCAACTAATATTCCACCCCATAATTTAGGAGAATTAATCAATGGTCTCAAATCAATAATCAACAATCCTT
CAATTGAAGATAGAGAACTTTTTGAACTAATTAAGGGTCCTGATTTTCCTACTGGTGGTCAAATATTAGGAAGAGATGGT
ATTAGAGAAACCTTCAAAACAGGAAGAGGTTCAATAACCATGAGAGGGGTAGCAAATATTGAGCAAATTAAATCAGCTGG
TAGGGCTGAAAAAGATGCCGTAATAATTACAGAACTCCCTTTTCAAACTAATAAAGCTGGATTGATAGAGAGAATTGCAG
ACTTGGTTAATGAGAGAAAATTAGAAGGTATTTCTGATATTAGAGATGAAAGTGATCGAGATGGGATGAGAATTGTTATC
GAGCTAAAAAGAGACGCATACCCACAAGTAGTTTTAAATAACTTATTTAAGTTAACACCTTTACAAAATAACTTTAGTGC
CAATATTTTAGCTTTAGTTAAAGGAGAACCCACAACTCTCTCACTTCGGAGAATGTTAGATGTATTTCTAGATTTTAGGG
TAGAGACCATAAGACGTAGAACAGGATTTCTATTAAGAAAGGCAGAAGAAAGAGATCACATCGTTAAAGGGCTTTTATTG
GCTTTAGATGCTATGGATGAAATTATCAATCTAATAAGATCTGCAAAAGATACAATTTCAGCTCGAGAAAAATTACAAAC
TGATCATGAATTATCTTCTACACAAGCAGAAGCTATTTTACAAATGCAGTTAAGAAGATTAACCGCCTTAGAGGCAGATA
AAATCAAAGCGGAACATGACGAATTAACTAAAAAAATCAACCAATATCAACAAATCTTAAATAGTAAAGAAAGAATTTTT
GAAATTATTCTCGAAGAACTTAATAAAATCGATGAAAGATTTTCTTCTCCAAGAAAAACAGAAATTTTAGATCTAGGAGG
TGGTCTTGATGATATTGATCTTATAGCTAATGATCGATCAGTAGTTTTATTAACTGAAGCAGGTTATTTAAAAAGGATGC
CTGTTAATGAATTTGAATCTACCAGTCGTGGGTCAAGGGGTAAAGCTGGCACAAAGACTCAAGGAGATGATGAGGTGAAA
TTATTTATAAGCTGCAACGATCATGATACTCTTTTGCTTTTCAGTGATAGAGGGGTAGCTTATGCTCTCCCAGCATATAG
AGTTCCTATGAGTAGCAGAACGGCAAAAGGTACTCCATCAGTTCAACTTCTCCCAATACCAAGAGAAGAAAAAATAACTT
CACTTGTTGCAGTTGATTCTTTTGATAACGATTGTTATTTATTAATGTTAACCAAGTCTGGATTTATAAAAAGGACTTCA
CTTTCTGCCTTCTCAAAAATTCGCTCAAATGGTCTAATAGCAATTAATCTTGAGGATGGAGACGCCCTAACATGGGTCAG
ACTATCCAAAGAAGGCGATAGTGTTTTAATTGGATCAAGAACAGGAATTGCGATTCATTTCAGATTAGATATAAACGAAT
TAAGACCCCTTGGCAGGACAGCAAGGGGGGTTAAATCAATGAACTTGAAAAAAGGGGATAATCTTGTATCCATGGATGTT
TTAACATCTGATTTGGTTGATAAATTAGCTAAAATTGATGATCTTAATAAAGAAATTGAAGAAAATATTGAAGTTAACTC
TTCGGATGGGCCCTGGGTATTAATAGCCAGTGCATTTGGTCTAGGAAAGAGAGTGCCAGTAACTCAGTTTAGATTACAAA
AAAGAGCAGGGATGGGTTTAAGAGCGATAAAATTCAGAATTCAAGATGATGTTCTTGTTTGTTTAAAGGTCCTAGGAGAA
GGAGAAGAATTACTTTTTGTGACCGAAAAAGGTGTAATAGTTAGAACAAATGCAGATAAAATTTCTCAGCAATCCAGAGC
AGCTACTGGAGTAAAATTACAACGACTGGACGAGGGCGATCATTTATCAGAAGTGGTATTAGTTCCTCGTGAACAAATAG
AGGAAATAGACCAAACAAGTCCAGAGGAATAA

Upstream 100 bases:

>100_bases
TTTAAATTTGTGTGTAAATGTGAGTATTTGGGAATTAAATATATCCTTTTTTTTATTCATTATGACAATCAGCGATTATT
ATTAAATAAAGGTTTTTTGT

Downstream 100 bases:

>100_bases
AATTAAAAACGAATGGTTAATTAGACAATATGGAAATACTTGATATTTTAATTTTAGGATCTGGTCCAGCAGCATTATGT
TTAGCTTCTGAATTAGCAAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 863; Mature: 862

Protein sequence:

>863_residues
MSDIIDSGNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARV
VGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDN
FDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFELIKGPDFPTGGQILGRDG
IRETFKTGRGSITMRGVANIEQIKSAGRAEKDAVIITELPFQTNKAGLIERIADLVNERKLEGISDIRDESDRDGMRIVI
ELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRRMLDVFLDFRVETIRRRTGFLLRKAEERDHIVKGLLL
ALDAMDEIINLIRSAKDTISAREKLQTDHELSSTQAEAILQMQLRRLTALEADKIKAEHDELTKKINQYQQILNSKERIF
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFESTSRGSRGKAGTKTQGDDEVK
LFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSLVAVDSFDNDCYLLMLTKSGFIKRTS
LSAFSKIRSNGLIAINLEDGDALTWVRLSKEGDSVLIGSRTGIAIHFRLDINELRPLGRTARGVKSMNLKKGDNLVSMDV
LTSDLVDKLAKIDDLNKEIEENIEVNSSDGPWVLIASAFGLGKRVPVTQFRLQKRAGMGLRAIKFRIQDDVLVCLKVLGE
GEELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDEGDHLSEVVLVPREQIEEIDQTSPEE

Sequences:

>Translated_863_residues
MSDIIDSGNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARV
VGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDN
FDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFELIKGPDFPTGGQILGRDG
IRETFKTGRGSITMRGVANIEQIKSAGRAEKDAVIITELPFQTNKAGLIERIADLVNERKLEGISDIRDESDRDGMRIVI
ELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRRMLDVFLDFRVETIRRRTGFLLRKAEERDHIVKGLLL
ALDAMDEIINLIRSAKDTISAREKLQTDHELSSTQAEAILQMQLRRLTALEADKIKAEHDELTKKINQYQQILNSKERIF
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFESTSRGSRGKAGTKTQGDDEVK
LFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSLVAVDSFDNDCYLLMLTKSGFIKRTS
LSAFSKIRSNGLIAINLEDGDALTWVRLSKEGDSVLIGSRTGIAIHFRLDINELRPLGRTARGVKSMNLKKGDNLVSMDV
LTSDLVDKLAKIDDLNKEIEENIEVNSSDGPWVLIASAFGLGKRVPVTQFRLQKRAGMGLRAIKFRIQDDVLVCLKVLGE
GEELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDEGDHLSEVVLVPREQIEEIDQTSPEE
>Mature_862_residues
SDIIDSGNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARVV
GEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDNF
DGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFELIKGPDFPTGGQILGRDGI
RETFKTGRGSITMRGVANIEQIKSAGRAEKDAVIITELPFQTNKAGLIERIADLVNERKLEGISDIRDESDRDGMRIVIE
LKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRRMLDVFLDFRVETIRRRTGFLLRKAEERDHIVKGLLLA
LDAMDEIINLIRSAKDTISAREKLQTDHELSSTQAEAILQMQLRRLTALEADKIKAEHDELTKKINQYQQILNSKERIFE
IILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFESTSRGSRGKAGTKTQGDDEVKL
FISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSLVAVDSFDNDCYLLMLTKSGFIKRTSL
SAFSKIRSNGLIAINLEDGDALTWVRLSKEGDSVLIGSRTGIAIHFRLDINELRPLGRTARGVKSMNLKKGDNLVSMDVL
TSDLVDKLAKIDDLNKEIEENIEVNSSDGPWVLIASAFGLGKRVPVTQFRLQKRAGMGLRAIKFRIQDDVLVCLKVLGEG
EELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDEGDHLSEVVLVPREQIEEIDQTSPEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=521, Percent_Identity=22.8406909788868, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI1788562, Length=858, Percent_Identity=41.958041958042, Blast_Score=663, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=613, Percent_Identity=37.8466557911909, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=357, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=293, Percent_Identity=27.3037542662116, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136538, Length=366, Percent_Identity=27.3224043715847, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96133; Mature: 96002

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIIDSGNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRIL
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHH
YAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNF
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDNFDGSQQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFELIKGPDFPTGGQILGRDG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCHH
IRETFKTGRGSITMRGVANIEQIKSAGRAEKDAVIITELPFQTNKAGLIERIADLVNERK
HHHHHHCCCCCEEECCCCCHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
LEGISDIRDESDRDGMRIVIELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTL
HCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCCHH
SLRRMLDVFLDFRVETIRRRTGFLLRKAEERDHIVKGLLLALDAMDEIINLIRSAKDTIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AREKLQTDHELSSTQAEAILQMQLRRLTALEADKIKAEHDELTKKINQYQQILNSKERIF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFES
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHEEECCCEEEEEECCCCCCCCCCCHHHH
TSRGSRGKAGTKTQGDDEVKLFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCCEECCCCCCCCCCCCC
VQLLPIPREEKITSLVAVDSFDNDCYLLMLTKSGFIKRTSLSAFSKIRSNGLIAINLEDG
EEEEECCCHHHHHEEEEEECCCCCEEEEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCC
DALTWVRLSKEGDSVLIGSRTGIAIHFRLDINELRPLGRTARGVKSMNLKKGDNLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEEEHHHCCCCCHHHHHHHHCCCCCCCCEEEHHH
LTSDLVDKLAKIDDLNKEIEENIEVNSSDGPWVLIASAFGLGKRVPVTQFRLQKRAGMGL
HHHHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCE
RAIKFRIQDDVLVCLKVLGEGEELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDEGD
EEEEEEECHHHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHHHHHHHCCCEEEECCCCC
HLSEVVLVPREQIEEIDQTSPEE
CCHHEEECCHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDIIDSGNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRIL
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHH
YAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNF
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDNFDGSQQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFELIKGPDFPTGGQILGRDG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCHH
IRETFKTGRGSITMRGVANIEQIKSAGRAEKDAVIITELPFQTNKAGLIERIADLVNERK
HHHHHHCCCCCEEECCCCCHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
LEGISDIRDESDRDGMRIVIELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTL
HCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCCHH
SLRRMLDVFLDFRVETIRRRTGFLLRKAEERDHIVKGLLLALDAMDEIINLIRSAKDTIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AREKLQTDHELSSTQAEAILQMQLRRLTALEADKIKAEHDELTKKINQYQQILNSKERIF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNEFES
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHEEECCCEEEEEECCCCCCCCCCCHHHH
TSRGSRGKAGTKTQGDDEVKLFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCCEECCCCCCCCCCCCC
VQLLPIPREEKITSLVAVDSFDNDCYLLMLTKSGFIKRTSLSAFSKIRSNGLIAINLEDG
EEEEECCCHHHHHEEEEEECCCCCEEEEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCC
DALTWVRLSKEGDSVLIGSRTGIAIHFRLDINELRPLGRTARGVKSMNLKKGDNLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEEEHHHCCCCCHHHHHHHHCCCCCCCCEEEHHH
LTSDLVDKLAKIDDLNKEIEENIEVNSSDGPWVLIASAFGLGKRVPVTQFRLQKRAGMGL
HHHHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCE
RAIKFRIQDDVLVCLKVLGEGEELLFVTEKGVIVRTNADKISQQSRAATGVKLQRLDEGD
EEEEEEECHHHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHHHHHHHCCCEEEECCCCC
HLSEVVLVPREQIEEIDQTSPEE
CCHHEEECCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]