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The map label for this gene is hom [H]

Identifier: 78779445

GI number: 78779445

Start: 973186

End: 974487

Strand: Reverse

Name: hom [H]

Synonym: PMT9312_1062

Alternate gene names: 78779445

Gene position: 974487-973186 (Counterclockwise)

Preceding gene: 78779446

Following gene: 78779444

Centisome position: 57.01

GC content: 32.1

Gene sequence:

>1302_bases
ATGAGAAAATGCAAAATTGGTATTGTAGGTTTCGGAACTGTTGGTTCAGGGGTTTATAAAATATTAAGTTCTGAAGTTGA
TTTACATCCAATTCTAAAAGAAATAGATATTGAAAAAATAGCGGTTAAAGATCTTAGTAAAAAAAGGGATTTTGATCTAG
ATAATAATTTATTAACTGATGATCCATTCAAATTAATTAATGACCCCTCTATAGATGTAATTGTTGAAGTAATGGGCGGG
GTTGATTTGGCGAAAGATATTATTCTGCAATCATTAAAATCAGGTAAATCTGTTGTTACAGCAAATAAAGCAGTAATTGC
AAGATATGGAGAAGAAATATACAAAACTGCAGCTAAAGAAGGAGTTTATATATTGTCAGAGGCTGCGGTCTGCGGAGGGA
TTCCAATAATTGAACCCTTAAAAAGATCATTAAAAAGTAACAGCATAAAAAAAATGGTTGGGATAATAAATGGCACAACA
AATTTTATTCTTTCAAAGATGGCAAATGAAAATGCCGATTATAAGGAAACCTTAAAATTAGCTCAAAGACTTGGGTATGC
AGAATTAGATCCAACTGCAGATGTTGAGGGACATGATGCTGCTGATAAGATTTCTATTCTTAGTGAACTCGCATTTGGAG
GTAAAATCAAAAGAGACGAGATACATTCGGAGGGCATTAGTAAAATTAATCTAAAGGATATTGAATATGCCAATAAATTA
GGATTTGAAATAAAACTTTTGGCGTTGTCCGAAAGGCGACAAATTAATAGTAACGATTCACTTGCTTTGAATATTTGGGT
AGGCCCTTCGTTGATTCCAAAATCTCATCCATTAGCAACAGTTATGGGAGTTAACAATGCATTATTGATAGAGGCTGATC
CTCTTGGAGAAATAATGTTATATGGTCCTGGTGCAGGAAGTGGTCCAACAGCTGCATCAGTAGTATCAGATATATTAAAT
CTGCATGCCTCTTCAGTAAAAAATAATAATTCAATCGATCCATTATTATCTTTTGATTTCTGGAGAAACTGTCATATCAT
AAAATCCAATGAAATAAATAAAAAAAATTATCTTAGAATTATTTGTCTTGATAGTCCAGGCGTTATAGGAAAGATTGGAG
ATATCTTTGGAAATAATAATGTATCAATCGAATCAATTGTTCAGCTAGATGCAAGTGAGGATAAAGCCGAAATTGTTGTT
ATAACTCATGAGGTGAATAATGGAAATTTTGAGAAATCGAAAGATGAAATAAATGCTCTTAATGAAGTCAAAATTATTGC
TAGTCAATTAAGTTGTATTTAG

Upstream 100 bases:

>100_bases
ATGGTTTTTTAAACATTTTATTGAAAATGCAGTCTCAAGCAAATGAATTTTTGTAGGCCCAATAATATAAAATTAAATTC
AAAGTAAAAAGAAATAAAAA

Downstream 100 bases:

>100_bases
AGAAATAGTTTGCAAATTTCTTTATAGCTTGTTAAACCGAAGAAAGTAAGTGTTTGGTTTTAGCACCTTAATGATTCATT
CAGAACTATTAGATAATAAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRKCKIGIVGFGTVGSGVYKILSSEVDLHPILKEIDIEKIAVKDLSKKRDFDLDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKDIILQSLKSGKSVVTANKAVIARYGEEIYKTAAKEGVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTT
NFILSKMANENADYKETLKLAQRLGYAELDPTADVEGHDAADKISILSELAFGGKIKRDEIHSEGISKINLKDIEYANKL
GFEIKLLALSERRQINSNDSLALNIWVGPSLIPKSHPLATVMGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHASSVKNNNSIDPLLSFDFWRNCHIIKSNEINKKNYLRIICLDSPGVIGKIGDIFGNNNVSIESIVQLDASEDKAEIVV
ITHEVNNGNFEKSKDEINALNEVKIIASQLSCI

Sequences:

>Translated_433_residues
MRKCKIGIVGFGTVGSGVYKILSSEVDLHPILKEIDIEKIAVKDLSKKRDFDLDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKDIILQSLKSGKSVVTANKAVIARYGEEIYKTAAKEGVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTT
NFILSKMANENADYKETLKLAQRLGYAELDPTADVEGHDAADKISILSELAFGGKIKRDEIHSEGISKINLKDIEYANKL
GFEIKLLALSERRQINSNDSLALNIWVGPSLIPKSHPLATVMGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHASSVKNNNSIDPLLSFDFWRNCHIIKSNEINKKNYLRIICLDSPGVIGKIGDIFGNNNVSIESIVQLDASEDKAEIVV
ITHEVNNGNFEKSKDEINALNEVKIIASQLSCI
>Mature_433_residues
MRKCKIGIVGFGTVGSGVYKILSSEVDLHPILKEIDIEKIAVKDLSKKRDFDLDNNLLTDDPFKLINDPSIDVIVEVMGG
VDLAKDIILQSLKSGKSVVTANKAVIARYGEEIYKTAAKEGVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTT
NFILSKMANENADYKETLKLAQRLGYAELDPTADVEGHDAADKISILSELAFGGKIKRDEIHSEGISKINLKDIEYANKL
GFEIKLLALSERRQINSNDSLALNIWVGPSLIPKSHPLATVMGVNNALLIEADPLGEIMLYGPGAGSGPTAASVVSDILN
LHASSVKNNNSIDPLLSFDFWRNCHIIKSNEINKKNYLRIICLDSPGVIGKIGDIFGNNNVSIESIVQLDASEDKAEIVV
ITHEVNNGNFEKSKDEINALNEVKIIASQLSCI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=273, Percent_Identity=26.007326007326, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786183, Length=122, Percent_Identity=32.7868852459016, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46990; Mature: 46990

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKCKIGIVGFGTVGSGVYKILSSEVDLHPILKEIDIEKIAVKDLSKKRDFDLDNNLLTD
CCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
DPFKLINDPSIDVIVEVMGGVDLAKDIILQSLKSGKSVVTANKAVIARYGEEIYKTAAKE
CCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHC
GVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTTNFILSKMANENADYKETLKL
CEEEEECCHHHCCCCCHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
AQRLGYAELDPTADVEGHDAADKISILSELAFGGKIKRDEIHSEGISKINLKDIEYANKL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHC
GFEIKLLALSERRQINSNDSLALNIWVGPSLIPKSHPLATVMGVNNALLIEADPLGEIML
CCEEEEEEECCHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCEEE
YGPGAGSGPTAASVVSDILNLHASSVKNNNSIDPLLSFDFWRNCHIIKSNEINKKNYLRI
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCEEEEECCCCCCCCCEEE
ICLDSPGVIGKIGDIFGNNNVSIESIVQLDASEDKAEIVVITHEVNNGNFEKSKDEINAL
EEECCCCCEECHHHHCCCCCCCHHHHEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHH
NEVKIIASQLSCI
HHHHHHHHHHCCC
>Mature Secondary Structure
MRKCKIGIVGFGTVGSGVYKILSSEVDLHPILKEIDIEKIAVKDLSKKRDFDLDNNLLTD
CCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
DPFKLINDPSIDVIVEVMGGVDLAKDIILQSLKSGKSVVTANKAVIARYGEEIYKTAAKE
CCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHC
GVYILSEAAVCGGIPIIEPLKRSLKSNSIKKMVGIINGTTNFILSKMANENADYKETLKL
CEEEEECCHHHCCCCCHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
AQRLGYAELDPTADVEGHDAADKISILSELAFGGKIKRDEIHSEGISKINLKDIEYANKL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHC
GFEIKLLALSERRQINSNDSLALNIWVGPSLIPKSHPLATVMGVNNALLIEADPLGEIML
CCEEEEEEECCHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCEEE
YGPGAGSGPTAASVVSDILNLHASSVKNNNSIDPLLSFDFWRNCHIIKSNEINKKNYLRI
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCEEEEECCCCCCCCCEEE
ICLDSPGVIGKIGDIFGNNNVSIESIVQLDASEDKAEIVVITHEVNNGNFEKSKDEINAL
EEECCCCCEECHHHHCCCCCCCHHHHEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHH
NEVKIIASQLSCI
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]