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The map label for this gene is fmt

Identifier: 78779343

GI number: 78779343

Start: 890500

End: 891486

Strand: Direct

Name: fmt

Synonym: PMT9312_0959

Alternate gene names: 78779343

Gene position: 890500-891486 (Clockwise)

Preceding gene: 78779342

Following gene: 78779345

Centisome position: 52.1

GC content: 29.18

Gene sequence:

>987_bases
GTGAGAATTATATTCTGGGGGACACCTGAATATTCAATTTCAAGCCTTGATATTTTTATTAAATCTAAGCACGAGGTAAT
TGCAGTAGTTAGCCAACCGGATAAGAAAAGATCTAGGGGAAAAAAATTAATATCTTCACCTGTTAAAAGCTTTGCCGAGC
AAGAATCTATAAAAATTTATACTCCGGAAAAAATTAGGGACAACATAAATTTTATAAATGAACTTAAATCACTATCCTGT
GATTTATTTATTGTTATAGCTTATGGAAAAATTTTACCTAAAGAGATATTAGAAATACCAAAATTTGGTTGTTGGAACGC
ACATGCTTCATTACTTCCAAGATGGCGTGGTGCGGCTCCAATCCAATGGTCCCTAATGAAAGGTGATGAATTTACTGGAG
TAGGAATTATGAAAATGAATGAGGGACTAGATACTGGCGACTTATTGTTGGAAGAAAAAATTAAAATCGATAATAACGAT
AATTTAATTACACTTACGGAAAAACTTAGTATTTTATCTGCAAAATTATTTTTAAATGCTACATCTTTACTCGAAGAAAA
TATTAATAAAAATACTAATTATCAATTAACAAAACAAAATACTCTTGGAAGAGAAATTACTTACGCAAGAATGATTGAAA
AATCTGACTATAAAGTGGATTGGGGTAATGAGGCAATTAAAATTTCTCGAAAAATAAAAGCATTATACCCACGAGCAAAT
ACAACTTTTAGAGGGAAGAACCTAAAAATAATCAAAATTAAAGTTTTAAGTAGTGATGAAATTAATAATGAAAAATACTG
TTTAATGAGCAATTATTCAAAACCAGGAATTATTCTTGCTGTCTTAGAAAATGAAGGAATAATAATTTCAACTAAAACTG
ATCCGATTATTTTGTTAGAAGCAAAACTTGAAGGCAAAAACATATCTAGCAAAAAACAATTAATACAACAGTTAAAGCCA
TCATTAGGTGAATATCTCTCAAATTAA

Upstream 100 bases:

>100_bases
TTTTGAAACATATAGTAAATATTGAATCCAACCAAGAGGTAACAACAAGTGGGGTCTCTCCACATATATGGGTAGATGAA
TTATCAATAACTGGTGACGC

Downstream 100 bases:

>100_bases
GTTTTTGATTCTTTTTTAGAGAATCCCCAAATGAAAGCAAAAAGAATCAAAATATAAAAATAATAGTCGGGAAGAATAGA
TTCTTTAATTAACGTATTTA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRIIFWGTPEYSISSLDIFIKSKHEVIAVVSQPDKKRSRGKKLISSPVKSFAEQESIKIYTPEKIRDNINFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLMKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNND
NLITLTEKLSILSAKLFLNATSLLEENINKNTNYQLTKQNTLGREITYARMIEKSDYKVDWGNEAIKISRKIKALYPRAN
TTFRGKNLKIIKIKVLSSDEINNEKYCLMSNYSKPGIILAVLENEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKP
SLGEYLSN

Sequences:

>Translated_328_residues
MRIIFWGTPEYSISSLDIFIKSKHEVIAVVSQPDKKRSRGKKLISSPVKSFAEQESIKIYTPEKIRDNINFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLMKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNND
NLITLTEKLSILSAKLFLNATSLLEENINKNTNYQLTKQNTLGREITYARMIEKSDYKVDWGNEAIKISRKIKALYPRAN
TTFRGKNLKIIKIKVLSSDEINNEKYCLMSNYSKPGIILAVLENEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKP
SLGEYLSN
>Mature_328_residues
MRIIFWGTPEYSISSLDIFIKSKHEVIAVVSQPDKKRSRGKKLISSPVKSFAEQESIKIYTPEKIRDNINFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLMKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNND
NLITLTEKLSILSAKLFLNATSLLEENINKNTNYQLTKQNTLGREITYARMIEKSDYKVDWGNEAIKISRKIKALYPRAN
TTFRGKNLKIIKIKVLSSDEINNEKYCLMSNYSKPGIILAVLENEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKP
SLGEYLSN

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=287, Percent_Identity=25.4355400696864, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI238814322, Length=282, Percent_Identity=24.468085106383, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI164663775, Length=304, Percent_Identity=22.3684210526316, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789683, Length=319, Percent_Identity=36.6771159874608, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1788589, Length=180, Percent_Identity=27.7777777777778, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI133930964, Length=179, Percent_Identity=29.0502793296089, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550868, Length=258, Percent_Identity=29.0697674418605, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571984, Length=179, Percent_Identity=32.9608938547486, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585660, Length=176, Percent_Identity=29.5454545454545, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_PROM9 (Q31AS6)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397455.1
- ProteinModelPortal:   Q31AS6
- SMR:   Q31AS6
- STRING:   Q31AS6
- GeneID:   3765762
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0959
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   WRGAGPI
- ProtClustDB:   CLSK921992
- BioCyc:   PMAR74546:PMT9312_0959-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 37227; Mature: 37227

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIFWGTPEYSISSLDIFIKSKHEVIAVVSQPDKKRSRGKKLISSPVKSFAEQESIKIY
CEEEEECCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
TPEKIRDNINFINELKSLSCDLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAP
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCHHHCCCCCCCCC
IQWSLMKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNNDNLITLTEKLSILSAKLFLNA
EEEEEECCCCCCCEEEEEECCCCCHHHEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHH
TSLLEENINKNTNYQLTKQNTLGREITYARMIEKSDYKVDWGNEAIKISRKIKALYPRAN
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEECCCCEEEEEEHHHEECCCCC
TTFRGKNLKIIKIKVLSSDEINNEKYCLMSNYSKPGIILAVLENEGIIISTKTDPIILLE
CEECCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCEEEEECCCCEEEEE
AKLEGKNISSKKQLIQQLKPSLGEYLSN
EEECCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIIFWGTPEYSISSLDIFIKSKHEVIAVVSQPDKKRSRGKKLISSPVKSFAEQESIKIY
CEEEEECCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
TPEKIRDNINFINELKSLSCDLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAP
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCHHHCCCCCCCCC
IQWSLMKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNNDNLITLTEKLSILSAKLFLNA
EEEEEECCCCCCCEEEEEECCCCCHHHEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHH
TSLLEENINKNTNYQLTKQNTLGREITYARMIEKSDYKVDWGNEAIKISRKIKALYPRAN
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEECCCCEEEEEEHHHEECCCCC
TTFRGKNLKIIKIKVLSSDEINNEKYCLMSNYSKPGIILAVLENEGIIISTKTDPIILLE
CEECCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCEEEEECCCCEEEEE
AKLEGKNISSKKQLIQQLKPSLGEYLSN
EEECCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA