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The map label for this gene is ilvA [H]

Identifier: 78779276

GI number: 78779276

Start: 823431

End: 824978

Strand: Reverse

Name: ilvA [H]

Synonym: PMT9312_0892

Alternate gene names: 78779276

Gene position: 824978-823431 (Counterclockwise)

Preceding gene: 78779278

Following gene: 78779275

Centisome position: 48.27

GC content: 31.33

Gene sequence:

>1548_bases
ATGTATATGAATGATTATTTTGAAAAAATACTTCAGGCTGAAGTCTATGAAGTAGCAAAAAAAACACCACTAGAAAAAGC
ACATAATTTAAGTAATAAGCTTAATAATGAAGTTTTCTTAAAAAGAGAAGATCTTCAAGATGTGTTTTCATTCAAAATAA
GAGGGGCATTTAACAAAATGAGTAAGCTCACTAAATCGCAGCTTGCTCAAGGAGTAATTACATCAAGTGCTGGAAATCAT
GCTCAGGGGGTAGCACTAAGTGCTCTCAAGTTAAATTGCCAAGCAACCATATTAATGCCCCTTACAACGCCTCTAGTAAA
AATTAATGCAGTAAAAAATCTAAAGGCAAAAGTTATATTATATGGAGATAATTATGATGAAACTTATAGAGAGGCAATAA
GGATTAGCAAAGAAAGAAATTTATGTTTTATTCATCCTTTTGATGATCCTGAAGTAATAGCAGGACAAGGAACTATAGCT
ATTGAACTTGAACAACAATTAAAAGACAAACCTTATGCTATTTATATTGCTGTTGGTGGTGGCGGATTGATATCAGGAAT
ATCCTTATACATTAAGAAAGTTTGGCCTGAAGTAAAAATAATTGGAGTAGAGCCTCAAGACGCAGATGCTATGTCAAAAT
CCTTAGAAGAATCAAAAATTGTTGAATTAGCTTCAGTAGGACAGTTTGCAGATGGAGTAGCCGTTAAAAAAGTTGGTAAT
AATACTTTTGATATTGGAAGAAAATATATAGATAAAATGATTAGGGTTAACACAGATGAAATATGTGCTGCAATCAAAGA
TGTTTTTGAAGACACTAGATCGATACTAGAGCCTGCAGGTGCATTATCAATTGCTGGAATGAAAAAAGATATTTTAAATT
CGAATCATTCAAATAAAAACATGGTTGCTATTGCATGCGGTGCAAATATGAACTTTGAGAGGCTTAGATTTGTAGCAGAA
AGAGCGGAACTTGGAGAATGCAAAGAGGTTATGATGGCAGTTGAAATTCCTGAATGTGCTGGTAGTTTAATAGATTTTTG
TAAGTTGCTTAAAAATAGAAATTTAACTGAATTTAGCTATAGAATGTCCAACTCTATAAATGCACAGATCTTTGTAGGAG
TTGAAGTTAATGGAATAGTTGATAAAAAAATTCTCTTGGATGAATTTAGGAATTCGCAGTACAAATTTATTGATTTAAGT
GAGGATGAATTATCCAAAAATCATCTAAGACATATGGTAGGTGGACGATTACCAAAGAATCTCAAAGAAATTAATAATAG
AAGTTTTGTTGAGTTGTTATATAGATTTGAATTTCCCGAAAAACCTGGAGCATTAATAAATTTCTTAAATAATATGAAAT
CTAATTGGTCAATAAGTGTATTTCATTATCGGAATTACGGTGCTGATGTAGGAAAAATTGTTATTGGAGTATTAATCGAT
AAAAGTGAAATTACGGAATGGAACAATTTTGTAAAATTTTTAGGTTACAAATACTGGGATGAAACTAAAAACGATACATA
TAAATTATTCCTTGGTGCACCAGAATAA

Upstream 100 bases:

>100_bases
TAGTTATACATATAATTTAAAACGCCGAGGTGCAAAATGAGTAATTTTTATGAAATCGATCATGTAATGTTTTATTAGAT
TAATAATTAATGCTAAAAAT

Downstream 100 bases:

>100_bases
ATATGAGTTATCTTAGGAAAGATTTCGGTAATAACAATTATTAAATCTGATCTAATTAATAAGCAACTATCTGATATAGA
TCTAGTTACCAGAATTGAAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MYMNDYFEKILQAEVYEVAKKTPLEKAHNLSNKLNNEVFLKREDLQDVFSFKIRGAFNKMSKLTKSQLAQGVITSSAGNH
AQGVALSALKLNCQATILMPLTTPLVKINAVKNLKAKVILYGDNYDETYREAIRISKERNLCFIHPFDDPEVIAGQGTIA
IELEQQLKDKPYAIYIAVGGGGLISGISLYIKKVWPEVKIIGVEPQDADAMSKSLEESKIVELASVGQFADGVAVKKVGN
NTFDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNKNMVAIACGANMNFERLRFVAE
RAELGECKEVMMAVEIPECAGSLIDFCKLLKNRNLTEFSYRMSNSINAQIFVGVEVNGIVDKKILLDEFRNSQYKFIDLS
EDELSKNHLRHMVGGRLPKNLKEINNRSFVELLYRFEFPEKPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLID
KSEITEWNNFVKFLGYKYWDETKNDTYKLFLGAPE

Sequences:

>Translated_515_residues
MYMNDYFEKILQAEVYEVAKKTPLEKAHNLSNKLNNEVFLKREDLQDVFSFKIRGAFNKMSKLTKSQLAQGVITSSAGNH
AQGVALSALKLNCQATILMPLTTPLVKINAVKNLKAKVILYGDNYDETYREAIRISKERNLCFIHPFDDPEVIAGQGTIA
IELEQQLKDKPYAIYIAVGGGGLISGISLYIKKVWPEVKIIGVEPQDADAMSKSLEESKIVELASVGQFADGVAVKKVGN
NTFDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNKNMVAIACGANMNFERLRFVAE
RAELGECKEVMMAVEIPECAGSLIDFCKLLKNRNLTEFSYRMSNSINAQIFVGVEVNGIVDKKILLDEFRNSQYKFIDLS
EDELSKNHLRHMVGGRLPKNLKEINNRSFVELLYRFEFPEKPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLID
KSEITEWNNFVKFLGYKYWDETKNDTYKLFLGAPE
>Mature_515_residues
MYMNDYFEKILQAEVYEVAKKTPLEKAHNLSNKLNNEVFLKREDLQDVFSFKIRGAFNKMSKLTKSQLAQGVITSSAGNH
AQGVALSALKLNCQATILMPLTTPLVKINAVKNLKAKVILYGDNYDETYREAIRISKERNLCFIHPFDDPEVIAGQGTIA
IELEQQLKDKPYAIYIAVGGGGLISGISLYIKKVWPEVKIIGVEPQDADAMSKSLEESKIVELASVGQFADGVAVKKVGN
NTFDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNKNMVAIACGANMNFERLRFVAE
RAELGECKEVMMAVEIPECAGSLIDFCKLLKNRNLTEFSYRMSNSINAQIFVGVEVNGIVDKKILLDEFRNSQYKFIDLS
EDELSKNHLRHMVGGRLPKNLKEINNRSFVELLYRFEFPEKPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLID
KSEITEWNNFVKFLGYKYWDETKNDTYKLFLGAPE

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=300, Percent_Identity=33.6666666666667, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=30.8681672025724, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI19923959, Length=313, Percent_Identity=29.073482428115, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790207, Length=512, Percent_Identity=45.3125, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1789505, Length=295, Percent_Identity=37.9661016949153, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71991565, Length=333, Percent_Identity=30.9309309309309, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=364, Percent_Identity=31.043956043956, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=296, Percent_Identity=30.0675675675676, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=527, Percent_Identity=45.3510436432638, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=35.8552631578947, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319788, Length=326, Percent_Identity=27.6073619631902, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322024, Length=188, Percent_Identity=28.1914893617021, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355833, Length=331, Percent_Identity=34.7432024169184, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 58060; Mature: 58060

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMNDYFEKILQAEVYEVAKKTPLEKAHNLSNKLNNEVFLKREDLQDVFSFKIRGAFNKM
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHH
SKLTKSQLAQGVITSSAGNHAQGVALSALKLNCQATILMPLTTPLVKINAVKNLKAKVIL
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEEEEEEECCCEEEEEE
YGDNYDETYREAIRISKERNLCFIHPFDDPEVIAGQGTIAIELEQQLKDKPYAIYIAVGG
EECCCCHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEEHHHHCCCCEEEEEEECC
GGLISGISLYIKKVWPEVKIIGVEPQDADAMSKSLEESKIVELASVGQFADGVAVKKVGN
CHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHCCEEEEECCC
NTFDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNKN
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHCCCCCCCC
MVAIACGANMNFERLRFVAERAELGECKEVMMAVEIPECAGSLIDFCKLLKNRNLTEFSY
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCCCHHHH
RMSNSINAQIFVGVEVNGIVDKKILLDEFRNSQYKFIDLSEDELSKNHLRHMVGGRLPKN
HHCCCCCEEEEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCHH
LKEINNRSFVELLYRFEFPEKPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLID
HHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEEEC
KSEITEWNNFVKFLGYKYWDETKNDTYKLFLGAPE
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MYMNDYFEKILQAEVYEVAKKTPLEKAHNLSNKLNNEVFLKREDLQDVFSFKIRGAFNKM
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHH
SKLTKSQLAQGVITSSAGNHAQGVALSALKLNCQATILMPLTTPLVKINAVKNLKAKVIL
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEEEEEEECCCEEEEEE
YGDNYDETYREAIRISKERNLCFIHPFDDPEVIAGQGTIAIELEQQLKDKPYAIYIAVGG
EECCCCHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEEHHHHCCCCEEEEEEECC
GGLISGISLYIKKVWPEVKIIGVEPQDADAMSKSLEESKIVELASVGQFADGVAVKKVGN
CHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHCCEEEEECCC
NTFDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNKN
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHCCCCCCCC
MVAIACGANMNFERLRFVAERAELGECKEVMMAVEIPECAGSLIDFCKLLKNRNLTEFSY
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCCCHHHH
RMSNSINAQIFVGVEVNGIVDKKILLDEFRNSQYKFIDLSEDELSKNHLRHMVGGRLPKN
HHCCCCCEEEEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCHH
LKEINNRSFVELLYRFEFPEKPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLID
HHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEEEC
KSEITEWNNFVKFLGYKYWDETKNDTYKLFLGAPE
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA