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The map label for this gene is umuC [H]

Identifier: 78779246

GI number: 78779246

Start: 798044

End: 799330

Strand: Reverse

Name: umuC [H]

Synonym: PMT9312_0862

Alternate gene names: 78779246

Gene position: 799330-798044 (Counterclockwise)

Preceding gene: 78779247

Following gene: 78779245

Centisome position: 46.77

GC content: 30.15

Gene sequence:

>1287_bases
ATGAGAATTTCAAGCATTGATGCTATAGCTCTTATAGATGCTAATAATTTTTATGCGTCATGTGAACAAACTATTAATCC
TCATTTGAGAAATAAACCAGTAGTAATTTTATCTAATAATGACGGATGTATCATTGCGAGAAGTCCCGAAGCGCGAGCTT
TGAAAATTAAAATGGGAACTCCTTATTTTAAGGTCAAAGAAAAATTAAATAAATTAGATGTAGCAGTCTTAAGCTCAAAC
TACTCGCTTTACGGCGATATGAGCAGAAGACTTATGAATTTACTAAAAAAATACTGTGAACAAATAGAAATTTATTCTAT
TGACGAAGCATTTGTCTCAATTTCTAGACCTAATGATAAAAATCTATATCCTTGGGCAAGAAACATAAGATCATTAATAT
ATCAGAATCTAGGCATCACACTAACAGTAGGTATAGGAGAAAATAAAGTAAGAGCAAAAATTGCTAATAAATTAGCTAAA
AATATTGATTATTCAGCTGGAATATTTGATTTATCTAGAACTAGAAATGAGAATAATTATTTAAAAAGAATTAGTGTAGA
TAACATATGGGGAGTCGGGAAACAAACCTCTAATTGGTTGAAAAGTAAAGGTATTAAAAATGCGAGAGAATTAAGAGATA
TGGAAGAAAATGAAATTATTAAGAAACTAGGCATAGTAGGGAAAAGATTACAATTAGAACTGAAAGGCTATAAATGCCTG
CCTCTAGAAAAAAGCAAGAAATCAAAAAAAGAAATTCAGGTAAGCAGGAGTTTCGGTACCCCTATCACAAAATTAGAAGA
CTTAACTCAAGCACTGGCGACTCATGCAATAAAAGCATCTGAAAAAATGAGAAGTCAGAATTTACAATCATCCGACATTA
GAGTATTTGCCAGAACCAGTAAATATTCAAGTCAAAATTATCAAAGAAGTGCTCATAGAAAACTTACAAATGCGACAGAC
GACACAAACAGCATTTTAAAAATAGTAGTTGAATTATCTAAAGAAATTTATAATCCCGAATATAAATTTTCAAAAGCTGG
TGTTTTAATGCAGGATTTAACTAATAGCGAATATTTACAGCAATCAGTTATCAATTACAAATCTCAGAAAGACCTAAAAA
AATCAGCAACTCTCATGAGAACTATTGATTTATTAAATAAAAGATTTAATAACAATGCAATTACATGGGCTATTACAAAA
ACGCAAAAAAGTTGGAAGATGAATAAGAATTTCTTAAGTCGCTCATCTACAACTGATATAGAACAAATCCCAACTATAGT
AAAGTAA

Upstream 100 bases:

>100_bases
ATTTAAAAGCAGAAAATCATAATTATCCTGATTTTAGATTTAAAAACCATATTGATGTACAGATATGGGGCGTTGTTATT
TATTCAATACATAGCTATTT

Downstream 100 bases:

>100_bases
ACACAATAAAATGGAATTTATAATATTTTTAAGCAAATTAGATAAAGAGATTCTAGACTTATTAATACAAGCAAACTACA
TAGTTGAAGAAAATAAAATT

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRISSIDAIALIDANNFYASCEQTINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGTPYFKVKEKLNKLDVAVLSSN
YSLYGDMSRRLMNLLKKYCEQIEIYSIDEAFVSISRPNDKNLYPWARNIRSLIYQNLGITLTVGIGENKVRAKIANKLAK
NIDYSAGIFDLSRTRNENNYLKRISVDNIWGVGKQTSNWLKSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGYKCL
PLEKSKKSKKEIQVSRSFGTPITKLEDLTQALATHAIKASEKMRSQNLQSSDIRVFARTSKYSSQNYQRSAHRKLTNATD
DTNSILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQQSVINYKSQKDLKKSATLMRTIDLLNKRFNNNAITWAITK
TQKSWKMNKNFLSRSSTTDIEQIPTIVK

Sequences:

>Translated_428_residues
MRISSIDAIALIDANNFYASCEQTINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGTPYFKVKEKLNKLDVAVLSSN
YSLYGDMSRRLMNLLKKYCEQIEIYSIDEAFVSISRPNDKNLYPWARNIRSLIYQNLGITLTVGIGENKVRAKIANKLAK
NIDYSAGIFDLSRTRNENNYLKRISVDNIWGVGKQTSNWLKSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGYKCL
PLEKSKKSKKEIQVSRSFGTPITKLEDLTQALATHAIKASEKMRSQNLQSSDIRVFARTSKYSSQNYQRSAHRKLTNATD
DTNSILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQQSVINYKSQKDLKKSATLMRTIDLLNKRFNNNAITWAITK
TQKSWKMNKNFLSRSSTTDIEQIPTIVK
>Mature_428_residues
MRISSIDAIALIDANNFYASCEQTINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGTPYFKVKEKLNKLDVAVLSSN
YSLYGDMSRRLMNLLKKYCEQIEIYSIDEAFVSISRPNDKNLYPWARNIRSLIYQNLGITLTVGIGENKVRAKIANKLAK
NIDYSAGIFDLSRTRNENNYLKRISVDNIWGVGKQTSNWLKSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGYKCL
PLEKSKKSKKEIQVSRSFGTPITKLEDLTQALATHAIKASEKMRSQNLQSSDIRVFARTSKYSSQNYQRSAHRKLTNATD
DTNSILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQQSVINYKSQKDLKKSATLMRTIDLLNKRFNNNAITWAITK
TQKSWKMNKNFLSRSSTTDIEQIPTIVK

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=414, Percent_Identity=37.1980676328502, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1786425, Length=225, Percent_Identity=24.4444444444444, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19923006, Length=302, Percent_Identity=23.5099337748344, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 48944; Mature: 48944

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISSIDAIALIDANNFYASCEQTINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGT
CCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEEECC
PYFKVKEKLNKLDVAVLSSNYSLYGDMSRRLMNLLKKYCEQIEIYSIDEAFVSISRPNDK
CHHHHHHHHHHHEEEEEECCCCEEHHHHHHHHHHHHHHHHHCEEEEECHHHEEECCCCCC
NLYPWARNIRSLIYQNLGITLTVGIGENKVRAKIANKLAKNIDYSAGIFDLSRTRNENNY
CCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCC
LKRISVDNIWGVGKQTSNWLKSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGYKCL
EEEEECCHHCCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEEECCEEEC
PLEKSKKSKKEIQVSRSFGTPITKLEDLTQALATHAIKASEKMRSQNLQSSDIRVFARTS
CCCCCCCHHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
KYSSQNYQRSAHRKLTNATDDTNSILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQ
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHCCCHHHHH
QSVINYKSQKDLKKSATLMRTIDLLNKRFNNNAITWAITKTQKSWKMNKNFLSRSSTTDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCH
EQIPTIVK
HHCCCCCC
>Mature Secondary Structure
MRISSIDAIALIDANNFYASCEQTINPHLRNKPVVILSNNDGCIIARSPEARALKIKMGT
CCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCEEEEEEECC
PYFKVKEKLNKLDVAVLSSNYSLYGDMSRRLMNLLKKYCEQIEIYSIDEAFVSISRPNDK
CHHHHHHHHHHHEEEEEECCCCEEHHHHHHHHHHHHHHHHHCEEEEECHHHEEECCCCCC
NLYPWARNIRSLIYQNLGITLTVGIGENKVRAKIANKLAKNIDYSAGIFDLSRTRNENNY
CCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCC
LKRISVDNIWGVGKQTSNWLKSKGIKNARELRDMEENEIIKKLGIVGKRLQLELKGYKCL
EEEEECCHHCCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEEECCEEEC
PLEKSKKSKKEIQVSRSFGTPITKLEDLTQALATHAIKASEKMRSQNLQSSDIRVFARTS
CCCCCCCHHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
KYSSQNYQRSAHRKLTNATDDTNSILKIVVELSKEIYNPEYKFSKAGVLMQDLTNSEYLQ
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHCCCHHHHH
QSVINYKSQKDLKKSATLMRTIDLLNKRFNNNAITWAITKTQKSWKMNKNFLSRSSTTDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCH
EQIPTIVK
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]