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The map label for this gene is csgA [H]

Identifier: 78778794

GI number: 78778794

Start: 388724

End: 389428

Strand: Direct

Name: csgA [H]

Synonym: PMT9312_0409

Alternate gene names: 78778794

Gene position: 388724-389428 (Clockwise)

Preceding gene: 78778793

Following gene: 78778798

Centisome position: 22.74

GC content: 31.35

Gene sequence:

>705_bases
ATGAAAGGCTTAGCCTTAGTTGTAGGCGCAGGTGGAATTGGAACACAACTAGCTAAAGATTTGAATGAAAGTGAAAAAGA
TTTAGATGTTGTTTTGTGTGGAAGAAAAAGTGAATTTAATCCTTTTTGGGCATTAGATATAGAGGATTCTCAATCCCTTT
TGCAGTTGAAAAATAAAATATCAAATCATCCTTCAAAATTAAGGTTAGTTGTTAATGCTACAGGTAGACTTCATAGTAAT
TCTCTTCAACCAGAAAAAAGATTACAACATCTTGATATAAAAAATATGATGGAAAGTTTTTCAATAAATGCCTTTTCTCC
TATTTTATTAGCTAAAGCGATTGAAGAATTTATACCAAAAGATTTTGATTTTAATTTTGCAAGTATAAGTGCAAGAGTGG
GAAGCATTGGAGATAATCAAACCGGAGGTTGGTATTCATATAGAGCTGCAAAATCTGCCCAAAATCAGTTTTTTAAATCT
TTAAGTATTGAGTGGGAAAGACGTTTCCCAAAGGCTACTATTACATTACTTCATCCAGGAACAGTAGATACAAATTTATC
TAGACCTTTTCATAAATTTGTTCCAGAGCATAAATTATTTAGTAAAGAAAAATCTTCCCAATTTTTGATCAATATTATTA
AAAATCAAACTCCAGCATCTTCTGGAAAATTTATTGCATGGGACAGCTCGGATATACCTTGGTAA

Upstream 100 bases:

>100_bases
AAAAAATAAATCTCAATAAAATTTCCTTATCAAATAAGAAAGATCTTTACGCAAATCACAAGAAAATTTTCTTAGAATCA
CTGGAGTTATTTTTAATAAA

Downstream 100 bases:

>100_bases
ACTAAATTTTTTCTTTATATCAATAGATATTTAAGTCAATATTTTTTTTACTTCTTTAGCAAGCAAATCAATCTCAGCTT
CTGTAGTCATTTGATGTACA

Product: putative short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKGLALVVGAGGIGTQLAKDLNESEKDLDVVLCGRKSEFNPFWALDIEDSQSLLQLKNKISNHPSKLRLVVNATGRLHSN
SLQPEKRLQHLDIKNMMESFSINAFSPILLAKAIEEFIPKDFDFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKS
LSIEWERRFPKATITLLHPGTVDTNLSRPFHKFVPEHKLFSKEKSSQFLINIIKNQTPASSGKFIAWDSSDIPW

Sequences:

>Translated_234_residues
MKGLALVVGAGGIGTQLAKDLNESEKDLDVVLCGRKSEFNPFWALDIEDSQSLLQLKNKISNHPSKLRLVVNATGRLHSN
SLQPEKRLQHLDIKNMMESFSINAFSPILLAKAIEEFIPKDFDFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKS
LSIEWERRFPKATITLLHPGTVDTNLSRPFHKFVPEHKLFSKEKSSQFLINIIKNQTPASSGKFIAWDSSDIPW
>Mature_234_residues
MKGLALVVGAGGIGTQLAKDLNESEKDLDVVLCGRKSEFNPFWALDIEDSQSLLQLKNKISNHPSKLRLVVNATGRLHSN
SLQPEKRLQHLDIKNMMESFSINAFSPILLAKAIEEFIPKDFDFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKS
LSIEWERRFPKATITLLHPGTVDTNLSRPFHKFVPEHKLFSKEKSSQFLINIIKNQTPASSGKFIAWDSSDIPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26280; Mature: 26280

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLALVVGAGGIGTQLAKDLNESEKDLDVVLCGRKSEFNPFWALDIEDSQSLLQLKNKI
CCCEEEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHH
SNHPSKLRLVVNATGRLHSNSLQPEKRLQHLDIKNMMESFSINAFSPILLAKAIEEFIPK
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCC
DFDFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKSLSIEWERRFPKATITLLHPG
CCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEEECC
TVDTNLSRPFHKFVPEHKLFSKEKSSQFLINIIKNQTPASSGKFIAWDSSDIPW
CCCCCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MKGLALVVGAGGIGTQLAKDLNESEKDLDVVLCGRKSEFNPFWALDIEDSQSLLQLKNKI
CCCEEEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHH
SNHPSKLRLVVNATGRLHSNSLQPEKRLQHLDIKNMMESFSINAFSPILLAKAIEEFIPK
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCC
DFDFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKSLSIEWERRFPKATITLLHPG
CCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEEECC
TVDTNLSRPFHKFVPEHKLFSKEKSSQFLINIIKNQTPASSGKFIAWDSSDIPW
CCCCCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]