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The map label for this gene is thyX

Identifier: 78778630

GI number: 78778630

Start: 237299

End: 237931

Strand: Reverse

Name: thyX

Synonym: PMT9312_0245

Alternate gene names: 78778630

Gene position: 237931-237299 (Counterclockwise)

Preceding gene: 78778631

Following gene: 78778628

Centisome position: 13.92

GC content: 31.6

Gene sequence:

>633_bases
ATGAGTAAAGTTGAACTAATTTCATTAACTCCTGATGCAGAAAAAACAATGGCTTACATTGCAAGAGTTAGTAATCCAAA
AAATCAGAAAAACGAAGATTATTCAAAATTATTGAGTTATTGTATTAAAAATGAACATTGGAGTGTCTTTGAGCAGTCAT
TTATGACCTTACAAATAGAAACCAACAGAGGAATTGCAGCTCAAATTTTAAGACATAGATCATTTACTTTCCAGGAATTT
TCACAGAGATACGCAGATAGTTCTCAATTAGGGAATATTCCTTTACCAGAGTTGAGAAGACAAGATTTTAAAAATAGGCA
AAATTCTATTCCTGACCTTTCTGATGAATTAAAAAAAAGATTCAATGCAAAAATTGCTTCACATTTTAAGGCTGCTTCAG
AATTATATGAAGATTTACTCTCTGAAGGAATAGCCAAAGAATGTGCGAGATTTGTTTTACCATTATCAACTCCAACAAGA
ATCTATATGTCTGGATCATGCAGATCATGGATACATTACATTAACTTAAGATCAGCTCATGGCACTCAAGAAGAGCACAA
GTCTATTGCCCAAAATTGTAAGTCTATTTTTAAAGACAGTTTTCCGATTGTATCAAAATCTTTAGATTGGTAA

Upstream 100 bases:

>100_bases
CTACTTTTTTTTGAAGGTGATCCTTGTTCTACAACTTATGAAGATAGAAGAGGTAAATATCAAAATCAACCAGAGAAAGT
GACTCTAGCAAGGATTTAAA

Downstream 100 bases:

>100_bases
GAATTATCTATCCATGACTACGAGGATTACCCTGATAATTTTTCTTTTGTTTGATTACTGAAAATTCAGCACTATGAATT
TCTTCATGAGATTTTGTCTC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSKVELISLTPDAEKTMAYIARVSNPKNQKNEDYSKLLSYCIKNEHWSVFEQSFMTLQIETNRGIAAQILRHRSFTFQEF
SQRYADSSQLGNIPLPELRRQDFKNRQNSIPDLSDELKKRFNAKIASHFKAASELYEDLLSEGIAKECARFVLPLSTPTR
IYMSGSCRSWIHYINLRSAHGTQEEHKSIAQNCKSIFKDSFPIVSKSLDW

Sequences:

>Translated_210_residues
MSKVELISLTPDAEKTMAYIARVSNPKNQKNEDYSKLLSYCIKNEHWSVFEQSFMTLQIETNRGIAAQILRHRSFTFQEF
SQRYADSSQLGNIPLPELRRQDFKNRQNSIPDLSDELKKRFNAKIASHFKAASELYEDLLSEGIAKECARFVLPLSTPTR
IYMSGSCRSWIHYINLRSAHGTQEEHKSIAQNCKSIFKDSFPIVSKSLDW
>Mature_209_residues
SKVELISLTPDAEKTMAYIARVSNPKNQKNEDYSKLLSYCIKNEHWSVFEQSFMTLQIETNRGIAAQILRHRSFTFQEFS
QRYADSSQLGNIPLPELRRQDFKNRQNSIPDLSDELKKRFNAKIASHFKAASELYEDLLSEGIAKECARFVLPLSTPTRI
YMSGSCRSWIHYINLRSAHGTQEEHKSIAQNCKSIFKDSFPIVSKSLDW

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 24290; Mature: 24159

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVELISLTPDAEKTMAYIARVSNPKNQKNEDYSKLLSYCIKNEHWSVFEQSFMTLQIE
CCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCEEEEEE
TNRGIAAQILRHRSFTFQEFSQRYADSSQLGNIPLPELRRQDFKNRQNSIPDLSDELKKR
CCCCHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
FNAKIASHFKAASELYEDLLSEGIAKECARFVLPLSTPTRIYMSGSCRSWIHYINLRSAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCC
GTQEEHKSIAQNCKSIFKDSFPIVSKSLDW
CCHHHHHHHHHHHHHHHHCCCCHHHCCCCC
>Mature Secondary Structure 
SKVELISLTPDAEKTMAYIARVSNPKNQKNEDYSKLLSYCIKNEHWSVFEQSFMTLQIE
CCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCEEEEEE
TNRGIAAQILRHRSFTFQEFSQRYADSSQLGNIPLPELRRQDFKNRQNSIPDLSDELKKR
CCCCHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
FNAKIASHFKAASELYEDLLSEGIAKECARFVLPLSTPTRIYMSGSCRSWIHYINLRSAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCC
GTQEEHKSIAQNCKSIFKDSFPIVSKSLDW
CCHHHHHHHHHHHHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]