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The map label for this gene is waaA [H]

Identifier: 78484847

GI number: 78484847

Start: 562142

End: 563452

Strand: Reverse

Name: waaA [H]

Synonym: Tcr_0502

Alternate gene names: 78484847

Gene position: 563452-562142 (Counterclockwise)

Preceding gene: 78484848

Following gene: 78484843

Centisome position: 23.21

GC content: 46.38

Gene sequence:

>1311_bases
ATGTCTTTATGGCTCTACCGTTTCTTGCTTCTACTCGCATCACCAGTAATCGTCTATTCTGGCTGGAAGCGATGCCATCG
AGCCAAAAAGTACGCTGAAAAAGATTCCGATTACGCGCCCATTCCACACTGTTTTGCCGCACGCTTTGGATGGAGCCGCC
AACCGTTTCAACAAGGTGGCATATGGGTGCACGCTGTTTCTGTGGGTGAAACTCGCTCCATCTTTCCATTGCTGACAGCG
CTTAAAAAAGCGTATCCGGACTTACCTATCACCGTTACCAGTGGGTCAACGCAAGGTGCCCAACAAGCTTTACGTTTTGC
GCCTGTCCCGATCCAACATCAGATGATCCCGTATGATTACCCGGGTGCCGTCAAACGATTCTTGAAAAAGCTACAACCCC
GTCTCGTGATAATGGTGGAAACAGAAATCTGGCCTAACTTATATCAGACGTGCTGGGATCAGCAAATCCCTTTAATCTTA
GCCAACGCGCGAATAAAAGAAAAATCATTTTACGCCTATCAAAAATGGGGTGGAAAATTGATTGCCAACGCGCTGAATCA
AACCCGTTTAATTGCCAGCCAGTTTGCATTAGACACCGACCATTTAATCGCCCTAGGCGCTCACCCAGCTCGGATCAAAC
AACTGGGAAATTTAAAATTTGATATTGATGTCCCTAAAGACTTAATGACAAACATGCAACAATGGCGTCACGAATATGGG
CTTGAAAATAAATTCCTCTGGGTGGCCGCCAGTACGCATGCCGATGAAGAAACACTGATGCTGGAAGCGCATCGACAACT
CAGACAACAGCATCCTAATGCGCTGTTGATACTGGTTCCTCGCCACACAGATCGGTTTAAGGAAGTGGCTGACTTACTGT
CTGAAAAATACATTCCATTTGCCAGCCGTTCTAAAGGTGAGCTGATTCAGTCGAACACACAAGTCTATTTAGCCGATACC
ATTGGAGAACTAATGAACTGGTTTGCAGCCAGTGATGCGGCATTTATAGGAGGCAGTCTGGTACCTTTTGGAGGGCATAA
TATCTTGGAGCCGGCCGCGCTGAAGAAACCGGTTTTATCGGGGCAATATCATCAAAACCTGCAGGCGCTCTATGATTCAT
TCAAACAAGACGATGCCATTTTGATTTCTCAGGATGAAAACGAGCTGGCTCAGCAATTAATTCAACTGGCGGACTCTACT
GAATGGCGCAACCAAAAAGCCGAAGAGGCCTATGCCTGTTTTGAAAAACAGTCGGGGGCTTTACCGAAATTAATGCATGA
AATTGGTCAATTACTCCCGCCAACAGAATAA

Upstream 100 bases:

>100_bases
GACGCAGAAAAAAATCACCTCTTTACTTGTGTCTGATCAGAACCAGGTTGTGGGCGTCATTCAAATTTACGATTTAAATA
ATTAATTACGGGTTGTCTTC

Downstream 100 bases:

>100_bases
ACAAAAAATGACCAGGCCTGGTCATTTTTAATCACTGGCTTAACAAATGCAATCGGCTTAAATCACTTTTGAAAACCGGT
TTTGAGTGCCTTGTTTTAAA

Product: three-deoxy-D-manno-octulosonic-acid transferase-like

Products: NA

Alternate protein names: KDO transferase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSLWLYRFLLLLASPVIVYSGWKRCHRAKKYAEKDSDYAPIPHCFAARFGWSRQPFQQGGIWVHAVSVGETRSIFPLLTA
LKKAYPDLPITVTSGSTQGAQQALRFAPVPIQHQMIPYDYPGAVKRFLKKLQPRLVIMVETEIWPNLYQTCWDQQIPLIL
ANARIKEKSFYAYQKWGGKLIANALNQTRLIASQFALDTDHLIALGAHPARIKQLGNLKFDIDVPKDLMTNMQQWRHEYG
LENKFLWVAASTHADEETLMLEAHRQLRQQHPNALLILVPRHTDRFKEVADLLSEKYIPFASRSKGELIQSNTQVYLADT
IGELMNWFAASDAAFIGGSLVPFGGHNILEPAALKKPVLSGQYHQNLQALYDSFKQDDAILISQDENELAQQLIQLADST
EWRNQKAEEAYACFEKQSGALPKLMHEIGQLLPPTE

Sequences:

>Translated_436_residues
MSLWLYRFLLLLASPVIVYSGWKRCHRAKKYAEKDSDYAPIPHCFAARFGWSRQPFQQGGIWVHAVSVGETRSIFPLLTA
LKKAYPDLPITVTSGSTQGAQQALRFAPVPIQHQMIPYDYPGAVKRFLKKLQPRLVIMVETEIWPNLYQTCWDQQIPLIL
ANARIKEKSFYAYQKWGGKLIANALNQTRLIASQFALDTDHLIALGAHPARIKQLGNLKFDIDVPKDLMTNMQQWRHEYG
LENKFLWVAASTHADEETLMLEAHRQLRQQHPNALLILVPRHTDRFKEVADLLSEKYIPFASRSKGELIQSNTQVYLADT
IGELMNWFAASDAAFIGGSLVPFGGHNILEPAALKKPVLSGQYHQNLQALYDSFKQDDAILISQDENELAQQLIQLADST
EWRNQKAEEAYACFEKQSGALPKLMHEIGQLLPPTE
>Mature_435_residues
SLWLYRFLLLLASPVIVYSGWKRCHRAKKYAEKDSDYAPIPHCFAARFGWSRQPFQQGGIWVHAVSVGETRSIFPLLTAL
KKAYPDLPITVTSGSTQGAQQALRFAPVPIQHQMIPYDYPGAVKRFLKKLQPRLVIMVETEIWPNLYQTCWDQQIPLILA
NARIKEKSFYAYQKWGGKLIANALNQTRLIASQFALDTDHLIALGAHPARIKQLGNLKFDIDVPKDLMTNMQQWRHEYGL
ENKFLWVAASTHADEETLMLEAHRQLRQQHPNALLILVPRHTDRFKEVADLLSEKYIPFASRSKGELIQSNTQVYLADTI
GELMNWFAASDAAFIGGSLVPFGGHNILEPAALKKPVLSGQYHQNLQALYDSFKQDDAILISQDENELAQQLIQLADSTE
WRNQKAEEAYACFEKQSGALPKLMHEIGQLLPPTE

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA [H]

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family [H]

Homologues:

Organism=Escherichia coli, GI1790064, Length=430, Percent_Identity=38.1395348837209, Blast_Score=301, Evalue=5e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001296
- InterPro:   IPR007507 [H]

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N [H]

EC number: 2.-.-.-

Molecular weight: Translated: 49576; Mature: 49444

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLWLYRFLLLLASPVIVYSGWKRCHRAKKYAEKDSDYAPIPHCFAARFGWSRQPFQQGG
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHCC
IWVHAVSVGETRSIFPLLTALKKAYPDLPITVTSGSTQGAQQALRFAPVPIQHQMIPYDY
EEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCC
PGAVKRFLKKLQPRLVIMVETEIWPNLYQTCWDQQIPLILANARIKEKSFYAYQKWGGKL
CHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCEEEECCEECHHHHHHHHHHCHHH
IANALNQTRLIASQFALDTDHLIALGAHPARIKQLGNLKFDIDVPKDLMTNMQQWRHEYG
HHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHC
LENKFLWVAASTHADEETLMLEAHRQLRQQHPNALLILVPRHTDRFKEVADLLSEKYIPF
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCC
ASRSKGELIQSNTQVYLADTIGELMNWFAASDAAFIGGSLVPFGGHNILEPAALKKPVLS
CCCCCCCHHHCCCCEEEHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHCCCCC
GQYHQNLQALYDSFKQDDAILISQDENELAQQLIQLADSTEWRNQKAEEAYACFEKQSGA
CHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LPKLMHEIGQLLPPTE
HHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLWLYRFLLLLASPVIVYSGWKRCHRAKKYAEKDSDYAPIPHCFAARFGWSRQPFQQGG
CHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCHHHCC
IWVHAVSVGETRSIFPLLTALKKAYPDLPITVTSGSTQGAQQALRFAPVPIQHQMIPYDY
EEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCC
PGAVKRFLKKLQPRLVIMVETEIWPNLYQTCWDQQIPLILANARIKEKSFYAYQKWGGKL
CHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCEEEECCEECHHHHHHHHHHCHHH
IANALNQTRLIASQFALDTDHLIALGAHPARIKQLGNLKFDIDVPKDLMTNMQQWRHEYG
HHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHC
LENKFLWVAASTHADEETLMLEAHRQLRQQHPNALLILVPRHTDRFKEVADLLSEKYIPF
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCC
ASRSKGELIQSNTQVYLADTIGELMNWFAASDAAFIGGSLVPFGGHNILEPAALKKPVLS
CCCCCCCHHHCCCCEEEHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHCCCCC
GQYHQNLQALYDSFKQDDAILISQDENELAQQLIQLADSTEWRNQKAEEAYACFEKQSGA
CHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LPKLMHEIGQLLPPTE
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]