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The map label for this gene is dsbD [H]

Identifier: 78484791

GI number: 78484791

Start: 498415

End: 500610

Strand: Reverse

Name: dsbD [H]

Synonym: Tcr_0446

Alternate gene names: 78484791

Gene position: 500610-498415 (Counterclockwise)

Preceding gene: 78484793

Following gene: 78484790

Centisome position: 20.62

GC content: 45.54

Gene sequence:

>2196_bases
ATGAGAAACACATCGTTTTTTAAATATCTATTAACGATATTGCTATTTTTAACACTTCATTCGGCTTCCGCATCGGATGA
ACTATTAGATGTTGATCAAGCTTTTTCCTTACAACCTGTGAAGGTTGAAAATGGTCAGGTGAAAATCAGTTGGAAAATTG
CAGACGGTTACTATTTATATAAAAAGCGCATTTCAATCGAATCGGATGATTTAGAACTCAGTCCACCGCATTTCCCAAAA
GCCATTACGAAAAACGATCCCATCTTTGGACAAACCGATGTGTTCAAACACCAGCTTACAGTGACACAACCTTACTCAGG
AGCGGCCACAAAAGCAGATTTAACAATTAAATACCAAGGCTGTGCTGAAAAACTTGGCGTTTGTTACCCACCTCAAACCC
AATCCGTCACGATTGAGCTGCCTGCCGCCGCAGACACCAACGGAAATACTCTTGCTGACTTAAACAGCTTGATTGTCGAC
AGTTCCGGGGCCGATTTACTGCCAGCAGATGAAGCTTTTCAGTTGCAAGTCACCCCCAACAATAACAATCAACTGATCCT
TGATTTCAGAGTGGCTGACGGCTACCACTTATACAAAGACAAAATCAAAACCTTGCTAAAACAGGGAAATGCAACACTGG
GAACCCTTGAATTACCGGAAGCGATTCAAACAAATGACCCGGTGTTTGGCGATGTTCAAGTCTATCACGGCGATTTCCAG
GCCATTTTACCGATTGAAACGATTGCTGACACGGCTGAAATTGAAATTCAATACCAAGGTTGCTCTTCAGAATCCGGCGT
ATGCTACCCGCCAGCTAAAAAACTAATGACGGTACAAGCCAGTGACTTCAGTCAAACAAGCACGAGTTTACCCCCTACTT
CTGGAACGAAAACACCCGAAACCTTGTCTGAAACCGATCAGATCACCAGCACCTTGCAAAACAGTTCGGTTTGGATTGTC
ATCGGCACTTTCTTCCTGTTTGGGCTCTTACTGTCTTTAACACCTTGTGTTTTTCCAATGATCCCAATCCTTTCCAGCAT
CATTGTTGGACAGGGTGACCAACTGACCACACGCAAAGCCTTTGTCATGTCTCTTGTCTATGTACTGGCCATGTCGGTTA
CCTATACCGTTGCCGGGGTTTTAGCCGGTATTTTTGGCGAAAACCTTCAAGTACTTTTCCAAAACCCATGGATTATTGGC
AGTTTCGCATTGATTTTCATTGCACTGGCCTTTTCCATGTTCGGTTTCTATGAACTGCAACTGCCTAGTGGCTTGCAATC
CAAAATCACAAATCTATCCAACAAACAGGAAGGCGGCACCTTAACCGGTGTCGCCATCATGGGGTTCTTGTCGGCTCTGA
TTGTCGGCCCTTGTGTTGCGCCGCCTCTTGCCGGTGCTCTGATCTACATTGGTCAAACCGGCGATGCCCTTCTTGGCGGC
ACCGCTTTATTTGCCATGAGCATGGGGATGGGCGTGCCTCTATTGTTATTAGGAACGTCCGCCGGAAAACTTCTACCTCG
CGCGGGTGCATGGATGGATAACGTTAAAGCCATTTTCGGTGTTCTGATGATCGGGGTTGCCATTTGGATGGCGGAAAGAA
TCCTTCCCGAATGGACAATTCTATTTGCCTGGGCGGCATTACTGATTGGTTCCGCCGTTTATCTGGGGGCTCTAGAACCG
GTTGGCGACAAATCCGGCTGGCATAAGCTGGCAAAATCTATTGGTGTGATCTTTTTGATCTACGGAGTGGTGATGCTGAT
CGGATTGGCCGGTGGTAGCAAAAATGTCTTGCAACCGTTAACGGTATTTCAGTCATCCGCAACCAGCAGTAGCAGCCAAA
CCGAACATCTTAACTTCAAGACCATCCGTACCTTAGCGGAACTGGAGCAAGAAGTCGCAAAAGGCAACCCAGTGATGCTC
GATTTCTATGCCGATTGGTGCATCAGCTGCAAGGAAATGGAAAAATTCACTTTTTCCGACCCATCCGTTCAAAGTGCACT
GGCAAATGTAACTCTTTTGAAAGCCGATGTAACCGCGAACAATGCAAATGATAAGGAATTAATGAAAGCGTTTAACATTA
TCGGACCGCCTGCTATTTTGTTCTTTAACCACCAACAAGAACAAAAAGCACAACGCGTGGTTGGCTTCAAAAAAGCGGCT
GACTTTAAACAAAACATCGACCAAGCCTTTCAATAA

Upstream 100 bases:

>100_bases
TTTACACAAAGTTTGCACAACATCGTAACGCGATTCTACGTTAAAATCGTGATTAACTTATTACATAAGTCTTTAAATTG
TTTTTTCAAGGTGAACATAA

Downstream 100 bases:

>100_bases
GCTTTATTTTCAATCAAAACTGTCATAAAAAACGGCCTGGCCTGGCCGTTTTTCACGCCTAAAACATACTATTTCAATAC
GTTTTTTATCTCACGTTCAT

Product: protein-disulfide reductase

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 731; Mature: 731

Protein sequence:

>731_residues
MRNTSFFKYLLTILLFLTLHSASASDELLDVDQAFSLQPVKVENGQVKISWKIADGYYLYKKRISIESDDLELSPPHFPK
AITKNDPIFGQTDVFKHQLTVTQPYSGAATKADLTIKYQGCAEKLGVCYPPQTQSVTIELPAAADTNGNTLADLNSLIVD
SSGADLLPADEAFQLQVTPNNNNQLILDFRVADGYHLYKDKIKTLLKQGNATLGTLELPEAIQTNDPVFGDVQVYHGDFQ
AILPIETIADTAEIEIQYQGCSSESGVCYPPAKKLMTVQASDFSQTSTSLPPTSGTKTPETLSETDQITSTLQNSSVWIV
IGTFFLFGLLLSLTPCVFPMIPILSSIIVGQGDQLTTRKAFVMSLVYVLAMSVTYTVAGVLAGIFGENLQVLFQNPWIIG
SFALIFIALAFSMFGFYELQLPSGLQSKITNLSNKQEGGTLTGVAIMGFLSALIVGPCVAPPLAGALIYIGQTGDALLGG
TALFAMSMGMGVPLLLLGTSAGKLLPRAGAWMDNVKAIFGVLMIGVAIWMAERILPEWTILFAWAALLIGSAVYLGALEP
VGDKSGWHKLAKSIGVIFLIYGVVMLIGLAGGSKNVLQPLTVFQSSATSSSSQTEHLNFKTIRTLAELEQEVAKGNPVML
DFYADWCISCKEMEKFTFSDPSVQSALANVTLLKADVTANNANDKELMKAFNIIGPPAILFFNHQQEQKAQRVVGFKKAA
DFKQNIDQAFQ

Sequences:

>Translated_731_residues
MRNTSFFKYLLTILLFLTLHSASASDELLDVDQAFSLQPVKVENGQVKISWKIADGYYLYKKRISIESDDLELSPPHFPK
AITKNDPIFGQTDVFKHQLTVTQPYSGAATKADLTIKYQGCAEKLGVCYPPQTQSVTIELPAAADTNGNTLADLNSLIVD
SSGADLLPADEAFQLQVTPNNNNQLILDFRVADGYHLYKDKIKTLLKQGNATLGTLELPEAIQTNDPVFGDVQVYHGDFQ
AILPIETIADTAEIEIQYQGCSSESGVCYPPAKKLMTVQASDFSQTSTSLPPTSGTKTPETLSETDQITSTLQNSSVWIV
IGTFFLFGLLLSLTPCVFPMIPILSSIIVGQGDQLTTRKAFVMSLVYVLAMSVTYTVAGVLAGIFGENLQVLFQNPWIIG
SFALIFIALAFSMFGFYELQLPSGLQSKITNLSNKQEGGTLTGVAIMGFLSALIVGPCVAPPLAGALIYIGQTGDALLGG
TALFAMSMGMGVPLLLLGTSAGKLLPRAGAWMDNVKAIFGVLMIGVAIWMAERILPEWTILFAWAALLIGSAVYLGALEP
VGDKSGWHKLAKSIGVIFLIYGVVMLIGLAGGSKNVLQPLTVFQSSATSSSSQTEHLNFKTIRTLAELEQEVAKGNPVML
DFYADWCISCKEMEKFTFSDPSVQSALANVTLLKADVTANNANDKELMKAFNIIGPPAILFFNHQQEQKAQRVVGFKKAA
DFKQNIDQAFQ
>Mature_731_residues
MRNTSFFKYLLTILLFLTLHSASASDELLDVDQAFSLQPVKVENGQVKISWKIADGYYLYKKRISIESDDLELSPPHFPK
AITKNDPIFGQTDVFKHQLTVTQPYSGAATKADLTIKYQGCAEKLGVCYPPQTQSVTIELPAAADTNGNTLADLNSLIVD
SSGADLLPADEAFQLQVTPNNNNQLILDFRVADGYHLYKDKIKTLLKQGNATLGTLELPEAIQTNDPVFGDVQVYHGDFQ
AILPIETIADTAEIEIQYQGCSSESGVCYPPAKKLMTVQASDFSQTSTSLPPTSGTKTPETLSETDQITSTLQNSSVWIV
IGTFFLFGLLLSLTPCVFPMIPILSSIIVGQGDQLTTRKAFVMSLVYVLAMSVTYTVAGVLAGIFGENLQVLFQNPWIIG
SFALIFIALAFSMFGFYELQLPSGLQSKITNLSNKQEGGTLTGVAIMGFLSALIVGPCVAPPLAGALIYIGQTGDALLGG
TALFAMSMGMGVPLLLLGTSAGKLLPRAGAWMDNVKAIFGVLMIGVAIWMAERILPEWTILFAWAALLIGSAVYLGALEP
VGDKSGWHKLAKSIGVIFLIYGVVMLIGLAGGSKNVLQPLTVFQSSATSSSSQTEHLNFKTIRTLAELEQEVAKGNPVML
DFYADWCISCKEMEKFTFSDPSVQSALANVTLLKADVTANNANDKELMKAFNIIGPPAILFFNHQQEQKAQRVVGFKKAA
DFKQNIDQAFQ

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=574, Percent_Identity=36.7595818815331, Blast_Score=385, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 79085; Mature: 79085

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTSFFKYLLTILLFLTLHSASASDELLDVDQAFSLQPVKVENGQVKISWKIADGYYLY
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHCHHHHCCCCCEEECCCEEEEEEEEECCEEEE
KKRISIESDDLELSPPHFPKAITKNDPIFGQTDVFKHQLTVTQPYSGAATKADLTIKYQG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCEEEEEEECC
CAEKLGVCYPPQTQSVTIELPAAADTNGNTLADLNSLIVDSSGADLLPADEAFQLQVTPN
HHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCEEEEECCC
NNNQLILDFRVADGYHLYKDKIKTLLKQGNATLGTLELPEAIQTNDPVFGDVQVYHGDFQ
CCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCEEEEEEEECCCE
AILPIETIADTAEIEIQYQGCSSESGVCYPPAKKLMTVQASDFSQTSTSLPPTSGTKTPE
EEEEHHHHCCCEEEEEEEECCCCCCCEECCCHHHEEEEECCCCCCCCCCCCCCCCCCCCH
TLSETDQITSTLQNSSVWIVIGTFFLFGLLLSLTPCVFPMIPILSSIIVGQGDQLTTRKA
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
FVMSLVYVLAMSVTYTVAGVLAGIFGENLQVLFQNPWIIGSFALIFIALAFSMFGFYELQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEHHHHHHHHHHHHHHHHCEEEEE
LPSGLQSKITNLSNKQEGGTLTGVAIMGFLSALIVGPCVAPPLAGALIYIGQTGDALLGG
CCCCHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHH
TALFAMSMGMGVPLLLLGTSAGKLLPRAGAWMDNVKAIFGVLMIGVAIWMAERILPEWTI
HHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LFAWAALLIGSAVYLGALEPVGDKSGWHKLAKSIGVIFLIYGVVMLIGLAGGSKNVLQPL
HHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
TVFQSSATSSSSQTEHLNFKTIRTLAELEQEVAKGNPVMLDFYADWCISCKEMEKFTFSD
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCHHHHHHCCCCC
PSVQSALANVTLLKADVTANNANDKELMKAFNIIGPPAILFFNHQQEQKAQRVVGFKKAA
CHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHH
DFKQNIDQAFQ
HHHHHHHHHCC
>Mature Secondary Structure
MRNTSFFKYLLTILLFLTLHSASASDELLDVDQAFSLQPVKVENGQVKISWKIADGYYLY
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHCHHHHCCCCCEEECCCEEEEEEEEECCEEEE
KKRISIESDDLELSPPHFPKAITKNDPIFGQTDVFKHQLTVTQPYSGAATKADLTIKYQG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCEEEEEEECC
CAEKLGVCYPPQTQSVTIELPAAADTNGNTLADLNSLIVDSSGADLLPADEAFQLQVTPN
HHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCEEEEECCC
NNNQLILDFRVADGYHLYKDKIKTLLKQGNATLGTLELPEAIQTNDPVFGDVQVYHGDFQ
CCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCEEEEEEEECCCE
AILPIETIADTAEIEIQYQGCSSESGVCYPPAKKLMTVQASDFSQTSTSLPPTSGTKTPE
EEEEHHHHCCCEEEEEEEECCCCCCCEECCCHHHEEEEECCCCCCCCCCCCCCCCCCCCH
TLSETDQITSTLQNSSVWIVIGTFFLFGLLLSLTPCVFPMIPILSSIIVGQGDQLTTRKA
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
FVMSLVYVLAMSVTYTVAGVLAGIFGENLQVLFQNPWIIGSFALIFIALAFSMFGFYELQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEHHHHHHHHHHHHHHHHCEEEEE
LPSGLQSKITNLSNKQEGGTLTGVAIMGFLSALIVGPCVAPPLAGALIYIGQTGDALLGG
CCCCHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHH
TALFAMSMGMGVPLLLLGTSAGKLLPRAGAWMDNVKAIFGVLMIGVAIWMAERILPEWTI
HHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LFAWAALLIGSAVYLGALEPVGDKSGWHKLAKSIGVIFLIYGVVMLIGLAGGSKNVLQPL
HHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
TVFQSSATSSSSQTEHLNFKTIRTLAELEQEVAKGNPVMLDFYADWCISCKEMEKFTFSD
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCHHHHHHCCCCC
PSVQSALANVTLLKADVTANNANDKELMKAFNIIGPPAILFFNHQQEQKAQRVVGFKKAA
CHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHH
DFKQNIDQAFQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]