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The map label for this gene is trxC [C]

Identifier: 78484447

GI number: 78484447

Start: 129570

End: 129992

Strand: Reverse

Name: trxC [C]

Synonym: Tcr_0102

Alternate gene names: 78484447

Gene position: 129992-129570 (Counterclockwise)

Preceding gene: 78484448

Following gene: 78484446

Centisome position: 5.35

GC content: 46.1

Gene sequence:

>423_bases
ATGATTATTATGTGCCCACACTGCGGTGGATTAAACCGCATCCCTGACGAAAAACTGAATGACCACCCAAATTGCGGTAA
ATGCCAATCAGCGCTTTTTACCGGCCAACCGATTGAAATGAATTCAGAACAATTTTTGCGTGCCTTACACAAAACCGACC
AACCCTTAGTCGTGGACTTTTGGGCCTCTTGGTGCGGTCCATGTAAGATGTTTGCACCGACCTTTTCTCAAGCGGCGGCC
CAACTGGAACCGCACGCAAAATTCATCAAAATAAACACGGAAACCGAACAGCAAATCGCCGCGCAGTTTAATATCCGTTC
GATCCCGACGCTGGCAATTTTTAAAAACGGTCAAGAAATCGCACGTCAGTCAGGCGCAATGGATTTAGGCAGTTTTACAA
ACTGGGTAAAAAGCACGATTTAA

Upstream 100 bases:

>100_bases
CCGAAACCAGATTGGCTTGAATAATATTCAAATTTTAAACTTGAATATCTAACTTTCAGTACTTATATAGCCATTATTAA
AGACGAAAGGAAGTAATCAA

Downstream 100 bases:

>100_bases
TGTGCGTGTGTTAGACTTAATGTTCAAAATTTAACGCAACTTAAAGGCAACCTTATGGAAATCGGTTCACCGCTTCACAG
ACAACTTCTCATGAAAGGCA

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MIIMCPHCGGLNRIPDEKLNDHPNCGKCQSALFTGQPIEMNSEQFLRALHKTDQPLVVDFWASWCGPCKMFAPTFSQAAA
QLEPHAKFIKINTETEQQIAAQFNIRSIPTLAIFKNGQEIARQSGAMDLGSFTNWVKSTI

Sequences:

>Translated_140_residues
MIIMCPHCGGLNRIPDEKLNDHPNCGKCQSALFTGQPIEMNSEQFLRALHKTDQPLVVDFWASWCGPCKMFAPTFSQAAA
QLEPHAKFIKINTETEQQIAAQFNIRSIPTLAIFKNGQEIARQSGAMDLGSFTNWVKSTI
>Mature_140_residues
MIIMCPHCGGLNRIPDEKLNDHPNCGKCQSALFTGQPIEMNSEQFLRALHKTDQPLVVDFWASWCGPCKMFAPTFSQAAA
QLEPHAKFIKINTETEQQIAAQFNIRSIPTLAIFKNGQEIARQSGAMDLGSFTNWVKSTI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=140, Percent_Identity=43.5714285714286, Blast_Score=140, Evalue=3e-35,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=34.9514563106796, Blast_Score=84, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=80, Percent_Identity=36.25, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=85, Percent_Identity=34.1176470588235, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=85, Percent_Identity=34.1176470588235, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=85, Percent_Identity=34.1176470588235, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=74, Percent_Identity=43.2432432432432, Blast_Score=74, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=38.3720930232558, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=81, Percent_Identity=37.037037037037, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=27.5510204081633, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17648013, Length=71, Percent_Identity=36.6197183098592, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=71, Percent_Identity=36.6197183098592, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639826, Length=65, Percent_Identity=36.9230769230769, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921434, Length=93, Percent_Identity=32.258064516129, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358065, Length=129, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 15610; Mature: 15610

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIMCPHCGGLNRIPDEKLNDHPNCGKCQSALFTGQPIEMNSEQFLRALHKTDQPLVVDF
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEE
WASWCGPCKMFAPTFSQAAAQLEPHAKFIKINTETEQQIAAQFNIRSIPTLAIFKNGQEI
HHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEECCCHHH
ARQSGAMDLGSFTNWVKSTI
HHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIIMCPHCGGLNRIPDEKLNDHPNCGKCQSALFTGQPIEMNSEQFLRALHKTDQPLVVDF
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEE
WASWCGPCKMFAPTFSQAAAQLEPHAKFIKINTETEQQIAAQFNIRSIPTLAIFKNGQEI
HHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEECCCHHH
ARQSGAMDLGSFTNWVKSTI
HHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8652661 [H]