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The map label for this gene is phoR [H]

Identifier: 78358820

GI number: 78358820

Start: 3725959

End: 3727779

Strand: Direct

Name: phoR [H]

Synonym: Dde_3782

Alternate gene names: 78358820

Gene position: 3725959-3727779 (Clockwise)

Preceding gene: 78358817

Following gene: 78358821

Centisome position: 99.89

GC content: 55.24

Gene sequence:

>1821_bases
ATGATGAAACATTACTCCATCCGCCACAGACTGTTTATAGGAAGCATCATACTGTTATTTCTGGCACTTATTCCGCCGTT
TATTTATGTCGGCGGGCTGCTGAAAGATGATGTGCTGACCGAATCGCGCCTGCGCGCACGCAACGGACTGGAAATGGCCG
CATGGCTGATGGAGGAACAGGCACCGTTTTCTGACACCGCTTCCATGAACGCATGGGCACACCGGTTCGGACAGCGTACG
GGTATACGCATCACCTACATCGAAAACGGCCGCGTTGTGGCTGATTCTGAAATTGCCTACGAACAGCTGCCGACGCTGGA
CAGCCATCGCAACAGGCCGGAAGTGAAAGCAGCTCTGGTCAACGGCGAAGGCATGGAAGTGCGCTACAGCACCACACTGG
GCAAAGACCTTATTTATATGGCGCGTACCATCACAGTGCCCGACAGCGGACTGGACGGTGTGCTGCGCATTGCCCTGCCC
GCGTCCGTGGTTAACGAGCGTCTGGCCGAGCTCAAAGAAGGTCTGGCTGCAGTGTTTCTGCTGGCCATGCTGGCCAGTGC
CGGCCTTGCCTATCTTGTAACCCGGTCTCTGGTGCGTTCCATCGAAGACCTTGCCGCAACAGCTCACGCCATCGGACAGG
GTGATTACGCCCGCAAAATCCGCGACTATCCGGGAACGGAACTGCGTCCGCTGGTTGATGCCATCAACGACATGGCAAAA
AACACCCGCAGGCAGATGCAGATGCTTACCGACCAGAAAGGACGCCTTGAAGCCATTCTGGACGGCATAACAGACGGAGT
GATGGTGCTGGACGAAGAAGGACGCATCCATTCTGTAAACACGGCACTTACCGATATGTTTCCGCAGGTGGCGGGCATGG
AAGGGGCCACCCCCCTTGAAGCCACCATGCAGCCGGATCTGCAGAAAGCAGTGGATGCCATGCTGCGCAGCGACACAGCC
CACAGCGGCCAGCCTATGCCCGATACCGGACGGGTGTGCAATGTGGAACTTTCCGGCGGGCGGTACATGGAAATAACTCT
GGTGCCTTTTGCCGACCCTGCCGGAACAAGAAAAATAGTACTGGCGTTTCATGATGTGAGTGAGCGCGAACAGCTGGAAA
AAGTACGTCGGGATTTTGTGGCCAACGTGTCGCATGAGCTGAAAACACCGCTCACCAGCATCAAGGGATACACCGAGATG
CTTATCGAATCACCGCCAGCAGGCCGCGAGCAGAACAGCATGTTTCTGCAGACCATCCTTAAAAATGCCAACCACATGAT
AAAAATGGTCAACAGCCTGCTGGTTCTGGCACGCGCCCAGCACAAACGCGAACAGACAGCCATGTCCGCAGTGGATGCCG
CAGCCGTCATCCGCCAGACCGTGCGAGAAATGGACCCTGCAGCGCACGAAAAAAATATCTCCATCGAAACACAGATGCCC
GAAACACCACTTATGGTCACAGGAGACAGAGATGCTCTGTGTGAAGTTTTCCGGAACCTGCTGGACAACGCCGTCAAATA
CAGTCCCAATAATTCTGCAGTGACCGTTTCTGCCCGAATAACCGAAGGCAGAGCAGCCTTCTGCATAAAAGACAGCGGTC
CGGGAATTCCCGAAGCCAGCAAGGAAAGAATCTTTGAACGCTTCTACAGGCTCGACAGAGACGGAGATACGCACAAAAAC
GGTTCCGCCGGTCTTGGACTGGCAATCTGCCGCAGAATAGTGAAAAGCCACGGTGGCGAAATATGGGTGGAAAGTCCCCT
GGACAGTAAAACCGGATCCGGCGCCGCCTTCTTTGTCACGCTGGATACGGCATCCGCATAA

Upstream 100 bases:

>100_bases
CTACTGGGAAAAGCGGCCTTTGTCAAAAAAGCGCCACCGTCTTACCTGCCAATTGTAACAATCGTGTGACAAAAACGCCA
TAAAGTGACGGTTAAATAAC

Downstream 100 bases:

>100_bases
CGCATCCTCTCAAAAAAAATTCAAAGGCTTCCGCTGGCAGAAACACTTCCGGCGGAAGCCTTTTTCATTCCCTGCAGCCC
TTTGTCCCCGCTCTCCTCTG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MMKHYSIRHRLFIGSIILLFLALIPPFIYVGGLLKDDVLTESRLRARNGLEMAAWLMEEQAPFSDTASMNAWAHRFGQRT
GIRITYIENGRVVADSEIAYEQLPTLDSHRNRPEVKAALVNGEGMEVRYSTTLGKDLIYMARTITVPDSGLDGVLRIALP
ASVVNERLAELKEGLAAVFLLAMLASAGLAYLVTRSLVRSIEDLAATAHAIGQGDYARKIRDYPGTELRPLVDAINDMAK
NTRRQMQMLTDQKGRLEAILDGITDGVMVLDEEGRIHSVNTALTDMFPQVAGMEGATPLEATMQPDLQKAVDAMLRSDTA
HSGQPMPDTGRVCNVELSGGRYMEITLVPFADPAGTRKIVLAFHDVSEREQLEKVRRDFVANVSHELKTPLTSIKGYTEM
LIESPPAGREQNSMFLQTILKNANHMIKMVNSLLVLARAQHKREQTAMSAVDAAAVIRQTVREMDPAAHEKNISIETQMP
ETPLMVTGDRDALCEVFRNLLDNAVKYSPNNSAVTVSARITEGRAAFCIKDSGPGIPEASKERIFERFYRLDRDGDTHKN
GSAGLGLAICRRIVKSHGGEIWVESPLDSKTGSGAAFFVTLDTASA

Sequences:

>Translated_606_residues
MMKHYSIRHRLFIGSIILLFLALIPPFIYVGGLLKDDVLTESRLRARNGLEMAAWLMEEQAPFSDTASMNAWAHRFGQRT
GIRITYIENGRVVADSEIAYEQLPTLDSHRNRPEVKAALVNGEGMEVRYSTTLGKDLIYMARTITVPDSGLDGVLRIALP
ASVVNERLAELKEGLAAVFLLAMLASAGLAYLVTRSLVRSIEDLAATAHAIGQGDYARKIRDYPGTELRPLVDAINDMAK
NTRRQMQMLTDQKGRLEAILDGITDGVMVLDEEGRIHSVNTALTDMFPQVAGMEGATPLEATMQPDLQKAVDAMLRSDTA
HSGQPMPDTGRVCNVELSGGRYMEITLVPFADPAGTRKIVLAFHDVSEREQLEKVRRDFVANVSHELKTPLTSIKGYTEM
LIESPPAGREQNSMFLQTILKNANHMIKMVNSLLVLARAQHKREQTAMSAVDAAAVIRQTVREMDPAAHEKNISIETQMP
ETPLMVTGDRDALCEVFRNLLDNAVKYSPNNSAVTVSARITEGRAAFCIKDSGPGIPEASKERIFERFYRLDRDGDTHKN
GSAGLGLAICRRIVKSHGGEIWVESPLDSKTGSGAAFFVTLDTASA
>Mature_606_residues
MMKHYSIRHRLFIGSIILLFLALIPPFIYVGGLLKDDVLTESRLRARNGLEMAAWLMEEQAPFSDTASMNAWAHRFGQRT
GIRITYIENGRVVADSEIAYEQLPTLDSHRNRPEVKAALVNGEGMEVRYSTTLGKDLIYMARTITVPDSGLDGVLRIALP
ASVVNERLAELKEGLAAVFLLAMLASAGLAYLVTRSLVRSIEDLAATAHAIGQGDYARKIRDYPGTELRPLVDAINDMAK
NTRRQMQMLTDQKGRLEAILDGITDGVMVLDEEGRIHSVNTALTDMFPQVAGMEGATPLEATMQPDLQKAVDAMLRSDTA
HSGQPMPDTGRVCNVELSGGRYMEITLVPFADPAGTRKIVLAFHDVSEREQLEKVRRDFVANVSHELKTPLTSIKGYTEM
LIESPPAGREQNSMFLQTILKNANHMIKMVNSLLVLARAQHKREQTAMSAVDAAAVIRQTVREMDPAAHEKNISIETQMP
ETPLMVTGDRDALCEVFRNLLDNAVKYSPNNSAVTVSARITEGRAAFCIKDSGPGIPEASKERIFERFYRLDRDGDTHKN
GSAGLGLAICRRIVKSHGGEIWVESPLDSKTGSGAAFFVTLDTASA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=371, Percent_Identity=29.3800539083558, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1790861, Length=236, Percent_Identity=31.7796610169492, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI48994928, Length=292, Percent_Identity=29.7945205479452, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=215, Percent_Identity=28.3720930232558, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=31.8367346938775, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=28.3898305084746, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788549, Length=399, Percent_Identity=24.812030075188, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=30.0448430493274, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786783, Length=260, Percent_Identity=27.3076923076923, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=28.8888888888889, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789403, Length=229, Percent_Identity=31.8777292576419, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1788713, Length=377, Percent_Identity=23.342175066313, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693157, Length=235, Percent_Identity=26.8085106382979, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790551, Length=263, Percent_Identity=28.1368821292776, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787894, Length=256, Percent_Identity=26.171875, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=28.755364806867, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082128, Length=287, Percent_Identity=26.1324041811847, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=243, Percent_Identity=29.2181069958848, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=24.2798353909465, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=204, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790300, Length=355, Percent_Identity=22.2535211267606, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66662; Mature: 66662

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKHYSIRHRLFIGSIILLFLALIPPFIYVGGLLKDDVLTESRLRARNGLEMAAWLMEEQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHC
APFSDTASMNAWAHRFGQRTGIRITYIENGRVVADSEIAYEQLPTLDSHRNRPEVKAALV
CCCCCCCHHHHHHHHHCCCCCEEEEEEECCEEEECCHHHHHHCCCCCCCCCCCCEEEEEE
NGEGMEVRYSTTLGKDLIYMARTITVPDSGLDGVLRIALPASVVNERLAELKEGLAAVFL
CCCCCEEEEECHHCHHHHHHHHEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LAMLASAGLAYLVTRSLVRSIEDLAATAHAIGQGDYARKIRDYPGTELRPLVDAINDMAK
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
NTRRQMQMLTDQKGRLEAILDGITDGVMVLDEEGRIHSVNTALTDMFPQVAGMEGATPLE
HHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCCCCCH
ATMQPDLQKAVDAMLRSDTAHSGQPMPDTGRVCNVELSGGRYMEITLVPFADPAGTRKIV
HHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEECCCCCCCCEEE
LAFHDVSEREQLEKVRRDFVANVSHELKTPLTSIKGYTEMLIESPPAGREQNSMFLQTIL
EEECCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
KNANHMIKMVNSLLVLARAQHKREQTAMSAVDAAAVIRQTVREMDPAAHEKNISIETQMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCC
ETPLMVTGDRDALCEVFRNLLDNAVKYSPNNSAVTVSARITEGRAAFCIKDSGPGIPEAS
CCCEEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCEEEEEECCCCCCCCHH
KERIFERFYRLDRDGDTHKNGSAGLGLAICRRIVKSHGGEIWVESPLDSKTGSGAAFFVT
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEE
LDTASA
ECCCCC
>Mature Secondary Structure
MMKHYSIRHRLFIGSIILLFLALIPPFIYVGGLLKDDVLTESRLRARNGLEMAAWLMEEQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHC
APFSDTASMNAWAHRFGQRTGIRITYIENGRVVADSEIAYEQLPTLDSHRNRPEVKAALV
CCCCCCCHHHHHHHHHCCCCCEEEEEEECCEEEECCHHHHHHCCCCCCCCCCCCEEEEEE
NGEGMEVRYSTTLGKDLIYMARTITVPDSGLDGVLRIALPASVVNERLAELKEGLAAVFL
CCCCCEEEEECHHCHHHHHHHHEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LAMLASAGLAYLVTRSLVRSIEDLAATAHAIGQGDYARKIRDYPGTELRPLVDAINDMAK
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
NTRRQMQMLTDQKGRLEAILDGITDGVMVLDEEGRIHSVNTALTDMFPQVAGMEGATPLE
HHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCCCCCH
ATMQPDLQKAVDAMLRSDTAHSGQPMPDTGRVCNVELSGGRYMEITLVPFADPAGTRKIV
HHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEECCCCCCCCEEE
LAFHDVSEREQLEKVRRDFVANVSHELKTPLTSIKGYTEMLIESPPAGREQNSMFLQTIL
EEECCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
KNANHMIKMVNSLLVLARAQHKREQTAMSAVDAAAVIRQTVREMDPAAHEKNISIETQMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCC
ETPLMVTGDRDALCEVFRNLLDNAVKYSPNNSAVTVSARITEGRAAFCIKDSGPGIPEAS
CCCEEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCEEEEEECCCCCCCCHH
KERIFERFYRLDRDGDTHKNGSAGLGLAICRRIVKSHGGEIWVESPLDSKTGSGAAFFVT
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEE
LDTASA
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]