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The map label for this gene is degP [C]

Identifier: 78358814

GI number: 78358814

Start: 3718647

End: 3720098

Strand: Reverse

Name: degP [C]

Synonym: Dde_3776

Alternate gene names: 78358814

Gene position: 3720098-3718647 (Counterclockwise)

Preceding gene: 78358818

Following gene: 78358813

Centisome position: 99.73

GC content: 61.23

Gene sequence:

>1452_bases
ATGGCAAGACAGCCGCATGGCGGAGAGGGAAATGCTATGAAAACAGCTGCTGCGGTAACGGAAAAAGGGCTGAGGCGTTT
ACGCGCGGTGTCTGCGGCAGGTGCTGCCTTGTGTCTGCGCATCGTTGTGGCGGTGATGTTTGTCTGTGTCGCGGCAGCGG
GCAGCAGGGCAGAACATGGCCCGTTGCCTGATTCGCCCAGGGTCACTCCTGTTGTGCGTGCTGTGCATGCCGTGGCTCCT
GCCGTGGTCAATATAACCACGGCCCGTATGGCTCAGGGGGCGGAACTGCCCGGACCCTTTGCGGAATCACCGCTGCTGCG
CGAGCTGTTACGTCTGCCCCAGAGGCAGCAGCCCATGCAGCGTCACAGTCTGGGCTCCGGCGTAATCATAGATGGTTCCA
GAGGCCTTGTCCTGACCAATGCCCATGTTATTTCGGGCGCCACGACCATCCGTGCACGGCTGCTTGACGGGCGCGAATTT
GAAGCCGACCTGCTGGGTGCCGCACCGGATTTTGATATTGCCGTACTGCGCCTGCAGGCTGCGCAATCGCTGCCGCAGGT
GCCTATGGCTGATTCTTCAGACATGATGCCCGGCGAAACAGTCATCGCCATAGGGAATCCGTTCGGATTCGGACATACGG
TGACCACCGGAGTGGTGTCTGCGCTGCAGCGTTCCATTCAGACAAGGCAGGGCGTGTTTACATATCTCATCCAGACCGAT
GCCGCAATCAATCCGGGAAACAGCGGAGGGCCGCTTATCAATATAGCCGGAGAGCTTGTGGGAGTGAACACCGCCATACA
GGCAAGTGCCGAGGGCATAGGTTTTGCCATTCCGGTCAACAAAGCCCGCAGGGTGGTGGATGAATTGCTGAGTTCCGGCC
GGGTACGGCCGGTGTGGCTGGGGGTGGAAGGGCAGGATATTGACCAGCGCACCGGAGCATGGCTGGGGCTGCGCGGCACC
GGCGGTATGCTGGTGACCCGCGTGTACGCGGACACTCCCGCGCAAAAAGCCGGTATCCAGCCCGGTGATGTCATTCTGCG
GATGGAAAATGATACGGTGCAGGATAAGGATCATTACCTGCAGCTACTGAGAAACCATACACGCGGTCGTCAGCTGGGGC
TGCAGATATTCCGGCAGGGGGAATTACGCCGCACGGCAGTGGTTCCTGTGGCGCTGGGGGCGCAGGATGCGCTTTCCATG
GCGGCCATGCGCTGGGGCATGCGCGTGCGTGATGCCCGCGGGCAGGGTGTGGTTATCGAATCAGTGCGTCCGGACAGCCC
TGCCGGCCGTCTGGGGCTGCAAGCCGGTGATGCCATTCTGCAGGTGGGCGGTCTGCGCACGGGATCGCTTCAGGACTTTG
CCGAGGCCTTTGTCAGGCACCGGCTTTCCGGTGCTGTTCTGCTGGTGGCGGCACGCGGCGGAAGAGCCGCCTATGTACGC
ATGATATTGTAA

Upstream 100 bases:

>100_bases
CGAAGTATCAACAGGGGGAATGTGCTGTATTATGTATTCCACGGAATGTGACATGAAAGACTCCTTTAAGAATCCTGATA
CCTACAATCGGCATGGTGAA

Downstream 100 bases:

>100_bases
GTTTTTCTGACAATTAGAAACTTTTTCCACAAGGTGCATTGAGAATCCACCTCAAGTCTTGACACGCTATTGGGGTAAAG
CTATCTGCACTGCAATGGTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MARQPHGGEGNAMKTAAAVTEKGLRRLRAVSAAGAALCLRIVVAVMFVCVAAAGSRAEHGPLPDSPRVTPVVRAVHAVAP
AVVNITTARMAQGAELPGPFAESPLLRELLRLPQRQQPMQRHSLGSGVIIDGSRGLVLTNAHVISGATTIRARLLDGREF
EADLLGAAPDFDIAVLRLQAAQSLPQVPMADSSDMMPGETVIAIGNPFGFGHTVTTGVVSALQRSIQTRQGVFTYLIQTD
AAINPGNSGGPLINIAGELVGVNTAIQASAEGIGFAIPVNKARRVVDELLSSGRVRPVWLGVEGQDIDQRTGAWLGLRGT
GGMLVTRVYADTPAQKAGIQPGDVILRMENDTVQDKDHYLQLLRNHTRGRQLGLQIFRQGELRRTAVVPVALGAQDALSM
AAMRWGMRVRDARGQGVVIESVRPDSPAGRLGLQAGDAILQVGGLRTGSLQDFAEAFVRHRLSGAVLLVAARGGRAAYVR
MIL

Sequences:

>Translated_483_residues
MARQPHGGEGNAMKTAAAVTEKGLRRLRAVSAAGAALCLRIVVAVMFVCVAAAGSRAEHGPLPDSPRVTPVVRAVHAVAP
AVVNITTARMAQGAELPGPFAESPLLRELLRLPQRQQPMQRHSLGSGVIIDGSRGLVLTNAHVISGATTIRARLLDGREF
EADLLGAAPDFDIAVLRLQAAQSLPQVPMADSSDMMPGETVIAIGNPFGFGHTVTTGVVSALQRSIQTRQGVFTYLIQTD
AAINPGNSGGPLINIAGELVGVNTAIQASAEGIGFAIPVNKARRVVDELLSSGRVRPVWLGVEGQDIDQRTGAWLGLRGT
GGMLVTRVYADTPAQKAGIQPGDVILRMENDTVQDKDHYLQLLRNHTRGRQLGLQIFRQGELRRTAVVPVALGAQDALSM
AAMRWGMRVRDARGQGVVIESVRPDSPAGRLGLQAGDAILQVGGLRTGSLQDFAEAFVRHRLSGAVLLVAARGGRAAYVR
MIL
>Mature_482_residues
ARQPHGGEGNAMKTAAAVTEKGLRRLRAVSAAGAALCLRIVVAVMFVCVAAAGSRAEHGPLPDSPRVTPVVRAVHAVAPA
VVNITTARMAQGAELPGPFAESPLLRELLRLPQRQQPMQRHSLGSGVIIDGSRGLVLTNAHVISGATTIRARLLDGREFE
ADLLGAAPDFDIAVLRLQAAQSLPQVPMADSSDMMPGETVIAIGNPFGFGHTVTTGVVSALQRSIQTRQGVFTYLIQTDA
AINPGNSGGPLINIAGELVGVNTAIQASAEGIGFAIPVNKARRVVDELLSSGRVRPVWLGVEGQDIDQRTGAWLGLRGTG
GMLVTRVYADTPAQKAGIQPGDVILRMENDTVQDKDHYLQLLRNHTRGRQLGLQIFRQGELRRTAVVPVALGAQDALSMA
AMRWGMRVRDARGQGVVIESVRPDSPAGRLGLQAGDAILQVGGLRTGSLQDFAEAFVRHRLSGAVLLVAARGGRAAYVRM
IL

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI7019477, Length=286, Percent_Identity=37.7622377622378, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4506141, Length=329, Percent_Identity=31.6109422492401, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI22129776, Length=298, Percent_Identity=34.5637583892617, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI24308541, Length=279, Percent_Identity=29.3906810035842, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI1786356, Length=407, Percent_Identity=34.1523341523341, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789629, Length=466, Percent_Identity=34.549356223176, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789630, Length=238, Percent_Identity=42.0168067226891, Blast_Score=160, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24646839, Length=289, Percent_Identity=34.2560553633218, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50998; Mature: 50866

Theoretical pI: Translated: 11.14; Mature: 11.14

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQPHGGEGNAMKTAAAVTEKGLRRLRAVSAAGAALCLRIVVAVMFVCVAAAGSRAEHG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PLPDSPRVTPVVRAVHAVAPAVVNITTARMAQGAELPGPFAESPLLRELLRLPQRQQPMQ
CCCCCCCCCHHHHHHHHHHHHHHEEHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHH
RHSLGSGVIIDGSRGLVLTNAHVISGATTIRARLLDGREFEADLLGAAPDFDIAVLRLQA
HHCCCCCEEEECCCCEEEECCEEECCCCEEEHHHCCCCCCCHHHCCCCCCCCHHHHHHHH
AQSLPQVPMADSSDMMPGETVIAIGNPFGFGHTVTTGVVSALQRSIQTRQGVFTYLIQTD
HHCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
AAINPGNSGGPLINIAGELVGVNTAIQASAEGIGFAIPVNKARRVVDELLSSGRVRPVWL
CCCCCCCCCCCEEEECCCEEECCHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEE
GVEGQDIDQRTGAWLGLRGTGGMLVTRVYADTPAQKAGIQPGDVILRMENDTVQDKDHYL
ECCCCCCHHCCCCEEEEECCCCEEEEEEECCCCHHHCCCCCCCEEEEECCCCCCCHHHHH
QLLRNHTRGRQLGLQIFRQGELRRTAVVPVALGAQDALSMAAMRWGMRVRDARGQGVVIE
HHHHHCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCEEECCCCCEEEEE
SVRPDSPAGRLGLQAGDAILQVGGLRTGSLQDFAEAFVRHRLSGAVLLVAARGGRAAYVR
CCCCCCCCCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEE
MIL
EEC
>Mature Secondary Structure 
ARQPHGGEGNAMKTAAAVTEKGLRRLRAVSAAGAALCLRIVVAVMFVCVAAAGSRAEHG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PLPDSPRVTPVVRAVHAVAPAVVNITTARMAQGAELPGPFAESPLLRELLRLPQRQQPMQ
CCCCCCCCCHHHHHHHHHHHHHHEEHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHH
RHSLGSGVIIDGSRGLVLTNAHVISGATTIRARLLDGREFEADLLGAAPDFDIAVLRLQA
HHCCCCCEEEECCCCEEEECCEEECCCCEEEHHHCCCCCCCHHHCCCCCCCCHHHHHHHH
AQSLPQVPMADSSDMMPGETVIAIGNPFGFGHTVTTGVVSALQRSIQTRQGVFTYLIQTD
HHCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
AAINPGNSGGPLINIAGELVGVNTAIQASAEGIGFAIPVNKARRVVDELLSSGRVRPVWL
CCCCCCCCCCCEEEECCCEEECCHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEE
GVEGQDIDQRTGAWLGLRGTGGMLVTRVYADTPAQKAGIQPGDVILRMENDTVQDKDHYL
ECCCCCCHHCCCCEEEEECCCCEEEEEEECCCCHHHCCCCCCCEEEEECCCCCCCHHHHH
QLLRNHTRGRQLGLQIFRQGELRRTAVVPVALGAQDALSMAAMRWGMRVRDARGQGVVIE
HHHHHCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCEEECCCCCEEEEE
SVRPDSPAGRLGLQAGDAILQVGGLRTGSLQDFAEAFVRHRLSGAVLLVAARGGRAAYVR
CCCCCCCCCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEE
MIL
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]