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The map label for this gene is mro [H]

Identifier: 78358694

GI number: 78358694

Start: 3617908

End: 3619149

Strand: Direct

Name: mro [H]

Synonym: Dde_3655

Alternate gene names: 78358694

Gene position: 3617908-3619149 (Clockwise)

Preceding gene: 78358693

Following gene: 78358695

Centisome position: 96.99

GC content: 61.43

Gene sequence:

>1242_bases
ATGAGCAGCACGCAGGATACATGTTTTACGCACCTGTCAGGTGCGCATACTGTCAGACCGCAACCCTGCGCAACAATACC
GCACTGTTCCTGCCCTGCCTTCCGGCGTATTCCGTGGCCCGGCCGCGCCGCATGTCCCGCCCCTCAGCCAGACGGCCGGT
CTCCTTCTGCGACACCCTCCCTGTTCATGCTGCGCAATACAAATGACATGACGGTTTGTATTACCGATTACGGAGCACGG
CTCGTTTCCGTTCTCTGGCCGCAAAGTAAACCGCCTTGTTCCGGCAGTACCGGCGCACCGGATTCCCGGCGCGATGTCAT
AACGGGGTATGATTCACCATACATGTACATGGACGATCCGTATTACATGGGCGCAATTATCGGCAGGCTGGCCAACCGGA
CCTCCGGAGCATGTTTTTCACTGGACGGGCAGCGCCACTGCCTGAAAGCCAACGACGGTCCGCATCATCTGCACGGCGGC
CCGCACGGTCTGCACAGCCGCATGTGGCAGGTGCAGGCAGGCGATTACGCCGAAAACGCAACAATCATATTGCGGTATGC
CAGCCCGCACGGAGAACAGGGATACCCCGGCACCGTGCAGTTCACCGTCAGCTGCACGCTGACAGACAGCAACACGCTGC
GTCTGACCATGCACGCGCAGGCCGATGTTCCCACGCCCGTCTCACTGACAGCGCATCCCTACTTCAACCTGAGCGGTCAT
CCGGCGGGCAGCCTGCACGGGCACCGGCTTACCGTTCACGCATCCCGTTATCTGCCCTGTACCACAGCACAGAAAAACGG
CTACGGCATTCCTGCCGGTCACACCGCGCCTGTGGCAGGCACCGCGCTGGACTTCACAACGCCGCGCGACCTGACACAGG
CCCTGCGGCAAACTCCGCAGGGCTTTGACCACTATGCCGTGCTGGACGCCGCAGCATCCGCAAGCGAACCGCAACACCCC
GCGCTGCGCCATGCCGCCACACTGCACCATGTGCCCACCGGCCGCAGCATGCAGGTACACACCGACCAGCCGGGGCTGCA
GATATATTCAGCCAATTTCATCGCCCCCCGCACACGGGGCAAGTACGGAACCTGCTACGGCCCCCAGACAGCTATCTGTC
TGGAGCCTCACGGCTTTCCCGATGCGGTGAACAACGCACACTTTCCCTCATGCATCATCGGGCCGCAGGCACCGTACACC
CAGACAACGGAGTACCGTTTTTTTACAGGACAGCAGGCGTAA

Upstream 100 bases:

>100_bases
GCCTGCTGCTGGAACAGATACGCGGCACCGCGGCACAAAGCACAGCAACCGTGTCATTGCCCACGCGTGTGGTTGTGCGC
GAATCGGCGTAGAGGCAGAC

Downstream 100 bases:

>100_bases
CAAGCCCCGCCGTCCGCAAGCAGCAACAGGATCACGGAAACGCCATGGAAAAAGTTTCGCTCAACGGTATAAGCAAGCGC
TTCGGCGACGTACGGGTCAT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSSTQDTCFTHLSGAHTVRPQPCATIPHCSCPAFRRIPWPGRAACPAPQPDGRSPSATPSLFMLRNTNDMTVCITDYGAR
LVSVLWPQSKPPCSGSTGAPDSRRDVITGYDSPYMYMDDPYYMGAIIGRLANRTSGACFSLDGQRHCLKANDGPHHLHGG
PHGLHSRMWQVQAGDYAENATIILRYASPHGEQGYPGTVQFTVSCTLTDSNTLRLTMHAQADVPTPVSLTAHPYFNLSGH
PAGSLHGHRLTVHASRYLPCTTAQKNGYGIPAGHTAPVAGTALDFTTPRDLTQALRQTPQGFDHYAVLDAAASASEPQHP
ALRHAATLHHVPTGRSMQVHTDQPGLQIYSANFIAPRTRGKYGTCYGPQTAICLEPHGFPDAVNNAHFPSCIIGPQAPYT
QTTEYRFFTGQQA

Sequences:

>Translated_413_residues
MSSTQDTCFTHLSGAHTVRPQPCATIPHCSCPAFRRIPWPGRAACPAPQPDGRSPSATPSLFMLRNTNDMTVCITDYGAR
LVSVLWPQSKPPCSGSTGAPDSRRDVITGYDSPYMYMDDPYYMGAIIGRLANRTSGACFSLDGQRHCLKANDGPHHLHGG
PHGLHSRMWQVQAGDYAENATIILRYASPHGEQGYPGTVQFTVSCTLTDSNTLRLTMHAQADVPTPVSLTAHPYFNLSGH
PAGSLHGHRLTVHASRYLPCTTAQKNGYGIPAGHTAPVAGTALDFTTPRDLTQALRQTPQGFDHYAVLDAAASASEPQHP
ALRHAATLHHVPTGRSMQVHTDQPGLQIYSANFIAPRTRGKYGTCYGPQTAICLEPHGFPDAVNNAHFPSCIIGPQAPYT
QTTEYRFFTGQQA
>Mature_412_residues
SSTQDTCFTHLSGAHTVRPQPCATIPHCSCPAFRRIPWPGRAACPAPQPDGRSPSATPSLFMLRNTNDMTVCITDYGARL
VSVLWPQSKPPCSGSTGAPDSRRDVITGYDSPYMYMDDPYYMGAIIGRLANRTSGACFSLDGQRHCLKANDGPHHLHGGP
HGLHSRMWQVQAGDYAENATIILRYASPHGEQGYPGTVQFTVSCTLTDSNTLRLTMHAQADVPTPVSLTAHPYFNLSGHP
AGSLHGHRLTVHASRYLPCTTAQKNGYGIPAGHTAPVAGTALDFTTPRDLTQALRQTPQGFDHYAVLDAAASASEPQHPA
LRHAATLHHVPTGRSMQVHTDQPGLQIYSANFIAPRTRGKYGTCYGPQTAICLEPHGFPDAVNNAHFPSCIIGPQAPYTQ
TTEYRFFTGQQA

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=304, Percent_Identity=37.171052631579, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786971, Length=371, Percent_Identity=31.8059299191375, Blast_Score=178, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17557428, Length=349, Percent_Identity=26.0744985673352, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI115533334, Length=349, Percent_Identity=26.0744985673352, Blast_Score=131, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6324399, Length=317, Percent_Identity=23.3438485804416, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319493, Length=316, Percent_Identity=25.6329113924051, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322004, Length=314, Percent_Identity=21.656050955414, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24659048, Length=361, Percent_Identity=34.9030470914127, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24583720, Length=354, Percent_Identity=32.4858757062147, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24668278, Length=369, Percent_Identity=30.3523035230352, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24668282, Length=360, Percent_Identity=31.3888888888889, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24641876, Length=360, Percent_Identity=27.2222222222222, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 44634; Mature: 44503

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTQDTCFTHLSGAHTVRPQPCATIPHCSCPAFRRIPWPGRAACPAPQPDGRSPSATPS
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCE
LFMLRNTNDMTVCITDYGARLVSVLWPQSKPPCSGSTGAPDSRRDVITGYDSPYMYMDDP
EEEEECCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCC
YYMGAIIGRLANRTSGACFSLDGQRHCLKANDGPHHLHGGPHGLHSRMWQVQAGDYAENA
HHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHEEEEECCCCCCCC
TIILRYASPHGEQGYPGTVQFTVSCTLTDSNTLRLTMHAQADVPTPVSLTAHPYFNLSGH
EEEEEECCCCCCCCCCCEEEEEEEEEEECCCEEEEEEEECCCCCCCEEEEECCEECCCCC
PAGSLHGHRLTVHASRYLPCTTAQKNGYGIPAGHTAPVAGTALDFTTPRDLTQALRQTPQ
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCCC
GFDHYAVLDAAASASEPQHPALRHAATLHHVPTGRSMQVHTDQPGLQIYSANFIAPRTRG
CCCCEEEEEHHHCCCCCCCHHHHHHHHEEECCCCCEEEEECCCCCEEEEEEEEECCCCCC
KYGTCYGPQTAICLEPHGFPDAVNNAHFPSCIIGPQAPYTQTTEYRFFTGQQA
CCEEEECCCEEEEECCCCCCHHCCCCCCCEEEECCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
SSTQDTCFTHLSGAHTVRPQPCATIPHCSCPAFRRIPWPGRAACPAPQPDGRSPSATPS
CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCE
LFMLRNTNDMTVCITDYGARLVSVLWPQSKPPCSGSTGAPDSRRDVITGYDSPYMYMDDP
EEEEECCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCC
YYMGAIIGRLANRTSGACFSLDGQRHCLKANDGPHHLHGGPHGLHSRMWQVQAGDYAENA
HHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHEEEEECCCCCCCC
TIILRYASPHGEQGYPGTVQFTVSCTLTDSNTLRLTMHAQADVPTPVSLTAHPYFNLSGH
EEEEEECCCCCCCCCCCEEEEEEEEEEECCCEEEEEEEECCCCCCCEEEEECCEECCCCC
PAGSLHGHRLTVHASRYLPCTTAQKNGYGIPAGHTAPVAGTALDFTTPRDLTQALRQTPQ
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCCC
GFDHYAVLDAAASASEPQHPALRHAATLHHVPTGRSMQVHTDQPGLQIYSANFIAPRTRG
CCCCEEEEEHHHCCCCCCCHHHHHHHHEEECCCCCEEEEECCCCCEEEEEEEEECCCCCC
KYGTCYGPQTAICLEPHGFPDAVNNAHFPSCIIGPQAPYTQTTEYRFFTGQQA
CCEEEECCCEEEEECCCCCCHHCCCCCCCEEEECCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]