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The map label for this gene is trpE [H]

Identifier: 78358657

GI number: 78358657

Start: 3578933

End: 3580201

Strand: Direct

Name: trpE [H]

Synonym: Dde_3618

Alternate gene names: 78358657

Gene position: 3578933-3580201 (Clockwise)

Preceding gene: 78358656

Following gene: 78358658

Centisome position: 95.94

GC content: 64.07

Gene sequence:

>1269_bases
ATGCTTCTTTCGGCACCTCCGGCCCGCGCAGAATCCTGTGCAGACGTCTGCGCAGGCTCCCCCGCGCCGCGGCAGGACGT
CCCCCTGCACCCCATGCACGAATCGGAATTCATGGCGGGCATCGAGCCTGTGGAATCGCTGCACATCACCGCAGCCACGC
CGCGGGAACACATGCAGCGCTTCTGCAGCAACCGGCATACGCCCGTCATCGGATATCTTTCATATACCTACGGCATGGAA
CAGTACGGCATTGCGGCGCGGGAGCACTCTTTTCCCGCCGGGCTGCTGCGCCGCTACCAGTGCGTCGTTACCGGCTGCAC
CCGCACCGGCAGGCTGCGCCTGCTGGCCGACAGACACGCCGACAGCGGTCTGGTGGACAGCCTGTGCCGGCTGCTGCAGG
CAGGCAGTCCCGAACCGCCGCGCCCCCACACCCCCGTAACCGCAGCCGGACCGCTGCGCCAGTCCCTCACGAGGGAAGAA
TATCAGGAGGGCGTAAGGCAGACACAGCGGCACATCGCGGCAGGCGACACATATCAGCTGAACCTGTCCATCAGATTCGA
CCTGCCGCTGGCAACCCCGCCGGATACCACCGCACTGTTCCTGCACCTGTGGCTCAACCGTCCGGCGCCGTTTTACGCAC
TGCTGCACGACGGGCCCCTGACCATTGTGTCCACCTCGCCGGAGCGGTATCTGCGCATCAGCCGGGGCACGGTGCTAACC
CAGCCCATCAAGGGCACGCTCGCCTTTGACACATGGCAGCCGCAACTGGTGCACACACTGACCTCGTCACCCAAAGAACG
CGCCGAACTGTCCATGATCGTCGATCTGCTGCGCAACGACATCTCCACCCGCTGCCGGTTCGGCTCCGTGCGGGTGACAG
ACCACTGCAGCACCTTTGTCGTGGACAGGCTCATTCAGATGTACAGCAACGTGCACGGCATACTGCGCCCGGACAGCACC
CCGCTGGACCTGCTGCTGGACGCATTTCCGGGCGGTTCCGTCACCGGCTGTCCCAAGCTGCGCACCATGCAGATAATCGA
CAGGCTGGAACCGCACAGCCGCGACCTGTACTGCGGCAGTATTTTCTGCTTCAACGGCCCTGACCATCTGGACGCATCCG
TCGCCATACGGACAGGCTGGCACGACGCCCGTACCGGCGTGTTTTCCTGGTTTGCCGGCAGCGGTCTGGTGACAGATTCC
GTACCGGAAAACGAATACGCCGAAACCATGGCCAAAGCCCGGAAATTTCAGGAGGCGCTCTGCCCGTGA

Upstream 100 bases:

>100_bases
GTCTGGTGCATCCGCCATGCGCTGCGTTCTCTGCATATCCTGTGATCCGCGGTGCATTCCTCCGCTGCTGGATTTTCTGG
CCCGGAGGCATCATGCCGAC

Downstream 100 bases:

>100_bases
CCTATGTACGCAACAATGCGTTGCATTGCGGCCCGCTGCCGCAACATGTGACCGCCCCTTCATTCCGTTCGGGAACAGGT
TTTTACGAAACCCTGCTGTA

Product: aminodeoxychorismate synthase subunit I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLLSAPPARAESCADVCAGSPAPRQDVPLHPMHESEFMAGIEPVESLHITAATPREHMQRFCSNRHTPVIGYLSYTYGME
QYGIAAREHSFPAGLLRRYQCVVTGCTRTGRLRLLADRHADSGLVDSLCRLLQAGSPEPPRPHTPVTAAGPLRQSLTREE
YQEGVRQTQRHIAAGDTYQLNLSIRFDLPLATPPDTTALFLHLWLNRPAPFYALLHDGPLTIVSTSPERYLRISRGTVLT
QPIKGTLAFDTWQPQLVHTLTSSPKERAELSMIVDLLRNDISTRCRFGSVRVTDHCSTFVVDRLIQMYSNVHGILRPDST
PLDLLLDAFPGGSVTGCPKLRTMQIIDRLEPHSRDLYCGSIFCFNGPDHLDASVAIRTGWHDARTGVFSWFAGSGLVTDS
VPENEYAETMAKARKFQEALCP

Sequences:

>Translated_422_residues
MLLSAPPARAESCADVCAGSPAPRQDVPLHPMHESEFMAGIEPVESLHITAATPREHMQRFCSNRHTPVIGYLSYTYGME
QYGIAAREHSFPAGLLRRYQCVVTGCTRTGRLRLLADRHADSGLVDSLCRLLQAGSPEPPRPHTPVTAAGPLRQSLTREE
YQEGVRQTQRHIAAGDTYQLNLSIRFDLPLATPPDTTALFLHLWLNRPAPFYALLHDGPLTIVSTSPERYLRISRGTVLT
QPIKGTLAFDTWQPQLVHTLTSSPKERAELSMIVDLLRNDISTRCRFGSVRVTDHCSTFVVDRLIQMYSNVHGILRPDST
PLDLLLDAFPGGSVTGCPKLRTMQIIDRLEPHSRDLYCGSIFCFNGPDHLDASVAIRTGWHDARTGVFSWFAGSGLVTDS
VPENEYAETMAKARKFQEALCP
>Mature_422_residues
MLLSAPPARAESCADVCAGSPAPRQDVPLHPMHESEFMAGIEPVESLHITAATPREHMQRFCSNRHTPVIGYLSYTYGME
QYGIAAREHSFPAGLLRRYQCVVTGCTRTGRLRLLADRHADSGLVDSLCRLLQAGSPEPPRPHTPVTAAGPLRQSLTREE
YQEGVRQTQRHIAAGDTYQLNLSIRFDLPLATPPDTTALFLHLWLNRPAPFYALLHDGPLTIVSTSPERYLRISRGTVLT
QPIKGTLAFDTWQPQLVHTLTSSPKERAELSMIVDLLRNDISTRCRFGSVRVTDHCSTFVVDRLIQMYSNVHGILRPDST
PLDLLLDAFPGGSVTGCPKLRTMQIIDRLEPHSRDLYCGSIFCFNGPDHLDASVAIRTGWHDARTGVFSWFAGSGLVTDS
VPENEYAETMAKARKFQEALCP

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=288, Percent_Identity=38.8888888888889, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1787518, Length=273, Percent_Identity=31.1355311355311, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320935, Length=295, Percent_Identity=31.1864406779661, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6324361, Length=266, Percent_Identity=28.1954887218045, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 46838; Mature: 46838

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSAPPARAESCADVCAGSPAPRQDVPLHPMHESEFMAGIEPVESLHITAATPREHMQR
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHEEEEECCCHHHHHH
FCSNRHTPVIGYLSYTYGMEQYGIAAREHSFPAGLLRRYQCVVTGCTRTGRLRLLADRHA
HHCCCCCCEEEEEHHHHCHHHHCCHHHCCCCCHHHHHHHHHEEEECCCCCCEEEEECCCC
DSGLVDSLCRLLQAGSPEPPRPHTPVTAAGPLRQSLTREEYQEGVRQTQRHIAAGDTYQL
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NLSIRFDLPLATPPDTTALFLHLWLNRPAPFYALLHDGPLTIVSTSPERYLRISRGTVLT
EEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCHHHHEEEECCEEEE
QPIKGTLAFDTWQPQLVHTLTSSPKERAELSMIVDLLRNDISTRCRFGSVRVTDHCSTFV
CCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCEEEEHHHHHHH
VDRLIQMYSNVHGILRPDSTPLDLLLDAFPGGSVTGCPKLRTMQIIDRLEPHSRDLYCGS
HHHHHHHHHCCCEEECCCCCCHHHHEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEE
IFCFNGPDHLDASVAIRTGWHDARTGVFSWFAGSGLVTDSVPENEYAETMAKARKFQEAL
EEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHH
CP
CC
>Mature Secondary Structure
MLLSAPPARAESCADVCAGSPAPRQDVPLHPMHESEFMAGIEPVESLHITAATPREHMQR
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHEEEEECCCHHHHHH
FCSNRHTPVIGYLSYTYGMEQYGIAAREHSFPAGLLRRYQCVVTGCTRTGRLRLLADRHA
HHCCCCCCEEEEEHHHHCHHHHCCHHHCCCCCHHHHHHHHHEEEECCCCCCEEEEECCCC
DSGLVDSLCRLLQAGSPEPPRPHTPVTAAGPLRQSLTREEYQEGVRQTQRHIAAGDTYQL
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NLSIRFDLPLATPPDTTALFLHLWLNRPAPFYALLHDGPLTIVSTSPERYLRISRGTVLT
EEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCHHHHEEEECCEEEE
QPIKGTLAFDTWQPQLVHTLTSSPKERAELSMIVDLLRNDISTRCRFGSVRVTDHCSTFV
CCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCEEEEHHHHHHH
VDRLIQMYSNVHGILRPDSTPLDLLLDAFPGGSVTGCPKLRTMQIIDRLEPHSRDLYCGS
HHHHHHHHHCCCEEECCCCCCHHHHEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEE
IFCFNGPDHLDASVAIRTGWHDARTGVFSWFAGSGLVTDSVPENEYAETMAKARKFQEAL
EEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHH
CP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]