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The map label for this gene is cobS [H]

Identifier: 78358472

GI number: 78358472

Start: 3397113

End: 3398129

Strand: Direct

Name: cobS [H]

Synonym: Dde_3433

Alternate gene names: 78358472

Gene position: 3397113-3398129 (Clockwise)

Preceding gene: 78358471

Following gene: 78358473

Centisome position: 91.07

GC content: 54.47

Gene sequence:

>1017_bases
ATGATTACACATGAACTTGACACCCTCACCACTACGGATATGGACGCCGGTACTCTGTTCAGCGGCAAAGCATCCGGCCG
CATGATACGCGGATATAGCGCTCCATGCAGCTTTACCCCCAGGATTGATCCTGACTATCTGTTCCATGATTCCATGCGGG
ATATCGTAGTCTGGCTTTTATCAGGAACTGAAGAGAAAGCCGACCCGCTTTACATTTTCGGGCCAACTGGAAGCGGAAAA
ACAAGCCTTGTGCGACAGCTTGCTGCTCGCCTGAATTATCCCGTCTTTGATGTCACAGGGCACGGCAGACTGGAGTTCCC
GGACCTTGCCGGTCACCTGAGCGTGCAGAGCGGAAACATGGTTTATCAGTATGGTCCGCTTGCGCTGGCTATGCGTTACG
GCGGTCTTTTCCTGCTCAATGAGGCGGACCTGCTCGACCCTGCCACGGCCACAGGTTTGAATGGTGTGCTCGATGGCGGA
CCGCTCTGCATCCCGGAAAACGGTGGAGAGATTATCCAGCCGCATCCCATGTTCCGGTTTGTGGCAACCGCCAATACTAA
CGGCGCATCCGACGAAAGCGGTTTATATCAAGGCACTCTGCGTCAGAACATCGCCCTGATGGACAGGTTCTACCTTTGCG
AGGTTGGCTATCCTGCTCAGGAAACAGAAGTAATGCTTCTTGAACGGATAGCGCCTGATATTCCACAAGATATCCGTGAA
ACAATGGCAAGCTTTGCGGGAGAAGTGCGTCGACTGTTCATGGGTGAAAGCGAAAAGCAGAAATACGGCGAAACCATCGA
CATAACCTTTTCCACCCGCACGCTGATCCGCTGGGCCACGCTTACCAGGCGATTCCAGCCTCTGGCAAGGCAGGGAATCC
AGCCCATCGGCTACGCTCTGGACAGAGCTCTGGGATTTCGAGCCTCTCGGGAGACACGCGCCATGCTGCACGAGCTGGCG
CAGCGCATGTTTCCCACAGCGGAATCGCAACAGACTACAGACATAGAGAACACTTGA

Upstream 100 bases:

>100_bases
GTCACCAGAACAGGTGCCCCTTTTCAGCGGCTATATATCAGCCCCCGCATGCCGGAGGTTTCAGCAACCAATACTCTGCC
AACACAAAAGGAAGTATAAG

Downstream 100 bases:

>100_bases
AGGGAGCCCTGAGAGATCAGCGGCTCCCTTTCTTATTCAATATACAAAACAGGAGGACTACCATGCATACAGATATCACC
GTGCTCGATAACCTTGTGGC

Product: ATPase

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLLSGTEEKADPLYIFGPTGSGK
TSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNMVYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGG
PLCIPENGGEIIQPHPMFRFVATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
TMASFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLTRRFQPLARQGIQPIGYALDRALGFRASRETRAMLHELA
QRMFPTAESQQTTDIENT

Sequences:

>Translated_338_residues
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLLSGTEEKADPLYIFGPTGSGK
TSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNMVYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGG
PLCIPENGGEIIQPHPMFRFVATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
TMASFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLTRRFQPLARQGIQPIGYALDRALGFRASRETRAMLHELA
QRMFPTAESQQTTDIENT
>Mature_338_residues
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLLSGTEEKADPLYIFGPTGSGK
TSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNMVYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGG
PLCIPENGGEIIQPHPMFRFVATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
TMASFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLTRRFQPLARQGIQPIGYALDRALGFRASRETRAMLHELA
QRMFPTAESQQTTDIENT

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=281, Percent_Identity=29.1814946619217, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI57863271, Length=228, Percent_Identity=25.8771929824561, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI57863273, Length=261, Percent_Identity=24.5210727969349, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323135, Length=231, Percent_Identity=31.6017316017316, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 37479; Mature: 37479

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLL
CCCCCCCCCEECCCCCCCEECCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
SGTEEKADPLYIFGPTGSGKTSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNM
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCEEEEECCCE
VYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGGPLCIPENGGEIIQPHPMFRF
EEEECCHHEEHHHCCEEEEECCCCCCCCHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEE
VATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
EEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCCHHHHH
TMASFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLTRRFQPLARQGIQPIGYAL
HHHHHHHHHHHHHCCCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
DRALGFRASRETRAMLHELAQRMFPTAESQQTTDIENT
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLL
CCCCCCCCCEECCCCCCCEECCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
SGTEEKADPLYIFGPTGSGKTSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNM
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCEEEEECCCE
VYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGGPLCIPENGGEIIQPHPMFRF
EEEECCHHEEHHHCCEEEEECCCCCCCCHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEE
VATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
EEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCCHHHHH
TMASFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLTRRFQPLARQGIQPIGYAL
HHHHHHHHHHHHHCCCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
DRALGFRASRETRAMLHELAQRMFPTAESQQTTDIENT
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]