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The map label for this gene is hbpA [H]

Identifier: 78358214

GI number: 78358214

Start: 3161454

End: 3163025

Strand: Direct

Name: hbpA [H]

Synonym: Dde_3174

Alternate gene names: 78358214

Gene position: 3161454-3163025 (Clockwise)

Preceding gene: 78358209

Following gene: 78358215

Centisome position: 84.75

GC content: 59.99

Gene sequence:

>1572_bases
ATGCCTGAGTCCACAGCGCGTCCTCACTTTGCGGCGGCGCGGCACATGATGGGCATTGCTGCGCTATTTGCGGCAATGCT
GACCGTTTTTGCGGCGTTCGCCCCGCAGCCCGCGGCCGCGGCCGGTTCGCTGGTTTTTGCGCGGGCCAGCGATGCCGTGA
CTCTGGACCCGGCGCGCGCACCGGACCTTGAATCCACCAAGGTCATCGCCAACATATACGAAGGGCTGGTCACCGTGGCA
GAAAGCGGCACGGAAATAGTGCCTGCGCTGGCCCGTTCGTGGGAAAGCTCCGCCGACGGTACCCGCTGGACATTCCACCT
GCGGCACGGGGTCGTGTTTCACGACGGCACGCCGCTTACCGCACAGGCCGTTGTGCAGTCGTTCATGCGGCAGATCGATC
CGGAACGTTCTGATTTCGCCGGAGATTCCGGCGTGTCACGGTTTACGTTCCGCCACATCACCGCCGTCAGCGCCCCCGAC
GACCACACCGTGCTCATAACGCTGGATGCGCCGTTCCCGCCTTTTCTGCACAATATGTCCATGGCCACCGCTTCGGTCAT
CAGTCCTGCCGGCGGTGATATTCCCGCCGGTACAGGGCCTTTCCGTCTGCATACGTGGGAAAAAGGCAGAAGAATAGTGC
TGAAGGCCCACACGGAATACTGGCGGGGCGCCCCTCAGCTGGATACCGTGGTGCTGGAGGTCATACCCAAAGCATCGGAC
AGGCTTACCGCACTTAACGTCGGCGCCATTGATGCCTTTGACGGAGTGACCAGTGACATAGCCCGCCATGCATCAGCTCA
AAGCTCCATACAGCTTTCCAGCCGTACCGGTCTGCGCATAGCCTATCTGGCCATGAACACGCAAAAGCCCCCTTTTGACA
ATCCGGCAGTGCGCAGAGCTCTGAACATGGCCGTGAATAAAATCCCCATGCAGACTCTGATCTACGGCAACACCGCCGTG
GTGGCGCACAATGTCATTCCCGAAACGGTATGGGCCTATGACGAAACCCTGCCCCCCTATGTCTACGATCCCGCGGCCGC
GCGTGACATGCTGGCACAGGCCGGTTATCCGCAGGGATTCACCGCCACGCTGTATTTCTGTCCGCGCCCTTTTTACCCCG
AAGGAATCGAAGCTCTTATCAGAAATGAACTGGCAGCCGTCAACGTGCGTCTGGATATCCGCTACACCGAATGGACCGAA
CACCTGAAAGCCACCGGCAACGCGGAGCACGATATGTGCATCATCAGCTGGGGCGGATACAACAGCGATCCCGACAACTT
CTTCTACCCGCTGTTCCATCCTCACAATGCCGTGACACCCCATGCCCAGAACAGGGCGTTTTATACCAACCCCCAAGTCA
GCCGGCTGATAGAAAAAGCCCAGCAGGAAACAGACCCCGGAATCCGCAAGGAACACTACCGGCGCATACAACGGCTTATC
AGAAATGACGCCCCGTGGATTCCGCTGGTCTACAACCGCGAACTGCTGGCGCATTCCGTCGACGTTACCGGTCTGCGCCT
GGACGCCACAGGCGTTGTGCGGTTTTACGGCGCCCACGTCCGCCACGACTGA

Upstream 100 bases:

>100_bases
GTTGTATGAGAAATTCGGGCCGGTAACAACCGCTGGTTGCCCGGCAATATCATGGCGCCACTTGCACCCGCGGGCTAGAG
TAAAAAAACAGGAAGCACAC

Downstream 100 bases:

>100_bases
CCGGCCGCAGCACAGCAGCCGCAGCGGGGCGAAATCACACAAGGATTCTGTTTTGATAACATTCCACGTTCAGACACACC
GCCGCGAAGAGCTTGTAGAC

Product: dipeptide ABC transporter substrate-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MPESTARPHFAAARHMMGIAALFAAMLTVFAAFAPQPAAAAGSLVFARASDAVTLDPARAPDLESTKVIANIYEGLVTVA
ESGTEIVPALARSWESSADGTRWTFHLRHGVVFHDGTPLTAQAVVQSFMRQIDPERSDFAGDSGVSRFTFRHITAVSAPD
DHTVLITLDAPFPPFLHNMSMATASVISPAGGDIPAGTGPFRLHTWEKGRRIVLKAHTEYWRGAPQLDTVVLEVIPKASD
RLTALNVGAIDAFDGVTSDIARHASAQSSIQLSSRTGLRIAYLAMNTQKPPFDNPAVRRALNMAVNKIPMQTLIYGNTAV
VAHNVIPETVWAYDETLPPYVYDPAAARDMLAQAGYPQGFTATLYFCPRPFYPEGIEALIRNELAAVNVRLDIRYTEWTE
HLKATGNAEHDMCIISWGGYNSDPDNFFYPLFHPHNAVTPHAQNRAFYTNPQVSRLIEKAQQETDPGIRKEHYRRIQRLI
RNDAPWIPLVYNRELLAHSVDVTGLRLDATGVVRFYGAHVRHD

Sequences:

>Translated_523_residues
MPESTARPHFAAARHMMGIAALFAAMLTVFAAFAPQPAAAAGSLVFARASDAVTLDPARAPDLESTKVIANIYEGLVTVA
ESGTEIVPALARSWESSADGTRWTFHLRHGVVFHDGTPLTAQAVVQSFMRQIDPERSDFAGDSGVSRFTFRHITAVSAPD
DHTVLITLDAPFPPFLHNMSMATASVISPAGGDIPAGTGPFRLHTWEKGRRIVLKAHTEYWRGAPQLDTVVLEVIPKASD
RLTALNVGAIDAFDGVTSDIARHASAQSSIQLSSRTGLRIAYLAMNTQKPPFDNPAVRRALNMAVNKIPMQTLIYGNTAV
VAHNVIPETVWAYDETLPPYVYDPAAARDMLAQAGYPQGFTATLYFCPRPFYPEGIEALIRNELAAVNVRLDIRYTEWTE
HLKATGNAEHDMCIISWGGYNSDPDNFFYPLFHPHNAVTPHAQNRAFYTNPQVSRLIEKAQQETDPGIRKEHYRRIQRLI
RNDAPWIPLVYNRELLAHSVDVTGLRLDATGVVRFYGAHVRHD
>Mature_522_residues
PESTARPHFAAARHMMGIAALFAAMLTVFAAFAPQPAAAAGSLVFARASDAVTLDPARAPDLESTKVIANIYEGLVTVAE
SGTEIVPALARSWESSADGTRWTFHLRHGVVFHDGTPLTAQAVVQSFMRQIDPERSDFAGDSGVSRFTFRHITAVSAPDD
HTVLITLDAPFPPFLHNMSMATASVISPAGGDIPAGTGPFRLHTWEKGRRIVLKAHTEYWRGAPQLDTVVLEVIPKASDR
LTALNVGAIDAFDGVTSDIARHASAQSSIQLSSRTGLRIAYLAMNTQKPPFDNPAVRRALNMAVNKIPMQTLIYGNTAVV
AHNVIPETVWAYDETLPPYVYDPAAARDMLAQAGYPQGFTATLYFCPRPFYPEGIEALIRNELAAVNVRLDIRYTEWTEH
LKATGNAEHDMCIISWGGYNSDPDNFFYPLFHPHNAVTPHAQNRAFYTNPQVSRLIEKAQQETDPGIRKEHYRRIQRLIR
NDAPWIPLVYNRELLAHSVDVTGLRLDATGVVRFYGAHVRHD

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=472, Percent_Identity=34.5338983050847, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1787052, Length=512, Percent_Identity=30.6640625, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1787762, Length=479, Percent_Identity=28.39248434238, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1787551, Length=549, Percent_Identity=28.9617486338798, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI87081878, Length=502, Percent_Identity=26.0956175298805, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1789397, Length=522, Percent_Identity=26.4367816091954, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1787495, Length=524, Percent_Identity=24.4274809160305, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1789887, Length=447, Percent_Identity=25.9507829977629, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57638; Mature: 57507

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESTARPHFAAARHMMGIAALFAAMLTVFAAFAPQPAAAAGSLVFARASDAVTLDPARA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEECCCCC
PDLESTKVIANIYEGLVTVAESGTEIVPALARSWESSADGTRWTFHLRHGVVFHDGTPLT
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCEEEECCCCCC
AQAVVQSFMRQIDPERSDFAGDSGVSRFTFRHITAVSAPDDHTVLITLDAPFPPFLHNMS
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHH
MATASVISPAGGDIPAGTGPFRLHTWEKGRRIVLKAHTEYWRGAPQLDTVVLEVIPKASD
HHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEECHHHHCCCCCHHHHHHHHHCCCCC
RLTALNVGAIDAFDGVTSDIARHASAQSSIQLSSRTGLRIAYLAMNTQKPPFDNPAVRRA
CEEEEECCCCHHHCCHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHHH
LNMAVNKIPMQTLIYGNTAVVAHNVIPETVWAYDETLPPYVYDPAAARDMLAQAGYPQGF
HHHHHHHCCCEEEEECCEEEEEECCCHHHHHHHCCCCCCCEECCHHHHHHHHHCCCCCCC
TATLYFCPRPFYPEGIEALIRNELAAVNVRLDIRYTEWTEHLKATGNAEHDMCIISWGGY
EEEEEECCCCCCHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEECCC
NSDPDNFFYPLFHPHNAVTPHAQNRAFYTNPQVSRLIEKAQQETDPGIRKEHYRRIQRLI
CCCCCCEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RNDAPWIPLVYNRELLAHSVDVTGLRLDATGVVRFYGAHVRHD
HCCCCCEEEEECCHHHHHCCCCEEEEECCCHHEEECCHHHCCC
>Mature Secondary Structure 
PESTARPHFAAARHMMGIAALFAAMLTVFAAFAPQPAAAAGSLVFARASDAVTLDPARA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEECCCCC
PDLESTKVIANIYEGLVTVAESGTEIVPALARSWESSADGTRWTFHLRHGVVFHDGTPLT
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCEEEECCCCCC
AQAVVQSFMRQIDPERSDFAGDSGVSRFTFRHITAVSAPDDHTVLITLDAPFPPFLHNMS
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHH
MATASVISPAGGDIPAGTGPFRLHTWEKGRRIVLKAHTEYWRGAPQLDTVVLEVIPKASD
HHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEECHHHHCCCCCHHHHHHHHHCCCCC
RLTALNVGAIDAFDGVTSDIARHASAQSSIQLSSRTGLRIAYLAMNTQKPPFDNPAVRRA
CEEEEECCCCHHHCCHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHHH
LNMAVNKIPMQTLIYGNTAVVAHNVIPETVWAYDETLPPYVYDPAAARDMLAQAGYPQGF
HHHHHHHCCCEEEEECCEEEEEECCCHHHHHHHCCCCCCCEECCHHHHHHHHHCCCCCCC
TATLYFCPRPFYPEGIEALIRNELAAVNVRLDIRYTEWTEHLKATGNAEHDMCIISWGGY
EEEEEECCCCCCHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEECCC
NSDPDNFFYPLFHPHNAVTPHAQNRAFYTNPQVSRLIEKAQQETDPGIRKEHYRRIQRLI
CCCCCCEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RNDAPWIPLVYNRELLAHSVDVTGLRLDATGVVRFYGAHVRHD
HCCCCCEEEEECCHHHHHCCCCEEEEECCCHHEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]