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The map label for this gene is ahcY

Identifier: 78358174

GI number: 78358174

Start: 3124684

End: 3126123

Strand: Reverse

Name: ahcY

Synonym: Dde_3134

Alternate gene names: 78358174

Gene position: 3126123-3124684 (Counterclockwise)

Preceding gene: 78358175

Following gene: 78358172

Centisome position: 83.81

GC content: 55.21

Gene sequence:

>1440_bases
ATGACAGATGCCCGCAAAGCCCTTCCTCTGGACTTGAGCCTTGAAAACAAGGTCAAAGATCTTTCCCAGGCCGATTTCGG
CTACAAGGAAATGCAGCTTTCCGAACGTGAAATGCCCGGCCTGATGGAACTGATAGCCAAGCACGGTGCCGAAAAGCCGC
TCAAGGGGCTCAAGGTCACAGGCTCGCTGCATATGACCATTCAGACCGCCATGCTTATCAAAACTCTGTACGAGCTGGGC
GCTGATATCCGCTGGGCTTCGTGCAACATATTCTCCACGCAGGACCATGCCGCAGCCGCCATTGCCGATTCGGGCATGGC
AAAGGTTTTTGCATGGAAAGGTGAAACGCTGGAAGAATACTGGTGGTGCACCGAAATGGCGCTTACCTGGCCCGACGGGT
CCGGTCCCGATCTTATCGTGGACGACGGCGGCGACGCCACCATGCTTATCCATAAAGGGGTGGAAGCAGAAAAGAATCCC
GCCCTGCTGGAAAAGTCCTACGATAACAAAGAATTTCAGATTGTGATGAACCGCATTGCCCTGAGCATGAAAAACGATCC
CGGCAAATGGACGCGTGTTGCCGCCAAAGTGCGCGGTGTTTCAGAAGAAACAACCACCGGCGTACACCGTCTGTACCATA
TGGAAAAAGACGGGTCGCTGCTGTTCCCGGCCATCAACGTCAACGACTCCGTTACCAAGTCCAAATTCGACAACCTGTAC
GGTTGCCGTGAATCGCTGGCAGACGGTATCAAACGCGCCACCGATGTGATGATTGCCGGAAAGACCGTTGTGGTGCTGGG
CTACGGCGATGTGGGCAAAGGCTGCGCCCATTCCATGCGCGGATTCGGCGCACGGGTGCTTGTAACCGAAATCGATCCCA
TCTGCGCGCTGCAGGCCGCCATGGAAGGCTTTGAAGTGGTCACCATGGATGAAGCCGCTCCCGAAGGTGATATCTTTGTG
ACGGCCACCGGCAACTTCAAGGTAATTACCGGCGAGCACATGGAACGGATGAAAGATGAAGCCATTGTCTGCAACATCGG
CCATTTTGATAACGAAATCGATATGGCTTACCTTGAAGACAGCACCGAATGCTCCTGCCTGAACATCAAACCGCAGGTGG
ACAAATGGACGCTGAAGTCCGGCCGTTCCATCATCGTTCTGGCAGAAGGCCGTCTGGTCAACCTCGGCTGCGCCACCGGG
CACCCCAGCTTTGTCATGTCCAACAGCTTTACCAATCAGGTGCTGGCACAGCTTGAGCTGGCTTCCAACCCCGATCTGGA
GCGCAAGGTCTACATCCTGCCCAAAAAGCTGGATGAAGAAGTGGCCCGTCTGCACCTTGCCCGTCTGGGGGCAAAGCTGA
CCACCCTGACCGACGAACAGGCAGAATACATCGGAGTGGACAAAACCGGTCCCTTCAAGCCCGACCACTACCGTTACTAA

Upstream 100 bases:

>100_bases
CGGTGCGCCACAGCGAGTTGCAGAACGTGGAAAGAAATCTTTCCATCCATCTGATCGTCGCACAGAACAACAGTTAACCC
ATATTTTTTCGGAGAACGTC

Downstream 100 bases:

>100_bases
CGGCAGGCGCTGCTGTGCAGCGCACCGTCATATGGTATCATACCGGCCGCCCCGCTTTTGCGGGGCGGCTTTTTTAGTGC
GCGGTCCCATTTTTTGTCAG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTDARKALPLDLSLENKVKDLSQADFGYKEMQLSEREMPGLMELIAKHGAEKPLKGLKVTGSLHMTIQTAMLIKTLYELG
ADIRWASCNIFSTQDHAAAAIADSGMAKVFAWKGETLEEYWWCTEMALTWPDGSGPDLIVDDGGDATMLIHKGVEAEKNP
ALLEKSYDNKEFQIVMNRIALSMKNDPGKWTRVAAKVRGVSEETTTGVHRLYHMEKDGSLLFPAINVNDSVTKSKFDNLY
GCRESLADGIKRATDVMIAGKTVVVLGYGDVGKGCAHSMRGFGARVLVTEIDPICALQAAMEGFEVVTMDEAAPEGDIFV
TATGNFKVITGEHMERMKDEAIVCNIGHFDNEIDMAYLEDSTECSCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATG
HPSFVMSNSFTNQVLAQLELASNPDLERKVYILPKKLDEEVARLHLARLGAKLTTLTDEQAEYIGVDKTGPFKPDHYRY

Sequences:

>Translated_479_residues
MTDARKALPLDLSLENKVKDLSQADFGYKEMQLSEREMPGLMELIAKHGAEKPLKGLKVTGSLHMTIQTAMLIKTLYELG
ADIRWASCNIFSTQDHAAAAIADSGMAKVFAWKGETLEEYWWCTEMALTWPDGSGPDLIVDDGGDATMLIHKGVEAEKNP
ALLEKSYDNKEFQIVMNRIALSMKNDPGKWTRVAAKVRGVSEETTTGVHRLYHMEKDGSLLFPAINVNDSVTKSKFDNLY
GCRESLADGIKRATDVMIAGKTVVVLGYGDVGKGCAHSMRGFGARVLVTEIDPICALQAAMEGFEVVTMDEAAPEGDIFV
TATGNFKVITGEHMERMKDEAIVCNIGHFDNEIDMAYLEDSTECSCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATG
HPSFVMSNSFTNQVLAQLELASNPDLERKVYILPKKLDEEVARLHLARLGAKLTTLTDEQAEYIGVDKTGPFKPDHYRY
>Mature_478_residues
TDARKALPLDLSLENKVKDLSQADFGYKEMQLSEREMPGLMELIAKHGAEKPLKGLKVTGSLHMTIQTAMLIKTLYELGA
DIRWASCNIFSTQDHAAAAIADSGMAKVFAWKGETLEEYWWCTEMALTWPDGSGPDLIVDDGGDATMLIHKGVEAEKNPA
LLEKSYDNKEFQIVMNRIALSMKNDPGKWTRVAAKVRGVSEETTTGVHRLYHMEKDGSLLFPAINVNDSVTKSKFDNLYG
CRESLADGIKRATDVMIAGKTVVVLGYGDVGKGCAHSMRGFGARVLVTEIDPICALQAAMEGFEVVTMDEAAPEGDIFVT
ATGNFKVITGEHMERMKDEAIVCNIGHFDNEIDMAYLEDSTECSCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGH
PSFVMSNSFTNQVLAQLELASNPDLERKVYILPKKLDEEVARLHLARLGAKLTTLTDEQAEYIGVDKTGPFKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=467, Percent_Identity=61.0278372591007, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI239937451, Length=443, Percent_Identity=62.3024830699774, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI298286489, Length=464, Percent_Identity=48.4913793103448, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI24308043, Length=464, Percent_Identity=48.4913793103448, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI195539337, Length=464, Percent_Identity=48.4913793103448, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI195539349, Length=464, Percent_Identity=48.4913793103448, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI21361647, Length=464, Percent_Identity=47.4137931034483, Blast_Score=431, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=58.8865096359743, Blast_Score=547, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=57.6200417536534, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=464, Percent_Identity=60.5603448275862, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24656245, Length=460, Percent_Identity=48.9130434782609, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=49.4600431965443, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=49.3506493506493, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_DESDG (Q30WL8)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389623.1
- HSSP:   P10760
- STRING:   Q30WL8
- GeneID:   3758108
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_3134
- NMPDR:   fig|207559.3.peg.3734
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- BioCyc:   DDES207559:DDE_3134-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52811; Mature: 52680

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 66-66 BINDING 142-142 BINDING 203-203 BINDING 233-233 BINDING 237-237 BINDING 238-238 BINDING 290-290 BINDING 325-325 BINDING 394-394

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDARKALPLDLSLENKVKDLSQADFGYKEMQLSEREMPGLMELIAKHGAEKPLKGLKVT
CCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEE
GSLHMTIQTAMLIKTLYELGADIRWASCNIFSTQDHAAAAIADSGMAKVFAWKGETLEEY
CEEEEHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHCCCCEEEEEECCCCHHHH
WWCTEMALTWPDGSGPDLIVDDGGDATMLIHKGVEAEKNPALLEKSYDNKEFQIVMNRIA
HEEEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCCHHCCCCCCCHHHHHEEHHH
LSMKNDPGKWTRVAAKVRGVSEETTTGVHRLYHMEKDGSLLFPAINVNDSVTKSKFDNLY
HEECCCCCHHHHHHHHHCCCCCHHHHHHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHH
GCRESLADGIKRATDVMIAGKTVVVLGYGDVGKGCAHSMRGFGARVLVTEIDPICALQAA
HHHHHHHHHHHHHHEEEEECCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHH
MEGFEVVTMDEAAPEGDIFVTATGNFKVITGEHMERMKDEAIVCNIGHFDNEIDMAYLED
HCCCEEEEECCCCCCCCEEEEECCCEEEEECHHHHHCCCCEEEEECCCCCCCCEEEEECC
STECSCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQLEL
CCCEEEEECCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHH
ASNPDLERKVYILPKKLDEEVARLHLARLGAKLTTLTDEQAEYIGVDKTGPFKPDHYRY
CCCCCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCHHEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TDARKALPLDLSLENKVKDLSQADFGYKEMQLSEREMPGLMELIAKHGAEKPLKGLKVT
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEE
GSLHMTIQTAMLIKTLYELGADIRWASCNIFSTQDHAAAAIADSGMAKVFAWKGETLEEY
CEEEEHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHCCCCEEEEEECCCCHHHH
WWCTEMALTWPDGSGPDLIVDDGGDATMLIHKGVEAEKNPALLEKSYDNKEFQIVMNRIA
HEEEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCCHHCCCCCCCHHHHHEEHHH
LSMKNDPGKWTRVAAKVRGVSEETTTGVHRLYHMEKDGSLLFPAINVNDSVTKSKFDNLY
HEECCCCCHHHHHHHHHCCCCCHHHHHHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHH
GCRESLADGIKRATDVMIAGKTVVVLGYGDVGKGCAHSMRGFGARVLVTEIDPICALQAA
HHHHHHHHHHHHHHEEEEECCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHH
MEGFEVVTMDEAAPEGDIFVTATGNFKVITGEHMERMKDEAIVCNIGHFDNEIDMAYLED
HCCCEEEEECCCCCCCCEEEEECCCEEEEECHHHHHCCCCEEEEECCCCCCCCEEEEECC
STECSCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQLEL
CCCEEEEECCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHH
ASNPDLERKVYILPKKLDEEVARLHLARLGAKLTTLTDEQAEYIGVDKTGPFKPDHYRY
CCCCCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCHHEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA