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The map label for this gene is dhaT [H]

Identifier: 78358102

GI number: 78358102

Start: 3054413

End: 3055591

Strand: Direct

Name: dhaT [H]

Synonym: Dde_3062

Alternate gene names: 78358102

Gene position: 3054413-3055591 (Clockwise)

Preceding gene: 78358101

Following gene: 78358103

Centisome position: 81.88

GC content: 58.44

Gene sequence:

>1179_bases
ATGATGCATTTTAATTTTCACATGCCCACACGGCTTATTTTCGGACAAGGCACCCTGCGCCGGCTGGCCGGAGAACCCCT
GCCGGGCACCAGAGCACTGGTTGTGGTCAGCGCCGGTGGTTCCATGAAAAAGCTCGGGTATCTGGAACAGGTACGCTCGC
TGCTGGCGCAAAACGGCTGCGAAAGCGAAGTGTATGATCGCATACAGCCAAACCCTGTCAAAGAGCATGTGATGGAAGGA
GCCGCGCTGGCACGCTCGGCCCGCTGCGATTTCATCGTCGGGCTGGGAGGCGGCAGCAGCATCGATTCCGCAAAATCCAT
CGCCCTCATGGCCGCAAACCCCGGAGACTACTGGGACTACATGGGCGGCACCGGCGGCGGCAAAACACCGCCGGAACCGG
CGCTGCCTGTCATTGCCATTCCCACCACCGCGGGTACCGGCACAGAGGCCGACCCGTGGACAGTCATCACCAACACCGCC
ACGCGTGAAAAAATAGGCTGGGGCAACGACTCCACGTTTCCCCGTTTTTCCATCATCGACCCCATGCTGATGCTCAGCGT
ACCGCCCAGTGTCACCGCCTATACCGGCATGGACGCCTTTTTCCACGCCACAGAAGCATATCTGGCCACCTGCAACCAGC
CCTCCAGCGACCTGCTGGCCCAGCAGGCCATCCATCTTATCTCGACATTTCTGCCGCAGTGCGTGCACGACGGAAGCAAC
CCCGAAACACGCACCATGCTTGCGTGGGCATCCACAGCCGCCGGCATCTGCGAATCACTGTCGTCGTGCATATCGCACCA
TTCGCTTGAGCATGCGCTTTCGGCATTTTATCCCGACATTCCGCATGGTGCCGGACTGGTCATGCTGTCCGAAGCGTACT
TCAGCCATCTGGCCAGATTTGTTCCCGAAAGAATGACGCATCTGGGCTATTTCATGGGTGTAGATGTGGACAGCCTGCCC
GAAGAACGTCAGCCTGAGGCATTTGTTCACGCGCTGGCAAAGCTGAAAGCCGACTGCGGGCTGGCAGAACTGAAAATGTC
TGATTTCGGTGTGAAGCGCTCCGACCTGCCCGCGCTTGCCCGTAATGCACGCGAAAGCATGGGCGGACTTTTTCATGTGA
CGCCGGTGGAACTGGACGAAGCCGCTGTCCTTGATATTTTCGAAAAAGCCTACAGATAA

Upstream 100 bases:

>100_bases
CATACCTGCTAGCCTGCTGTAAACTTGCCACACATGACAGGGCAGCCGCACGTCGCGCGGTCTGCCGCCGCACAGTAAAT
CCGCCGGAAGGAGTGTTATC

Downstream 100 bases:

>100_bases
TCTCCGTCACCGCACCGCGGGAACGCCCTGTGCGCTCCCGCGGTGCGGCCGTATCCTGTCCCGCACGGTTCACGGAGTAC
CGGACCGCGCCTGTTTTTTA

Product: alcohol dehydrogenase, iron-containing

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MMHFNFHMPTRLIFGQGTLRRLAGEPLPGTRALVVVSAGGSMKKLGYLEQVRSLLAQNGCESEVYDRIQPNPVKEHVMEG
AALARSARCDFIVGLGGGSSIDSAKSIALMAANPGDYWDYMGGTGGGKTPPEPALPVIAIPTTAGTGTEADPWTVITNTA
TREKIGWGNDSTFPRFSIIDPMLMLSVPPSVTAYTGMDAFFHATEAYLATCNQPSSDLLAQQAIHLISTFLPQCVHDGSN
PETRTMLAWASTAAGICESLSSCISHHSLEHALSAFYPDIPHGAGLVMLSEAYFSHLARFVPERMTHLGYFMGVDVDSLP
EERQPEAFVHALAKLKADCGLAELKMSDFGVKRSDLPALARNARESMGGLFHVTPVELDEAAVLDIFEKAYR

Sequences:

>Translated_392_residues
MMHFNFHMPTRLIFGQGTLRRLAGEPLPGTRALVVVSAGGSMKKLGYLEQVRSLLAQNGCESEVYDRIQPNPVKEHVMEG
AALARSARCDFIVGLGGGSSIDSAKSIALMAANPGDYWDYMGGTGGGKTPPEPALPVIAIPTTAGTGTEADPWTVITNTA
TREKIGWGNDSTFPRFSIIDPMLMLSVPPSVTAYTGMDAFFHATEAYLATCNQPSSDLLAQQAIHLISTFLPQCVHDGSN
PETRTMLAWASTAAGICESLSSCISHHSLEHALSAFYPDIPHGAGLVMLSEAYFSHLARFVPERMTHLGYFMGVDVDSLP
EERQPEAFVHALAKLKADCGLAELKMSDFGVKRSDLPALARNARESMGGLFHVTPVELDEAAVLDIFEKAYR
>Mature_392_residues
MMHFNFHMPTRLIFGQGTLRRLAGEPLPGTRALVVVSAGGSMKKLGYLEQVRSLLAQNGCESEVYDRIQPNPVKEHVMEG
AALARSARCDFIVGLGGGSSIDSAKSIALMAANPGDYWDYMGGTGGGKTPPEPALPVIAIPTTAGTGTEADPWTVITNTA
TREKIGWGNDSTFPRFSIIDPMLMLSVPPSVTAYTGMDAFFHATEAYLATCNQPSSDLLAQQAIHLISTFLPQCVHDGSN
PETRTMLAWASTAAGICESLSSCISHHSLEHALSAFYPDIPHGAGLVMLSEAYFSHLARFVPERMTHLGYFMGVDVDSLP
EERQPEAFVHALAKLKADCGLAELKMSDFGVKRSDLPALARNARESMGGLFHVTPVELDEAAVLDIFEKAYR

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=397, Percent_Identity=27.9596977329975, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI48994951, Length=361, Percent_Identity=34.6260387811634, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1789163, Length=366, Percent_Identity=29.2349726775956, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1787493, Length=314, Percent_Identity=31.5286624203822, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789386, Length=372, Percent_Identity=28.2258064516129, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI87082107, Length=302, Percent_Identity=32.4503311258278, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17537053, Length=423, Percent_Identity=26.0047281323877, Blast_Score=131, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6321181, Length=391, Percent_Identity=31.4578005115089, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24657991, Length=399, Percent_Identity=26.5664160401003, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 42232; Mature: 42232

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHFNFHMPTRLIFGQGTLRRLAGEPLPGTRALVVVSAGGSMKKLGYLEQVRSLLAQNGC
CCEEECCCCCEEEECCCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCC
ESEVYDRIQPNPVKEHVMEGAALARSARCDFIVGLGGGSSIDSAKSIALMAANPGDYWDY
CHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHHC
MGGTGGGKTPPEPALPVIAIPTTAGTGTEADPWTVITNTATREKIGWGNDSTFPRFSIID
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCHHHHC
PMLMLSVPPSVTAYTGMDAFFHATEAYLATCNQPSSDLLAQQAIHLISTFLPQCVHDGSN
CHHHEECCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PETRTMLAWASTAAGICESLSSCISHHSLEHALSAFYPDIPHGAGLVMLSEAYFSHLARF
CCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHH
VPERMTHLGYFMGVDVDSLPEERQPEAFVHALAKLKADCGLAELKMSDFGVKRSDLPALA
HHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHCCCHHHEEHHHCCCCCCCHHHHH
RNARESMGGLFHVTPVELDEAAVLDIFEKAYR
HHHHHHHCCEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MMHFNFHMPTRLIFGQGTLRRLAGEPLPGTRALVVVSAGGSMKKLGYLEQVRSLLAQNGC
CCEEECCCCCEEEECCCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCC
ESEVYDRIQPNPVKEHVMEGAALARSARCDFIVGLGGGSSIDSAKSIALMAANPGDYWDY
CHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHHC
MGGTGGGKTPPEPALPVIAIPTTAGTGTEADPWTVITNTATREKIGWGNDSTFPRFSIID
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCHHHHC
PMLMLSVPPSVTAYTGMDAFFHATEAYLATCNQPSSDLLAQQAIHLISTFLPQCVHDGSN
CHHHEECCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PETRTMLAWASTAAGICESLSSCISHHSLEHALSAFYPDIPHGAGLVMLSEAYFSHLARF
CCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHH
VPERMTHLGYFMGVDVDSLPEERQPEAFVHALAKLKADCGLAELKMSDFGVKRSDLPALA
HHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHCCCHHHEEHHHCCCCCCCHHHHH
RNARESMGGLFHVTPVELDEAAVLDIFEKAYR
HHHHHHHCCEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]