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The map label for this gene is tlpA [H]

Identifier: 78358008

GI number: 78358008

Start: 2952176

End: 2954197

Strand: Reverse

Name: tlpA [H]

Synonym: Dde_2968

Alternate gene names: 78358008

Gene position: 2954197-2952176 (Counterclockwise)

Preceding gene: 78358009

Following gene: 78358002

Centisome position: 79.2

GC content: 56.33

Gene sequence:

>2022_bases
ATGAAGATGAATCTCAGGGCACGCTTTCTGGTGCCGACACTGACTATTCTGGTTATCGGCATGGGGGCCTCGGCATGGCT
TACCCAGACATATTCCAAACAGGCGGTCACCGCGGCCGTCAACGCGCATATGACACAGGTTTCCGAATCTGTGGCCGGAC
TTATAGGCACCTGGGTGCAGGATGCCAAACGCGATCTTACGCTGCAGGCGCAGCGCGATGAGATTACACAGGCTTTTGCA
GGTGGCGATATGAATGAAGTCACCCGCGAAATGCAGCAGTTTAAAAAGAACTACCCCGACTTTGACGCTGTCAAACTGGC
GGACGCGGACGGAAATATTATTGCCAGCACCTACCCCCAAGAAGTCGGCAGGCTTGATATAAGCAGCCGGAAATACTTCA
GGGGAGCCATGAACGGAACCCCTGTGGTTTCAGACGCGCTGAAAAGTCAGTTGACAGGTAACCTGATTTTTGTGGTGTCT
GTACCGTGTATGCGTGACGGCCGAGTGGCCGGCGTCTTTCTGGGTACGCTGGAACTGGGCAGCTTTTCGGAACACTTTGT
GGCGCCGGTAACCATAGGAAAGGAAGGCTACGCATTTATTATGGCCTCCGACGGTAACGTGCTGGCGCATCCTGATTCCT
CGCGGCTGATGACCAATCTGCTGAAGCAGAACTGGGCCGGAGAAATGCTCAAAAACGATTCCGGCAAATTGAATCATGAG
GAAAATGGCCGGTGGAAAGAACTTGTATATTCACGGGAACCGGAAACCGGCTGGGTTGTGGGTGTGACCGCCTTTGAAGA
TGACATCTACTCTGCTGCTTACGAGCTTGCCAATATCGTGCGGCTCATATCCGTGATTGTGGCACTGCTTGTTGCCGGTG
TTCTGTTCCTTATTGTGCGCAATATCGCGGGGGCCATGAGTGAGACCGCGGGATACGCCGAGGCCGTTGCCGAAGGTCAG
CTGGACCATTCACTGCACGTTCAGCGGCAGGACGAAATAGGCGTACTGGCTGATGCGCTGCGTAAAATGGTGCAGAATCT
CAAAAGCATGATTCAGACGGCGGAAGCCAAGACCATTGAGGCCGAGGAACAGAGCAGAAAAGCCAATGTGGCCATGCAGG
AGGCTGAAGAAGCCCGCAAAGCGGCGGATAATGCCAAGCGCGAAGGTATGCTGCAGGCTGCCGCCCAGCTGGAGCACGTG
GTTCTGTCACTTTCGTCGGCGTCGGAACAGCTGGCGGCACAGGTGGAAGAAGCGAGCCGCGGAAGCGATGTGCAGCGCGA
GCGTACTTCTGAAACTGCCGCTGCCATAGAAGAAATGAATGCCACGGTGCTGGAAGTGGCCAGAAATGCGTCGGAAGCCG
CAGGAAGTGCCGACAATGCCAGAAACAATGCCGAAGAGGGACAGGGGATTGTGGAAGCGGTTATCCAGTCCATCACCGAG
GTGAAAAACCGCGCCACCAGTCTGAAGGAAAGCCTGAACACGCTGGGCGACCACGCCGAGGGTATAGGCAAGATCATGAC
CGTTATCAGCGACATAGCCGACCAGACAAATCTGCTGGCGCTTAACGCGGCCATTGAAGCTGCCCGTGCGGGCGATGCCG
GACGCGGGTTTGCCGTGGTGGCCGACGAAGTGCGTAAACTGGCCGAAAAGACCATGCAGGCCACCTCGGAAGTGGGCGCA
GCGGTAAGCGCCATCCAGCAGGGCACGCGTGAAAACATTGAAGGAATGGACAAGGCGGGCGAGGCCGTTTTGAAATCGAC
AGAACTTGCCGGTCGTGCTGGCAAGTCACTGGGCAGCATCCATTCCGTGGTGGAAAGCACCGCCGATCAGGTGCGCTCCA
TCGCAACTGCGTCGGAACAGCAGTCTGCCGCCAGCGAGCAGATAGCCCGTGGTGCGGAAGAAATAAACCGCATTGCGGCG
GAAACGTCCGAGGTGATGACGCAGTCCAGCGAAGCGGTAAGCAACGTCGCCCGTATGGCTCAGGAACTGCAAAACGTGGT
TGAGCAGCTTAAAAGACAGTAG

Upstream 100 bases:

>100_bases
GCGTGTTGCCGGTGCCGCGTGGAGTGCGGCGGCAGAGAGGAGCGTCTGATCCGGTTCTGCGGTCAGGCAGGAGCATGTTT
TTTTACAATGGGGCAATAGA

Downstream 100 bases:

>100_bases
CGCGGGCTGCGGCTGTCTGTGAAATATGAAGACTCCGTACCGGAGCACCGCAGGGTGGCCGGTACGGAGTCTTTTTTATG
GCTGTGCCGCAGAGGGCGGC

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MKMNLRARFLVPTLTILVIGMGASAWLTQTYSKQAVTAAVNAHMTQVSESVAGLIGTWVQDAKRDLTLQAQRDEITQAFA
GGDMNEVTREMQQFKKNYPDFDAVKLADADGNIIASTYPQEVGRLDISSRKYFRGAMNGTPVVSDALKSQLTGNLIFVVS
VPCMRDGRVAGVFLGTLELGSFSEHFVAPVTIGKEGYAFIMASDGNVLAHPDSSRLMTNLLKQNWAGEMLKNDSGKLNHE
ENGRWKELVYSREPETGWVVGVTAFEDDIYSAAYELANIVRLISVIVALLVAGVLFLIVRNIAGAMSETAGYAEAVAEGQ
LDHSLHVQRQDEIGVLADALRKMVQNLKSMIQTAEAKTIEAEEQSRKANVAMQEAEEARKAADNAKREGMLQAAAQLEHV
VLSLSSASEQLAAQVEEASRGSDVQRERTSETAAAIEEMNATVLEVARNASEAAGSADNARNNAEEGQGIVEAVIQSITE
VKNRATSLKESLNTLGDHAEGIGKIMTVISDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMQATSEVGA
AVSAIQQGTRENIEGMDKAGEAVLKSTELAGRAGKSLGSIHSVVESTADQVRSIATASEQQSAASEQIARGAEEINRIAA
ETSEVMTQSSEAVSNVARMAQELQNVVEQLKRQ

Sequences:

>Translated_673_residues
MKMNLRARFLVPTLTILVIGMGASAWLTQTYSKQAVTAAVNAHMTQVSESVAGLIGTWVQDAKRDLTLQAQRDEITQAFA
GGDMNEVTREMQQFKKNYPDFDAVKLADADGNIIASTYPQEVGRLDISSRKYFRGAMNGTPVVSDALKSQLTGNLIFVVS
VPCMRDGRVAGVFLGTLELGSFSEHFVAPVTIGKEGYAFIMASDGNVLAHPDSSRLMTNLLKQNWAGEMLKNDSGKLNHE
ENGRWKELVYSREPETGWVVGVTAFEDDIYSAAYELANIVRLISVIVALLVAGVLFLIVRNIAGAMSETAGYAEAVAEGQ
LDHSLHVQRQDEIGVLADALRKMVQNLKSMIQTAEAKTIEAEEQSRKANVAMQEAEEARKAADNAKREGMLQAAAQLEHV
VLSLSSASEQLAAQVEEASRGSDVQRERTSETAAAIEEMNATVLEVARNASEAAGSADNARNNAEEGQGIVEAVIQSITE
VKNRATSLKESLNTLGDHAEGIGKIMTVISDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMQATSEVGA
AVSAIQQGTRENIEGMDKAGEAVLKSTELAGRAGKSLGSIHSVVESTADQVRSIATASEQQSAASEQIARGAEEINRIAA
ETSEVMTQSSEAVSNVARMAQELQNVVEQLKRQ
>Mature_673_residues
MKMNLRARFLVPTLTILVIGMGASAWLTQTYSKQAVTAAVNAHMTQVSESVAGLIGTWVQDAKRDLTLQAQRDEITQAFA
GGDMNEVTREMQQFKKNYPDFDAVKLADADGNIIASTYPQEVGRLDISSRKYFRGAMNGTPVVSDALKSQLTGNLIFVVS
VPCMRDGRVAGVFLGTLELGSFSEHFVAPVTIGKEGYAFIMASDGNVLAHPDSSRLMTNLLKQNWAGEMLKNDSGKLNHE
ENGRWKELVYSREPETGWVVGVTAFEDDIYSAAYELANIVRLISVIVALLVAGVLFLIVRNIAGAMSETAGYAEAVAEGQ
LDHSLHVQRQDEIGVLADALRKMVQNLKSMIQTAEAKTIEAEEQSRKANVAMQEAEEARKAADNAKREGMLQAAAQLEHV
VLSLSSASEQLAAQVEEASRGSDVQRERTSETAAAIEEMNATVLEVARNASEAAGSADNARNNAEEGQGIVEAVIQSITE
VKNRATSLKESLNTLGDHAEGIGKIMTVISDIADQTNLLALNAAIEAARAGDAGRGFAVVADEVRKLAEKTMQATSEVGA
AVSAIQQGTRENIEGMDKAGEAVLKSTELAGRAGKSLGSIHSVVESTADQVRSIATASEQQSAASEQIARGAEEINRIAA
ETSEVMTQSSEAVSNVARMAQELQNVVEQLKRQ

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=369, Percent_Identity=30.0813008130081, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788195, Length=243, Percent_Identity=34.156378600823, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788194, Length=399, Percent_Identity=26.8170426065163, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1787690, Length=397, Percent_Identity=28.463476070529, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1789453, Length=270, Percent_Identity=28.1481481481481, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 72086; Mature: 72086

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMNLRARFLVPTLTILVIGMGASAWLTQTYSKQAVTAAVNAHMTQVSESVAGLIGTWVQ
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAKRDLTLQAQRDEITQAFAGGDMNEVTREMQQFKKNYPDFDAVKLADADGNIIASTYPQ
HHHHCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCHH
EVGRLDISSRKYFRGAMNGTPVVSDALKSQLTGNLIFVVSVPCMRDGRVAGVFLGTLELG
HHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEHHCCC
SFSEHFVAPVTIGKEGYAFIMASDGNVLAHPDSSRLMTNLLKQNWAGEMLKNDSGKLNHE
CCHHHCEEEEEECCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ENGRWKELVYSREPETGWVVGVTAFEDDIYSAAYELANIVRLISVIVALLVAGVLFLIVR
CCCCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIAGAMSETAGYAEAVAEGQLDHSLHVQRQDEIGVLADALRKMVQNLKSMIQTAEAKTIE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEEQSRKANVAMQEAEEARKAADNAKREGMLQAAAQLEHVVLSLSSASEQLAAQVEEASR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSDVQRERTSETAAAIEEMNATVLEVARNASEAAGSADNARNNAEEGQGIVEAVIQSITE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
VKNRATSLKESLNTLGDHAEGIGKIMTVISDIADQTNLLALNAAIEAARAGDAGRGFAVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEHHHHHHHHHCCCCCCCHHHH
ADEVRKLAEKTMQATSEVGAAVSAIQQGTRENIEGMDKAGEAVLKSTELAGRAGKSLGSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSVVESTADQVRSIATASEQQSAASEQIARGAEEINRIAAETSEVMTQSSEAVSNVARMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QELQNVVEQLKRQ
HHHHHHHHHHHCC
>Mature Secondary Structure
MKMNLRARFLVPTLTILVIGMGASAWLTQTYSKQAVTAAVNAHMTQVSESVAGLIGTWVQ
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAKRDLTLQAQRDEITQAFAGGDMNEVTREMQQFKKNYPDFDAVKLADADGNIIASTYPQ
HHHHCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCHH
EVGRLDISSRKYFRGAMNGTPVVSDALKSQLTGNLIFVVSVPCMRDGRVAGVFLGTLELG
HHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEHHCCC
SFSEHFVAPVTIGKEGYAFIMASDGNVLAHPDSSRLMTNLLKQNWAGEMLKNDSGKLNHE
CCHHHCEEEEEECCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ENGRWKELVYSREPETGWVVGVTAFEDDIYSAAYELANIVRLISVIVALLVAGVLFLIVR
CCCCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIAGAMSETAGYAEAVAEGQLDHSLHVQRQDEIGVLADALRKMVQNLKSMIQTAEAKTIE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEEQSRKANVAMQEAEEARKAADNAKREGMLQAAAQLEHVVLSLSSASEQLAAQVEEASR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSDVQRERTSETAAAIEEMNATVLEVARNASEAAGSADNARNNAEEGQGIVEAVIQSITE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
VKNRATSLKESLNTLGDHAEGIGKIMTVISDIADQTNLLALNAAIEAARAGDAGRGFAVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEHHHHHHHHHCCCCCCCHHHH
ADEVRKLAEKTMQATSEVGAAVSAIQQGTRENIEGMDKAGEAVLKSTELAGRAGKSLGSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSVVESTADQVRSIATASEQQSAASEQIARGAEEINRIAAETSEVMTQSSEAVSNVARMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QELQNVVEQLKRQ
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]