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The map label for this gene is algC [H]

Identifier: 78357985

GI number: 78357985

Start: 2924009

End: 2925382

Strand: Reverse

Name: algC [H]

Synonym: Dde_2945

Alternate gene names: 78357985

Gene position: 2925382-2924009 (Counterclockwise)

Preceding gene: 78357993

Following gene: 78357984

Centisome position: 78.42

GC content: 59.02

Gene sequence:

>1374_bases
ATGAAACCGGTTAACAAGGCTGTTTTCAGGGCTTATGATATTCGCGGTCTGGTGGATGTGGACTTTGATGAAGAATGGGT
GGAACTGCTGGGCAGGGCCGTGGGCACCTATATGCTGCGGCGCGGCATCGGCGCGGCGGTTACGGGGCACGACTGCCGGC
ACAGTTCTCCGGGGTACCATGCCGCACTGACCCGCGGCATGCTTTCCACCGGACTGGACGTGACCAGTGTGGGCATGGTG
CCTACACCTGTGCTGTATTTTGCGGTCAGGCACCTGAACAGACAGGGCGGGGTTGTCATCACTGCAAGCCATAATCCGCC
TGAATATAACGGGTTCAAGGTGTGGGCGGGCCGCACCACCATTCATACAGACCAGATAACAGCCATATACGACATACTGG
CCGCACGCGATTTTGAATCGGGCAGCGGCGCAGGGTGCGATGTGGACATTATTCCGGACTATATCGAGGCGGCTTCGCGC
GATATAACGCTCAGGCGGCCGGTGCGGGTGGTGCTGGACGGCGGCAACGGAGCCGGGGGGCTGGTGTGTGCGGAGCTGCT
GCGGCGTATCGGCGCCGATGTTGTGGAGCAGTACTGCGAGCCGGACGGCAGTTTTCCCAACCATCATCCGGATCCTGTGG
TGGAAAAAAACATGGGTGACCTGCAGGCACGCGTGCGGGCTGAAAAAGCCTGCTGCGGCATAGGACTGGACGGTGATGCG
GACAGGCTGGGCGTGGTGGACGAAAACGGGCGGCTGCTGTTCGGCGATCAGCTGCTGGCCATGTATGCCCGCGATACGCT
GCGCCGTTTTCCCGGTGCGCTGGTAATGGGAGACGTGAAGTGCTCGCATCTGCTTTTCAGAGATATCGAACAGCACGGTG
GCCGCCCGCTGATGTGGATAACCGGACATTCGGTCATGAAGGCCAAAATGCTTGAAGCAGATGCCAAGCTGGCGGGGGAA
ATGAGCGGTCACATGTTTTTCAATGACCGCTGGTACGGTTTTGATGACGCCATTTACGGAGCCGCGCGTTTTCTTGAAAT
TCTTGCGGCGTCGGATCAGCCTGTTTCGGCCATGCCGGGCTGGCCGGAAACAGCCAGTACGCCGGAACTGCATATGGAAT
GCCCCGATGCCGTGAAGTTTGACATTGTACGCAGAGCGCAGGAATTTTTCGGCAGCCGGTATACAGTAGATACCATTGAC
GGTGTGCGGCTGCTGTTTGAAGATGGCTGGGGACTTGTGCGCGCTTCCAACACCCAGCCTGTGCTGGTGCTGCGCTTTGA
GGCGCAGACGGCCGAGAGACTGGCACAGATACGTGCCATTGTTGAAAATCCTCTGCGCGACTGGGTAGCACAGGCTGTGA
AGGCGCAGGCCTGA

Upstream 100 bases:

>100_bases
CCGAAAAATAGGGCAGTTGCGAGGGGCGGTCAAGTGGGATAGCCATAAAGTTTAGGAATGTCGCAACGCGGACGAAACTG
TCGCACCTAACGGAGAACGT

Downstream 100 bases:

>100_bases
AAACGGCGCGGATGCCTGCGGCGCGCGCTGCAGGCGGTGTATCTTTTTACTGCTGCGGGTTGCCCCTGCAGCAGCATTGC
AGACCGCGCTTCAGCGGCGG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKPVNKAVFRAYDIRGLVDVDFDEEWVELLGRAVGTYMLRRGIGAAVTGHDCRHSSPGYHAALTRGMLSTGLDVTSVGMV
PTPVLYFAVRHLNRQGGVVITASHNPPEYNGFKVWAGRTTIHTDQITAIYDILAARDFESGSGAGCDVDIIPDYIEAASR
DITLRRPVRVVLDGGNGAGGLVCAELLRRIGADVVEQYCEPDGSFPNHHPDPVVEKNMGDLQARVRAEKACCGIGLDGDA
DRLGVVDENGRLLFGDQLLAMYARDTLRRFPGALVMGDVKCSHLLFRDIEQHGGRPLMWITGHSVMKAKMLEADAKLAGE
MSGHMFFNDRWYGFDDAIYGAARFLEILAASDQPVSAMPGWPETASTPELHMECPDAVKFDIVRRAQEFFGSRYTVDTID
GVRLLFEDGWGLVRASNTQPVLVLRFEAQTAERLAQIRAIVENPLRDWVAQAVKAQA

Sequences:

>Translated_457_residues
MKPVNKAVFRAYDIRGLVDVDFDEEWVELLGRAVGTYMLRRGIGAAVTGHDCRHSSPGYHAALTRGMLSTGLDVTSVGMV
PTPVLYFAVRHLNRQGGVVITASHNPPEYNGFKVWAGRTTIHTDQITAIYDILAARDFESGSGAGCDVDIIPDYIEAASR
DITLRRPVRVVLDGGNGAGGLVCAELLRRIGADVVEQYCEPDGSFPNHHPDPVVEKNMGDLQARVRAEKACCGIGLDGDA
DRLGVVDENGRLLFGDQLLAMYARDTLRRFPGALVMGDVKCSHLLFRDIEQHGGRPLMWITGHSVMKAKMLEADAKLAGE
MSGHMFFNDRWYGFDDAIYGAARFLEILAASDQPVSAMPGWPETASTPELHMECPDAVKFDIVRRAQEFFGSRYTVDTID
GVRLLFEDGWGLVRASNTQPVLVLRFEAQTAERLAQIRAIVENPLRDWVAQAVKAQA
>Mature_457_residues
MKPVNKAVFRAYDIRGLVDVDFDEEWVELLGRAVGTYMLRRGIGAAVTGHDCRHSSPGYHAALTRGMLSTGLDVTSVGMV
PTPVLYFAVRHLNRQGGVVITASHNPPEYNGFKVWAGRTTIHTDQITAIYDILAARDFESGSGAGCDVDIIPDYIEAASR
DITLRRPVRVVLDGGNGAGGLVCAELLRRIGADVVEQYCEPDGSFPNHHPDPVVEKNMGDLQARVRAEKACCGIGLDGDA
DRLGVVDENGRLLFGDQLLAMYARDTLRRFPGALVMGDVKCSHLLFRDIEQHGGRPLMWITGHSVMKAKMLEADAKLAGE
MSGHMFFNDRWYGFDDAIYGAARFLEILAASDQPVSAMPGWPETASTPELHMECPDAVKFDIVRRAQEFFGSRYTVDTID
GVRLLFEDGWGLVRASNTQPVLVLRFEAQTAERLAQIRAIVENPLRDWVAQAVKAQA

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=449, Percent_Identity=31.1804008908686, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1789566, Length=359, Percent_Identity=31.1977715877437, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50216; Mature: 50216

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVNKAVFRAYDIRGLVDVDFDEEWVELLGRAVGTYMLRRGIGAAVTGHDCRHSSPGYH
CCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHH
AALTRGMLSTGLDVTSVGMVPTPVLYFAVRHLNRQGGVVITASHNPPEYNGFKVWAGRTT
HHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCEE
IHTDQITAIYDILAARDFESGSGAGCDVDIIPDYIEAASRDITLRRPVRVVLDGGNGAGG
EEHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHCCCCEEEECCEEEEEECCCCCHH
LVCAELLRRIGADVVEQYCEPDGSFPNHHPDPVVEKNMGDLQARVRAEKACCGIGLDGDA
HHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCCC
DRLGVVDENGRLLFGDQLLAMYARDTLRRFPGALVMGDVKCSHLLFRDIEQHGGRPLMWI
CCCCEEECCCCEEEHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCEEEEE
TGHSVMKAKMLEADAKLAGEMSGHMFFNDRWYGFDDAIYGAARFLEILAASDQPVSAMPG
ECCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
WPETASTPELHMECPDAVKFDIVRRAQEFFGSRYTVDTIDGVRLLFEDGWGLVRASNTQP
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCEEEECCCCC
VLVLRFEAQTAERLAQIRAIVENPLRDWVAQAVKAQA
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPVNKAVFRAYDIRGLVDVDFDEEWVELLGRAVGTYMLRRGIGAAVTGHDCRHSSPGYH
CCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHH
AALTRGMLSTGLDVTSVGMVPTPVLYFAVRHLNRQGGVVITASHNPPEYNGFKVWAGRTT
HHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCEE
IHTDQITAIYDILAARDFESGSGAGCDVDIIPDYIEAASRDITLRRPVRVVLDGGNGAGG
EEHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHCCCCEEEECCEEEEEECCCCCHH
LVCAELLRRIGADVVEQYCEPDGSFPNHHPDPVVEKNMGDLQARVRAEKACCGIGLDGDA
HHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCCC
DRLGVVDENGRLLFGDQLLAMYARDTLRRFPGALVMGDVKCSHLLFRDIEQHGGRPLMWI
CCCCEEECCCCEEEHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCEEEEE
TGHSVMKAKMLEADAKLAGEMSGHMFFNDRWYGFDDAIYGAARFLEILAASDQPVSAMPG
ECCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
WPETASTPELHMECPDAVKFDIVRRAQEFFGSRYTVDTIDGVRLLFEDGWGLVRASNTQP
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCEEEECCCCC
VLVLRFEAQTAERLAQIRAIVENPLRDWVAQAVKAQA
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]