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The map label for this gene is lepB [H]

Identifier: 78357857

GI number: 78357857

Start: 2801914

End: 2802576

Strand: Reverse

Name: lepB [H]

Synonym: Dde_2816

Alternate gene names: 78357857

Gene position: 2802576-2801914 (Counterclockwise)

Preceding gene: 78357858

Following gene: 78357856

Centisome position: 75.13

GC content: 54.75

Gene sequence:

>663_bases
ATGCAAAACAAGCACGGCGACTTCTGCGCCGCCGCGCGCATGAGAAAGGAAAAACCCATGTCGGAACCGAGAAAGCATCC
CTTTGTGGAATTTCTGGAAGCTATTTCCGTGGCCGTGGTGCTGGCCCTTGTCATACGCACCTTTATTGTGCAGGCCTACA
CCATCCCTTCAGGCTCCATGCTTGAAACATTGCAGATAGGTGACTACCTGCTGGTGAACAAATTCAGCTACGGTGTGAAG
ATTCCCTTCACACATGACTATCTGCTGGAGCGTTCCGGCCCGGAACACGGTGATATCATTGTCTTTGAGTTTCCCGACAA
TCCCGATGTCGATTATATCAAACGTGTCATCGGCGTGCCCGGCGATGTCATAGAAGTGCGTGACAAAGAAGTATACCGCA
ACGGCCAGCGGCTGGAAGAACCCTATGCCGTGCACGGTGACCCCGGCTACCAGATGCGCAGGGACAACTTCGGCCCTGTG
ACCGTGCCCGGGGGCAGCTACTTCTGCCTTGGTGACAACCGCGACTTTTCGCAGGATTCGCGCTTCTGGCAGAACACCTT
TGTGCGTAAGGAAGCCATCAGAGGCAAGGCGCTGTTCATTTACTGGTCCATGGACGGCTTCACCGACATCCGCTGGGGCC
GCATAGGCTCTTTTGTGCATTGA

Upstream 100 bases:

>100_bases
TGAAGCGCATGGGCAACGTCGAACTGCCGCAGGAGGCCTTTCTTGCCGCGCTGCAGGTGGATGACGAATAGCGGCAGGGC
GCCCGGCACAGCAGAAAACG

Downstream 100 bases:

>100_bases
CCCCGCCTGCGGGGCGGCTGCCGTACACAGGTTGCAGCCGCCGCAGCCCCGCAGCCCCGCAGCATATGATATGACAACGC
CCCGCCGTCCCGTGTGACGG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MQNKHGDFCAAARMRKEKPMSEPRKHPFVEFLEAISVAVVLALVIRTFIVQAYTIPSGSMLETLQIGDYLLVNKFSYGVK
IPFTHDYLLERSGPEHGDIIVFEFPDNPDVDYIKRVIGVPGDVIEVRDKEVYRNGQRLEEPYAVHGDPGYQMRRDNFGPV
TVPGGSYFCLGDNRDFSQDSRFWQNTFVRKEAIRGKALFIYWSMDGFTDIRWGRIGSFVH

Sequences:

>Translated_220_residues
MQNKHGDFCAAARMRKEKPMSEPRKHPFVEFLEAISVAVVLALVIRTFIVQAYTIPSGSMLETLQIGDYLLVNKFSYGVK
IPFTHDYLLERSGPEHGDIIVFEFPDNPDVDYIKRVIGVPGDVIEVRDKEVYRNGQRLEEPYAVHGDPGYQMRRDNFGPV
TVPGGSYFCLGDNRDFSQDSRFWQNTFVRKEAIRGKALFIYWSMDGFTDIRWGRIGSFVH
>Mature_220_residues
MQNKHGDFCAAARMRKEKPMSEPRKHPFVEFLEAISVAVVLALVIRTFIVQAYTIPSGSMLETLQIGDYLLVNKFSYGVK
IPFTHDYLLERSGPEHGDIIVFEFPDNPDVDYIKRVIGVPGDVIEVRDKEVYRNGQRLEEPYAVHGDPGYQMRRDNFGPV
TVPGGSYFCLGDNRDFSQDSRFWQNTFVRKEAIRGKALFIYWSMDGFTDIRWGRIGSFVH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=119, Percent_Identity=41.1764705882353, Blast_Score=104, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25293; Mature: 25293

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKHGDFCAAARMRKEKPMSEPRKHPFVEFLEAISVAVVLALVIRTFIVQAYTIPSGSM
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCH
LETLQIGDYLLVNKFSYGVKIPFTHDYLLERSGPEHGDIIVFEFPDNPDVDYIKRVIGVP
HHHHCCCCEEEEEECCCCEECCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCC
GDVIEVRDKEVYRNGQRLEEPYAVHGDPGYQMRRDNFGPVTVPGGSYFCLGDNRDFSQDS
CCEEEECCHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCEEECCCCEEEECCCCCCCHHH
RFWQNTFVRKEAIRGKALFIYWSMDGFTDIRWGRIGSFVH
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQNKHGDFCAAARMRKEKPMSEPRKHPFVEFLEAISVAVVLALVIRTFIVQAYTIPSGSM
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCH
LETLQIGDYLLVNKFSYGVKIPFTHDYLLERSGPEHGDIIVFEFPDNPDVDYIKRVIGVP
HHHHCCCCEEEEEECCCCEECCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCC
GDVIEVRDKEVYRNGQRLEEPYAVHGDPGYQMRRDNFGPVTVPGGSYFCLGDNRDFSQDS
CCEEEECCHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCEEECCCCEEEECCCCCCCHHH
RFWQNTFVRKEAIRGKALFIYWSMDGFTDIRWGRIGSFVH
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]