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The map label for this gene is ppnK

Identifier: 78357660

GI number: 78357660

Start: 2633999

End: 2634877

Strand: Reverse

Name: ppnK

Synonym: Dde_2618

Alternate gene names: 78357660

Gene position: 2634877-2633999 (Counterclockwise)

Preceding gene: 78357664

Following gene: 78357659

Centisome position: 70.64

GC content: 61.21

Gene sequence:

>879_bases
ATGCATCGCGAATTGAAAAGAGTTTTTATAGTCACCAAGCAGGCCCATGCCGGAGCCGCTGCCCTTGCCGCCGATATGCA
GGCATGGTTTGCCGCGCGCGGCATAGAAGCGGCAACGGAAGAAAACGATACCGCATCGGCTCTTCCTGACTTTGCGCGCA
GTGCTTCGTGCATCATGGTGCTGGGCGGCGACGGCACCATGCTGAGTGTTTCGCGCAGAGCAGTGGGGCTTGATGTGCCG
TTGCTCGGCGTCAATCTGGGCAAGGTGGGCTTTCTGGCAGAGGTTTCAGCCGCAGGCTGGCAGCAGGCTTTTACCCGGCT
GGCGGAAAACGGCCTGACGTGTTCGGAGCGGCTGGCGCTGCATTTTGCCGTGAGCCGGGAAGGACGCTGCGTTTTTGAGG
GCACGGCCGTCAACGATGTTGTGCTGCACCGCGGCGTACTGGCCCGGGTGATCAATCTGGGGCTGGGCGTGGACGGCGAA
TGGCTGGGCGATCTGCGTGCGGACGGGCTTATCGTGTCCACCCCCACCGGAGCCACCGGGTATGCCGTATCGGCGGGGGG
ACCGCTGGTGCATCCCGATATGTCTGTCTATGCCATCACACCTATCTGTCCGTTTCTCAACAATTTTCATCCCATGGTGC
TGGCCGGTTCCATGCGGTTCGAGATCAGGATTCTGGAAGGGCCGCAGGAAGTGTATGTGACGCAGGACGGTCAGGAATGC
TTTGCCCTGCAGGCGGGTGATCTTGTCACCGTCACGCAGGCTTCCCGCGGGTTGCTTTTTGTCGCTGTTGAAGGCTCCAC
CTATTTCACGCGGCTGCGTGCCAAAGGCTTTGTACGCGACCCGAGAGGACGCGGGCGGGCCGTTCCCGCATCAAGCTGA

Upstream 100 bases:

>100_bases
GCGGGCTTTTATTCTTGTCCGGCGGGCGCATGTGGGGTAGTCCCTGCCGCAAAGCCTTACGGCTTCTTGATGGAATCTGT
GCTTTCTACTAGGGATAGTC

Downstream 100 bases:

>100_bases
TGCGCGGCCGTTTTTCCGGAGGTTAGAATGACTGCGCTTCCCGAACTTGCTTCCGTGCGCGAAGTGCGCCAGGGGGTTGA
TCCTGTGCTGGATGCATGGC

Product: NAD(+) kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MHRELKRVFIVTKQAHAGAAALAADMQAWFAARGIEAATEENDTASALPDFARSASCIMVLGGDGTMLSVSRRAVGLDVP
LLGVNLGKVGFLAEVSAAGWQQAFTRLAENGLTCSERLALHFAVSREGRCVFEGTAVNDVVLHRGVLARVINLGLGVDGE
WLGDLRADGLIVSTPTGATGYAVSAGGPLVHPDMSVYAITPICPFLNNFHPMVLAGSMRFEIRILEGPQEVYVTQDGQEC
FALQAGDLVTVTQASRGLLFVAVEGSTYFTRLRAKGFVRDPRGRGRAVPASS

Sequences:

>Translated_292_residues
MHRELKRVFIVTKQAHAGAAALAADMQAWFAARGIEAATEENDTASALPDFARSASCIMVLGGDGTMLSVSRRAVGLDVP
LLGVNLGKVGFLAEVSAAGWQQAFTRLAENGLTCSERLALHFAVSREGRCVFEGTAVNDVVLHRGVLARVINLGLGVDGE
WLGDLRADGLIVSTPTGATGYAVSAGGPLVHPDMSVYAITPICPFLNNFHPMVLAGSMRFEIRILEGPQEVYVTQDGQEC
FALQAGDLVTVTQASRGLLFVAVEGSTYFTRLRAKGFVRDPRGRGRAVPASS
>Mature_292_residues
MHRELKRVFIVTKQAHAGAAALAADMQAWFAARGIEAATEENDTASALPDFARSASCIMVLGGDGTMLSVSRRAVGLDVP
LLGVNLGKVGFLAEVSAAGWQQAFTRLAENGLTCSERLALHFAVSREGRCVFEGTAVNDVVLHRGVLARVINLGLGVDGE
WLGDLRADGLIVSTPTGATGYAVSAGGPLVHPDMSVYAITPICPFLNNFHPMVLAGSMRFEIRILEGPQEVYVTQDGQEC
FALQAGDLVTVTQASRGLLFVAVEGSTYFTRLRAKGFVRDPRGRGRAVPASS

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=283, Percent_Identity=28.2685512367491, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788968, Length=284, Percent_Identity=27.8169014084507, Blast_Score=134, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6322509, Length=240, Percent_Identity=31.6666666666667, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320794, Length=228, Percent_Identity=28.0701754385965, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325068, Length=178, Percent_Identity=34.2696629213483, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161077047, Length=224, Percent_Identity=31.6964285714286, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573828, Length=260, Percent_Identity=30, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573832, Length=260, Percent_Identity=30, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573830, Length=260, Percent_Identity=30, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573826, Length=260, Percent_Identity=30, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363321, Length=249, Percent_Identity=26.5060240963855, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653422, Length=247, Percent_Identity=26.7206477732794, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129957, Length=285, Percent_Identity=25.6140350877193, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281363323, Length=247, Percent_Identity=26.7206477732794, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653424, Length=249, Percent_Identity=26.5060240963855, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_DESDG (Q30Y32)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389109.1
- ProteinModelPortal:   Q30Y32
- SMR:   Q30Y32
- STRING:   Q30Y32
- GeneID:   3757640
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2618
- NMPDR:   fig|207559.3.peg.2805
- eggNOG:   COG0061
- HOGENOM:   HBG713904
- OMA:   LNEMVLH
- ProtClustDB:   CLSK705469
- BioCyc:   DDES207559:DDE_2618-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 30945; Mature: 30945

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRELKRVFIVTKQAHAGAAALAADMQAWFAARGIEAATEENDTASALPDFARSASCIMV
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCHHHHCCCCEEEE
LGGDGTMLSVSRRAVGLDVPLLGVNLGKVGFLAEVSAAGWQQAFTRLAENGLTCSERLAL
ECCCCCEEEEECCEECCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHEEE
HFAVSREGRCVFEGTAVNDVVLHRGVLARVINLGLGVDGEWLGDLRADGLIVSTPTGATG
EEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEECCCCCCC
YAVSAGGPLVHPDMSVYAITPICPFLNNFHPMVLAGSMRFEIRILEGPQEVYVTQDGQEC
EEEECCCCEECCCCCEEEECCHHHHHCCCCCEEEECCEEEEEEEEECCCEEEEEECCCEE
FALQAGDLVTVTQASRGLLFVAVEGSTYFTRLRAKGFVRDPRGRGRAVPASS
EEEECCCEEEEEECCCCEEEEEECCCCEEEEEECCCCEECCCCCCCCCCCCC
>Mature Secondary Structure
MHRELKRVFIVTKQAHAGAAALAADMQAWFAARGIEAATEENDTASALPDFARSASCIMV
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCHHHHCCCCEEEE
LGGDGTMLSVSRRAVGLDVPLLGVNLGKVGFLAEVSAAGWQQAFTRLAENGLTCSERLAL
ECCCCCEEEEECCEECCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHEEE
HFAVSREGRCVFEGTAVNDVVLHRGVLARVINLGLGVDGEWLGDLRADGLIVSTPTGATG
EEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEECCCCCCC
YAVSAGGPLVHPDMSVYAITPICPFLNNFHPMVLAGSMRFEIRILEGPQEVYVTQDGQEC
EEEECCCCEECCCCCEEEECCHHHHHCCCCCEEEECCEEEEEEEEECCCEEEEEECCCEE
FALQAGDLVTVTQASRGLLFVAVEGSTYFTRLRAKGFVRDPRGRGRAVPASS
EEEECCCEEEEEECCCCEEEEEECCCCEEEEEECCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA