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The map label for this gene is ahpC [C]

Identifier: 78357602

GI number: 78357602

Start: 2578541

End: 2579188

Strand: Direct

Name: ahpC [C]

Synonym: Dde_2560

Alternate gene names: 78357602

Gene position: 2578541-2579188 (Clockwise)

Preceding gene: 78357600

Following gene: 78357603

Centisome position: 69.13

GC content: 52.62

Gene sequence:

>648_bases
ATGGAAGAAGGCAAATTCGTGCTTATCGGCGACGCACTGCCCGAAATGCACGTCACCACCACAAGAGGTCCCATGACGCT
GCCCGGCGACCTGAAAGGCAAATGGTTTGTGCTTTTCAGCCATCCGGCAGACTATACTCCCGTATGCACCACCGAATTCG
TGGCGTTTCAGAAACGGTACGATGAATTCCGCAAACTGAATTGCGAACTCGTGGGCCTTTCCATTGATCAGGTTTTCTCG
CACATCAAATGGGTTGACTGGATCAAGGAAAAAATCGGCGTGGAAATTGAGTTTCCCATCATCGCCGATGATATGGGACA
GGTTGCCTCGCGCCTCGGCATGATTCACCCCGGCAAGGGGACCAATACCGTGCGCGCCGTCTTCATAGTGGACGACAAAG
GCATTGTCAGAATAATCTTTTATTACCCGCAGGAACTGGGCAGAAACATGGATGAAATTCTGCGTGCGGTGAAAGGCATG
CAGGTTTCCGACGCACAGTCCGTCGCCATTCCGGCAGGATGGCCCGAAAATGAAATAGTCCGCGATCACGTTATTGTACC
GCCGCCCAAAAGCGTGCAGGAAGCACAGAAGCGCCTTACAGAAGGCCACGAATGCTACGACTGGTGGTTCTGCCACAAAA
AGCTGTAG

Upstream 100 bases:

>100_bases
TTTTACCGAAAAGGGCTTCACGGGGGTTCCAACGCGGCTAATTTGTGCTAGTGTGGTCAGCACTCGCAAACCTCTACTTT
CATCCCTGGAGGACACAACC

Downstream 100 bases:

>100_bases
CACAAGGCATCACTGGCCGCCATGACGGCACAGGACGCCACACGAACATTCCGCGCGCCCGGCACCGCGACGGCATCCGC
TTTTCCGGCGCCGTCCGGTA

Product: 3-Cys thioredoxin peroxidase / 1-Cys peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MEEGKFVLIGDALPEMHVTTTRGPMTLPGDLKGKWFVLFSHPADYTPVCTTEFVAFQKRYDEFRKLNCELVGLSIDQVFS
HIKWVDWIKEKIGVEIEFPIIADDMGQVASRLGMIHPGKGTNTVRAVFIVDDKGIVRIIFYYPQELGRNMDEILRAVKGM
QVSDAQSVAIPAGWPENEIVRDHVIVPPPKSVQEAQKRLTEGHECYDWWFCHKKL

Sequences:

>Translated_215_residues
MEEGKFVLIGDALPEMHVTTTRGPMTLPGDLKGKWFVLFSHPADYTPVCTTEFVAFQKRYDEFRKLNCELVGLSIDQVFS
HIKWVDWIKEKIGVEIEFPIIADDMGQVASRLGMIHPGKGTNTVRAVFIVDDKGIVRIIFYYPQELGRNMDEILRAVKGM
QVSDAQSVAIPAGWPENEIVRDHVIVPPPKSVQEAQKRLTEGHECYDWWFCHKKL
>Mature_215_residues
MEEGKFVLIGDALPEMHVTTTRGPMTLPGDLKGKWFVLFSHPADYTPVCTTEFVAFQKRYDEFRKLNCELVGLSIDQVFS
HIKWVDWIKEKIGVEIEFPIIADDMGQVASRLGMIHPGKGTNTVRAVFIVDDKGIVRIIFYYPQELGRNMDEILRAVKGM
QVSDAQSVAIPAGWPENEIVRDHVIVPPPKSVQEAQKRLTEGHECYDWWFCHKKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=157, Percent_Identity=38.8535031847134, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI32455266, Length=157, Percent_Identity=38.8535031847134, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI32455264, Length=157, Percent_Identity=38.8535031847134, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4758638, Length=205, Percent_Identity=36.5853658536585, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI32189392, Length=157, Percent_Identity=36.9426751592357, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI5453549, Length=162, Percent_Identity=38.2716049382716, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI5802974, Length=174, Percent_Identity=31.6091954022989, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI32483377, Length=174, Percent_Identity=31.6091954022989, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI33188454, Length=58, Percent_Identity=50, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1786822, Length=150, Percent_Identity=31.3333333333333, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25153706, Length=205, Percent_Identity=35.1219512195122, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17554494, Length=150, Percent_Identity=37.3333333333333, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI193204376, Length=172, Percent_Identity=34.3023255813954, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI32565831, Length=172, Percent_Identity=34.3023255813954, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319407, Length=204, Percent_Identity=40.6862745098039, Blast_Score=145, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6323613, Length=144, Percent_Identity=31.25, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320661, Length=144, Percent_Identity=31.25, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581278, Length=179, Percent_Identity=39.6648044692737, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17975518, Length=205, Percent_Identity=36.0975609756098, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24652434, Length=205, Percent_Identity=36.0975609756098, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24652436, Length=205, Percent_Identity=36.0975609756098, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17157991, Length=147, Percent_Identity=38.0952380952381, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24641739, Length=147, Percent_Identity=38.0952380952381, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17738015, Length=150, Percent_Identity=34.6666666666667, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24656348, Length=143, Percent_Identity=33.5664335664336, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17864676, Length=143, Percent_Identity=33.5664335664336, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21357347, Length=146, Percent_Identity=35.6164383561644, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 24559; Mature: 24559

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEGKFVLIGDALPEMHVTTTRGPMTLPGDLKGKWFVLFSHPADYTPVCTTEFVAFQKRY
CCCCCEEEEECCCCCEEEEECCCCEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
DEFRKLNCELVGLSIDQVFSHIKWVDWIKEKIGVEIEFPIIADDMGQVASRLGMIHPGKG
HHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCEEEECEECCHHHHHHHHHCCCCCCCC
TNTVRAVFIVDDKGIVRIIFYYPQELGRNMDEILRAVKGMQVSDAQSVAIPAGWPENEIV
CCEEEEEEEECCCCEEEEEEECCHHHCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCHH
RDHVIVPPPKSVQEAQKRLTEGHECYDWWFCHKKL
HCCEECCCCHHHHHHHHHHHCCCCEEEEEEEECCC
>Mature Secondary Structure
MEEGKFVLIGDALPEMHVTTTRGPMTLPGDLKGKWFVLFSHPADYTPVCTTEFVAFQKRY
CCCCCEEEEECCCCCEEEEECCCCEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
DEFRKLNCELVGLSIDQVFSHIKWVDWIKEKIGVEIEFPIIADDMGQVASRLGMIHPGKG
HHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCEEEECEECCHHHHHHHHHCCCCCCCC
TNTVRAVFIVDDKGIVRIIFYYPQELGRNMDEILRAVKGMQVSDAQSVAIPAGWPENEIV
CCEEEEEEEECCCCEEEEEEECCHHHCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCHH
RDHVIVPPPKSVQEAQKRLTEGHECYDWWFCHKKL
HCCEECCCCHHHHHHHHHHHCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]