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The map label for this gene is uvrA [H]

Identifier: 78357529

GI number: 78357529

Start: 2505290

End: 2508070

Strand: Reverse

Name: uvrA [H]

Synonym: Dde_2486

Alternate gene names: 78357529

Gene position: 2508070-2505290 (Counterclockwise)

Preceding gene: 78357530

Following gene: 78357528

Centisome position: 67.24

GC content: 58.18

Gene sequence:

>2781_bases
ATGAGCAAACCCTGCATTCATATAGAAGGTGCCCGTCAGCACAACCTGAAAAACCTGACGCTGGATATTCCCAGAGACGA
ACTGGTCGTAGTCTGCGGTCCGTCCGGTTCGGGCAAATCCACCCTTGCGTTCGACCTTGTCTATGCCGAAGGGCAGCGGC
GTTATGTGGAATCGCTTTCCGCCTATGCGCGTCAGTTTCTGCCCCAGATGGACAAGCCTGATGTGGATAAGATCGAGGGG
TTGTCTCCGGCCATATCGCTGGAACAGCAGTCCACTTCGCGTAACCCGCGTTCCACAGTGGGAACAGTGACCGAGGTGTA
CGACTTTCTGCGTGTTTTTTATGCCCGGCTGGGCATGATGTATTGCCCCAAGTGCGGCAAGCCCATTGCCGCGCGTGCCG
CGGACGAGATCATCGCCGATATTCTGTCCATGGAGCAGGGCACCAAGTTCATGGTCATGGCGCCTTTGGTGGAACACCAG
AAGGGAACGCATGCAGACAGGCTTAAAAGGCTGAAAGCACAAGGCTTTGTGCGTATCCGGCTGAACGGCGAAGTTATGAC
GCTGGACGAGGTGCCGGCTCTTGAAAAAAACAAAAAGCATTCCATTGATCTGGTGGTGGACCGGCTGGTGCTTAAAGACG
GCATACGGGGACGCCTTGCGGATTCTGTGGAACTGGCTCTGCGTTTTGGCGAGGGGCGACTTATCGTCAGTATTCCCGGC
GGGGCAGAACAGGTGCACAGCACCGAATCTGTGTGTCCCACCTGCAAGCTCAGCCTGCCGCCGCTCAGCCCGCAGCTTTT
TTCATTCAACAGCCCGCAAGGGGCGTGTCCGCGGTGTTCCGGTATAGGCAGCATCGATTATTTCGAGCCCAATCTTCTCG
CCCCCAACAAGGGCCTGTCGCTTGTGTCCGGCGGCCTGCTGCCGTGGAAAAACCCTAAAGTATTCGAGCGGTACAAGCCT
GCTCTTGAAGCGTTGGGCAAAGAACTGGGGTTTGCTGCCGACACGCCGTTTCGCGAGTATTCCGAAAAGGCGTGGAATGC
ATTGTTTCACGGAGAAAAAGAGACCGGCTGGCCGGGAGTGGTTCTGCTGCTGGAAAGGGGAATGCAGCTGGGCAGCCAGT
GGCGTGACGAACTTTCGCGGTACCGGCAGTCGCATCCGTGTCCGGCATGTGACGGCGCGCGGCTGAAACCGGAAGCGCTG
GCCGTCCGAGTGGACGATCTGAATATTTCGCAGTTCTGCTCATTGTCCATAACCCGTGCGCTTGAATGGCTGCGCGGGCG
TGATTTCAGACAATCGCAGGCGGTCATTGCCGAGCCGCTGCTCAAGGAACTGACTCACCGCCTCGGGTTCATGGAGAATG
TGGGGCTTGATTATATTTCGCTGGGCCGCAACATGTCCACCCTGTCCGGCGGAGAAGCTCAGCGCATCAGGCTGGCTTCG
CAGCTGGGATCCGGTCTCGTGGGGGTTACCTATGTGCTGGACGAACCCTCCATCGGCCTGCACCCCAAGGATAATGAGCG
GCTCATCCGTACGCTGCGCAGTCTGCAGAAGAGGGGCAATACCGTACTTGTGGTGGAACACGACGAAGCCACCATTCTGG
AAGCCGACACGGTGGTGGAACTGGGCCCCGGTTCGGGAATGCTCGGCGGCGAAATAGTGTTCAACGGCAGTGTGAAGTCG
TTGCTGAGCGATTCGGATTCGCTGACGGCCCGCTATCTGCGGGGCGAGATGACCATCCCGCTGCCGGAAAAACGGCGGCA
GGGCAGCGGCAGCATTGTCCTGCGCGGGGTGACCACCAACAATCTGCAGGATATCGATTGTGAAATTCCTCTGGGGGCGC
TTACCTGCGTCACCGGTCCTTCCGGATCGGGCAAAAGCTCGCTTGTGGTTGATTCGCTGTACAAGCATATCGCACTGCAT
CAGTCCATCAAAGTGGACAGCCCCGGGCAGATACGGGGCATAGACGGGCTGGAGAACATCGAACGGCTGGTGGCCATCGA
CCAGACGCCCATCGGGCGTACTCCACGCTCCAACCCCGCCACCTACACAAAGATATTTGATGAAATCCGCAATATTTTTG
CCATGACGCCCGATGCCCGCAAACGCGGTTACAAACCGGGGCGGTTCAGCTTCAACGTGCGCGGCGGGCGGTGCGAAGCC
TGCGGCGGCGACGGGCAGATACGTGTGGAGATGCATTTTCTGCCCGATATCTATGTGACCTGCGATGTGTGCGGTGGCAA
GCGCTATAACCATGAAACGCTTGAAGTCCGTTACAAGGGTATGAACATTGCCGATGTGCTGGGCATGACTGTGCGTCAGG
CAAAGGCGTTTTTTGAAAATTACCCTGCGCTTGAAAGACGGCTTGCCGTGCTTGAGGATGTGGGGCTTGAATATCTGCGG
CTGGGGCAGCCTGCCACCACGTTGTCCGGCGGCGAGGCCCAGCGGATCAAGATTTCGCGGGAACTGGGCAAACGCAGTCT
GCCCGGCACGCTGTATATTCTTGACGAACCGACAACAGGTCTGCACATGCACGAGGTCGGCAAACTTATCCGGGTGCTGC
ATCAGCTGGTGGACAGAGGCGCCACGGTGGTTGTCATCGAGCATAACACCGATGTCATCATGGCGGCGGACACTGTCATC
GATCTGGGGCCGGGCGGGGGTGAATACGGGGGGCGTATCGTTTCCAGCGGTACTCCCGAAGAAATCATGGCCGATCCGGC
TTCTGTTACAGGAAGTTTTTTGAAGCACGAGGCCGTGGCGGTCAAGGCGGCAGGGCGCTAG

Upstream 100 bases:

>100_bases
AAAACATTCATCCCTTGCTCTTCTATTGTAAGGCATTATCATTAAGCGTCCGGCGCCGGAATATTCTCAGGGCGCCGCTT
AATGCGCACACGGAGAATTC

Downstream 100 bases:

>100_bases
CCACCCCGCCTGTCTGTGTTCCGGCGTAATCCGGCGCCGCAGCGGAAATTCCGCTGCGGCGCTTTTTGTGTGCTGCAGAA
AAGGGACGCGCGGGTGGATT

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 926; Mature: 925

Protein sequence:

>926_residues
MSKPCIHIEGARQHNLKNLTLDIPRDELVVVCGPSGSGKSTLAFDLVYAEGQRRYVESLSAYARQFLPQMDKPDVDKIEG
LSPAISLEQQSTSRNPRSTVGTVTEVYDFLRVFYARLGMMYCPKCGKPIAARAADEIIADILSMEQGTKFMVMAPLVEHQ
KGTHADRLKRLKAQGFVRIRLNGEVMTLDEVPALEKNKKHSIDLVVDRLVLKDGIRGRLADSVELALRFGEGRLIVSIPG
GAEQVHSTESVCPTCKLSLPPLSPQLFSFNSPQGACPRCSGIGSIDYFEPNLLAPNKGLSLVSGGLLPWKNPKVFERYKP
ALEALGKELGFAADTPFREYSEKAWNALFHGEKETGWPGVVLLLERGMQLGSQWRDELSRYRQSHPCPACDGARLKPEAL
AVRVDDLNISQFCSLSITRALEWLRGRDFRQSQAVIAEPLLKELTHRLGFMENVGLDYISLGRNMSTLSGGEAQRIRLAS
QLGSGLVGVTYVLDEPSIGLHPKDNERLIRTLRSLQKRGNTVLVVEHDEATILEADTVVELGPGSGMLGGEIVFNGSVKS
LLSDSDSLTARYLRGEMTIPLPEKRRQGSGSIVLRGVTTNNLQDIDCEIPLGALTCVTGPSGSGKSSLVVDSLYKHIALH
QSIKVDSPGQIRGIDGLENIERLVAIDQTPIGRTPRSNPATYTKIFDEIRNIFAMTPDARKRGYKPGRFSFNVRGGRCEA
CGGDGQIRVEMHFLPDIYVTCDVCGGKRYNHETLEVRYKGMNIADVLGMTVRQAKAFFENYPALERRLAVLEDVGLEYLR
LGQPATTLSGGEAQRIKISRELGKRSLPGTLYILDEPTTGLHMHEVGKLIRVLHQLVDRGATVVVIEHNTDVIMAADTVI
DLGPGGGEYGGRIVSSGTPEEIMADPASVTGSFLKHEAVAVKAAGR

Sequences:

>Translated_926_residues
MSKPCIHIEGARQHNLKNLTLDIPRDELVVVCGPSGSGKSTLAFDLVYAEGQRRYVESLSAYARQFLPQMDKPDVDKIEG
LSPAISLEQQSTSRNPRSTVGTVTEVYDFLRVFYARLGMMYCPKCGKPIAARAADEIIADILSMEQGTKFMVMAPLVEHQ
KGTHADRLKRLKAQGFVRIRLNGEVMTLDEVPALEKNKKHSIDLVVDRLVLKDGIRGRLADSVELALRFGEGRLIVSIPG
GAEQVHSTESVCPTCKLSLPPLSPQLFSFNSPQGACPRCSGIGSIDYFEPNLLAPNKGLSLVSGGLLPWKNPKVFERYKP
ALEALGKELGFAADTPFREYSEKAWNALFHGEKETGWPGVVLLLERGMQLGSQWRDELSRYRQSHPCPACDGARLKPEAL
AVRVDDLNISQFCSLSITRALEWLRGRDFRQSQAVIAEPLLKELTHRLGFMENVGLDYISLGRNMSTLSGGEAQRIRLAS
QLGSGLVGVTYVLDEPSIGLHPKDNERLIRTLRSLQKRGNTVLVVEHDEATILEADTVVELGPGSGMLGGEIVFNGSVKS
LLSDSDSLTARYLRGEMTIPLPEKRRQGSGSIVLRGVTTNNLQDIDCEIPLGALTCVTGPSGSGKSSLVVDSLYKHIALH
QSIKVDSPGQIRGIDGLENIERLVAIDQTPIGRTPRSNPATYTKIFDEIRNIFAMTPDARKRGYKPGRFSFNVRGGRCEA
CGGDGQIRVEMHFLPDIYVTCDVCGGKRYNHETLEVRYKGMNIADVLGMTVRQAKAFFENYPALERRLAVLEDVGLEYLR
LGQPATTLSGGEAQRIKISRELGKRSLPGTLYILDEPTTGLHMHEVGKLIRVLHQLVDRGATVVVIEHNTDVIMAADTVI
DLGPGGGEYGGRIVSSGTPEEIMADPASVTGSFLKHEAVAVKAAGR
>Mature_925_residues
SKPCIHIEGARQHNLKNLTLDIPRDELVVVCGPSGSGKSTLAFDLVYAEGQRRYVESLSAYARQFLPQMDKPDVDKIEGL
SPAISLEQQSTSRNPRSTVGTVTEVYDFLRVFYARLGMMYCPKCGKPIAARAADEIIADILSMEQGTKFMVMAPLVEHQK
GTHADRLKRLKAQGFVRIRLNGEVMTLDEVPALEKNKKHSIDLVVDRLVLKDGIRGRLADSVELALRFGEGRLIVSIPGG
AEQVHSTESVCPTCKLSLPPLSPQLFSFNSPQGACPRCSGIGSIDYFEPNLLAPNKGLSLVSGGLLPWKNPKVFERYKPA
LEALGKELGFAADTPFREYSEKAWNALFHGEKETGWPGVVLLLERGMQLGSQWRDELSRYRQSHPCPACDGARLKPEALA
VRVDDLNISQFCSLSITRALEWLRGRDFRQSQAVIAEPLLKELTHRLGFMENVGLDYISLGRNMSTLSGGEAQRIRLASQ
LGSGLVGVTYVLDEPSIGLHPKDNERLIRTLRSLQKRGNTVLVVEHDEATILEADTVVELGPGSGMLGGEIVFNGSVKSL
LSDSDSLTARYLRGEMTIPLPEKRRQGSGSIVLRGVTTNNLQDIDCEIPLGALTCVTGPSGSGKSSLVVDSLYKHIALHQ
SIKVDSPGQIRGIDGLENIERLVAIDQTPIGRTPRSNPATYTKIFDEIRNIFAMTPDARKRGYKPGRFSFNVRGGRCEAC
GGDGQIRVEMHFLPDIYVTCDVCGGKRYNHETLEVRYKGMNIADVLGMTVRQAKAFFENYPALERRLAVLEDVGLEYLRL
GQPATTLSGGEAQRIKISRELGKRSLPGTLYILDEPTTGLHMHEVGKLIRVLHQLVDRGATVVVIEHNTDVIMAADTVID
LGPGGGEYGGRIVSSGTPEEIMADPASVTGSFLKHEAVAVKAAGR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=937, Percent_Identity=50.4802561366062, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI1788644, Length=145, Percent_Identity=31.0344827586207, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 101394; Mature: 101263

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPCIHIEGARQHNLKNLTLDIPRDELVVVCGPSGSGKSTLAFDLVYAEGQRRYVESLS
CCCCCEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHH
AYARQFLPQMDKPDVDKIEGLSPAISLEQQSTSRNPRSTVGTVTEVYDFLRVFYARLGMM
HHHHHHCCCCCCCCHHHHCCCCCCEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHH
YCPKCGKPIAARAADEIIADILSMEQGTKFMVMAPLVEHQKGTHADRLKRLKAQGFVRIR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCHHHHHHHHHCCEEEEE
LNGEVMTLDEVPALEKNKKHSIDLVVDRLVLKDGIRGRLADSVELALRFGEGRLIVSIPG
ECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCEEEEEEECCCEEEEECCC
GAEQVHSTESVCPTCKLSLPPLSPQLFSFNSPQGACPRCSGIGSIDYFEPNLLAPNKGLS
CHHHHHCCHHCCCEEEEECCCCCCHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
LVSGGLLPWKNPKVFERYKPALEALGKELGFAADTPFREYSEKAWNALFHGEKETGWPGV
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHH
VLLLERGMQLGSQWRDELSRYRQSHPCPACDGARLKPEALAVRVDDLNISQFCSLSITRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
LEWLRGRDFRQSQAVIAEPLLKELTHRLGFMENVGLDYISLGRNMSTLSGGEAQRIRLAS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCCCCCCCCCCCHHHHHHHH
QLGSGLVGVTYVLDEPSIGLHPKDNERLIRTLRSLQKRGNTVLVVEHDEATILEADTVVE
HHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEE
LGPGSGMLGGEIVFNGSVKSLLSDSDSLTARYLRGEMTIPLPEKRRQGSGSIVLRGVTTN
ECCCCCCCCCEEEECCCHHHHHCCCCHHHHHHHCCCEECCCCHHHCCCCCCEEEEEEECC
NLQDIDCEIPLGALTCVTGPSGSGKSSLVVDSLYKHIALHQSIKVDSPGQIRGIDGLENI
CCCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHH
ERLVAIDQTPIGRTPRSNPATYTKIFDEIRNIFAMTPDARKRGYKPGRFSFNVRGGRCEA
HHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEECCCEEEE
CGGDGQIRVEMHFLPDIYVTCDVCGGKRYNHETLEVRYKGMNIADVLGMTVRQAKAFFEN
CCCCCEEEEEEEECCCEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHC
YPALERRLAVLEDVGLEYLRLGQPATTLSGGEAQRIKISRELGKRSLPGTLYILDEPTTG
CHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCEEEEEEHHHCCCCCCCEEEEEECCCCC
LHMHEVGKLIRVLHQLVDRGATVVVIEHNTDVIMAADTVIDLGPGGGEYGGRIVSSGTPE
CCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECEEEEECCCCCCCCCEEECCCCCH
EIMADPASVTGSFLKHEAVAVKAAGR
HHHCCCHHHHHHHHHHHEEEEEECCC
>Mature Secondary Structure 
SKPCIHIEGARQHNLKNLTLDIPRDELVVVCGPSGSGKSTLAFDLVYAEGQRRYVESLS
CCCCEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHH
AYARQFLPQMDKPDVDKIEGLSPAISLEQQSTSRNPRSTVGTVTEVYDFLRVFYARLGMM
HHHHHHCCCCCCCCHHHHCCCCCCEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHH
YCPKCGKPIAARAADEIIADILSMEQGTKFMVMAPLVEHQKGTHADRLKRLKAQGFVRIR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCHHHHHHHHHCCEEEEE
LNGEVMTLDEVPALEKNKKHSIDLVVDRLVLKDGIRGRLADSVELALRFGEGRLIVSIPG
ECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCEEEEEEECCCEEEEECCC
GAEQVHSTESVCPTCKLSLPPLSPQLFSFNSPQGACPRCSGIGSIDYFEPNLLAPNKGLS
CHHHHHCCHHCCCEEEEECCCCCCHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
LVSGGLLPWKNPKVFERYKPALEALGKELGFAADTPFREYSEKAWNALFHGEKETGWPGV
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHH
VLLLERGMQLGSQWRDELSRYRQSHPCPACDGARLKPEALAVRVDDLNISQFCSLSITRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
LEWLRGRDFRQSQAVIAEPLLKELTHRLGFMENVGLDYISLGRNMSTLSGGEAQRIRLAS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCCCCCCCCCCCHHHHHHHH
QLGSGLVGVTYVLDEPSIGLHPKDNERLIRTLRSLQKRGNTVLVVEHDEATILEADTVVE
HHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEE
LGPGSGMLGGEIVFNGSVKSLLSDSDSLTARYLRGEMTIPLPEKRRQGSGSIVLRGVTTN
ECCCCCCCCCEEEECCCHHHHHCCCCHHHHHHHCCCEECCCCHHHCCCCCCEEEEEEECC
NLQDIDCEIPLGALTCVTGPSGSGKSSLVVDSLYKHIALHQSIKVDSPGQIRGIDGLENI
CCCCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHH
ERLVAIDQTPIGRTPRSNPATYTKIFDEIRNIFAMTPDARKRGYKPGRFSFNVRGGRCEA
HHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEECCCEEEE
CGGDGQIRVEMHFLPDIYVTCDVCGGKRYNHETLEVRYKGMNIADVLGMTVRQAKAFFEN
CCCCCEEEEEEEECCCEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHC
YPALERRLAVLEDVGLEYLRLGQPATTLSGGEAQRIKISRELGKRSLPGTLYILDEPTTG
CHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCEEEEEEHHHCCCCCCCEEEEEECCCCC
LHMHEVGKLIRVLHQLVDRGATVVVIEHNTDVIMAADTVIDLGPGGGEYGGRIVSSGTPE
CCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECEEEEECCCCCCCCCEEECCCCCH
EIMADPASVTGSFLKHEAVAVKAAGR
HHHCCCHHHHHHHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]