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The map label for this gene is groEL

Identifier: 78357516

GI number: 78357516

Start: 2492742

End: 2494388

Strand: Reverse

Name: groEL

Synonym: Dde_2473

Alternate gene names: 78357516

Gene position: 2494388-2492742 (Counterclockwise)

Preceding gene: 78357517

Following gene: 78357515

Centisome position: 66.87

GC content: 57.44

Gene sequence:

>1647_bases
ATGGCTTCCAAAGAAATCGTTTTTGATACCAAGGCCCGTGAAAGACTGGCCCGCGGCGTGGACAAACTGGCCAACGCTGT
CAAGGTGACCCTCGGCCCCAAAGGCCGTAATGTTGTCATCGAAAAGTCCTTCGGCGCACCCGTCATCACCAAGGACGGTG
TTTCCGTAGCCAAGGAAATCGAGCTGGAAGACAAGTTCGAAAACATGGGCGCTCAGATGGTTAAGGAAGTTGCTTCCAAA
ACCTCCGACATCGCCGGTGACGGCACCACCACTGCAACCATTCTGGCTCAGGCCATCTACAAAGAAGGCGTAAAGCTGGT
GGCCGCAGGCCGTAACCCCATGGCCATCAAGCGTGGCGTGGACAAGGCCGTTGAAGCTCTGGTGAAGGAACTGGGCAACC
TTGCAAAGCCCACCCGCGACCAGAAGGAAATTGCTCAGGTCGGCACCATTTCCGCCAACTCCGACACCACCATCGGCAAC
ATCATTGCCGAAGCCATGAGCAAAGTGGGCAAGGAAGGCGTTATCACCGTTGAAGAAGCCAAAGGCCTCGAAACCACTCT
CGAAGTCGTGGAAGGCATGCAGTTCGACCGCGGCTACCTGTCCCCCTACTTCGTGACCGATCCTGAAAAGATGGTCTGCG
AAATGGACGAGCCTCTGATTCTCATCAACGAGAAGAAGATTTCCAGCATGAAAGACATGCTGCCCGTGCTTGAGCAGGTT
GCCAAGATGAACCGTCCGCTCGTGATCATCGCTGAAGATGTGGACGGCGAAGCTCTGGCCACTCTGGTTGTGAACAAGCT
GCGCGGCACCCTGCAGGTTGTGGCCGTCAAGGCTCCCGGCTTCGGCGAACGCCGCAAGGCCATGCTCGAAGACATCGCCA
CCCTTACCGGCGGCCGTGTGATCTCCGAAGAAATGGGCATCAAGCTTGAAAACGCCACCGTTGCCGATCTGGGTAACGCA
AAGCGCATCGTGGTGGACAAAGAAAACACCACCATCGTTGACGGCGCCGGTGAAAGCGAAGCCATCAAGGCCCGCGTGAA
AATGATCCGCGCTCAGATCGAAGAAACTTCCTCCGATTACGATCGTGAAAAGCTGCAGGAACGTCTGGCAAAGATCGTCG
GCGGTGTTGCCGTGATCAATGTGGGCGCAGCTACCGAAACCGAAATGAAGGAAAAGAAAGACCGCGTGGAAGACGCTCTG
AACGCTACCCGCGCTGCAGTGGAAGAAGGCATCGTCCCCGGTGGCGGTACCGCTCTGGTCCGTTGCTGCAAGGTGCTGGA
CGACGTGAAGCCCGCTGATGACGACGAAGCAGCAGGTGTCACCATCATCCGCCGCGCAATCGAAGAGCCCCTGCGTCAGA
TTGCTGCCAACGCCGGTTTCGAAGGCTCCATCATCTGCGAAAAGGTGAAGGAAGGCAAAGACGCTTTCGGCTTTAACGCT
GCCACCGGTGAGTTCGAAGACCTCATCGCCGCCGGCGTTATCGACCCCAAAAAGGTAAGCCGTATCGCTCTGCAGAACGC
CGCTTCCGTTGCTTCTCTGCTGCTCACCACCGAGTGCGCCATTGCAGAAAAGCCCAAAGAAGACGCTCCCGCTGCTCCCG
CCATGGGCGGCATGGGCGGCATGGGCGGTATGGGCGGCATGTACTAG

Upstream 100 bases:

>100_bases
CGTTGACCATCTGGTCATGCGTGAAGACGACATTCTGGCTATCATTCAGTAACTGACTTTCCCACTGACTTAGTCCTATC
CTTTCAGGAGGAGAAGAAAT

Downstream 100 bases:

>100_bases
TCGCTACGACTGGTCGCACCAACCGAACCTTCAGGGCCGGAGTTTACTCCGGCCCTTTTTTTGCGTTCGCTGTGCGCTTT
TGTTGTTTCTGCTGCCCGAC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MASKEIVFDTKARERLARGVDKLANAVKVTLGPKGRNVVIEKSFGAPVITKDGVSVAKEIELEDKFENMGAQMVKEVASK
TSDIAGDGTTTATILAQAIYKEGVKLVAAGRNPMAIKRGVDKAVEALVKELGNLAKPTRDQKEIAQVGTISANSDTTIGN
IIAEAMSKVGKEGVITVEEAKGLETTLEVVEGMQFDRGYLSPYFVTDPEKMVCEMDEPLILINEKKISSMKDMLPVLEQV
AKMNRPLVIIAEDVDGEALATLVVNKLRGTLQVVAVKAPGFGERRKAMLEDIATLTGGRVISEEMGIKLENATVADLGNA
KRIVVDKENTTIVDGAGESEAIKARVKMIRAQIEETSSDYDREKLQERLAKIVGGVAVINVGAATETEMKEKKDRVEDAL
NATRAAVEEGIVPGGGTALVRCCKVLDDVKPADDDEAAGVTIIRRAIEEPLRQIAANAGFEGSIICEKVKEGKDAFGFNA
ATGEFEDLIAAGVIDPKKVSRIALQNAASVASLLLTTECAIAEKPKEDAPAAPAMGGMGGMGGMGGMY

Sequences:

>Translated_548_residues
MASKEIVFDTKARERLARGVDKLANAVKVTLGPKGRNVVIEKSFGAPVITKDGVSVAKEIELEDKFENMGAQMVKEVASK
TSDIAGDGTTTATILAQAIYKEGVKLVAAGRNPMAIKRGVDKAVEALVKELGNLAKPTRDQKEIAQVGTISANSDTTIGN
IIAEAMSKVGKEGVITVEEAKGLETTLEVVEGMQFDRGYLSPYFVTDPEKMVCEMDEPLILINEKKISSMKDMLPVLEQV
AKMNRPLVIIAEDVDGEALATLVVNKLRGTLQVVAVKAPGFGERRKAMLEDIATLTGGRVISEEMGIKLENATVADLGNA
KRIVVDKENTTIVDGAGESEAIKARVKMIRAQIEETSSDYDREKLQERLAKIVGGVAVINVGAATETEMKEKKDRVEDAL
NATRAAVEEGIVPGGGTALVRCCKVLDDVKPADDDEAAGVTIIRRAIEEPLRQIAANAGFEGSIICEKVKEGKDAFGFNA
ATGEFEDLIAAGVIDPKKVSRIALQNAASVASLLLTTECAIAEKPKEDAPAAPAMGGMGGMGGMGGMY
>Mature_547_residues
ASKEIVFDTKARERLARGVDKLANAVKVTLGPKGRNVVIEKSFGAPVITKDGVSVAKEIELEDKFENMGAQMVKEVASKT
SDIAGDGTTTATILAQAIYKEGVKLVAAGRNPMAIKRGVDKAVEALVKELGNLAKPTRDQKEIAQVGTISANSDTTIGNI
IAEAMSKVGKEGVITVEEAKGLETTLEVVEGMQFDRGYLSPYFVTDPEKMVCEMDEPLILINEKKISSMKDMLPVLEQVA
KMNRPLVIIAEDVDGEALATLVVNKLRGTLQVVAVKAPGFGERRKAMLEDIATLTGGRVISEEMGIKLENATVADLGNAK
RIVVDKENTTIVDGAGESEAIKARVKMIRAQIEETSSDYDREKLQERLAKIVGGVAVINVGAATETEMKEKKDRVEDALN
ATRAAVEEGIVPGGGTALVRCCKVLDDVKPADDDEAAGVTIIRRAIEEPLRQIAANAGFEGSIICEKVKEGKDAFGFNAA
TGEFEDLIAAGVIDPKKVSRIALQNAASVASLLLTTECAIAEKPKEDAPAAPAMGGMGGMGGMGGMY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=51.9924098671727, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=51.9924098671727, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI5453607, Length=539, Percent_Identity=23.191094619666, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI38455427, Length=135, Percent_Identity=32.5925925925926, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=66.1625708884688, Blast_Score=694, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.4177693761815, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=49.2890995260664, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.2737642585551, Blast_Score=563, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322350, Length=549, Percent_Identity=24.0437158469945, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.561669829222, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.561669829222, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.4743833017078, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.4743833017078, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.4743833017078, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI17864606, Length=553, Percent_Identity=43.7613019891501, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=36.7041198501873, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=36.7041198501873, Blast_Score=335, Evalue=7e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_DESDG (Q30YH6)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388965.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q30YH6
- SMR:   Q30YH6
- STRING:   Q30YH6
- GeneID:   3757489
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2473
- NMPDR:   fig|207559.3.peg.3199
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- ProtClustDB:   PRK00013
- BioCyc:   DDES207559:DDE_2473-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58130; Mature: 57999

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKEIVFDTKARERLARGVDKLANAVKVTLGPKGRNVVIEKSFGAPVITKDGVSVAKEI
CCCCCEEECCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCHHHHHHH
ELEDKFENMGAQMVKEVASKTSDIAGDGTTTATILAQAIYKEGVKLVAAGRNPMAIKRGV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
DKAVEALVKELGNLAKPTRDQKEIAQVGTISANSDTTIGNIIAEAMSKVGKEGVITVEEA
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHH
KGLETTLEVVEGMQFDRGYLSPYFVTDPEKMVCEMDEPLILINEKKISSMKDMLPVLEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHH
AKMNRPLVIIAEDVDGEALATLVVNKLRGTLQVVAVKAPGFGERRKAMLEDIATLTGGRV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEMGIKLENATVADLGNAKRIVVDKENTTIVDGAGESEAIKARVKMIRAQIEETSSDY
EHHHHCCEECCCCCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKIVGGVAVINVGAATETEMKEKKDRVEDALNATRAAVEEGIVPGGGTALV
HHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RCCKVLDDVKPADDDEAAGVTIIRRAIEEPLRQIAANAGFEGSIICEKVKEGKDAFGFNA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCC
ATGEFEDLIAAGVIDPKKVSRIALQNAASVASLLLTTECAIAEKPKEDAPAAPAMGGMGG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MGGMGGMY
CCCCCCCC
>Mature Secondary Structure 
ASKEIVFDTKARERLARGVDKLANAVKVTLGPKGRNVVIEKSFGAPVITKDGVSVAKEI
CCCCEEECCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCEEECCCHHHHHHH
ELEDKFENMGAQMVKEVASKTSDIAGDGTTTATILAQAIYKEGVKLVAAGRNPMAIKRGV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
DKAVEALVKELGNLAKPTRDQKEIAQVGTISANSDTTIGNIIAEAMSKVGKEGVITVEEA
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHH
KGLETTLEVVEGMQFDRGYLSPYFVTDPEKMVCEMDEPLILINEKKISSMKDMLPVLEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHH
AKMNRPLVIIAEDVDGEALATLVVNKLRGTLQVVAVKAPGFGERRKAMLEDIATLTGGRV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEMGIKLENATVADLGNAKRIVVDKENTTIVDGAGESEAIKARVKMIRAQIEETSSDY
EHHHHCCEECCCCCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKIVGGVAVINVGAATETEMKEKKDRVEDALNATRAAVEEGIVPGGGTALV
HHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RCCKVLDDVKPADDDEAAGVTIIRRAIEEPLRQIAANAGFEGSIICEKVKEGKDAFGFNA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCC
ATGEFEDLIAAGVIDPKKVSRIALQNAASVASLLLTTECAIAEKPKEDAPAAPAMGGMGG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MGGMGGMY
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA