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The map label for this gene is fabF [H]

Identifier: 78357474

GI number: 78357474

Start: 2451902

End: 2453149

Strand: Direct

Name: fabF [H]

Synonym: Dde_2431

Alternate gene names: 78357474

Gene position: 2451902-2453149 (Clockwise)

Preceding gene: 78357473

Following gene: 78357475

Centisome position: 65.73

GC content: 60.34

Gene sequence:

>1248_bases
ATGACTGGAAAACGAGTAGTAGTAACCGGACTTGCCGCAATAACCCCGCTTGGCAACAATGTTGAAACCAGCTGGGAAAA
TCTCATTGCCGGAAAGTCCGGAATCGGGCCCATCACCCGTTTTGATGCCAGCGAATATACATCCCGCGTGGCGGGCGAGG
TAAAAGGCCTCGACCTGGGCGAGTATATTCCCCCCAAACAGGCACGCCGCATGGACCGCTTTACGCAGTACGCGGTGGCC
TGCGCCAAGCAGCTCATGAAGCACGCAGAATACACCGTGCCCGAAGAAACGGCCCATCGCGTGGCCTGTCTTCTGGGTGT
GGGGCTGGGCGGACTGGAAACCATCGAGCAGTTTCATACCAAACTGGTCGAAGCCGGTCCCAACCGCATCTCCCCCTTCA
TGATTCCCCAGCTTATCTCCAACATGGCCCCCGGCCAGATTGCCATGGAAATAGGCGCCAAAGGCGGCAACGTTGTGATG
ACCAGTGCATGCGCATCGGGCACCCACGCCATCGGCTATGCTTTTACCGAGGTAAAAGTGGGCCGCTACGACGCTGTGGT
CACCGGCGGTGCCGAATCCACCATCACCCCCATGGGCGTGTCCGGGTTCACAGCACTGCGTGCGCTTTCCACCGCAAGCA
ACGATGCCCCCGAAAAGGCTTCGCGTCCCTTTGATGCCAACCGTGACGGCTTTGTCATCGGCGAAGGCGCAGGGCTGCTG
CTGGTCGAATCGCTTGAGTCCGCCCGGGCCCGCGGGGCAACCATATACGCGGAAATCGTGGGCTTCGGCTCTTCGGACGA
CGCGTTTCATATGACCGCCCCCCGCGACGACGCCGAAGGCATGGCACGCGCCATGCTGATGGCCATTGAAGAAGCCGGCA
TCAGCCCCGCTGATGTGGACTGCATCAATGCCCACGGCACCTCGACACAGCTGAACGACAAGAGCGAAACACTGGCACTG
AAAAAAGTGTTCGGCGACCACGCGTCCAAGCTGCGCATCAGCGCCAACAAATCGCAGACGGGCCACCTGCTGGGGGCCGC
CGGCGGCGTGGAAGGCGTTTTCAGCTGTCTTACCCTTGCAACCGGCACCGTGCCCGGCACCGCAAACTATGAAACCCCCG
ACGAAGACTGCGACCTCAACTATATGGGTGGCGGTTCCGAGTCGTATCAGGCACAATACGTGCTGAGCAACTCCTTCGGC
TTCGGCGGCACCAACGCGTGCATGCTGTTCAAGCGCTGGGAAGGCTAA

Upstream 100 bases:

>100_bases
GGCTGCTGCGAAAAAGGCTTTTTTCCGCCCCCTGCCACCGGCCAGACCGGACACCGGACGGACGGCTTTTACGCCGCGTT
ATGCCCACGAGGAACATAGA

Downstream 100 bases:

>100_bases
TACCGAATCCCTCCGCCGCGCATCCCCCTGCGGGGTGCGCGGCATAACCACAACGCGGAGAGTGGAAACCATGGACGAAC
TGCTTATTCAGGATCCGGAA

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MTGKRVVVTGLAAITPLGNNVETSWENLIAGKSGIGPITRFDASEYTSRVAGEVKGLDLGEYIPPKQARRMDRFTQYAVA
CAKQLMKHAEYTVPEETAHRVACLLGVGLGGLETIEQFHTKLVEAGPNRISPFMIPQLISNMAPGQIAMEIGAKGGNVVM
TSACASGTHAIGYAFTEVKVGRYDAVVTGGAESTITPMGVSGFTALRALSTASNDAPEKASRPFDANRDGFVIGEGAGLL
LVESLESARARGATIYAEIVGFGSSDDAFHMTAPRDDAEGMARAMLMAIEEAGISPADVDCINAHGTSTQLNDKSETLAL
KKVFGDHASKLRISANKSQTGHLLGAAGGVEGVFSCLTLATGTVPGTANYETPDEDCDLNYMGGGSESYQAQYVLSNSFG
FGGTNACMLFKRWEG

Sequences:

>Translated_415_residues
MTGKRVVVTGLAAITPLGNNVETSWENLIAGKSGIGPITRFDASEYTSRVAGEVKGLDLGEYIPPKQARRMDRFTQYAVA
CAKQLMKHAEYTVPEETAHRVACLLGVGLGGLETIEQFHTKLVEAGPNRISPFMIPQLISNMAPGQIAMEIGAKGGNVVM
TSACASGTHAIGYAFTEVKVGRYDAVVTGGAESTITPMGVSGFTALRALSTASNDAPEKASRPFDANRDGFVIGEGAGLL
LVESLESARARGATIYAEIVGFGSSDDAFHMTAPRDDAEGMARAMLMAIEEAGISPADVDCINAHGTSTQLNDKSETLAL
KKVFGDHASKLRISANKSQTGHLLGAAGGVEGVFSCLTLATGTVPGTANYETPDEDCDLNYMGGGSESYQAQYVLSNSFG
FGGTNACMLFKRWEG
>Mature_414_residues
TGKRVVVTGLAAITPLGNNVETSWENLIAGKSGIGPITRFDASEYTSRVAGEVKGLDLGEYIPPKQARRMDRFTQYAVAC
AKQLMKHAEYTVPEETAHRVACLLGVGLGGLETIEQFHTKLVEAGPNRISPFMIPQLISNMAPGQIAMEIGAKGGNVVMT
SACASGTHAIGYAFTEVKVGRYDAVVTGGAESTITPMGVSGFTALRALSTASNDAPEKASRPFDANRDGFVIGEGAGLLL
VESLESARARGATIYAEIVGFGSSDDAFHMTAPRDDAEGMARAMLMAIEEAGISPADVDCINAHGTSTQLNDKSETLALK
KVFGDHASKLRISANKSQTGHLLGAAGGVEGVFSCLTLATGTVPGTANYETPDEDCDLNYMGGGSESYQAQYVLSNSFGF
GGTNACMLFKRWEG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=39.4230769230769, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=40.2366863905325, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=23.7089201877934, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=47.710843373494, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=38.4615384615385, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=34.4578313253012, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=38.1132075471698, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=430, Percent_Identity=23.953488372093, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=273, Percent_Identity=27.8388278388278, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=35.920177383592, Blast_Score=272, Evalue=9e-74,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=41.8269230769231, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI19920632, Length=432, Percent_Identity=24.537037037037, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221330659, Length=432, Percent_Identity=24.537037037037, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24581345, Length=437, Percent_Identity=25.4004576659039, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43530; Mature: 43398

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKRVVVTGLAAITPLGNNVETSWENLIAGKSGIGPITRFDASEYTSRVAGEVKGLDLG
CCCCEEEEEEHHHHCCCCCCCHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHCCCCCCCC
EYIPPKQARRMDRFTQYAVACAKQLMKHAEYTVPEETAHRVACLLGVGLGGLETIEQFHT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
KLVEAGPNRISPFMIPQLISNMAPGQIAMEIGAKGGNVVMTSACASGTHAIGYAFTEVKV
HHHHCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCHHEEEEEEEEE
GRYDAVVTGGAESTITPMGVSGFTALRALSTASNDAPEKASRPFDANRDGFVIGEGAGLL
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEE
LVESLESARARGATIYAEIVGFGSSDDAFHMTAPRDDAEGMARAMLMAIEEAGISPADVD
EEHHHHHHHHCCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCE
CINAHGTSTQLNDKSETLALKKVFGDHASKLRISANKSQTGHLLGAAGGVEGVFSCLTLA
EEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHH
TGTVPGTANYETPDEDCDLNYMGGGSESYQAQYVLSNSFGFGGTNACMLFKRWEG
CCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TGKRVVVTGLAAITPLGNNVETSWENLIAGKSGIGPITRFDASEYTSRVAGEVKGLDLG
CCCEEEEEEHHHHCCCCCCCHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHCCCCCCCC
EYIPPKQARRMDRFTQYAVACAKQLMKHAEYTVPEETAHRVACLLGVGLGGLETIEQFHT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
KLVEAGPNRISPFMIPQLISNMAPGQIAMEIGAKGGNVVMTSACASGTHAIGYAFTEVKV
HHHHCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCHHEEEEEEEEE
GRYDAVVTGGAESTITPMGVSGFTALRALSTASNDAPEKASRPFDANRDGFVIGEGAGLL
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEE
LVESLESARARGATIYAEIVGFGSSDDAFHMTAPRDDAEGMARAMLMAIEEAGISPADVD
EEHHHHHHHHCCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCE
CINAHGTSTQLNDKSETLALKKVFGDHASKLRISANKSQTGHLLGAAGGVEGVFSCLTLA
EEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHH
TGTVPGTANYETPDEDCDLNYMGGGSESYQAQYVLSNSFGFGGTNACMLFKRWEG
CCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]